PH12019502122A1 - Pyrimidinyl-pyridyloxy-naphthyl compounds and methods of treating ire1-related diseases and disorders - Google Patents

Pyrimidinyl-pyridyloxy-naphthyl compounds and methods of treating ire1-related diseases and disorders

Info

Publication number
PH12019502122A1
PH12019502122A1 PH12019502122A PH12019502122A PH12019502122A1 PH 12019502122 A1 PH12019502122 A1 PH 12019502122A1 PH 12019502122 A PH12019502122 A PH 12019502122A PH 12019502122 A PH12019502122 A PH 12019502122A PH 12019502122 A1 PH12019502122 A1 PH 12019502122A1
Authority
PH
Philippines
Prior art keywords
ire1
pyridyloxy
pyrimidinyl
methods
treating
Prior art date
Application number
PH12019502122A
Inventor
Marie-Gabrielle Braun
Paul Gibbons
Wendy Lee
Cuong Ly
Joachim Rudolph
Jacob Schwarz
Avi Ashkenazi
Leo Fu
Tommy Lai
Fei Wang
Ramsay Beveridge
Liang Zhao
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PH12019502122A1 publication Critical patent/PH12019502122A1/en

Links

Abstract

Described herein are pyrimidinyl-pyridyloxy-naphthyl compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula (I) or (I') structure : or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula (I) or (I') compounds, as well as methods of using such IRE1 modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
PH12019502122A 2017-03-17 2019-09-16 Pyrimidinyl-pyridyloxy-naphthyl compounds and methods of treating ire1-related diseases and disorders PH12019502122A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2017077059 2017-03-17
CN2018050281 2018-03-16

Publications (1)

Publication Number Publication Date
PH12019502122A1 true PH12019502122A1 (en) 2020-07-06

Family

ID=71571944

Family Applications (1)

Application Number Title Priority Date Filing Date
PH12019502122A PH12019502122A1 (en) 2017-03-17 2019-09-16 Pyrimidinyl-pyridyloxy-naphthyl compounds and methods of treating ire1-related diseases and disorders

Country Status (1)

Country Link
PH (1) PH12019502122A1 (en)

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