PE20170916A1 - COMPOSITIONS AND METHODS FOR ANTIBODIES TARGETING BMP6 - Google Patents

COMPOSITIONS AND METHODS FOR ANTIBODIES TARGETING BMP6

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Publication number
PE20170916A1
PE20170916A1 PE2017001091A PE2017001091A PE20170916A1 PE 20170916 A1 PE20170916 A1 PE 20170916A1 PE 2017001091 A PE2017001091 A PE 2017001091A PE 2017001091 A PE2017001091 A PE 2017001091A PE 20170916 A1 PE20170916 A1 PE 20170916A1
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Peru
Prior art keywords
sequence
amino acids
seq
compositions
methods
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PE2017001091A
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Spanish (es)
Inventor
Feng Cong
William Dietrich
Nathalie George
Dong Liu
Asher Scachter
Aditi Soni
Jing Zhou
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Novartis Ag
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Publication of PE20170916A1 publication Critical patent/PE20170916A1/en

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    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

SE REFIERE A UN ANTICUERPO AISLADO O FRAGMENTO DEL MISMO DE UNION AL ANTIGENO QUE SE UNE A BMP6 HUMANA QUE COMPRENDE: A) LAS SIGUIENTES TRES REGIONES DETERMINANTES DE COMPLEMENTARIEDAD DE CADENA PESADA (HCDR) i) HCDR1 QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEC ID NO: 69, ii) HCDR2 QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEC ID NO: 70, Y iii) HCDR3 QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEC ID NO: 71; Y B) LAS SIGUIENTES TRES REGIONES DETERMINANTES DE COMPLEMENTARIEDAD DE CADENA LIGERA (LCDR) i) LCDR1 QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEC ID NO: 79, ii) LCDR2 QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEC ID NO: 80, Y iii) LCDR3 QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEC ID NO: 81. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA, UN POLINUCLEOTIDO, UN VECTOR DE EXPRESION Y A UNA CELULA HUESPED. DICHO ANTICUERPO ES UTIL EN EL TRATAMIENTO DE LA ANEMIA, CANCERIT REFERS TO AN ISOLATED ANTIBODY OR FRAGMENT OF THE SAME BINDING TO THE ANTIGEN THAT IS BINDING TO HUMAN BMP6, INCLUDING: A) THE FOLLOWING THREE DETERMINING REGIONS OF HEAVY CHAIN COMPLEMENTARITY (HCDR) i) HCDR1 SEQUENCE OF IDENTIFICATION NO: 69, ii) HCDR2 THAT INCLUDES THE SEQUENCE OF AMINO ACIDS OF SEQ ID NO: 70, AND iii) HCDR3 THAT INCLUDES THE SEQUENCE OF AMINO ACIDS OF SEQ ID NO: 71; AND B) THE FOLLOWING THREE DETERMINING REGIONS OF LIGHT CHAIN COMPLEMENTARITY (LCDR) i) LCDR1 THAT INCLUDES THE SEQUENCE OF AMINO ACIDS OF SEQ ID NO: 79, ii) LCDR2 THAT INCLUDES THE SEQUENCE OF AMINO ACIDS OF SEC ID NO: 80, AND iii) LCDR3 INCLUDING THE SEQUENCE OF AMINO ACIDS OF SEQ ID NO: 81. ALSO REFERS TO A PHARMACEUTICAL COMPOSITION, A POLYNUCLEOTIDE, A VECTOR OF EXPRESSION AND A HOST CELL. SAID ANTIBODY IS USEFUL IN THE TREATMENT OF ANEMIA, CANCER

PE2017001091A 2014-12-19 2015-12-18 COMPOSITIONS AND METHODS FOR ANTIBODIES TARGETING BMP6 PE20170916A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462094716P 2014-12-19 2014-12-19
US201562181803P 2015-06-19 2015-06-19

Publications (1)

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PE20170916A1 true PE20170916A1 (en) 2017-07-12

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Family Applications (1)

Application Number Title Priority Date Filing Date
PE2017001091A PE20170916A1 (en) 2014-12-19 2015-12-18 COMPOSITIONS AND METHODS FOR ANTIBODIES TARGETING BMP6

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US (3) US9862764B2 (en)
EP (1) EP3233913B1 (en)
JP (2) JP6802796B2 (en)
KR (1) KR20170089010A (en)
CN (1) CN107531783B (en)
AU (2) AU2015365373C1 (en)
BR (1) BR112017012954A2 (en)
CA (1) CA2970869A1 (en)
CL (1) CL2017001461A1 (en)
CO (1) CO2017005941A2 (en)
CR (1) CR20170262A (en)
EC (1) ECSP17045736A (en)
ES (1) ES2957214T3 (en)
GT (1) GT201700131A (en)
IL (1) IL252966B (en)
JO (1) JO3791B1 (en)
MX (1) MX2017008191A (en)
MY (1) MY183779A (en)
PE (1) PE20170916A1 (en)
PH (1) PH12017501077A1 (en)
SG (1) SG11201704634SA (en)
TN (1) TN2017000242A1 (en)
TW (1) TWI714545B (en)
UY (1) UY36449A (en)
WO (1) WO2016098079A2 (en)
ZA (1) ZA201703897B (en)

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EP3471759A1 (en) * 2016-06-15 2019-04-24 Novartis AG Methods for treating disease using inhibitors of bone morphogenetic protein 6 (bmp6)
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