PH26014A - Water dispersible gemfibrozil compositions - Google Patents
Water dispersible gemfibrozil compositions Download PDFInfo
- Publication number
- PH26014A PH26014A PH39964A PH39964A PH26014A PH 26014 A PH26014 A PH 26014A PH 39964 A PH39964 A PH 39964A PH 39964 A PH39964 A PH 39964A PH 26014 A PH26014 A PH 26014A
- Authority
- PH
- Philippines
- Prior art keywords
- gemfibrozil
- wax
- water
- finely divided
- hydrophilic material
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 40
- HEMJJKBWTPKOJG-UHFFFAOYSA-N Gemfibrozil Chemical compound CC1=CC=C(C)C(OCCCC(C)(C)C(O)=O)=C1 HEMJJKBWTPKOJG-UHFFFAOYSA-N 0.000 title claims abstract description 20
- 229960003627 gemfibrozil Drugs 0.000 title claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims description 7
- 238000009472 formulation Methods 0.000 claims abstract description 20
- 239000002245 particle Substances 0.000 claims abstract description 18
- 239000000463 material Substances 0.000 claims abstract description 15
- 239000004094 surface-active agent Substances 0.000 claims abstract description 5
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 10
- 238000013268 sustained release Methods 0.000 claims description 8
- 239000012730 sustained-release form Substances 0.000 claims description 8
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 5
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 4
- 239000000194 fatty acid Substances 0.000 claims description 4
- 229930195729 fatty acid Natural products 0.000 claims description 4
- -1 fatty acid alcohols Chemical class 0.000 claims description 4
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 4
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 229920005862 polyol Polymers 0.000 claims description 2
- 150000003077 polyols Chemical class 0.000 claims description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 2
- 235000004443 Ricinus communis Nutrition 0.000 claims 1
- 239000001993 wax Substances 0.000 description 8
- 239000011248 coating agent Substances 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 239000000306 component Substances 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 3
- 239000004200 microcrystalline wax Substances 0.000 description 3
- 235000019808 microcrystalline wax Nutrition 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 206010013911 Dysgeusia Diseases 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 239000008199 coating composition Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 239000004014 plasticizer Substances 0.000 description 2
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 229940068968 polysorbate 80 Drugs 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- LGJMUZUPVCAVPU-ANOYILKDSA-N (3s,8r,9s,10s,13r,14s,17r)-17-[(2r,5s)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-ol Chemical class C1CC2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@H](CC)C(C)C)[C@@]1(C)CC2 LGJMUZUPVCAVPU-ANOYILKDSA-N 0.000 description 1
- 229920002126 Acrylic acid copolymer Polymers 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 1
- 208000035150 Hypercholesterolemia Diseases 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 229940111131 antiinflammatory and antirheumatic product propionic acid derivative Drugs 0.000 description 1
- 239000008365 aqueous carrier Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003613 bile acid Substances 0.000 description 1
- 210000005178 buccal mucosa Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000006194 liquid suspension Substances 0.000 description 1
- 229920003146 methacrylic ester copolymer Polymers 0.000 description 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
- 239000008180 pharmaceutical surfactant Substances 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000447 polyanionic polymer Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 150000005599 propionic acid derivatives Chemical class 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000015500 sitosterol Nutrition 0.000 description 1
- 229940083492 sitosterols Drugs 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000003784 tall oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Paints Or Removers (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Laminated Bodies (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Detergent Compositions (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/305,081 US4971804A (en) | 1989-02-02 | 1989-02-02 | Water dispersible gemfibrozil compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH26014A true PH26014A (en) | 1992-01-29 |
Family
ID=23179247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH39964A PH26014A (en) | 1989-02-02 | 1990-01-30 | Water dispersible gemfibrozil compositions |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4971804A (de) |
| EP (1) | EP0381220B1 (de) |
| JP (1) | JPH02240016A (de) |
| CN (1) | CN1044591A (de) |
| AT (1) | ATE89720T1 (de) |
| AU (1) | AU623731B2 (de) |
| CA (1) | CA2009136A1 (de) |
| DE (1) | DE69001682T2 (de) |
| DK (1) | DK0381220T3 (de) |
| ES (1) | ES2055178T3 (de) |
| FI (1) | FI900490A0 (de) |
| HU (1) | HU204193B (de) |
| IE (1) | IE900370L (de) |
| IL (1) | IL92993A (de) |
| NO (1) | NO900482L (de) |
| NZ (1) | NZ232323A (de) |
| PH (1) | PH26014A (de) |
| PT (1) | PT93027A (de) |
| ZA (1) | ZA90773B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6056992A (en) * | 1988-06-02 | 2000-05-02 | Campbell Soup Company | Encapsulated additives |
| US5290569A (en) * | 1990-04-12 | 1994-03-01 | Shionogi & Co., Ltd. | Coated composition and its preparation process |
| EP0462067A1 (de) * | 1990-06-15 | 1991-12-18 | Warner-Lambert Company | Gemfibrozil-Formulierung |
| EP0475894A1 (de) * | 1990-08-27 | 1992-03-18 | Warner-Lambert Company | Verbesserte Gemfibrozil-Formulierungen |
| US5190775A (en) * | 1991-05-29 | 1993-03-02 | Balchem Corporation | Encapsulated bioactive substances |
| US5358723A (en) * | 1991-11-26 | 1994-10-25 | Warner-Lambert Company | Process and composition for the development of controlled release gemfibrozil dosage form |
| US5492700A (en) * | 1991-11-26 | 1996-02-20 | Warner-Lambert Company | Process and composition for the development of controlled release gemfibrozil dosage form |
| US5430021A (en) * | 1994-03-18 | 1995-07-04 | Pharmavene, Inc. | Hydrophobic drug delivery systems |
| HU212428B (en) * | 1994-05-13 | 1996-06-28 | Egyt Gyogyszervegyeszeti Gyar | Process to prepare pharmaceutical compositions containing gemfibrozyl |
| JP3466921B2 (ja) * | 1998-06-03 | 2003-11-17 | 大塚製薬株式会社 | 味マスキング医薬製剤 |
| US20050265955A1 (en) * | 2004-05-28 | 2005-12-01 | Mallinckrodt Inc. | Sustained release preparations |
| CN101081213B (zh) * | 2007-06-26 | 2010-10-06 | 中山大学 | 丁二酸(5-雄甾烯-17-酮-3β-羟基)二酯固体分散体及其制备方法与应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4132753A (en) * | 1965-02-12 | 1979-01-02 | American Cyanamid Company | Process for preparing oral sustained release granules |
| FR2284318A1 (fr) * | 1974-09-13 | 1976-04-09 | Rech Ind Therapeutiqu | Compositions d'antibiotiques du type virginiamycine pour administration orale |
| US4291016A (en) * | 1976-07-27 | 1981-09-22 | Sandoz Ltd. | Enteric coated mixture of 4-(2-hydroxy-3-isopropylamino-propoxy) indole and sodium lauryl sulphate |
| US4195084A (en) * | 1977-01-07 | 1980-03-25 | Eli Lilly And Company | Taste-stable aqueous pharmaceutical suspension of tall oil sitosterols and a method for the preparation thereof |
| IT1101649B (it) * | 1978-12-15 | 1985-10-07 | Lehner Ag | Composizione farmaceutica ad azione prolungata contenente acidi biliari |
| JPS57171428A (en) * | 1981-04-13 | 1982-10-22 | Sankyo Co Ltd | Preparation of coated solid preparation |
| JPS59193831A (ja) * | 1983-04-18 | 1984-11-02 | Sankyo Co Ltd | 腸溶性製剤の製造法 |
| HU190619B (en) * | 1983-11-11 | 1986-09-29 | Bezzegh,Denes,Hu | Process for producing tablets with controlled dissolution of active ingredients |
| JPS60248541A (ja) * | 1984-05-24 | 1985-12-09 | Ckd Corp | シ−ト状部材の搬送方法およびその装置 |
| JPS6175703A (ja) * | 1984-09-19 | 1986-04-18 | Hitachi Ltd | 搬送ステ−シヨン |
| US4797288A (en) * | 1984-10-05 | 1989-01-10 | Warner-Lambert Company | Novel drug delivery system |
| JPH07106977B2 (ja) * | 1984-12-14 | 1995-11-15 | ゲルゲリイ、ゲルハルト | 疎水性又は難溶性物質の粒子の親水化の方法 |
| DE3678644D1 (de) * | 1985-08-16 | 1991-05-16 | Procter & Gamble | Wirkstoffpartikel mit sowohl kontinuierlicher als auch schneller freisetzung. |
| US4853249A (en) * | 1985-11-15 | 1989-08-01 | Taisho Pharmaceutical Co., Ltd. | Method of preparing sustained-release pharmaceutical/preparation |
| US4778676A (en) * | 1985-12-20 | 1988-10-18 | Warner-Lambert Company | Confectionery delivery system for actives |
-
1989
- 1989-02-02 US US07/305,081 patent/US4971804A/en not_active Expired - Fee Related
-
1990
- 1990-01-08 IL IL9299390A patent/IL92993A/en not_active IP Right Cessation
- 1990-01-30 PH PH39964A patent/PH26014A/en unknown
- 1990-01-31 FI FI900490A patent/FI900490A0/fi not_active Application Discontinuation
- 1990-01-31 NZ NZ232323A patent/NZ232323A/en unknown
- 1990-02-01 JP JP2020551A patent/JPH02240016A/ja active Pending
- 1990-02-01 AU AU48993/90A patent/AU623731B2/en not_active Ceased
- 1990-02-01 PT PT93027A patent/PT93027A/pt unknown
- 1990-02-01 CA CA002009136A patent/CA2009136A1/en not_active Abandoned
- 1990-02-01 IE IE900370A patent/IE900370L/xx unknown
- 1990-02-01 HU HU90639A patent/HU204193B/hu unknown
- 1990-02-01 ZA ZA90773A patent/ZA90773B/xx unknown
- 1990-02-01 EP EP90102023A patent/EP0381220B1/de not_active Expired - Lifetime
- 1990-02-01 AT AT90102023T patent/ATE89720T1/de not_active IP Right Cessation
- 1990-02-01 DE DE9090102023T patent/DE69001682T2/de not_active Expired - Fee Related
- 1990-02-01 ES ES90102023T patent/ES2055178T3/es not_active Expired - Lifetime
- 1990-02-01 DK DK90102023.0T patent/DK0381220T3/da active
- 1990-02-01 NO NO90900482A patent/NO900482L/no unknown
- 1990-02-02 CN CN90100780A patent/CN1044591A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NZ232323A (en) | 1992-04-28 |
| US4971804A (en) | 1990-11-20 |
| HU204193B (en) | 1991-12-30 |
| EP0381220A2 (de) | 1990-08-08 |
| HUT52951A (en) | 1990-09-28 |
| HU900639D0 (en) | 1990-04-28 |
| AU4899390A (en) | 1990-08-09 |
| ES2055178T3 (es) | 1994-08-16 |
| NO900482D0 (no) | 1990-02-01 |
| NO900482L (no) | 1990-08-03 |
| PT93027A (pt) | 1990-08-31 |
| DE69001682D1 (de) | 1993-07-01 |
| AU623731B2 (en) | 1992-05-21 |
| FI900490A0 (fi) | 1990-01-31 |
| IL92993A (en) | 1994-04-12 |
| ATE89720T1 (de) | 1993-06-15 |
| DK0381220T3 (da) | 1993-06-14 |
| JPH02240016A (ja) | 1990-09-25 |
| IE900370L (en) | 1990-08-02 |
| EP0381220A3 (en) | 1990-12-05 |
| IL92993A0 (en) | 1990-09-17 |
| ZA90773B (en) | 1991-10-30 |
| CN1044591A (zh) | 1990-08-15 |
| EP0381220B1 (de) | 1993-05-26 |
| DE69001682T2 (de) | 1993-09-16 |
| CA2009136A1 (en) | 1990-08-02 |
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