PH12014501909A1 - Method for preparing human immunoglobulin - Google Patents

Method for preparing human immunoglobulin

Info

Publication number
PH12014501909A1
PH12014501909A1 PH12014501909A PH12014501909A PH12014501909A1 PH 12014501909 A1 PH12014501909 A1 PH 12014501909A1 PH 12014501909 A PH12014501909 A PH 12014501909A PH 12014501909 A PH12014501909 A PH 12014501909A PH 12014501909 A1 PH12014501909 A1 PH 12014501909A1
Authority
PH
Philippines
Prior art keywords
human immunoglobulin
preparation
preparing human
anion exchange
exchange chromatography
Prior art date
Application number
PH12014501909A
Other versions
PH12014501909B1 (en
Inventor
Yang Huichuan
Lv Jiacheng
Liang Hong
Wang Yan
Wu Peng
Li Zelin
Lan Xueyuan
Original Assignee
Chengdu Rongsheng Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chengdu Rongsheng Pharmaceuticals Co Ltd filed Critical Chengdu Rongsheng Pharmaceuticals Co Ltd
Publication of PH12014501909A1 publication Critical patent/PH12014501909A1/en
Publication of PH12014501909B1 publication Critical patent/PH12014501909B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides a method for preparing human immunoglobulin, comprising such steps as: dissolution of Cohn component I+??+?II or Cohn component II+?II, caprylic acid precipitation, first-step anion exchange chromatography, IgM precipitation, second-step anion exchange chromatography, ultrafiltration or dialysis, preparation, and inactivation of virus; as a result, high-purity human immunoglobulin is obtained through the preparation. Also provided is a human immunoglobulin prepared through the method and a pharmaceutical combination. The preparation method of the present invention is simple, has a low cost, and has a good industrial application prospect.
PH12014501909A 2012-02-22 2014-08-22 Method for preparing human immunoglobulin PH12014501909B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2012100410986A CN102532307B (en) 2012-02-22 2012-02-22 Method for preparing human immunoglobulin
PCT/CN2013/071754 WO2013123889A1 (en) 2012-02-22 2013-02-22 Method for preparing human immunoglobulin

Publications (2)

Publication Number Publication Date
PH12014501909A1 true PH12014501909A1 (en) 2014-11-24
PH12014501909B1 PH12014501909B1 (en) 2014-11-24

Family

ID=46340458

Family Applications (1)

Application Number Title Priority Date Filing Date
PH12014501909A PH12014501909B1 (en) 2012-02-22 2014-08-22 Method for preparing human immunoglobulin

Country Status (7)

Country Link
CN (1) CN102532307B (en)
BR (1) BR112014020734B1 (en)
CO (1) CO7141451A2 (en)
IN (1) IN2014DN07228A (en)
PH (1) PH12014501909B1 (en)
RU (1) RU2614119C9 (en)
WO (1) WO2013123889A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104356231B (en) * 2014-11-10 2017-08-08 北海开元生物科技有限公司 A kind of effective method for removing human immunoglobulin(HIg) polymer
CN105126100B (en) * 2015-09-23 2021-01-26 成都蓉生药业有限责任公司 IgM-rich human immunoglobulin preparation and preparation method thereof
AU2016231646B2 (en) * 2016-09-26 2021-04-08 Instituto Grifols, S.A. Method for the preparation of immunoglobulins
CN108101981B (en) * 2018-01-15 2019-06-04 四川远大蜀阳药业有限责任公司 A kind of production technology of intravenous immunoglobulin
CN109575129B (en) * 2018-12-29 2022-04-26 贵州泰邦生物制品有限公司 Preparation process of intravenous injection human immunoglobulin
CN110330565B (en) * 2019-07-11 2021-07-30 国药集团武汉血液制品有限公司 Method for extracting intravenous injection human immune globulin from plasma separation component I and III
CN111234009A (en) * 2020-01-20 2020-06-05 华兰生物工程重庆有限公司 Chromatography process for removing IgA and IgM in specific human immunoglobulin
BE1029863B1 (en) * 2022-05-10 2023-05-12 Prothya Biosolutions Belgium METHODS FOR PRODUCING IMMUNOGLOBULIN G (IgG) PREPARATIONS AND/OR SOLUTIONS

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4374763A (en) * 1979-09-17 1983-02-22 Morishita Pharmaceutical Co., Ltd. Method for producing gamma-globulin for use in intravenous administration and method for producing a pharmaceutical preparation thereof
JPS58180433A (en) * 1982-04-16 1983-10-21 Fujirebio Inc Removing method of anticomplementary substance from immunoglobulin
PL196770B1 (en) * 1998-06-09 2008-01-31 Statens Seruminstitut Process for producing immunoglobulins for intravenous administration and other immunoglobulin products
EP2277912B1 (en) * 2004-06-07 2016-09-28 Therapure Biopharma Inc. Isolation of plasma proteins
RU2361612C1 (en) * 2007-12-21 2009-07-20 Федеральное Государственное учреждение науки "Московский научно-исследовательский институт эпидемиологии и микробиологии им. Г.Н. Габричевского" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека Immunoglobulin marker base for immunobiological preparations and way of its reception, suppositories and ointment for prevention and therapy of bacteriemic and virus diseases
CA2763138A1 (en) * 2009-05-27 2010-12-02 Baxter International Inc. A method to produce a highly concentrated immunoglobulin preparation for subcutaneous use
RU2470664C2 (en) * 2010-08-23 2012-12-27 Андрей Германович Лютов Method for producing immunoglobulin for intravenous introduction of immunoglobulin m enriched preparation, and preparation prepared by such method

Also Published As

Publication number Publication date
BR112014020734B1 (en) 2021-03-02
IN2014DN07228A (en) 2015-04-24
CN102532307A (en) 2012-07-04
BR112014020734A2 (en) 2017-08-22
RU2614119C2 (en) 2017-03-22
RU2014135665A (en) 2016-04-10
WO2013123889A1 (en) 2013-08-29
CO7141451A2 (en) 2014-12-12
CN102532307B (en) 2013-06-12
RU2614119C9 (en) 2017-08-15
PH12014501909B1 (en) 2014-11-24

Similar Documents

Publication Publication Date Title
PH12014501909A1 (en) Method for preparing human immunoglobulin
JOP20200091A1 (en) Antibody neutralizing human respiratory syncytial virus
PH12015500355A1 (en) Compounds for the treatment of paramoxyvirus viral infections
EA202090675A3 (en) STABILIZED SOLUBLE F-POLYPEPTIDES RSV BEFORE FUSION
EA201690031A1 (en) STABILIZED SOLUBLE RSV F-POLYPEPTIDES BEFORE MERGING
MX2016002199A (en) Antiviral compounds.
PH12015501558B1 (en) Human antibodies to respiratory syncytial virus f protein and methods of use thereof
MY164352A (en) Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
MX337060B (en) Process for preparing an immunoglobulin composition.
MX2015007841A (en) Filtration systems and membranes with enhanced flux and method for their preparation.
EA201590890A1 (en) DERIVATIVES 5-FLUOR-N- (PYRIDIN-2-IL) PYRIDIN-2-AMINE CONTAINING A SULPHOXIMINE GROUP
MX356337B (en) Antibodies against human csf-1r and uses thereof.
IN2015DN03327A (en)
WO2014178078A3 (en) Novel cloning, expression & purification method for the preparation of ranibizumab
BR112012025678A2 (en) composition for inhibiting HIV transmission, use of same, method for preparing same and method for inhibiting HIV transmission.
MX362858B (en) Process for the preparation of pemetrexed and lysin salt thereof.
MX351610B (en) ACID ADDITION SALTS OF 5a-HYDROXY-6ß-[2-(1H-IMIDAZOL-4-YL)ETHYL AMINO]CHOLESTAN-3ß-OL.
WO2011107866A3 (en) Silyl-derivatives of polysaccharides
WO2013152274A8 (en) Epitope- scaffold immunogens against respiratory syncytial virus (rsv)
WO2012155226A8 (en) Method for producing pyrostegia venusta derivatives, pyrostegia venusta derivatives, pharmaceutical compositions and uses thereof
WO2013173256A3 (en) New and improved influenza vaccines
WO2013055825A3 (en) Guanidinyl-substituted polyamides useful for treating human papilloma virus
EA201591192A1 (en) ANTIBACTERIAL CONNECTIONS
AU2014230304A8 (en) Complex preparation including valsartan and rosuvastatin calcium and manufacturing method therefor
WO2014124092A3 (en) Lamivudine crystalline salts