PE20212263A1 - Formas solidas de un inhibidor de glyt1 - Google Patents

Formas solidas de un inhibidor de glyt1

Info

Publication number
PE20212263A1
PE20212263A1 PE2021001800A PE2021001800A PE20212263A1 PE 20212263 A1 PE20212263 A1 PE 20212263A1 PE 2021001800 A PE2021001800 A PE 2021001800A PE 2021001800 A PE2021001800 A PE 2021001800A PE 20212263 A1 PE20212263 A1 PE 20212263A1
Authority
PE
Peru
Prior art keywords
ppm
peaks
magnetic resonance
nuclear magnetic
chemical shifts
Prior art date
Application number
PE2021001800A
Other languages
English (en)
Spanish (es)
Inventor
Joe Ju Gao
Peter Sieger
Bing-Shiou Yang
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE20212263A1 publication Critical patent/PE20212263A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/422Oxazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
PE2021001800A 2019-05-01 2020-04-30 Formas solidas de un inhibidor de glyt1 PE20212263A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962841401P 2019-05-01 2019-05-01
PCT/US2020/030580 WO2020223419A1 (en) 2019-05-01 2020-04-30 Solid forms of a glyt1 inhibitor

Publications (1)

Publication Number Publication Date
PE20212263A1 true PE20212263A1 (es) 2021-11-29

Family

ID=70740812

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2021001800A PE20212263A1 (es) 2019-05-01 2020-04-30 Formas solidas de un inhibidor de glyt1

Country Status (25)

Country Link
US (2) US11447474B2 (https=)
EP (1) EP3962911A1 (https=)
JP (2) JP7513349B2 (https=)
KR (1) KR20220004174A (https=)
CN (1) CN113784966B (https=)
AR (1) AR118839A1 (https=)
AU (1) AU2020266566B2 (https=)
BR (1) BR112021020883A2 (https=)
CA (1) CA3138288A1 (https=)
CL (2) CL2021002837A1 (https=)
CO (1) CO2021014260A2 (https=)
CR (1) CR20210545A (https=)
DO (1) DOP2021000224A (https=)
EA (1) EA202192925A1 (https=)
EC (1) ECSP21082195A (https=)
IL (1) IL287630A (https=)
JO (1) JOP20210295A1 (https=)
MA (1) MA55801A (https=)
MX (1) MX2021013341A (https=)
PE (1) PE20212263A1 (https=)
PH (1) PH12021552741A1 (https=)
SG (1) SG11202111972YA (https=)
TW (1) TW202106680A (https=)
UA (1) UA129159C2 (https=)
WO (1) WO2020223419A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7930336B2 (en) 2006-12-05 2011-04-19 Altera Corporation Large multiplier for programmable logic device
EA202192925A1 (ru) * 2019-05-01 2022-03-23 Бёрингер Ингельхайм Интернациональ Гмбх Твердые формы ингибитора glyt1
US11813257B2 (en) 2020-01-09 2023-11-14 Disc Medicine, Inc. Methods of treating erythropoietic protoporphyria, X-linked protoporphyria, or congenital erythropoietic porphyria with glycine transport inhibitors
MX2023001818A (es) * 2020-08-13 2023-03-13 Boehringer Ingelheim Int Compuestos para usarse en tratamiento de deterioro cognitivo asociado con la esquizofrenia.
IL301829A (en) 2020-10-13 2023-06-01 Boehringer Ingelheim Int Process of reworking
WO2025140479A1 (zh) * 2023-12-29 2025-07-03 苏州科睿思制药有限公司 Iclepertin的晶型及其制备方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL65843A (en) * 1977-08-11 1986-12-31 American Cyanamid Co Pharmaceutical compositions for the treatment of depression containing 3-aza-bicyclo(3.1.0)hexane derivatives and certain novel compounds of this type
RS20060190A (sr) * 2003-10-14 2008-08-07 Pfizer Products Inc., Biciklični /3.1.0/ derivati kao inhibitori transportera glicina
CA2745690A1 (en) * 2008-12-04 2010-06-10 Evgeny Zlotinikov Novel polymorphic forms of an azabicyclo-trifluoromethyl benzamide derivative
EP2381941A4 (en) * 2008-12-29 2012-08-01 Univ Vanderbilt 3.1.0 BICYCLIC GLYTI INHIBITORS AND METHOD FOR THE PRODUCTION AND USE THEREOF
US9012489B2 (en) 2011-08-03 2015-04-21 Boehringer Ingelheim International Gmbh Phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones and the use thereof as medicament
IL270155B (en) * 2017-04-27 2022-07-01 Takeda Pharmaceuticals Co Heterocyclic compound
EA202192925A1 (ru) * 2019-05-01 2022-03-23 Бёрингер Ингельхайм Интернациональ Гмбх Твердые формы ингибитора glyt1
MX2023001818A (es) * 2020-08-13 2023-03-13 Boehringer Ingelheim Int Compuestos para usarse en tratamiento de deterioro cognitivo asociado con la esquizofrenia.
IL301829A (en) * 2020-10-13 2023-06-01 Boehringer Ingelheim Int Process of reworking

Also Published As

Publication number Publication date
CN113784966B (zh) 2024-07-19
JOP20210295A1 (ar) 2023-01-30
JP2024100792A (ja) 2024-07-26
DOP2021000224A (https=) 2021-12-15
TW202106680A (zh) 2021-02-16
NZ781254A (en) 2025-03-28
CR20210545A (es) 2021-12-23
JP7714727B2 (ja) 2025-07-29
JP2022530630A (ja) 2022-06-30
CL2021002837A1 (es) 2022-07-29
PH12021552741A1 (en) 2022-07-11
CA3138288A1 (en) 2020-11-05
EA202192925A1 (ru) 2022-03-23
EP3962911A1 (en) 2022-03-09
ECSP21082195A (es) 2021-12-30
WO2020223419A1 (en) 2020-11-05
AU2020266566B2 (en) 2025-11-06
MX2021013341A (es) 2021-11-17
US11447474B2 (en) 2022-09-20
MA55801A (fr) 2022-03-09
US20220332710A1 (en) 2022-10-20
AR118839A1 (es) 2021-11-03
CL2024000829A1 (es) 2024-09-27
KR20220004174A (ko) 2022-01-11
IL287630A (en) 2021-12-01
US20200347041A1 (en) 2020-11-05
SG11202111972YA (en) 2021-11-29
AU2020266566A1 (en) 2021-11-11
JP7513349B2 (ja) 2024-07-09
CO2021014260A2 (es) 2021-10-29
UA129159C2 (uk) 2025-01-29
BR112021020883A2 (pt) 2022-04-19
CN113784966A (zh) 2021-12-10

Similar Documents

Publication Publication Date Title
PE20212263A1 (es) Formas solidas de un inhibidor de glyt1
AR082699A1 (es) Sales de fenotiazindiaminio, composicion farmaceutica en base al compuesto y proceso de preparacion del compuesto
ES2687368T3 (es) Inhibidores de proteasa de epoxi cetona dipeptídica y tripeptídica
CO2019007711A2 (es) N-[4-fluoro-5-[[(2s,4s)-2-metil-4-[(5-metil-1,2,4-oxadiazol-3-il)metoxi]-1-piperidil]metil]tiazol-2-il]acetamida como inhibidor de oga
ECSP14013221A (es) Fenil-3-aza-biciclo [3.1.0] hex-3-il-metanonas y su uso como medicamento.
CY1120104T1 (el) Αναστολεις της syk
JOP20230235A1 (ar) عقاقير أولية جديدة من الكاتيكولامين للاستخدام في علاج مرض باركنسون
PE20160863A1 (es) Proceso para la sintesis de un inhibidor de indolamina 2,3-dioxigenasa
EA201490650A1 (ru) Фармацевтические композиции
EA201690153A1 (ru) Замещенные бензофуранильные и бензоксазолильные соединения и их применения
EA201791802A1 (ru) СШИТЫЕ ДИГИДРО-4H-ПИРАЗОЛО[5,1-c][1,4]ОКСАЗИНИЛОВЫЕ СОЕДИНЕНИЯ И АНАЛОГИ ДЛЯ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЙ ЦНС
JP2015520769A5 (https=)
CO6680645A2 (es) Inhibidores de oxadiazol de la producción de leucotrieno
EA201290872A1 (ru) Способ получения бензоксаборолов
EA201592255A1 (ru) Производные пиразолопирролидин-4-она в качестве ингибиторов вет и их применение при лечении заболевания
EA201790337A1 (ru) Кристаллические формы ингибиторов глутаминазы
EA201391097A1 (ru) СОЕДИНЕНИЯ ДЛЯ СНИЖЕНИЯ ВЫРАБОТКИ β-АМИЛОИДА
AR063945A1 (es) Acidos carboxilicos inhibidores de la metalproteinasa matriz.
AR087672A1 (es) Forma cristalina del sulfamato de {(1s,2s,4r)-4-[(6-{[(1r,2s)-5-cloro-2-metoxi-2,3-dihidro-1h-inden-1-il]amino}pirimidin-4-il)oxi]-2-hidroxiciclopentil}metilo, composiciones farmaceuticas que la contienen y uso de las mismas para tratar cancer
EA201690755A1 (ru) Солевые и кристаллические формы ингибитора plk-4
CR20210394A (es) Formas de sal y cristalinas de un compuesto orgánico y composiciones farmacéuticas del mismo
MX2021007511A (es) Procedimiento para la preparacion de anilinas sustituidas.
EA201490383A1 (ru) Способ получения ситаглиптина и его фармацевтически приемлемых солей
AR086196A1 (es) Derivados de pirazolo[3,4-c]quinolina, inhibidores de quinasa
CY1122375T1 (el) Συμπυκνωμενα με τετραϋδροφουρανιο αμινοϋδροθειαζινικα αναλογα τα οποια ειναι χρησιμα στη θεραπεια της νοσου toy alzheimer