PL1814843T3 - (2R)-enancjomer chlorku DOTAP - Google Patents
(2R)-enancjomer chlorku DOTAPInfo
- Publication number
- PL1814843T3 PL1814843T3 PL05802304T PL05802304T PL1814843T3 PL 1814843 T3 PL1814843 T3 PL 1814843T3 PL 05802304 T PL05802304 T PL 05802304T PL 05802304 T PL05802304 T PL 05802304T PL 1814843 T3 PL1814843 T3 PL 1814843T3
- Authority
- PL
- Poland
- Prior art keywords
- dotap
- enantiomer
- chloride
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/08—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to an acyclic carbon atom of an acyclic unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004057303A DE102004057303A1 (de) | 2004-11-26 | 2004-11-26 | Stabile Kristallmodifikationen von DOTAP Chlorid |
| PCT/EP2005/011874 WO2006056312A1 (de) | 2004-11-26 | 2005-11-07 | Stabile kristallmodifikationen von dotap chlorid |
| EP05802304.5A EP1814843B1 (de) | 2004-11-26 | 2005-11-07 | (2r)-enantiomer von dotap-chlorid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1814843T3 true PL1814843T3 (pl) | 2015-11-30 |
Family
ID=35789283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL05802304T PL1814843T3 (pl) | 2004-11-26 | 2005-11-07 | (2R)-enancjomer chlorku DOTAP |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US8853283B2 (pl) |
| EP (1) | EP1814843B1 (pl) |
| JP (1) | JP4880612B2 (pl) |
| KR (1) | KR101249370B1 (pl) |
| CN (2) | CN102796016B (pl) |
| AU (1) | AU2005309107B2 (pl) |
| BR (2) | BRPI0518489B8 (pl) |
| CA (1) | CA2589218C (pl) |
| DE (1) | DE102004057303A1 (pl) |
| ES (1) | ES2545906T3 (pl) |
| HK (1) | HK1178143A1 (pl) |
| HU (1) | HUE027554T2 (pl) |
| IL (1) | IL183324A (pl) |
| MX (1) | MX2007006128A (pl) |
| NO (1) | NO338885B1 (pl) |
| NZ (2) | NZ556060A (pl) |
| PL (1) | PL1814843T3 (pl) |
| PT (1) | PT1814843E (pl) |
| RU (1) | RU2463291C2 (pl) |
| WO (1) | WO2006056312A1 (pl) |
| ZA (1) | ZA200705169B (pl) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10347710B4 (de) | 2003-10-14 | 2006-03-30 | Johannes-Gutenberg-Universität Mainz | Rekombinante Impfstoffe und deren Verwendung |
| US7303881B2 (en) * | 2004-04-30 | 2007-12-04 | Pds Biotechnology Corporation | Antigen delivery compositions and methods of use |
| DE102005046490A1 (de) | 2005-09-28 | 2007-03-29 | Johannes-Gutenberg-Universität Mainz | Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen |
| US8877206B2 (en) * | 2007-03-22 | 2014-11-04 | Pds Biotechnology Corporation | Stimulation of an immune response by cationic lipids |
| EP2276495B1 (en) | 2008-04-17 | 2018-11-21 | PDS Biotechnology Corporation | Stimulation of an immune response by enantiomers of cationic lipids |
| CN108285422A (zh) * | 2011-05-20 | 2018-07-17 | 默克专利股份有限公司 | 稳定的dotap氯化物晶体变体 |
| CN103608033B (zh) | 2011-05-24 | 2016-06-15 | 生物技术公司 | 用于癌症的个体化疫苗 |
| ES2689799T3 (es) * | 2011-09-12 | 2018-11-15 | Pds Biotechnology Corporation | Formulaciones de vacunas particuladas |
| WO2013143555A1 (en) | 2012-03-26 | 2013-10-03 | Biontech Ag | Rna formulation for immunotherapy |
| US20150250872A1 (en) | 2012-09-21 | 2015-09-10 | Frank Bedu-Addo | Vaccine compositions and methods of use |
| EP2925348B1 (en) | 2012-11-28 | 2019-03-06 | BioNTech RNA Pharmaceuticals GmbH | Individualized vaccines for cancer |
| WO2014180490A1 (en) | 2013-05-10 | 2014-11-13 | Biontech Ag | Predicting immunogenicity of t cell epitopes |
| WO2016045732A1 (en) | 2014-09-25 | 2016-03-31 | Biontech Rna Pharmaceuticals Gmbh | Stable formulations of lipids and liposomes |
| WO2016128060A1 (en) | 2015-02-12 | 2016-08-18 | Biontech Ag | Predicting t cell epitopes useful for vaccination |
| WO2017059902A1 (en) | 2015-10-07 | 2017-04-13 | Biontech Rna Pharmaceuticals Gmbh | 3' utr sequences for stabilization of rna |
| AU2016354590B2 (en) | 2015-11-13 | 2023-11-23 | Pds Biotechnology Corporation | Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| DE4013632A1 (de) * | 1990-04-27 | 1991-10-31 | Max Planck Gesellschaft | Liposomen mit positiver ueberschussladung |
| DE19521412A1 (de) * | 1995-06-14 | 1996-12-19 | Boehringer Mannheim Gmbh | Neue kationische und polykationische Amphiphile, diese enthaltende Reagenzien und deren Verwendung |
| BR9709224A (pt) * | 1996-05-08 | 1999-08-10 | Nika Health Products Ltd | Virossomas catiônicos como sistema de tranferência para material genético |
| ATE228824T1 (de) * | 1996-09-13 | 2002-12-15 | Lipoxen Technologies Ltd | Liposomenzusammensetzung |
| US6458382B1 (en) * | 1999-11-12 | 2002-10-01 | Mirus Corporation | Nucleic acid transfer complexes |
| ES2183720B1 (es) * | 2001-06-18 | 2004-01-16 | Esteve Labor Dr | Procedimiento para la preparacion de derivados de 1,5-diaril-3-trifluorometil-delta2-pirazolinas racemicas y enantiomericamente puras. |
| ITMI20032185A1 (it) | 2003-11-12 | 2005-05-13 | Chemi Spa | Processo per la sintesi di lipidi cationici. |
-
2004
- 2004-11-26 DE DE102004057303A patent/DE102004057303A1/de not_active Withdrawn
-
2005
- 2005-11-07 WO PCT/EP2005/011874 patent/WO2006056312A1/de active Application Filing
- 2005-11-07 MX MX2007006128A patent/MX2007006128A/es active IP Right Grant
- 2005-11-07 BR BRPI0518489A patent/BRPI0518489B8/pt active IP Right Grant
- 2005-11-07 JP JP2007541742A patent/JP4880612B2/ja active Active
- 2005-11-07 ES ES05802304.5T patent/ES2545906T3/es active Active
- 2005-11-07 BR BR122019018186A patent/BR122019018186B8/pt active IP Right Grant
- 2005-11-07 EP EP05802304.5A patent/EP1814843B1/de active Active
- 2005-11-07 PL PL05802304T patent/PL1814843T3/pl unknown
- 2005-11-07 RU RU2007123673/04A patent/RU2463291C2/ru active
- 2005-11-07 AU AU2005309107A patent/AU2005309107B2/en active Active
- 2005-11-07 NZ NZ556060A patent/NZ556060A/en unknown
- 2005-11-07 KR KR1020077011691A patent/KR101249370B1/ko active IP Right Grant
- 2005-11-07 US US11/720,263 patent/US8853283B2/en active Active
- 2005-11-07 CN CN201210067110.0A patent/CN102796016B/zh active Active
- 2005-11-07 CA CA2589218A patent/CA2589218C/en active Active
- 2005-11-07 HU HUE05802304A patent/HUE027554T2/en unknown
- 2005-11-07 NZ NZ582382A patent/NZ582382A/en unknown
- 2005-11-07 PT PT58023045T patent/PT1814843E/pt unknown
- 2005-11-07 CN CNA2005800405153A patent/CN101065350A/zh active Pending
-
2007
- 2007-05-20 IL IL183324A patent/IL183324A/en active IP Right Grant
- 2007-06-25 NO NO20073286A patent/NO338885B1/no unknown
- 2007-06-25 ZA ZA200705169A patent/ZA200705169B/xx unknown
-
2013
- 2013-05-20 HK HK13105884.3A patent/HK1178143A1/zh unknown
-
2014
- 2014-09-02 US US14/474,789 patent/US9457087B2/en active Active
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