IS4152A - Water-soluble Camptothecin derivatives and their method of production - Google Patents

Water-soluble Camptothecin derivatives and their method of production

Info

Publication number
IS4152A
IS4152A IS4152A IS4152A IS4152A IS 4152 A IS4152 A IS 4152A IS 4152 A IS4152 A IS 4152A IS 4152 A IS4152 A IS 4152A IS 4152 A IS4152 A IS 4152A
Authority
IS
Iceland
Prior art keywords
production
water
camptothecin derivatives
soluble camptothecin
soluble
Prior art date
Application number
IS4152A
Other languages
Icelandic (is)
Inventor
Joseph Luzzio Michael
Mark Besterman Jeffrey
G. Evans Michael
Leslie Myers Peter
Original Assignee
Glaxo Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Inc. filed Critical Glaxo Inc.
Publication of IS4152A publication Critical patent/IS4152A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66Nitrogen atoms not forming part of a nitro radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/101,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/141,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/161,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18Ethylenedioxybenzenes, not substituted on the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IS4152A 1993-04-29 1994-04-25 Water-soluble Camptothecin derivatives and their method of production IS4152A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5458593A 1993-04-29 1993-04-29
US8104293A 1993-06-22 1993-06-22

Publications (1)

Publication Number Publication Date
IS4152A true IS4152A (en) 1994-10-30

Family

ID=26733234

Family Applications (1)

Application Number Title Priority Date Filing Date
IS4152A IS4152A (en) 1993-04-29 1994-04-25 Water-soluble Camptothecin derivatives and their method of production

Country Status (10)

Country Link
EP (1) EP0696285A1 (en)
JP (1) JPH08509740A (en)
AP (1) AP9400638A0 (en)
AU (1) AU6777194A (en)
CA (1) CA2161681A1 (en)
IL (1) IL109470A0 (en)
IS (1) IS4152A (en)
MY (1) MY141374A (en)
PE (1) PE52894A1 (en)
WO (1) WO1994025466A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6504029B1 (en) * 1995-04-10 2003-01-07 Daiichi Pharmaceutical Co., Ltd. Condensed-hexacyclic compounds and a process therefor
US5663177A (en) * 1995-05-31 1997-09-02 Smithkline Beecham Corporation Water soluble camptothecin analogs
SG104284A1 (en) 1996-10-30 2004-06-21 Tanabe Seiyaku Co S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
US6559309B2 (en) 1996-11-01 2003-05-06 Osi Pharmaceuticals, Inc. Preparation of a camptothecin derivative by intramolecular cyclisation
US6046209A (en) * 1997-05-27 2000-04-04 Smithkline Beecham Corporation Water soluble camptothecin analogs
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6288072B1 (en) * 1999-12-29 2001-09-11 Monroe E. Wall Camptothecin β-alanine esters with topoisomerase I inhibition

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2165346T3 (en) * 1989-09-15 2002-03-16 Res Triangle Inst ANALOGS OF 10,11-METHYLENDIOXI-20 (RS) -CAMPTOTECINE AND 10.11-METHYLENDIOXI-20 (S) -CAMPTOTECINE.
DK0540099T3 (en) * 1991-10-29 1996-06-17 Glaxo Wellcome Inc Water-soluble camptothecin derivatives
EP0556585A3 (en) * 1992-01-24 1993-09-01 Takeda Chemical Industries, Ltd. Condensed camptothecin derivatives their production and use as antitumor agents

Also Published As

Publication number Publication date
MY141374A (en) 2010-04-16
EP0696285A1 (en) 1996-02-14
PE52894A1 (en) 1995-01-06
AP9400638A0 (en) 1995-10-28
IL109470A0 (en) 1994-07-31
JPH08509740A (en) 1996-10-15
WO1994025466A1 (en) 1994-11-10
CA2161681A1 (en) 1994-11-10
AU6777194A (en) 1994-11-21

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