PL162918B1 - Base substance for therapeutical ointments and cosmetic creams and method of obtaining same - Google Patents

Abstract

1. Base for medicated ointments and cosmetic creams containing beeswax and olive oil, characterized by the fact that it consists of yellow beeswax, 95% or 70% ethyl alcohol and olive oil mixed in volumes: 150 parts. vol. wax, 150 parts vol. ethyl alcohol and 450-750 parts vol. olive oil. 2. A method of producing a base for therapeutic ointments and cosmetic creams consisting in melting and mixing ingredients, characterized in that up to 500 parts vol. olive oil is added with constant stirring, 150 parts. vol. molten yellow beeswax in the liquid phase and, with constant stirring, bring it to the wax melting point and then introduce 150 parts of it. vol. ethyl alcohol, while stirring and heating until a transparent liquid is obtained, then it is cooled down by stirring constantly and adding the remaining 200 parts. vol. olive oil until a solid base, the wax of which is the hardener, is obtained. PL

Description

The subject of the invention is a base for medicinal ointments and cosmetic creams and a method of its preparation.

From the publication of E. Sagarin (editor) .: Cosmetics. Science and technology, 1957,83, media containing beeswax and olive oil are known. The Greek physician Galen, who lived around 150 AD, is considered the inventor of the first cold cream. Galen devised the inclusion of water in a liquid (molten) mixture of beeswax and olive oil. The product, however, was unstable and became easily rancid. At that time, olive oil was replaced with sweet almond oil, and borax was introduced, followed by olbrot (spermaceti). According to the above publication, cold cream has the following composition:

Spermaceti (spermaceti) ............................... 12.5%

Beeswax (beeswax) ...................... 12.0

Almond oil (almond oil) ............... 56.0

Borax (borax) ........................................ 0.5

Rose water ...................... 5.0

Distilled water ...... 14-, 0

Rose oil ........................ wgpotreeby

From Polish Pharmacopeia, second edition, Pharmacopoea Polonica II. Warsaw, by the Society of Friends of Pharmaceutical Faculties and Branches at Universities in Poland. 1937. page 902, a softening ointment is known with the following composition:

Cetaceum (olbiro) ............................... 15 cc.

Cera alba (white wax) .......................... 8 pcs.

Oleum soybeans (soybean oil) ..................... 62 cc ..

Agua (water) ........................................ 15th part.

Oleum rosae (rose oil) ................. OJ part.

Broth and white wax cut into pieces, melt the cold water bath, add soybean oil and pour the melted mixture into a mortar. Add small amounts to the half-cooled mass, stirring and rubbing with warm water, and stir until it solidifies into a uniform ointment. then rose oil is added and mixed thoroughly. The softening ointment is white.

162 918

From the publication: Applied Pharmacy, edited by Adolf Fiebig, PZWL, Warsaw, 1987, W. Stożkowska. page 212, a softening ointment is known with the following composition:

Cetaceum (olbrot) ........................................ 15 part.

Cera alba (white wax) ................................... c.

Oleum rapae (rapeseed oil) ................... 62 part.

Agua (water) .............................................. ... 15zz.

Oleum levandulae (lavender oil) ....... 2 drops / 100g

According to of the German Pharmacopoeia (Deutsches Arzneibuch, Berlin, 1964) peanut oil is used. Melt lipophilic ingredients (spiked wax, white wax and rapeseed oil) in a water bath, and then gradually add warm water to the slightly cooled mass, stirring constantly. Levende oil is added to the combined phases. The ointment in the base gives the ointment its proper consistency.

The substrate according to the invention has the following composition:

Yellow beeswax ................................. 100 zz. Vol.

Etel alcohol 95% or 70% ................ 10 0 zzodbj.

Olive oil (oleum olivae) .................... 450-750 p. vol.

Due to the use of ethyl alcohol instead of water, the medium according to the invention is characterized by the splitting (dispersion) of a solid - yellow beeswax with 95% or 70% ethyl alcohol in an olive oil oil solvent in a water bath, in a liquid and transparent mixture, at the wax melting point. After cooling and mixing, the solid consistency of the base is obtained, which, thanks to the use of ethyl alcohol instead of water, is antiseptic. The substrates known from the literature are characterized by splitting (dispersion) with warm water, cooled, but previously melted in a water bath, of a mixture of dairy solids and beeswax in an oily solvent - almond, soybean or rapeseed oil.

Obtaining a substrate with excellent properties is possible thanks to the use of a new production method.

The method of producing the substrate according to the invention consists in the fact that up to 500 parts vol. olive oil is gradually introduced while stirring continuously 150 parts. vol. melted beeswax in a liquid phase water bath and bring the mixture of olive oil and wax to the melting point of the wax with constant stirring. Then 150 parts are gradually introduced. vol. ethyl alcohol of 95% or 70% and, with constant stirring, the mixture of olive oil, wax and ethyl alcohol is brought to the melting point of the wax. After obtaining a homogeneous, transparent liquid mixture at the melting point of the wax, it is cooled with constant stirring, the remaining 200 parts are added. vol. olive oil and mixed until a solid consistency is obtained.

The medium according to the invention serves as a basis for the preparation of a new form of drugs in the field of phytotherapy, absorbed through the skin and for use in research with drugs used in modern chemotherapy.

The substrate according to the invention is characterized by excellent properties, forming a very thin layer on the surface of the body, allowing easy and long-lasting penetration of medicinal substances into the body and their rapid absorption. In many cases, it can replace the oral administration of drugs.

Thanks to the use of ethyl alcohol for the production of the medium according to the invention, it is possible to use a liquid extract (extractum fluidum) of medicinal plants based on 95% or 70% ethyl alcohol as a carrier of medicinal substances and to obtain a new form of a drug absorbed through the skin - a dermatological lotion.

The method of making a dermatological lotion does not differ from the preparation of the base according to the invention. The consistency of the dermatological lotion can be changed to a semi-fluid and then a liquid consistency. The change in consistency is achieved by increasing the amount of the mixture of olive oil and liquid extract (extractum fluidum 1: 1) while maintaining the same amount of beeswax.

Example.

Yellow beeswax is used to prepare the substrate, which is previously melted in a water bath and filtered through a triple layer of gauze. The substrate is prepared in a water bath. Up to 500 parts vol. olive oil is gradually introduced while stirring continuously 150 parts. vol. molten

162,918 wax in the liquid phase and bring the olive oil and wax mixture to the melting point of the wax with constant stirring. Then 150 parts are gradually introduced. vol. ethyl alcohol of 95% or 70% and, with constant stirring, the mixture of olive oil, wax and ethyl alcohol is brought to the melting point of the wax. After obtaining a homogeneous, transparent liquid mixture at the melting point of the wax, it is cooled with constant stirring, the remaining 200 parts are added. vol. olive oil and mixed until a solid consistency is obtained.

The Publishing House of the Polish Patent Office. Circulation of 90 copies. Price: PLN 10,000

Claims (2)

Patent claims 1. Base for medicinal ointments and cosmetic creams containing beeswax and olive oil, characterized in that it consists of yellow beeswax, 95% or 70% ethyl alcohol and olive oil mixed in amounts by volume: 150 parts. vol. wax, 150 parts vol. ethyl alcohol and 450-750 parts vol. olive oil. 2. A method of producing a base for medicinal ointments and cosmetic creams by melting and mixing the ingredients, characterized in that up to 500 parts vol. olive oil is added with constant stirring, 150 parts vol. molten yellow beeswax in the liquid phase and, with constant stirring, it is heated to the wax melting point, and then 150 parts of vol. of ethyl alcohol, while stirring and heating until a liquid, transparent mixture is obtained, then it is cooled down, stirring continuously and adding the remaining 200 parts. vol. olive oil until the consistency of the base, the wax of which is the hardener, is obtained.