PH22114A - New substituted 2,3-alkylene bis(oxy) benzamides, their derivatives, pharmaceutical compositions containing same and method of use thereof - Google Patents
New substituted 2,3-alkylene bis(oxy) benzamides, their derivatives, pharmaceutical compositions containing same and method of use thereofInfo
- Publication number
- PH22114A PH22114A PH20078A PH20078A PH22114A PH 22114 A PH22114 A PH 22114A PH 20078 A PH20078 A PH 20078A PH 20078 A PH20078 A PH 20078A PH 22114 A PH22114 A PH 22114A
- Authority
- PH
- Philippines
- Prior art keywords
- substd
- opt
- alkyl
- alkenyl
- forms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/02—Seven-membered rings
- C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
2,3-Alkylenedioxybenzamides of formula (I) and their acid -addn. salts, quat. ammonium salts, oxides and optical isomers are new. In (I), A is 1-3C alkylene opt. substd by 1-4C alkyl, 2-4C alkenyl or 1-4C hydroxyalkyl. R is H, 1-4C alkyl or -B-NR1R2; B is a direct bond or a 1-3C alkylene gp. opt. substd. by 1-4C alkyl or 2-4C alkenyl; R1 is H, 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl, substd. alkyl, or forms a heterocyclic ring with B, and R2 is H, 1-4C alkyl, 2-4C alkenyl or alkynyl, substd. alkyl, an opt. substd. heterocyclic gp., or a phenyl, adamantyl, cycloalkyl, bicycloalkyl or cycloalkenyl gp. bonded directly to the N atom or via an opt. substd. alkylene chain, or NR1R2 is a heterocycle opt. contg. other heteroatoms (including NR'', where R'' is H- 1-4C alkyl, 2-4C alkenyl or alkynyl, phenyl, benzyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl, adamantyl, bicycloalkyl or alkyl substd by OH, SH, acyl, thioacyl, alkoxy or alkylthio). - R' is H, 1-4c alkyl, 2-4C alkenyl or alkynyl, adamantyl, pyrimidinyl, pyrazinyl, diazepinyl, quinuclidinyl, azabicycloalkyl, diazabicycloalkyl, bicycloalkyl, or opt. substd. phenyl or aralkyl, or R'+B forms an opt. substd. heterocycle contg. a single N atom, or R'+R1 forms an opt. substd. heterocycle contg. two heteroatoms, X is H, halogen, OH, 1-4C alkoxy, 1-4C alkyl, amino opt. mono- or disubstd. by 1-4C alkyl, acyl, aralkyl, furyl, pyranyl or alkoxycacarbonyl, or forms an A' chain with Y. Y is as defined for X or is NO2, 1-4C alkylsulphonyl, adamantyl-sulphonyl, cycloalkyl sulphonyl or SO2NR3R'; R3 and R4 are H, 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl, phenyl, benzyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl, bicycloalkyl, adamantyl, pyrimidinyl, pyrazinyl, or alkyl substd. by OH, SH, acyl, thioacyl, alkoxy or alkylthio, or NR3R4 is an opt. substd. heterocycle opt. congt. another heteroatom; or Y forms an A chain with X or Z. Z is as defined for X or is NO2, or forms an A chain with Y. A is a carbon chain opt. substd. or opt. interrupted by one or more opt. substd. heteroatoms. - Cpds. (I) have anxiolytic, antidepressant and antiemetic activity with little or no cataleptic activity. A typical cpd. of N-(1-allyl-2-pyrrolidinylmethyl)-7-methylsulphamoyl-1, 4-benzodioxan-5-carboxamide. In an example, this is prepd. from 1,4-benzodioxan-5-carboxylic acid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7623835A FR2360305A1 (en) | 1976-08-04 | 1976-08-04 | NEW 2,3-ALKYLENE BIS (OXY) BENZAMIDE SUBSTITUTES, THEIR DERIVATIVES AND THEIR PREPARATION METHODS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH22114A true PH22114A (en) | 1988-06-01 |
Family
ID=9176558
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH20078A PH22114A (en) | 1976-08-04 | 1977-08-04 | New substituted 2,3-alkylene bis(oxy) benzamides, their derivatives, pharmaceutical compositions containing same and method of use thereof |
| PH25426-AA PH18629A (en) | 1976-08-04 | 1981-03-25 | Substituted 2,3-alkylene bis (oxy) benzoic acid derivatives |
| PH26025A PH17710A (en) | 1976-08-04 | 1981-08-07 | Process for producing 2,3-alkylene bis(oxy)benzamides |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH25426-AA PH18629A (en) | 1976-08-04 | 1981-03-25 | Substituted 2,3-alkylene bis (oxy) benzoic acid derivatives |
| PH26025A PH17710A (en) | 1976-08-04 | 1981-08-07 | Process for producing 2,3-alkylene bis(oxy)benzamides |
Country Status (37)
| Country | Link |
|---|---|
| JP (1) | JPS57167914A (en) |
| AR (1) | AR219709A1 (en) |
| AT (1) | AT358034B (en) |
| AU (1) | AU516033B2 (en) |
| BE (1) | BE857350A (en) |
| BG (1) | BG36496A3 (en) |
| CA (1) | CA1114371A (en) |
| CH (1) | CH629198A5 (en) |
| CS (1) | CS216246B2 (en) |
| DD (1) | DD133237A5 (en) |
| DE (1) | DE2760414C2 (en) |
| DK (1) | DK152366C (en) |
| EG (1) | EG12716A (en) |
| ES (1) | ES461175A1 (en) |
| FI (1) | FI63938C (en) |
| GR (1) | GR61351B (en) |
| HK (2) | HK40382A (en) |
| HU (1) | HU179064B (en) |
| IE (2) | IE45646B1 (en) |
| IL (2) | IL52644A0 (en) |
| IN (1) | IN145473B (en) |
| LU (1) | LU77897A1 (en) |
| MC (1) | MC1154A1 (en) |
| MW (1) | MW2077A1 (en) |
| NL (1) | NL172063C (en) |
| NO (1) | NO152133C (en) |
| NZ (1) | NZ184816A (en) |
| OA (1) | OA05728A (en) |
| PH (3) | PH22114A (en) |
| PL (1) | PL111071B1 (en) |
| PT (1) | PT66865B (en) |
| RO (1) | RO72963A (en) |
| SE (2) | SE440776B (en) |
| SU (1) | SU716523A3 (en) |
| YU (1) | YU40005B (en) |
| ZA (1) | ZA774701B (en) |
| ZM (1) | ZM6077A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9027098D0 (en) * | 1990-12-13 | 1991-02-06 | Beecham Group Plc | Pharmaceuticals |
| US10083697B2 (en) | 2015-05-27 | 2018-09-25 | Google Llc | Local persisting of data for selectively offline capable voice action in a voice-enabled electronic device |
| JP6452575B2 (en) * | 2015-08-19 | 2019-01-16 | 株式会社トクヤマ | Manufacturing method of mirtazapine |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1473829A (en) * | 1964-06-09 | 1967-03-24 | Ile De France | Nu- (tertiary-aminoalkyl) -methylene dioxybenzamides and their preparation |
-
1977
- 1977-07-11 MC MC771250A patent/MC1154A1/en unknown
- 1977-07-29 IN IN1165/CAL/77A patent/IN145473B/en unknown
- 1977-07-29 ES ES461175A patent/ES461175A1/en not_active Expired
- 1977-07-29 BG BG037047A patent/BG36496A3/en unknown
- 1977-07-29 GR GR54066A patent/GR61351B/en unknown
- 1977-07-29 PT PT6686577A patent/PT66865B/en unknown
- 1977-07-29 DE DE19772760414 patent/DE2760414C2/de not_active Expired - Fee Related
- 1977-08-01 OA OA56243A patent/OA05728A/en unknown
- 1977-08-01 AU AU27507/77A patent/AU516033B2/en not_active Expired
- 1977-08-01 YU YU188277A patent/YU40005B/en unknown
- 1977-08-01 BE BE1008313A patent/BE857350A/en not_active IP Right Cessation
- 1977-08-02 AT AT569677A patent/AT358034B/en not_active IP Right Cessation
- 1977-08-02 IE IE1600/77A patent/IE45646B1/en not_active IP Right Cessation
- 1977-08-02 LU LU77897A patent/LU77897A1/xx unknown
- 1977-08-02 IE IE2409/80A patent/IE45647B1/en not_active IP Right Cessation
- 1977-08-02 RO RO9124577A patent/RO72963A/en unknown
- 1977-08-02 EG EG45577A patent/EG12716A/en active
- 1977-08-03 HU HUSO001195 patent/HU179064B/en not_active IP Right Cessation
- 1977-08-03 DK DK346977A patent/DK152366C/en not_active IP Right Cessation
- 1977-08-03 ZA ZA00774701A patent/ZA774701B/en unknown
- 1977-08-03 CA CA283,994A patent/CA1114371A/en not_active Expired
- 1977-08-03 DD DD20042077A patent/DD133237A5/en not_active IP Right Cessation
- 1977-08-03 IL IL52644A patent/IL52644A0/en not_active IP Right Cessation
- 1977-08-03 NL NL7708616A patent/NL172063C/en not_active IP Right Cessation
- 1977-08-03 NZ NZ18481677A patent/NZ184816A/en unknown
- 1977-08-03 SE SE7708849A patent/SE440776B/en not_active IP Right Cessation
- 1977-08-03 NO NO772739A patent/NO152133C/en unknown
- 1977-08-03 MW MW2077A patent/MW2077A1/en unknown
- 1977-08-03 CH CH956277A patent/CH629198A5/en not_active IP Right Cessation
- 1977-08-04 PL PL1977200066A patent/PL111071B1/en not_active IP Right Cessation
- 1977-08-04 FI FI772362A patent/FI63938C/en not_active IP Right Cessation
- 1977-08-04 ZM ZM6077A patent/ZM6077A1/en unknown
- 1977-08-04 CS CS775179A patent/CS216246B2/en unknown
- 1977-08-04 PH PH20078A patent/PH22114A/en unknown
- 1977-08-04 SU SU772507701A patent/SU716523A3/en active
- 1977-08-08 AR AR26867377A patent/AR219709A1/en active
-
1981
- 1981-03-25 PH PH25426-AA patent/PH18629A/en unknown
- 1981-08-07 PH PH26025A patent/PH17710A/en unknown
-
1982
- 1982-03-19 JP JP4547682A patent/JPS57167914A/en active Granted
- 1982-06-25 IL IL66138A patent/IL66138A0/en not_active IP Right Cessation
- 1982-09-16 HK HK403/82A patent/HK40382A/en unknown
- 1982-09-16 HK HK404/82A patent/HK40482A/en unknown
- 1982-11-17 SE SE8206546A patent/SE453390B/en not_active IP Right Cessation
Also Published As
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