PH26078A - Oral compositions - Google Patents
Oral compositions Download PDFInfo
- Publication number
- PH26078A PH26078A PH39660A PH39660A PH26078A PH 26078 A PH26078 A PH 26078A PH 39660 A PH39660 A PH 39660A PH 39660 A PH39660 A PH 39660A PH 26078 A PH26078 A PH 26078A
- Authority
- PH
- Philippines
- Prior art keywords
- alumina trihydrate
- microns
- weight
- particle size
- average particle
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 17
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 28
- 150000004684 trihydrates Chemical class 0.000 claims description 24
- 239000002245 particle Substances 0.000 claims description 16
- 150000003752 zinc compounds Chemical class 0.000 claims description 5
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims description 4
- 229940068475 zinc citrate Drugs 0.000 claims description 4
- 235000006076 zinc citrate Nutrition 0.000 claims description 4
- 239000011746 zinc citrate Substances 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 239000000606 toothpaste Substances 0.000 description 10
- 239000000551 dentifrice Substances 0.000 description 5
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 4
- 229910052782 aluminium Inorganic materials 0.000 description 4
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 4
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 239000004411 aluminium Substances 0.000 description 3
- 229940091249 fluoride supplement Drugs 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 229940034610 toothpaste Drugs 0.000 description 3
- 239000011701 zinc Substances 0.000 description 3
- 229910052725 zinc Inorganic materials 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229940074371 monofluorophosphate Drugs 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000004131 Bayer process Methods 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 102100038644 Four and a half LIM domains protein 2 Human genes 0.000 description 1
- 101001031714 Homo sapiens Four and a half LIM domains protein 2 Proteins 0.000 description 1
- MXRIRQGCELJRSN-UHFFFAOYSA-N O.O.O.[Al] Chemical compound O.O.O.[Al] MXRIRQGCELJRSN-UHFFFAOYSA-N 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 239000004141 Sodium laurylsulphate Substances 0.000 description 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229910021502 aluminium hydroxide Inorganic materials 0.000 description 1
- 230000002272 anti-calculus Effects 0.000 description 1
- 230000000675 anti-caries Effects 0.000 description 1
- 230000002882 anti-plaque Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 229940000425 combination drug Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- YRIUSKIDOIARQF-UHFFFAOYSA-N dodecyl benzenesulfonate Chemical compound CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 YRIUSKIDOIARQF-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000009852 extractive metallurgy Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- VMXUWOKSQNHOCA-UKTHLTGXSA-N ranitidine Chemical compound [O-][N+](=O)\C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-UKTHLTGXSA-N 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- VSJRDSLPNMGNFG-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate;trihydrate Chemical compound O.O.O.[Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O VSJRDSLPNMGNFG-UHFFFAOYSA-H 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 229940085658 zinc citrate trihydrate Drugs 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
DRAL COMPOSITIONS
This invention relates to oral compositions, more : particulary to oral compositions comprising as an abrasive cleaning agent particles of alumina trihydrate a (A1,0,3H,0), sometimes referred to as aluminium trihydrate or aluminium hydroxide. . Alumina trihydrate is a well-known abrasive agent of aral compositions such as toothpastes. It is made by the Bayer process which produces a coarse grade of material which is then milled to a particle size appropriate for use in oral composition.
In GR-A-1 277 58% (Unilever) it is disclosed that toothpastes containing milled alumina trihydrate can cause corrosion of aluminium toothpaste tubes and that 18 sodium monofluorophosphate and other sources of monofluorophosphate ions are effective to inhibit this corrosion. Certain phosphate esters are also disclosed as being effective in GB-A-1 4705 252 (Colgate-
Falmolive). The presence of certain materials during the milling process as disclosed in GR-A-1 537 823 (British Aluminium Co., Ltd.) and GR-A-) G44 337 (Colgate-Falmolive) is said to modify the surface of the milled alumina trihydrate particles and make them more suitable for inclusion in toothpastes contained in aluminium tubes. 1t is nowadays common to include sodium monofluo-
raphosphate in dentifrices as & source of fluoride to protect the teeth against dental caries. : be have determined that there is some interaction between sodium monofluorophosphate and an alumina 3 trihydrate abrasive resulting in a loss of scluble fluoride on storage of a dentifrice, which is more marked at elevated temperatures. Thus, there may be some loss of anti-caries efficacy of such toothpastes. t
It has now been discovered that the stability of monofluorophosphate in dentifrices containing an alumina trihydrate abrasive, and also containing zinc citrate, is surprisingly improved if instead of employing a milled alumina trihydrate there is used an unmilled precipitated alumina trihydrate of appropriate particle size. The stability of soluble zinc in the dentifrice is also improved. Zinc citrate is a know anti-calculus and anti-plaque agent (see US-A-4 100 269 (Lever Rrothers Co.) fccordingly the invention relates to an oral composition comprising 20 te 70% by weight of an unmilled precipitated alumina trihydrate of average particle size 3 to 15 microns, preferably 5 to 10 microns, sodium monofluorophosphate in an amount of 0.1 to 2% by weight and zinc citrate in an amount of 0.032 2% toy 5% by weight.
The alumina abrasive used in oral compositions of thie invention is made by a precipitation process which mf)
: is a modification of that conventionally used to produce very fine alumina precipitates of average particle size 1-2 microns and helow, in which process the precipitation conditions are varied so as to allow 3 the growth of larger crystal aggresgates. A suitable method to prepare the aluminas is described by J. Scott in a paper, "The effect of Seed and Temperature on the
Farticle Size of Bayer Hydrate", presented at the
International Symposium on the Extractive Metallurgy of
Aluminium, New York February 1962.
As indicated above, it has been found that the unmilled precipitated alumina abrasive has improved compatibility with scluble zinc and therefore in accordance with a further aspect of the invention there iz provided an oral composition comprising in combina- tion an unmilled precipitated alumina trihydrate abrasive and a water-soluble zinc compound. It is well known to include water-secluble zinc compounds in oral compositions. Many are disclosed in ua-A-4 100 269 referred to above. Others are disclosed in US-A-4 022 880, US-A-4 144 323, US-A-4 656 031 and US-A-4 160 821.
The amount of the zinc compound may he from about 0.02% to about 5% by weight of the oral composition.
Oral composition of the invention will also contain other conventional ingredients. These in the form of a dentifrice cream or gel will usually contain an humectant liquid, a surface-active agent, a binder = 5 a=
' ’ 26078 or thickener and flavour. Other minor ingredients may also be present, such as up to 1% by weight of 2°, 4, 4 —-trichlora-2-hydrosy-diphenylether as antimicrobial agent.
Ti In GE-A-2 009 5396 (Unilever) there is described a toothpaste containing MRF and alumina trihydrate abrazive but not containing zinc ion-producing compounds, wherein the abrasive consists of a mixture . of arn alumina trihydrate baving an average particle 149 size of from 3 to 13 microns and an alumina trihydrate having an average particle size of less than 1 micron, the weight ratic of the two alumina trihydratez being from 30:70 to 70:30. The sub-micron alumina trihydrate described has an average particle size of 0.2 to 0.9 micron, particularly about 0.5% micron. It is produced commercially as a fine precipitate and not by grinding larger particles.
The following experiments illustrate the inven-— tion. Fercentages are by weight.
Toothpastes were made having the following composition.
Ingredient %
Alumina Trihydrate GOL 0
Sorbitol syrup (70% solution) 27.0 28 Sodium lauryl sulphate 1.875
Sadium dodecylbenzene sulphonate 0.6 = fy mm
Spdium carboxymethylcellulose 0.8
Zinc citrate trihydrate 0.3
Sodium monofluorophosphate 0.8%
Flavour 1.2 a Sadium saccharin 0.2
Formalin 0.04
Calour . * 21.006
Water to 100.0
A number of toothpastes were formulated using the different grades of alumina trihydrate mentioned below: ' 1. Milled alumina trihydrate of average particle size 6-8 microns (available commercially from EA
Chemicals as AF 280). 2, Milled alumina trihydrate of average particle size about 10 microns (available commercially from
BA Chemicals as AF 240). 3. A precipitated {not milled) alumina trihydrate of average particle size about 6 microns. : The respective toothpastes were stored at 37°C for & months. The amount of water-soluble fluoride available after storage expressed as a percentage of that available immediately after manufacture is indicated in the Table below. The percentage of soluble zinc is also given in the Table.
Abrasive present “FE A In
Milled alumina trihydrate, a1 48 aps¥ 6-8 microns
Milled alumina trihydrate, 2 37 = aps about 19 microns
Frecipitated alumina trihydrate, 29 54 aps about & microns ¥ average particle size
The results show the superior properties of the toothpaste according to this invention.
Claims (3)
1. 6n oral composition comprising 0.1-2% by weight of sodium monoflucrophosphate, 0.02-5% by weight of a water-soluble zinc compound and from 20-70% by weight of an unmilled precipitated alumina trihydrate with an average particle size of between 3X and 15 microns.
2. A composition according to claim 1. wherein
. the zinc compound is zinc citrate.
3. A composition according to claim 1, wherein the alumina trihydrate has an average particle size of between 5B and 10 microns. KENNETH ARTHUR EVANS PAUL. TAN RILEY BRIAN ROSSALL Inventors
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PH39660A PH26078A (en) | 1989-12-08 | 1989-12-08 | Oral compositions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PH39660A PH26078A (en) | 1989-12-08 | 1989-12-08 | Oral compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH26078A true PH26078A (en) | 1992-02-06 |
Family
ID=19935793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH39660A PH26078A (en) | 1989-12-08 | 1989-12-08 | Oral compositions |
Country Status (1)
| Country | Link |
|---|---|
| PH (1) | PH26078A (en) |
-
1989
- 1989-12-08 PH PH39660A patent/PH26078A/en unknown
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