PE20211480A1 - Sales de meglumina de tienopirimidinas - Google Patents
Sales de meglumina de tienopirimidinasInfo
- Publication number
- PE20211480A1 PE20211480A1 PE2020001614A PE2020001614A PE20211480A1 PE 20211480 A1 PE20211480 A1 PE 20211480A1 PE 2020001614 A PE2020001614 A PE 2020001614A PE 2020001614 A PE2020001614 A PE 2020001614A PE 20211480 A1 PE20211480 A1 PE 20211480A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- alkylene
- heterocyclyl
- aryl
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/40—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton with quaternised nitrogen atoms bound to carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
En la presente se divulgan las sales de meglumina de tienopirimidina formula (I), donde: R1 es hidrogeno, (C1-C6) alquilo, (C1-C6) alcoxi o (C1-C6)haloalquilo que contiene 1-6 atomos de halogeno; R2 es hidrogeno, (C1-C6)alquilo, [(C1-C6) alquileno]arilo o amino; R3 es hidrogeno, (C1-C6)alquilo, (C2-C6) alquinilo, [(C1-C6)alquileno]N(R4)(R5), [(C1-C6) alquileno]S(R4) o -X-Y, o R2 y R3 junto con los atomos que estan unidos forman un heterociclilo; R4 y R5 son independientemente H o (C1-C6) alquilo; X es un enlace quimico, -CH2-.-CH(OH)-, -CH(C6 H5)-, -CO-, -CH2CH2-,CH2CO-,-COCH2-,S,O o NH; Y es cicloalquilo, heterociclilo, arilo o heteroarilo; Z es S u O; n es 0,1,2,3 o 4; M+ es (a); y en donde cualquier alquilo, alquileno, cicloalquilo, heterociclilo, heteroarilo o arilo se substituye opcionalmente con 1,2 o 3 grupos seleccionados de OH, CN, halogeno, (C1-C6)alquilo, O(C1-C6) alquilo, 5 (C2-C6)alquenilo, haloalquilo, amino, oxo y nitro. Dichos compuestos son utiles para tratar o prevenir la insuficiencia cardiaca.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862658683P | 2018-04-17 | 2018-04-17 | |
| PCT/US2019/027665 WO2019204298A1 (en) | 2018-04-17 | 2019-04-16 | Meglumine salts of thienopyrimidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20211480A1 true PE20211480A1 (es) | 2021-08-05 |
Family
ID=68161061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2020001614A PE20211480A1 (es) | 2018-04-17 | 2019-04-16 | Sales de meglumina de tienopirimidinas |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US10822346B2 (es) |
| EP (1) | EP3781155A4 (es) |
| JP (1) | JP2021522186A (es) |
| KR (1) | KR20210002541A (es) |
| CN (1) | CN112367989A (es) |
| AU (1) | AU2019255233A1 (es) |
| BR (1) | BR112020021153A2 (es) |
| CA (1) | CA3097384A1 (es) |
| CL (1) | CL2020002671A1 (es) |
| CO (1) | CO2020014069A2 (es) |
| IL (1) | IL278064A (es) |
| MX (1) | MX2020010884A (es) |
| PE (1) | PE20211480A1 (es) |
| PH (1) | PH12020551701A1 (es) |
| SG (1) | SG11202010161UA (es) |
| WO (1) | WO2019204298A1 (es) |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4377583A (en) | 1981-08-21 | 1983-03-22 | Mead Johnson & Company | N-Methyl-D-glucamine salt of with 3,4-dihydro-5-methyl-6-(2-methylpropyl)-4-oxothieno[2,3-d]pyrimidine-2-carboxylic acid |
| WO1989008113A1 (fr) * | 1988-03-02 | 1989-09-08 | Yoshitomi Pharmaceutical Industries, Ltd. | COMPOSES DE 3,4-DIHYDROTHIENO[2,3-d]PYRIMIDINE ET LEURS APPLICATIONS PHARMACOLOGIQUES |
| US5795909A (en) * | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
| US6576636B2 (en) | 1996-05-22 | 2003-06-10 | Protarga, Inc. | Method of treating a liver disorder with fatty acid-antiviral agent conjugates |
| US6331543B1 (en) | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
| EP1908765B1 (en) * | 2005-06-14 | 2014-10-22 | ASKA Pharmaceutical Co., Ltd. | Thienopyrimidine derivative |
| EP2402347A1 (en) | 2006-04-26 | 2012-01-04 | F. Hoffmann-La Roche AG | Pharmaceutical compounds |
| GB2465405A (en) | 2008-11-10 | 2010-05-19 | Univ Basel | Triazine, pyrimidine and pyridine analogues and their use in therapy |
| CN103038238B (zh) * | 2010-05-31 | 2016-05-04 | Aska制药株式会社 | 噻吩并嘧啶衍生物的结晶 |
| WO2014110344A1 (en) * | 2013-01-11 | 2014-07-17 | Novartis Ag | Meglumine salt forms of 2-((1 r,4r)-4-(4-(5-(benzoxazol-2-ylamino)pyridin-2-yl)phenyl)cyclohexyl) acetic acid and their use as dgat1 inhibitors |
| CA3030021A1 (en) * | 2016-07-07 | 2018-01-11 | Cardurion Pharmaceuticals, Llc | Methods for treatment of heart failure |
-
2019
- 2019-04-16 EP EP19788035.4A patent/EP3781155A4/en not_active Withdrawn
- 2019-04-16 WO PCT/US2019/027665 patent/WO2019204298A1/en unknown
- 2019-04-16 JP JP2020557319A patent/JP2021522186A/ja not_active Withdrawn
- 2019-04-16 KR KR1020207032912A patent/KR20210002541A/ko not_active Application Discontinuation
- 2019-04-16 SG SG11202010161UA patent/SG11202010161UA/en unknown
- 2019-04-16 CA CA3097384A patent/CA3097384A1/en active Pending
- 2019-04-16 CN CN201980026565.8A patent/CN112367989A/zh active Pending
- 2019-04-16 PE PE2020001614A patent/PE20211480A1/es unknown
- 2019-04-16 MX MX2020010884A patent/MX2020010884A/es unknown
- 2019-04-16 BR BR112020021153-2A patent/BR112020021153A2/pt not_active Application Discontinuation
- 2019-04-16 AU AU2019255233A patent/AU2019255233A1/en not_active Abandoned
- 2019-04-16 US US16/385,748 patent/US10822346B2/en active Active
-
2020
- 2020-10-14 PH PH12020551701A patent/PH12020551701A1/en unknown
- 2020-10-15 IL IL278064A patent/IL278064A/en unknown
- 2020-10-15 CL CL2020002671A patent/CL2020002671A1/es unknown
- 2020-10-20 US US17/075,148 patent/US20210139499A1/en not_active Abandoned
- 2020-11-11 CO CONC2020/0014069A patent/CO2020014069A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019204298A1 (en) | 2019-10-24 |
| KR20210002541A (ko) | 2021-01-08 |
| IL278064A (en) | 2020-11-30 |
| EP3781155A1 (en) | 2021-02-24 |
| CO2020014069A2 (es) | 2021-01-29 |
| MX2020010884A (es) | 2021-02-26 |
| JP2021522186A (ja) | 2021-08-30 |
| CL2020002671A1 (es) | 2021-04-16 |
| SG11202010161UA (en) | 2020-11-27 |
| CA3097384A1 (en) | 2019-10-24 |
| PH12020551701A1 (en) | 2021-09-06 |
| CN112367989A (zh) | 2021-02-12 |
| US20190315765A1 (en) | 2019-10-17 |
| US20210139499A1 (en) | 2021-05-13 |
| AU2019255233A1 (en) | 2020-11-26 |
| BR112020021153A2 (pt) | 2021-03-23 |
| EP3781155A4 (en) | 2021-10-06 |
| US10822346B2 (en) | 2020-11-03 |
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