PE52894A1 - DERIVATIVE FROM CAMPTOTECINA SOLUBLE IN WATER - Google Patents

DERIVATIVE FROM CAMPTOTECINA SOLUBLE IN WATER

Info

Publication number
PE52894A1
PE52894A1 PE1994241061A PE24106194A PE52894A1 PE 52894 A1 PE52894 A1 PE 52894A1 PE 1994241061 A PE1994241061 A PE 1994241061A PE 24106194 A PE24106194 A PE 24106194A PE 52894 A1 PE52894 A1 PE 52894A1
Authority
PE
Peru
Prior art keywords
soluble
water
camptotecina
derivative
variations
Prior art date
Application number
PE1994241061A
Other languages
Spanish (es)
Inventor
Michael Joseph Luzzio
Peter Leslie Myers
Jeffrey Mark Besterman
Michael Glenn Evans
Original Assignee
Glaxo Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Inc filed Critical Glaxo Inc
Publication of PE52894A1 publication Critical patent/PE52894A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE: 1) n VARIA DE 1 A 2; 2) R1 ES H, ALQUILO INFERIOR, CICLOALQUILO C3-C7, (CICLOALQUILO C3-C7)-ALQUILO INFERIOR, ALQUENILO INFERIOR, HIDROXIALQUILO INFERIOR, (CH2)t-Ar, DONDE t VARIA DE CERO A 5 Y Ar ES FENILO, FURILO, PIRIDILO, N-METILPIRROLILO, IMIDAZOLILO, SOLO O CON 1 o MAS SUSTITUYENTES COMO OH, OCH3, HALOGENO, AMINO; 3) R2 ES DIFENILMETILO, (CH2)t-Ar; o R1 Y R2 JUNTO CON EL ATOMO DE NITROGENO FORMAN N-TETRAHIDROQUINOLILO, N-TETRAHIDROISOQUINOLILO; EL CUAL A DIFERENCIA DE LA CAMPTOTECINA ES SOLUBLE EN AGUA Y PUEDE TENER ACTIVIDAD INHIBITORIA DE LA TOPOISOMERASA I - DNA IN VITRO Y ACTIVIDAD ANTITUMORAL IN VIVOIT REFERS TO A COMPOUND OF FORMULA I WHERE: 1) n VARIATIONS FROM 1 TO 2; 2) R1 IS H, LOWER ALKYL, CYCLOALKYL C3-C7, (CYCLLOALKYL C3-C7) -LOWER ALKYL, LOWER ALKYLENE, (CH2) t-Ar, WHERE t VARIATIONS FROM ZERO TO 5 AND Ar ES FENIL , PIRIDYL, N-METHYLPYRROLYL, IMIDAZOLYL, ALONE OR WITH 1 or MORE SUBSTITUTES LIKE OH, OCH3, HALOGEN, AMINO; 3) R2 IS DIPHENYLMETHYLL, (CH2) t-Ar; or R1 AND R2 TOGETHER WITH THE NITROGEN ATOM FORM N-TETRAHIDROQUINOLILO, N-TETRAHIDROISOQUINOLILO; WHICH, UNLIKE THE CAMPTOTECINE, IS SOLUBLE IN WATER AND MAY HAVE INHIBITORY ACTIVITY OF TOPOISOMERASE I - DNA IN VITRO AND ANTITUMORAL ACTIVITY IN VIVO

PE1994241061A 1993-04-29 1994-04-27 DERIVATIVE FROM CAMPTOTECINA SOLUBLE IN WATER PE52894A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5458593A 1993-04-29 1993-04-29
US8104293A 1993-06-22 1993-06-22

Publications (1)

Publication Number Publication Date
PE52894A1 true PE52894A1 (en) 1995-01-06

Family

ID=26733234

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1994241061A PE52894A1 (en) 1993-04-29 1994-04-27 DERIVATIVE FROM CAMPTOTECINA SOLUBLE IN WATER

Country Status (10)

Country Link
EP (1) EP0696285A1 (en)
JP (1) JPH08509740A (en)
AP (1) AP9400638A0 (en)
AU (1) AU6777194A (en)
CA (1) CA2161681A1 (en)
IL (1) IL109470A0 (en)
IS (1) IS4152A (en)
MY (1) MY141374A (en)
PE (1) PE52894A1 (en)
WO (1) WO1994025466A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6504029B1 (en) * 1995-04-10 2003-01-07 Daiichi Pharmaceutical Co., Ltd. Condensed-hexacyclic compounds and a process therefor
US5663177A (en) * 1995-05-31 1997-09-02 Smithkline Beecham Corporation Water soluble camptothecin analogs
SG104284A1 (en) 1996-10-30 2004-06-21 Tanabe Seiyaku Co S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
US6559309B2 (en) 1996-11-01 2003-05-06 Osi Pharmaceuticals, Inc. Preparation of a camptothecin derivative by intramolecular cyclisation
US6046209A (en) * 1997-05-27 2000-04-04 Smithkline Beecham Corporation Water soluble camptothecin analogs
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6288072B1 (en) * 1999-12-29 2001-09-11 Monroe E. Wall Camptothecin β-alanine esters with topoisomerase I inhibition

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69033880T2 (en) * 1989-09-15 2002-06-06 Research Triangle Institute, Research Triangle Park Process for the preparation of 10,11-methylenedioxy-20 (RS) -camptothecin and 10,11-methylenedioxy-20 (S) -camptothecin-analog
EP0540099B1 (en) * 1991-10-29 1996-04-17 Glaxo Wellcome Inc. Water soluble camptothecin derivatives
EP0556585A3 (en) * 1992-01-24 1993-09-01 Takeda Chemical Industries, Ltd. Condensed camptothecin derivatives their production and use as antitumor agents

Also Published As

Publication number Publication date
IS4152A (en) 1994-10-30
CA2161681A1 (en) 1994-11-10
MY141374A (en) 2010-04-16
AP9400638A0 (en) 1995-10-28
WO1994025466A1 (en) 1994-11-10
EP0696285A1 (en) 1996-02-14
AU6777194A (en) 1994-11-21
IL109470A0 (en) 1994-07-31
JPH08509740A (en) 1996-10-15

Similar Documents

Publication Publication Date Title
LU91519I2 (en) "Doripenem and its pharmaceutically acceptable derivatives - DORIBAXr"
ATE253343T1 (en) SUCTION BODY FOR HYGIENE ARTICLES
DE60015927D1 (en) Phenylharnstoff und phenylthioharnstoffderivate
BG104316A (en) Tetrazolecontaining analogues of rapamycin, having reduced period of semidecomposition
TW334423B (en) Tricyclic 1-aminoethylpyrrole-derivatives
CA2100258A1 (en) Acridine Derivatives
SE8501067L (en) ANTIPSYCOTIC 1-FLUORPHENYL BUTYL-4- (2-PYRIMIDIMYL) -PIPERAZINE DERIVATE
CA2000468A1 (en) Piperidinyl benzimidazoles
PE52894A1 (en) DERIVATIVE FROM CAMPTOTECINA SOLUBLE IN WATER
FI894867A0 (en) Analogous process for the preparation of a 1,4-diazepine derivative and its pharmaceutically acceptable salt
ES2083771T3 (en) AMIDIC DERIVATIVES OF VITAMIN D.
MY108430A (en) Polyethoxylated vitamin e and a method for the preparation thereof.
DK0565863T3 (en) Semisynthetic clycosaminoglycans with heparin or heparan structure of alpha-L-iduron-2-O-sulfate acid modified at the 2-position
FI871345A (en) ZWITTERJONISKA, BICYCLISKA FOERENINGAR OCH DERAS SALTER, SOLVATER, HYDRATER OCH ESTRAR.
ATE88711T1 (en) GLYCEROL DERIVATIVES, THEIR PRODUCTION AND THERAPEUTIC USE.
EG14365A (en) Derives de l'imidazole et medicaments qui en contiennent
FI851261A0 (en) SUBSTITUTE BENSOPYRANER, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DERAS ANVAENDNING I LAEKEMEDEL.
ES2094622T3 (en) TRITERPEN DERIVATIVES AND ANTAGONISTS OF THE ENDOTHELIN RECEPTOR THAT CONTAINS THEM.
ES2155827T3 (en) 4-CARBOXIIMIDAZOLES AS ANTAGONISTS OF ANGIOTENSIN II AND ITS THERAPEUTIC USE.
FI931740A (en) SEMI-SYNTHETIC GLUCOSAMINOGLYCANNER INNEHAOLLANDE A-L-GALACTURONSYRA SOMAER SUBSTITUTES I 3-STATIONARY NUCLEOPHYLIC RADICAL
ES2099800T3 (en) DIHYDROPYRIDINES USABLE IN ANTITUMORAL THERAPY.
NO164351C (en) ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 5-ALKYL-L-PHENYL-2-PIPERAZINOALKYLPYRAZOLINE-3-ON COMPOUNDS.
IL114698A0 (en) Derivatives of dihydrobenzofurans and pharmaceutical compositions containing them
ES2179362T3 (en) DERIVATIVES OF 4-AMINOETOXI INDOLONA.
FI872566A (en) FUSIONERADE HETEROCYKLISKA IMIDAZOFOERENINGAR.

Legal Events

Date Code Title Description
FX Voluntary withdrawal