PL140258B1 - Method of obtaining novel derivatives of pyrazolopyridine - Google Patents
Method of obtaining novel derivatives of pyrazolopyridine Download PDFInfo
- Publication number
- PL140258B1 PL140258B1 PL24192183A PL24192183A PL140258B1 PL 140258 B1 PL140258 B1 PL 140258B1 PL 24192183 A PL24192183 A PL 24192183A PL 24192183 A PL24192183 A PL 24192183A PL 140258 B1 PL140258 B1 PL 140258B1
- Authority
- PL
- Poland
- Prior art keywords
- radical
- formula
- substituted
- aryl
- pattern
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 4
- 150000005229 pyrazolopyridines Chemical class 0.000 title claims 2
- -1 alkyl radical Chemical class 0.000 claims 24
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- 150000005840 aryl radicals Chemical class 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 125000003107 substituted aryl group Chemical group 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 150000003254 radicals Chemical class 0.000 claims 1
- 238000007363 ring formation reaction Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (2)
- Zastrzezenia patentowe 1. Sposób wytwarzania nowych pochodnych pirazolopirydyny o wzorze 1, w którym R oznacza rodnik alkilowy, podstawiony rodnik alkilowy, rodnik cykloalkilowy, rodnik cykloalkiloalki- lowy, rodnik alkenylowy, rodnik alkinylowy, rodnik arylowy, podstawiony rodnik arylowy, rod¬ nik aryloalkilowy lub podstawiony w grupie arylowej rodnik aryloalkilowy, Ftr oznacza atom wodoru lub rodnik alkilowy, R oznacza atom wodoru, D oznacza atom tlenu lub grupe NR , R oznacza atom wodoru, rodnik alkilowy, podstawiony rodnik alkilowy, rodnik cykloalkilowy, ro¬ dnik cykloalkiloalkilowy, rodnik alkenylowy, rodnik alkinylowy, rodnik arylowy, podstawiony rodnik arylowy, rodnik aryloalkilowy, podstawiony w grupie arylowej rodnik aryloalkilowy lub podstawiony grupa okso w grupie alkilowej rodnik aryloalkilowy, n oznacza 1 lub 2, R' ozna¬ cza atom wodoru, rodnik alkilowy, arylowy, podstawiony rodnik arylowy, rodnik aryloalkilowy 7 lub podstawiony w grupie arylowej rodnik aryloalkilowy, a R oznacza atom wodoru, rodnik al¬ kilowy, rodnik arylowy, podstawiony rodnik arylowy, rodnik aryloalkilowy lub podstawiony w grupie arylowej rodnik aryloalkilowy, oraz ich farmaceutycznie dopuszczalnych soli addy¬ cyjnych z kwasami, znamienny tym, ze zwiazek o wzorze 5, w którym R , R , R , R , n i D maja znaczenie wyzej podane, poddaje sie wewnetrznej cyklizacji w temperaturze 150-250°, po czym w przypadku otrzymania zwiazku o wzorze 1 w postaci wolnej zasady zwiazek o wzorze 1 ewentualnie poddaje sie reakcji z kwasem zawierajacym farmaceutycznie dopuszczal¬ ny anion*
- 2. Sposób wedlug zastrz* 1, znamienny tym, ze reakcje prowadzi sie w obe¬ cnosci ZnClp* 3# Sposób wedlug zastrz* 1 albo 2, znamienny tym, ze cyklizacji poddaje sie zwiazek o wzorze 5, w którym R oznacza rodnik n-pentylowy, Ir, R' i R8 oznaczaja atomy wodoru, n oznacza 1, a D oznacza grupe NR , w której R oznacza rodnik n-propylowy#140 258 # R7 R8 WZÓR 1 WZÓR 2 R3 CN O Ja R7 R8 WZÓR 4 NsJ\ R1 H R7 F R1 H R7 R8 NT\ K I, NH2 WZÓR 5 R' WZÓR3 NH2 O r N^,JkN^H4 /\ 1 R7 R8 WZÓR 61fcO 258 N— CH2—<] WZÓR 7 N—CH0— ~\ / WZÓR 8 OMe Cl / N —CH0— WZÓR 9 WZdR 11 / CR N—CH,— "\ fi N—CHo— •Me WZÓR 10 WZdR 12 / Cl N—ChL— ~\ / ¦Cl WZÓR 13 WZÓR 14140 253 Cl WZÓR 15 WZÓR 16 WZÓR 17 Pracownia PoligiaGczna UP PRL. Naklad 100 egz. Cena 130 zl PL
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL24192183A PL140258B1 (en) | 1983-05-11 | 1983-05-11 | Method of obtaining novel derivatives of pyrazolopyridine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL24192183A PL140258B1 (en) | 1983-05-11 | 1983-05-11 | Method of obtaining novel derivatives of pyrazolopyridine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL241921A1 PL241921A1 (en) | 1985-03-12 |
| PL140258B1 true PL140258B1 (en) | 1987-04-30 |
Family
ID=20016993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL24192183A PL140258B1 (en) | 1983-05-11 | 1983-05-11 | Method of obtaining novel derivatives of pyrazolopyridine |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL140258B1 (pl) |
-
1983
- 1983-05-11 PL PL24192183A patent/PL140258B1/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL241921A1 (en) | 1985-03-12 |
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