PH12020551631A1 - Methods for protecting porcine fetuses from infection with virus - Google Patents

Methods for protecting porcine fetuses from infection with virus

Info

Publication number
PH12020551631A1
PH12020551631A1 PH12020551631A PH12020551631A PH12020551631A1 PH 12020551631 A1 PH12020551631 A1 PH 12020551631A1 PH 12020551631 A PH12020551631 A PH 12020551631A PH 12020551631 A PH12020551631 A PH 12020551631A PH 12020551631 A1 PH12020551631 A1 PH 12020551631A1
Authority
PH
Philippines
Prior art keywords
infection
methods
porcine animal
porcine
virus
Prior art date
Application number
PH12020551631A
Inventor
Randall S Prather
Kevin D Wells
Kristin M Whitworth
Original Assignee
Univ Missouri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Missouri filed Critical Univ Missouri
Publication of PH12020551631A1 publication Critical patent/PH12020551631A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Husbandry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Methods for protecting porcine fetuses from infection with Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). The methods comprise breeding a female porcine animal with a male porcine animal. The female porcine animal comprises modified chromosomal sequences in both alleles of its CD163 gene, wherein the modified chromosomal sequences reduce the susceptibility of the female porcine animal to infection by PRRSV, as compared to the susceptibility to infection by PRRSV of a female porcine animal that does not comprise any modified chromosomal sequences in the alleles of its CD163 gene. The male porcine animal comprises at least one wild-type CD163 allele.
PH12020551631A 2018-04-17 2020-10-02 Methods for protecting porcine fetuses from infection with virus PH12020551631A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2018/027944 WO2019203807A1 (en) 2018-04-17 2018-04-17 Methods for protecting porcine fetuses from infection with virus

Publications (1)

Publication Number Publication Date
PH12020551631A1 true PH12020551631A1 (en) 2021-07-05

Family

ID=68239779

Family Applications (1)

Application Number Title Priority Date Filing Date
PH12020551631A PH12020551631A1 (en) 2018-04-17 2020-10-02 Methods for protecting porcine fetuses from infection with virus

Country Status (8)

Country Link
JP (2) JP2021526353A (en)
KR (2) KR102680060B1 (en)
AU (1) AU2018419649A1 (en)
BR (1) BR112020021066A2 (en)
CA (1) CA3096022A1 (en)
MX (1) MX2020010925A (en)
PH (1) PH12020551631A1 (en)
WO (1) WO2019203807A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230006827A (en) 2020-05-05 2023-01-11 제너스 피엘씨 Methods for improving the health of pig species through targeted inactivation of CD163

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2836288A1 (en) * 2011-05-16 2012-11-22 The Curators Of The University Of Missouri Porcine reproductive and respiratory syndrome virus resistant animals
GB201313235D0 (en) 2013-07-24 2013-09-04 Univ Edinburgh Antiviral Compositions Methods and Animals
WO2017023337A1 (en) * 2015-08-06 2017-02-09 The Curators Of The University Of Missouri Pathogen-resistant animals having modified cd163 genes

Also Published As

Publication number Publication date
MX2020010925A (en) 2021-01-08
KR20240108545A (en) 2024-07-09
KR102680060B1 (en) 2024-07-02
WO2019203807A1 (en) 2019-10-24
BR112020021066A2 (en) 2021-02-17
JP2021526353A (en) 2021-10-07
CA3096022A1 (en) 2019-10-24
KR20210005074A (en) 2021-01-13
JP2023098940A (en) 2023-07-11
AU2018419649A1 (en) 2020-10-22

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