HN1998000073A - DERIVATIVES OF 9 - OXIMA ERYTHROMYCIN - Google Patents
DERIVATIVES OF 9 - OXIMA ERYTHROMYCINInfo
- Publication number
- HN1998000073A HN1998000073A HN1998000073A HN1998000073A HN1998000073A HN 1998000073 A HN1998000073 A HN 1998000073A HN 1998000073 A HN1998000073 A HN 1998000073A HN 1998000073 A HN1998000073 A HN 1998000073A HN 1998000073 A HN1998000073 A HN 1998000073A
- Authority
- HN
- Honduras
- Prior art keywords
- compounds
- derivatives
- oxima
- erythromycin
- well
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
ESTA INVENCION SE REFIERE A LOS NUEVOS DERIVADOS 3 CETO 9 OXIMA 11,12 CARBAZATO O CARBAMATO DE LA 6 0METILERITROMICINA A. LOS COMPUESTOS DE ESTA INVENCION SON UTILES COMO ANTIBIOTICOS EN MAMIFEROS, INCLUIDO EL HOMBRE, ASI COMO EN PECES Y AVES. LOS COMPUESTOS DE LA PRESENTE INVENCION CON ANTIBIOTICOS MACROLIDOS DE AMPLIO ESPECTRO QUE SON EFICACES CONTRA LAS INFECCIONES PROVOCADAS POR DETERMINADAS BACTERIAS GRAM POSITIVAS Y GRAM NEGATIVAS, ASI COMO POR PROTOZOOS. ESTOS COMPUESTOS TIENEN LA ESTRUCTURA QUIMICA (I), EN LA QUE R1, R2, R6 Y X SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTETHIS INVENTION IS REFERRED TO THE NEW DERIVATIVES 3 CETO 9 OXIME 11.12 CARBAZATE OR CARBAMATE OF 6 METHYLERITHROMYCIN A. THE COMPOUNDS OF THIS INVENTION ARE USEFUL AS ANTIBIOTICS IN MAMMALS, INCLUDING MAN, AS WELL AS IN FISH AND BIRDS. THE COMPOUNDS OF THE PRESENT INVENTION WITH BROAD SPECTRUM MACROLID ANTIBIOTICS THAT ARE EFFECTIVE AGAINST INFECTIONS CAUSED BY CERTAIN NEGATIVE GRAM BACTERIA, AS WELL AS PROTOZOA. THESE COMPOUNDS HAVE THE CHEMICAL STRUCTURE (I), IN WHICH R1, R2, R6 AND X ARE FUNCTIONAL GROUPS DESCRIBED IN THE FILE
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4934997P | 1997-06-11 | 1997-06-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HN1998000073A true HN1998000073A (en) | 1999-01-08 |
Family
ID=21959341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HN1998000073A HN1998000073A (en) | 1997-06-11 | 1998-05-19 | DERIVATIVES OF 9 - OXIMA ERYTHROMYCIN |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP0988308A1 (en) |
| JP (1) | JP2000513026A (en) |
| KR (1) | KR20010013660A (en) |
| CN (1) | CN1259135A (en) |
| AP (1) | AP9801253A0 (en) |
| AR (1) | AR012244A1 (en) |
| AU (1) | AU7226798A (en) |
| BG (1) | BG103947A (en) |
| BR (1) | BR9810021A (en) |
| CA (1) | CA2293335A1 (en) |
| CO (1) | CO4940506A1 (en) |
| CZ (1) | CZ9904388A3 (en) |
| EA (1) | EA199901016A1 (en) |
| GT (1) | GT199800074A (en) |
| HN (1) | HN1998000073A (en) |
| HR (1) | HRP980316A2 (en) |
| HU (1) | HUP0002252A3 (en) |
| ID (1) | ID24529A (en) |
| IL (1) | IL132767A0 (en) |
| IS (1) | IS5251A (en) |
| MA (1) | MA26505A1 (en) |
| NO (1) | NO996108L (en) |
| OA (1) | OA11225A (en) |
| PA (1) | PA8451801A1 (en) |
| PE (1) | PE79899A1 (en) |
| PL (1) | PL337606A1 (en) |
| TN (1) | TNSN98083A1 (en) |
| TR (1) | TR199902995T2 (en) |
| TW (1) | TW448174B (en) |
| WO (1) | WO1998056800A1 (en) |
| ZA (1) | ZA985018B (en) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HN1998000159A (en) * | 1997-10-29 | 1999-02-09 | Monsanto Co | DERIVATIVES OF 9- AMINO - 3 CETO ERITROMICINA |
| WO2000017218A1 (en) | 1998-09-22 | 2000-03-30 | Pfizer Products Inc. | Carbamate and carbazate ketolide antibiotics |
| FR2786188B1 (en) * | 1998-11-24 | 2002-10-31 | Hoechst Marion Roussel Inc | NOVEL ERYTHROMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS |
| US6258785B1 (en) | 1998-12-02 | 2001-07-10 | Pfizer Inc. | Crystalline 9-E-(O-methyl)oxime of 11, 12-dideoxy-3-de(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribohexopyranosyloxy)-6-O-methyl-12,11-(iminocarbonyl-(2-(3-(4-(3-pyridinyl)1H-imadazol-1-yl)propyl)hydrazono))-3-oxoerythromycin |
| EP1298138B1 (en) * | 1998-12-10 | 2006-11-02 | Pfizer Products Inc. | Carbamate and Carbazate Ketolide Antibiotics |
| US6284732B1 (en) * | 1998-12-18 | 2001-09-04 | Bio-Rad Laboratories, Inc. | Peptides and peptide analogues designed from HFE protein and their uses in the treatment of iron overload diseases |
| WO2000063224A2 (en) * | 1999-04-16 | 2000-10-26 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| IL145739A0 (en) | 1999-05-24 | 2002-07-25 | Pfizer Prod Inc | 13-methyl-erythromycin derivatives |
| ES2208334T3 (en) * | 1999-06-07 | 2004-06-16 | Abbott Laboratories | CETOLIDE DERIVATIVES OF 6-0 CARBAMATE. |
| ID27331A (en) * | 1999-09-29 | 2001-03-29 | Pfizer Prod Inc | MAKING ANTIBIOTIC-ANTIBIOTIC KETOLIDA CARBAMATE |
| EP1439186A3 (en) * | 1999-12-29 | 2004-11-03 | Pfizer Products Inc. | Intermediates for novel antibacterial and prokinetic macrolides |
| EP1114826A3 (en) * | 1999-12-29 | 2001-10-31 | Pfizer Products Inc. | Novel antibacterial and prokinetic macrolides |
| US6946446B2 (en) | 2000-02-24 | 2005-09-20 | Abbott Laboratories | Anti-infective agents useful against multidrug-resistant strains of bacteria |
| US6403776B1 (en) | 2000-07-05 | 2002-06-11 | Pfizer Inc. | Synthesis of carbamate ketolide antibiotics |
| WO2003090761A1 (en) * | 2002-04-25 | 2003-11-06 | Abbott Laboratories | 9-oxime macrolide antibacterials |
| AR043050A1 (en) | 2002-09-26 | 2005-07-13 | Rib X Pharmaceuticals Inc | BIFunctional HETEROCICLICAL COMPOUNDS AND METHODS TO PREPARE AND USE THE SAME |
| US7601695B2 (en) * | 2003-03-10 | 2009-10-13 | Optimer Pharmaceuticals, Inc. | Antibacterial agents |
| CN102816194A (en) | 2004-02-27 | 2012-12-12 | 瑞伯-X医药品有限公司 | Macrocyclic compounds and methods of making and using the same |
| CA2703475A1 (en) | 2007-10-25 | 2009-04-30 | Cempra Pharmaceuticals, Inc. | Process for the preparation of macrolide antibacterial agents |
| CN102245195B (en) | 2008-10-24 | 2016-01-13 | 森普拉制药公司 | Use the biophylaxis of the macrolide containing triazole |
| US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
| EP2475253B1 (en) | 2009-09-10 | 2016-10-26 | Cempra Pharmaceuticals, Inc. | Methods for treating malaria, tuberculosis and mac diseases |
| CN102146085B (en) * | 2010-02-09 | 2014-03-26 | 北京理工大学 | 9-oxime-ether ketolide derivative, and preparation method and medical composite thereof |
| WO2011119604A1 (en) | 2010-03-22 | 2011-09-29 | Cempra Pharmaceuticals, Inc. | Crystalline forms of a macrolide, and uses therefor |
| AU2011255464C1 (en) | 2010-05-20 | 2017-02-23 | Cempra Pharmaceuticals, Inc. | Processes for preparing macrolides and ketolides and intermediates therefor |
| EP2613630A4 (en) | 2010-09-10 | 2014-01-15 | Cempra Pharmaceuticals Inc | Hydrogen bond forming fluoro ketolides for treating diseases |
| EP2830632A4 (en) | 2012-03-27 | 2015-10-21 | Cempra Pharmaceuticals Inc | Parenteral formulations for administering macrolide antibiotics |
| AU2014239959A1 (en) | 2013-03-14 | 2015-10-01 | Cempra Pharmaceuticals, Inc. | Methods for treating respiratory diseases and formulations therefor |
| US9751908B2 (en) | 2013-03-15 | 2017-09-05 | Cempra Pharmaceuticals, Inc. | Convergent processes for preparing macrolide antibacterial agents |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL99995A (en) * | 1990-11-21 | 1997-11-20 | Roussel Uclaf | Erythromycin derivatives, their preparation and pharmaceutical compositions containing them |
| US5527780A (en) * | 1992-11-05 | 1996-06-18 | Roussel Uclaf | Erythromycin derivatives |
| FR2718450B1 (en) * | 1994-04-08 | 1997-01-10 | Roussel Uclaf | New erythromycin derivatives, their preparation process and their use as drugs. |
-
1998
- 1998-05-15 PL PL98337606A patent/PL337606A1/en unknown
- 1998-05-15 TR TR1999/02995T patent/TR199902995T2/en unknown
- 1998-05-15 CZ CZ19994388A patent/CZ9904388A3/en unknown
- 1998-05-15 CA CA002293335A patent/CA2293335A1/en not_active Abandoned
- 1998-05-15 AU AU72267/98A patent/AU7226798A/en not_active Abandoned
- 1998-05-15 ID IDW991570A patent/ID24529A/en unknown
- 1998-05-15 IL IL13276798A patent/IL132767A0/en unknown
- 1998-05-15 EP EP98919394A patent/EP0988308A1/en not_active Withdrawn
- 1998-05-15 BR BR9810021-1A patent/BR9810021A/en not_active IP Right Cessation
- 1998-05-15 WO PCT/IB1998/000741 patent/WO1998056800A1/en not_active Application Discontinuation
- 1998-05-15 KR KR1019997011672A patent/KR20010013660A/en not_active Application Discontinuation
- 1998-05-15 EA EA199901016A patent/EA199901016A1/en unknown
- 1998-05-15 HU HU0002252A patent/HUP0002252A3/en unknown
- 1998-05-15 CN CN98805848A patent/CN1259135A/en active Pending
- 1998-05-15 JP JP11501928A patent/JP2000513026A/en active Pending
- 1998-05-19 HN HN1998000073A patent/HN1998000073A/en unknown
- 1998-05-21 PA PA19988451801A patent/PA8451801A1/en unknown
- 1998-06-04 AP APAP/P/1998/001253A patent/AP9801253A0/en unknown
- 1998-06-05 GT GT199800074A patent/GT199800074A/en unknown
- 1998-06-08 PE PE1998000470A patent/PE79899A1/en not_active Application Discontinuation
- 1998-06-08 TW TW087109086A patent/TW448174B/en active
- 1998-06-09 AR ARP980102703A patent/AR012244A1/en unknown
- 1998-06-10 MA MA25105A patent/MA26505A1/en unknown
- 1998-06-10 TN TNTNSN98083A patent/TNSN98083A1/en unknown
- 1998-06-10 ZA ZA9805018A patent/ZA985018B/en unknown
- 1998-06-11 HR HR60/049,349A patent/HRP980316A2/en not_active Application Discontinuation
- 1998-06-11 CO CO98033538A patent/CO4940506A1/en unknown
-
1999
- 1999-11-16 IS IS5251A patent/IS5251A/en unknown
- 1999-12-03 BG BG103947A patent/BG103947A/en unknown
- 1999-12-03 OA OA9900269A patent/OA11225A/en unknown
- 1999-12-10 NO NO996108A patent/NO996108L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1259135A (en) | 2000-07-05 |
| IL132767A0 (en) | 2001-03-19 |
| HUP0002252A3 (en) | 2002-01-28 |
| AU7226798A (en) | 1998-12-30 |
| GT199800074A (en) | 1999-11-27 |
| CO4940506A1 (en) | 2000-07-24 |
| HRP980316A2 (en) | 1999-04-30 |
| CA2293335A1 (en) | 1998-12-17 |
| BR9810021A (en) | 2000-09-19 |
| CZ9904388A3 (en) | 2002-10-16 |
| AP9801253A0 (en) | 1999-12-04 |
| TW448174B (en) | 2001-08-01 |
| MA26505A1 (en) | 2004-12-20 |
| WO1998056800A1 (en) | 1998-12-17 |
| EA199901016A1 (en) | 2000-06-26 |
| NO996108D0 (en) | 1999-12-10 |
| AR012244A1 (en) | 2000-09-27 |
| KR20010013660A (en) | 2001-02-26 |
| TR199902995T2 (en) | 2000-02-21 |
| NO996108L (en) | 2000-02-10 |
| ID24529A (en) | 2000-07-20 |
| TNSN98083A1 (en) | 2005-03-15 |
| PL337606A1 (en) | 2000-08-28 |
| ZA985018B (en) | 1999-12-10 |
| BG103947A (en) | 2000-07-31 |
| IS5251A (en) | 1999-11-16 |
| PA8451801A1 (en) | 2000-05-24 |
| OA11225A (en) | 2003-07-17 |
| JP2000513026A (en) | 2000-10-03 |
| HUP0002252A2 (en) | 2000-12-28 |
| EP0988308A1 (en) | 2000-03-29 |
| PE79899A1 (en) | 1999-08-25 |
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