PE20211195A1 - A METHOD TO MODIFY THE RELEASE OF A THERAPEUTICALLY ACTIVE AGENT FROM AN ELASTOMERIC MATRIX - Google Patents

A METHOD TO MODIFY THE RELEASE OF A THERAPEUTICALLY ACTIVE AGENT FROM AN ELASTOMERIC MATRIX

Info

Publication number
PE20211195A1
PE20211195A1 PE2020000735A PE2020000735A PE20211195A1 PE 20211195 A1 PE20211195 A1 PE 20211195A1 PE 2020000735 A PE2020000735 A PE 2020000735A PE 2020000735 A PE2020000735 A PE 2020000735A PE 20211195 A1 PE20211195 A1 PE 20211195A1
Authority
PE
Peru
Prior art keywords
core
pyycomethycene
therapeutically active
active agent
elastomeric matrix
Prior art date
Application number
PE2020000735A
Other languages
Spanish (es)
Inventor
Manja Ahola
Risto Hakala
Piia Hara
Antti Keinanen
Henriikka Korolainen
Jyrki Pihlaja
Original Assignee
Bayer Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Oy filed Critical Bayer Oy
Publication of PE20211195A1 publication Critical patent/PE20211195A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0039—Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Abstract

SE REFIERE A UN METODO PARA MODIFICAR LA LIBERACION DE UN AGENTE TERAPEUTICAMENTE ACTIVO DE UNA MATRIZ ELASTOMERICA, EL CUAL COMPRENDE: A) PROPORCIONAR UN NUCLEO QUE COMPRENDE UNA MATRIZ ELASTOMERICA Y UN AGENTE TERAPEUTICAMENTE ACTIVO TAL COMO INDOMETACINA, DICLOFENACO, PIROXICAM, MELOXICAM Y CETOPROFENO; B) SUMERGIR EL NUCLEO EN UNA SOLUCION DE RECUBRIMIENTO QUE COMPRENDE UN ELASTOMERO QUE CONTIENE 20-35% EN PESO DE UN AGENTE DE RELLENO TAL COMO SILICE, DIOXIDO DE TITANIO, SULFATO DE BARIO, CARBONO Y LAS MEZCLAS DE LOS MISMOS, CALCULADO DE LA CANTIDAD TOTAL DE AGENTE DE RELLENO Y ELASTOMERO; C) CURAR EL NUCLEO SUMERGIDO PARA PROPORCIONAR UN NUCLEO RECUBIERTO; DONDE EL ELASTOMERO COMPRENDIDO EN EL NUCLEO Y EL ELASTOMERO COMPRENDIDO EN LA SOLUCION DE RECUBRIMIENTO SE SELECCIONAN DE POLI(DIMETIL)SILOXANOS, POLIETILENO ACETATOS DE VINILO (EVA), POLIURETANOS (PU), POLIHIDROXIETIL-METACRILATOS (PHEMA) Y POLIMETIL-METACRILATOS (PMMA).IT REFERS TO A METHOD TO MODIFY THE RELEASE OF A THERAPEUTICALLY ACTIVE AGENT FROM AN ELASTOMERIC MATRIX, WHICH INCLUDES: A) PROVIDE A CORE THAT INCLUDES AN ELASTOMERIC MATRIX AND A THERAPEUTICALLY ACTIVE AGENT, PYYCOMETHYCENE, PYYCOMETHYCENE, SUCH AS INDICOMETHYCENE, PYYCOMETHYCENE, PYYCOMETHYCENE. B) IMMERSE THE CORE IN A COATING SOLUTION THAT INCLUDES AN ELASTOMER CONTAINING 20-35% BY WEIGHT OF A FILLING AGENT SUCH AS SILICA, TITANIUM DIOXIDE, BARIUM SULPHATE, CARBON AND THE MIXTURES OF THE SAME, CALCULATED TOTAL AMOUNT OF FILLING AGENT AND ELASTOMER; C) CURE THE SUBMERGED CORE TO PROVIDE A COATED CORE; WHERE THE ELASTOMER INCLUDED IN THE CORE AND THE ELASTOMER INCLUDED IN THE COATING SOLUTION ARE SELECTED FROM POLY (DIMETHYL) SILOXANES, POLYETHYLENE ACETATES OF VINYL (EVA), POLYURETHANES (PU), POLYHYDROCEMETHYL METHYL METHYL METHYL-PMMAXYL EYLETHYLS ).

PE2020000735A 2017-09-27 2018-09-19 A METHOD TO MODIFY THE RELEASE OF A THERAPEUTICALLY ACTIVE AGENT FROM AN ELASTOMERIC MATRIX PE20211195A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17193367 2017-09-27
EP18167014 2018-04-12
PCT/EP2018/075331 WO2019063382A1 (en) 2017-09-27 2018-09-19 A method for modifying release of a therapeutically active agent from an elastomeric matrix

Publications (1)

Publication Number Publication Date
PE20211195A1 true PE20211195A1 (en) 2021-07-01

Family

ID=63592747

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2020000735A PE20211195A1 (en) 2017-09-27 2018-09-19 A METHOD TO MODIFY THE RELEASE OF A THERAPEUTICALLY ACTIVE AGENT FROM AN ELASTOMERIC MATRIX

Country Status (18)

Country Link
US (1) US11666552B2 (en)
EP (1) EP3687495A1 (en)
JP (1) JP7242648B2 (en)
KR (1) KR20200059224A (en)
CN (1) CN111148507B (en)
AU (1) AU2018340266A1 (en)
BR (1) BR112020005928A2 (en)
CA (1) CA3076768A1 (en)
CL (1) CL2020000778A1 (en)
CO (1) CO2020003454A2 (en)
IL (1) IL272878A (en)
JO (1) JOP20200067A1 (en)
MX (1) MX2020007323A (en)
PE (1) PE20211195A1 (en)
SG (1) SG11202001293SA (en)
TW (1) TW201919587A (en)
UY (1) UY37906A (en)
WO (1) WO2019063382A1 (en)

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US6063395A (en) * 1998-11-12 2000-05-16 Leiras Oy Drug delivery device especially for the delivery of progestins and estrogens
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AU2002210580A1 (en) 2000-10-20 2002-04-29 Leiras Oy Drug delivery system
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US20070043332A1 (en) * 2003-07-10 2007-02-22 Galen (Chemiclas) Liimited Intravaginal drug delivery devices
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EP2140860A1 (en) 2008-07-03 2010-01-06 Bayer Schering Pharma Oy An improved method of contraception
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AR089765A1 (en) * 2012-01-23 2014-09-17 Bayer Oy A SYSTEM FOR THE SUPPLY OF A PHARMACO
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Also Published As

Publication number Publication date
CN111148507A (en) 2020-05-12
IL272878A (en) 2020-04-30
CN111148507B (en) 2023-09-26
JP2020535159A (en) 2020-12-03
MX2020007323A (en) 2020-09-07
EP3687495A1 (en) 2020-08-05
SG11202001293SA (en) 2020-03-30
TW201919587A (en) 2019-06-01
US11666552B2 (en) 2023-06-06
CA3076768A1 (en) 2019-04-04
US20200276159A1 (en) 2020-09-03
RU2020113426A3 (en) 2022-02-22
BR112020005928A2 (en) 2020-10-06
UY37906A (en) 2019-02-28
WO2019063382A1 (en) 2019-04-04
RU2020113426A (en) 2021-10-27
CL2020000778A1 (en) 2020-09-25
CO2020003454A2 (en) 2020-04-13
JP7242648B2 (en) 2023-03-20
AU2018340266A1 (en) 2020-03-05
JOP20200067A1 (en) 2020-04-27
KR20200059224A (en) 2020-05-28

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