PE79899A1 - DERIVATIVES OF 9-OXYME ERYTHROMYCIN - Google Patents
DERIVATIVES OF 9-OXYME ERYTHROMYCINInfo
- Publication number
- PE79899A1 PE79899A1 PE1998000470A PE00047098A PE79899A1 PE 79899 A1 PE79899 A1 PE 79899A1 PE 1998000470 A PE1998000470 A PE 1998000470A PE 00047098 A PE00047098 A PE 00047098A PE 79899 A1 PE79899 A1 PE 79899A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- replaced
- alcanoyl
- cr7r8
- optionally replaced
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (I), X ES -CR7R8- o -NR7-; X JUNTO CON R2 FORMA -N=CR4R5; X Y R2 FORMAN JUNTOS UN HETEROCICLO DE FORMULA (XVI), DONDE r Y p SON 1-3; q ES 0-1 Y X1 ES -CH2-, O, S, -C(O)-, ENTRE OTROS; (CH2)r, (CH2)p; X1 ES -NH- ESTA OPCIONALMENTE SUSTITUIDA POR -C(O)O(ALQUILO C1-C10), ALCANOILO C1-C10, ENTRE OTROS; R1 ES H o ALQUILO C1-C10, REEMPLAZADO CON 1-3 O, S o N, OPCIONALMENTE SUSTITUIDO CON 1-3 -C(O)O(ALQUILO C1-C10), -NR7R8, S(O)n(ALQUILO C1-C10), n ES 0-2; R2 ES (i) H, R4, -C(O)R4, ENTRE OTROS CUANDO X ES -NR7-; (ii) H, R4 o -(CR7R8)mR3, CUANDO X ES -CR7R8-, m ES 0-6, R3 ES ARILO C6-C10 o UN HETEROCICLO DE 5-10 MIEMBROS OPCIONALMENTE SUSTITUIDOS POR 1-3 -C(O)O(ALQUILO C1-C10), ALCANOILO C1-C10, ENTRE OTROS; R4 Y R5 SON H Y ALQUILO C1-C12 OPCIONALMENTE REEMPLAZADOS POR O, S Y N Y SUSTITUIDO CON 1-3 -C(O)O(ALQUILO C1-C10), ALCOXI C1-C10, HALOGENO; R6 ES H, -C(O)R3 O ALCANOILO C1-C18 OPCIONALMENTE REEMPLAZADO POR O, S Y N; Y CADA R7 Y R8 SON H o ALQUILO C1-C6. UN COMPUESTO PREFERIDO ES 11,12-CARBAMATO DE 9-DESOXO-11-DESOXI-5-O-DESOSAMINIL-11-(3-(4-PIRIDIN-3-IL-IMIDAZOL-1-IL)-PROPIL)HIDRAZO-9-HIDROXIIMINO-6-O-METIL-3-OXOERITRONOLIDA A, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I PUEDE SER UTIL PARA TRATAR UNA INFECCION BACTERIANA O PROTOZOARIAREFERS TO A COMPOUND OF FORMULA (I), X IS -CR7R8- or -NR7-; X TOGETHER WITH R2 FORM -N = CR4R5; X AND R2 TOGETHER TOGETHER A HETERO-CYCLE OF FORMULA (XVI), WHERE r AND p ARE 1-3; q IS 0-1 AND X1 IS -CH2-, O, S, -C (O) -, AMONG OTHERS; (CH2) r, (CH2) p; X1 IS -NH- IS OPTIONALLY REPLACED BY -C (O) O (C1-C10 ALKYL), C1-C10 ALCANOYL, AMONG OTHERS; R1 IS H or C1-C10 ALKYL, REPLACED WITH 1-3 O, S or N, OPTIONALLY REPLACED WITH 1-3 -C (O) O (C1-C10 ALKYL), -NR7R8, S (O) n (C1 RENT -C10), n ES 0-2; R2 IS (i) H, R4, -C (O) R4, AMONG OTHERS WHEN X IS -NR7-; (ii) H, R4 or - (CR7R8) mR3, WHEN X IS -CR7R8-, m IS 0-6, R3 IS ARYL C6-C10 or A HETEROCICLE OF 5-10 MEMBERS OPTIONALLY SUBSTITUTED BY 1-3 -C (OR ) OR (C1-C10 ALKYL), C1-C10 ALCANOYL, AMONG OTHERS; R4 AND R5 ARE H AND C1-C12 ALKYL OPTIONALLY REPLACED BY O, S AND N AND REPLACED WITH 1-3-C (O) O (C1-C10 ALKYL), ALCOXI C1-C10, HALOGEN; R6 IS H, -C (O) R3 OR C1-C18 ALCANOYL OPTIONALLY REPLACED BY O, S AND N; AND EACH R7 AND R8 ARE H or ALKYL C1-C6. A PREFERRED COMPOUND IS 11,12-9-DESOXO-11-DESOXI-5-O-DESOSAMINIL-11- (3- (4-PIRIDIN-3-IL-IMIDAZOL-1-IL) -PROPIL) HYDRAZO-9 -HYDROXYIMINO-6-O-METHYL-3-OXOERITRONOLIDE A, AMONG OTHERS. IT ALSO REFERS TO A PROCEDURE FOR PREPARATION. COMPOUND I MAY BE USEFUL FOR TREATING A BACTERIAL OR PROTOZOARY INFECTION
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4934997P | 1997-06-11 | 1997-06-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE79899A1 true PE79899A1 (en) | 1999-08-25 |
Family
ID=21959341
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1998000470A PE79899A1 (en) | 1997-06-11 | 1998-06-08 | DERIVATIVES OF 9-OXYME ERYTHROMYCIN |
Country Status (31)
Country | Link |
---|---|
EP (1) | EP0988308A1 (en) |
JP (1) | JP2000513026A (en) |
KR (1) | KR20010013660A (en) |
CN (1) | CN1259135A (en) |
AP (1) | AP9801253A0 (en) |
AR (1) | AR012244A1 (en) |
AU (1) | AU7226798A (en) |
BG (1) | BG103947A (en) |
BR (1) | BR9810021A (en) |
CA (1) | CA2293335A1 (en) |
CO (1) | CO4940506A1 (en) |
CZ (1) | CZ9904388A3 (en) |
EA (1) | EA199901016A1 (en) |
GT (1) | GT199800074A (en) |
HN (1) | HN1998000073A (en) |
HR (1) | HRP980316A2 (en) |
HU (1) | HUP0002252A3 (en) |
ID (1) | ID24529A (en) |
IL (1) | IL132767A0 (en) |
IS (1) | IS5251A (en) |
MA (1) | MA26505A1 (en) |
NO (1) | NO996108L (en) |
OA (1) | OA11225A (en) |
PA (1) | PA8451801A1 (en) |
PE (1) | PE79899A1 (en) |
PL (1) | PL337606A1 (en) |
TN (1) | TNSN98083A1 (en) |
TR (1) | TR199902995T2 (en) |
TW (1) | TW448174B (en) |
WO (1) | WO1998056800A1 (en) |
ZA (1) | ZA985018B (en) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HN1998000159A (en) * | 1997-10-29 | 1999-02-09 | Monsanto Co | DERIVATIVES OF 9- AMINO - 3 CETO ERITROMICINA |
WO2000017218A1 (en) | 1998-09-22 | 2000-03-30 | Pfizer Products Inc. | Carbamate and carbazate ketolide antibiotics |
FR2786188B1 (en) * | 1998-11-24 | 2002-10-31 | Hoechst Marion Roussel Inc | NOVEL ERYTHROMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS |
US6258785B1 (en) | 1998-12-02 | 2001-07-10 | Pfizer Inc. | Crystalline 9-E-(O-methyl)oxime of 11, 12-dideoxy-3-de(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribohexopyranosyloxy)-6-O-methyl-12,11-(iminocarbonyl-(2-(3-(4-(3-pyridinyl)1H-imadazol-1-yl)propyl)hydrazono))-3-oxoerythromycin |
EP1298138B1 (en) * | 1998-12-10 | 2006-11-02 | Pfizer Products Inc. | Carbamate and Carbazate Ketolide Antibiotics |
US6284732B1 (en) * | 1998-12-18 | 2001-09-04 | Bio-Rad Laboratories, Inc. | Peptides and peptide analogues designed from HFE protein and their uses in the treatment of iron overload diseases |
WO2000063224A2 (en) * | 1999-04-16 | 2000-10-26 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
IL145739A0 (en) | 1999-05-24 | 2002-07-25 | Pfizer Prod Inc | 13-methyl-erythromycin derivatives |
ES2208334T3 (en) * | 1999-06-07 | 2004-06-16 | Abbott Laboratories | CETOLIDE DERIVATIVES OF 6-0 CARBAMATE. |
ID27331A (en) * | 1999-09-29 | 2001-03-29 | Pfizer Prod Inc | MAKING ANTIBIOTIC-ANTIBIOTIC KETOLIDA CARBAMATE |
EP1439186A3 (en) * | 1999-12-29 | 2004-11-03 | Pfizer Products Inc. | Intermediates for novel antibacterial and prokinetic macrolides |
EP1114826A3 (en) * | 1999-12-29 | 2001-10-31 | Pfizer Products Inc. | Novel antibacterial and prokinetic macrolides |
US6946446B2 (en) | 2000-02-24 | 2005-09-20 | Abbott Laboratories | Anti-infective agents useful against multidrug-resistant strains of bacteria |
US6403776B1 (en) | 2000-07-05 | 2002-06-11 | Pfizer Inc. | Synthesis of carbamate ketolide antibiotics |
WO2003090761A1 (en) * | 2002-04-25 | 2003-11-06 | Abbott Laboratories | 9-oxime macrolide antibacterials |
AR043050A1 (en) | 2002-09-26 | 2005-07-13 | Rib X Pharmaceuticals Inc | BIFunctional HETEROCICLICAL COMPOUNDS AND METHODS TO PREPARE AND USE THE SAME |
US7601695B2 (en) * | 2003-03-10 | 2009-10-13 | Optimer Pharmaceuticals, Inc. | Antibacterial agents |
CN102816194A (en) | 2004-02-27 | 2012-12-12 | 瑞伯-X医药品有限公司 | Macrocyclic compounds and methods of making and using the same |
CA2703475A1 (en) | 2007-10-25 | 2009-04-30 | Cempra Pharmaceuticals, Inc. | Process for the preparation of macrolide antibacterial agents |
CN102245195B (en) | 2008-10-24 | 2016-01-13 | 森普拉制药公司 | Use the biophylaxis of the macrolide containing triazole |
US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
EP2475253B1 (en) | 2009-09-10 | 2016-10-26 | Cempra Pharmaceuticals, Inc. | Methods for treating malaria, tuberculosis and mac diseases |
CN102146085B (en) * | 2010-02-09 | 2014-03-26 | 北京理工大学 | 9-oxime-ether ketolide derivative, and preparation method and medical composite thereof |
WO2011119604A1 (en) | 2010-03-22 | 2011-09-29 | Cempra Pharmaceuticals, Inc. | Crystalline forms of a macrolide, and uses therefor |
AU2011255464C1 (en) | 2010-05-20 | 2017-02-23 | Cempra Pharmaceuticals, Inc. | Processes for preparing macrolides and ketolides and intermediates therefor |
EP2613630A4 (en) | 2010-09-10 | 2014-01-15 | Cempra Pharmaceuticals Inc | Hydrogen bond forming fluoro ketolides for treating diseases |
EP2830632A4 (en) | 2012-03-27 | 2015-10-21 | Cempra Pharmaceuticals Inc | Parenteral formulations for administering macrolide antibiotics |
AU2014239959A1 (en) | 2013-03-14 | 2015-10-01 | Cempra Pharmaceuticals, Inc. | Methods for treating respiratory diseases and formulations therefor |
US9751908B2 (en) | 2013-03-15 | 2017-09-05 | Cempra Pharmaceuticals, Inc. | Convergent processes for preparing macrolide antibacterial agents |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL99995A (en) * | 1990-11-21 | 1997-11-20 | Roussel Uclaf | Erythromycin derivatives, their preparation and pharmaceutical compositions containing them |
US5527780A (en) * | 1992-11-05 | 1996-06-18 | Roussel Uclaf | Erythromycin derivatives |
FR2718450B1 (en) * | 1994-04-08 | 1997-01-10 | Roussel Uclaf | New erythromycin derivatives, their preparation process and their use as drugs. |
-
1998
- 1998-05-15 PL PL98337606A patent/PL337606A1/en unknown
- 1998-05-15 TR TR1999/02995T patent/TR199902995T2/en unknown
- 1998-05-15 CZ CZ19994388A patent/CZ9904388A3/en unknown
- 1998-05-15 CA CA002293335A patent/CA2293335A1/en not_active Abandoned
- 1998-05-15 AU AU72267/98A patent/AU7226798A/en not_active Abandoned
- 1998-05-15 ID IDW991570A patent/ID24529A/en unknown
- 1998-05-15 IL IL13276798A patent/IL132767A0/en unknown
- 1998-05-15 EP EP98919394A patent/EP0988308A1/en not_active Withdrawn
- 1998-05-15 BR BR9810021-1A patent/BR9810021A/en not_active IP Right Cessation
- 1998-05-15 WO PCT/IB1998/000741 patent/WO1998056800A1/en not_active Application Discontinuation
- 1998-05-15 KR KR1019997011672A patent/KR20010013660A/en not_active Application Discontinuation
- 1998-05-15 EA EA199901016A patent/EA199901016A1/en unknown
- 1998-05-15 HU HU0002252A patent/HUP0002252A3/en unknown
- 1998-05-15 CN CN98805848A patent/CN1259135A/en active Pending
- 1998-05-15 JP JP11501928A patent/JP2000513026A/en active Pending
- 1998-05-19 HN HN1998000073A patent/HN1998000073A/en unknown
- 1998-05-21 PA PA19988451801A patent/PA8451801A1/en unknown
- 1998-06-04 AP APAP/P/1998/001253A patent/AP9801253A0/en unknown
- 1998-06-05 GT GT199800074A patent/GT199800074A/en unknown
- 1998-06-08 PE PE1998000470A patent/PE79899A1/en not_active Application Discontinuation
- 1998-06-08 TW TW087109086A patent/TW448174B/en active
- 1998-06-09 AR ARP980102703A patent/AR012244A1/en unknown
- 1998-06-10 MA MA25105A patent/MA26505A1/en unknown
- 1998-06-10 TN TNTNSN98083A patent/TNSN98083A1/en unknown
- 1998-06-10 ZA ZA9805018A patent/ZA985018B/en unknown
- 1998-06-11 HR HR60/049,349A patent/HRP980316A2/en not_active Application Discontinuation
- 1998-06-11 CO CO98033538A patent/CO4940506A1/en unknown
-
1999
- 1999-11-16 IS IS5251A patent/IS5251A/en unknown
- 1999-12-03 BG BG103947A patent/BG103947A/en unknown
- 1999-12-03 OA OA9900269A patent/OA11225A/en unknown
- 1999-12-10 NO NO996108A patent/NO996108L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1259135A (en) | 2000-07-05 |
IL132767A0 (en) | 2001-03-19 |
HUP0002252A3 (en) | 2002-01-28 |
AU7226798A (en) | 1998-12-30 |
GT199800074A (en) | 1999-11-27 |
CO4940506A1 (en) | 2000-07-24 |
HRP980316A2 (en) | 1999-04-30 |
CA2293335A1 (en) | 1998-12-17 |
BR9810021A (en) | 2000-09-19 |
CZ9904388A3 (en) | 2002-10-16 |
AP9801253A0 (en) | 1999-12-04 |
TW448174B (en) | 2001-08-01 |
MA26505A1 (en) | 2004-12-20 |
WO1998056800A1 (en) | 1998-12-17 |
EA199901016A1 (en) | 2000-06-26 |
NO996108D0 (en) | 1999-12-10 |
AR012244A1 (en) | 2000-09-27 |
HN1998000073A (en) | 1999-01-08 |
KR20010013660A (en) | 2001-02-26 |
TR199902995T2 (en) | 2000-02-21 |
NO996108L (en) | 2000-02-10 |
ID24529A (en) | 2000-07-20 |
TNSN98083A1 (en) | 2005-03-15 |
PL337606A1 (en) | 2000-08-28 |
ZA985018B (en) | 1999-12-10 |
BG103947A (en) | 2000-07-31 |
IS5251A (en) | 1999-11-16 |
PA8451801A1 (en) | 2000-05-24 |
OA11225A (en) | 2003-07-17 |
JP2000513026A (en) | 2000-10-03 |
HUP0002252A2 (en) | 2000-12-28 |
EP0988308A1 (en) | 2000-03-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |