PE20151137A1 - CYCLOPENTILPYRAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS - Google Patents

CYCLOPENTILPYRAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS

Info

Publication number
PE20151137A1
PE20151137A1 PE2015000205A PE2015000205A PE20151137A1 PE 20151137 A1 PE20151137 A1 PE 20151137A1 PE 2015000205 A PE2015000205 A PE 2015000205A PE 2015000205 A PE2015000205 A PE 2015000205A PE 20151137 A1 PE20151137 A1 PE 20151137A1
Authority
PE
Peru
Prior art keywords
cyclopentilpyrazoles
calcium channel
channel blockers
type calcium
alkyl
Prior art date
Application number
PE2015000205A
Other languages
Spanish (es)
Inventor
Michael Winters
Zhihua Sui
Christopher Flores
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49036654&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20151137(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PE20151137A1 publication Critical patent/PE20151137A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Abstract

La invencion se refiere a compuestos, composiciones y metodos para el tratamiento de varias enfermedades, sindromes, afecciones y trastornos, que incluyen el dolor. Tales compuestos estan representados por la Formula (I) como sigue: en donde R1, es alquilo C1-C4, alcoxi C1-C4, entre otros; R2 es H; R3 es H, Cl o F; Q es Q1, Q2 o Q3; R4 es H, alquilo C1-C4, entre otros; R5 y R6 son H, alquilo C1-C4, entre otros; G es alquilo C1-C6, alcoxi C1-C4, entre otrosThe invention relates to compounds, compositions, and methods for the treatment of various diseases, syndromes, conditions, and disorders, including pain. Such compounds are represented by Formula (I) as follows: where R1 is C1-C4 alkyl, C1-C4 alkoxy, among others; R2 is H; R3 is H, Cl, or F; Q is Q1, Q2 or Q3; R4 is H, C1-C4 alkyl, among others; R5 and R6 are H, C1-C4 alkyl, among others; G is C1-C6 alkyl, C1-C4 alkoxy, among others

PE2015000205A 2012-08-16 2013-08-16 CYCLOPENTILPYRAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS PE20151137A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261683775P 2012-08-16 2012-08-16

Publications (1)

Publication Number Publication Date
PE20151137A1 true PE20151137A1 (en) 2015-08-07

Family

ID=49036654

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2015000205A PE20151137A1 (en) 2012-08-16 2013-08-16 CYCLOPENTILPYRAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS

Country Status (21)

Country Link
US (1) US8853418B2 (en)
EP (1) EP2885279A1 (en)
JP (1) JP6262231B2 (en)
KR (1) KR20150042270A (en)
CN (1) CN105189464B (en)
AU (1) AU2013302469B2 (en)
BR (1) BR112015003328A2 (en)
CA (1) CA2882042A1 (en)
CL (1) CL2015000357A1 (en)
CR (1) CR20150068A (en)
EA (1) EA201590382A1 (en)
EC (1) ECSP15009830A (en)
HK (1) HK1217690A1 (en)
IL (1) IL237189A0 (en)
IN (1) IN2015DN01237A (en)
MX (1) MX2015002037A (en)
PE (1) PE20151137A1 (en)
PH (1) PH12015500314A1 (en)
SG (1) SG11201501140RA (en)
WO (1) WO2014028801A1 (en)
ZA (1) ZA201501746B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9974775B2 (en) 2013-08-16 2018-05-22 Janssen Pharmaceutica Nv Substituted imidazoles as N-type calcium channel blockers

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015003393A2 (en) 2012-08-16 2017-07-04 Janssen Pharmaceutica Nv substituted pyrazoles as n-type calcium channel blockers
EP2957559A1 (en) * 2014-06-18 2015-12-23 L'Universite de Strasbourg Iminosydnone derivatives for conjugation and release of compounds of interest

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1287174B1 (en) * 1996-11-15 1998-08-04 Angelini Ricerche Spa PHARMACOLOGICALLY ACTIVE DIARYL-CYCLOMETHYLENPYRAZOLES, PROCEDURE FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
JP2001220390A (en) * 2000-02-09 2001-08-14 Yamanouchi Pharmaceut Co Ltd Condensed pyrazole derivative
CN1938023A (en) * 2004-03-08 2007-03-28 惠氏公司 Ion channel modulators
BRPI0508552A (en) * 2004-03-08 2007-08-14 Wyeth Corp ion channel modulators
WO2007056091A2 (en) * 2005-11-09 2007-05-18 Abbott Laboratories 2-phenyl-2h-pyraz0le derivatives as p2x7 receptor antagonists and uses thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9974775B2 (en) 2013-08-16 2018-05-22 Janssen Pharmaceutica Nv Substituted imidazoles as N-type calcium channel blockers

Also Published As

Publication number Publication date
IN2015DN01237A (en) 2015-06-26
CR20150068A (en) 2015-04-30
WO2014028801A1 (en) 2014-02-20
AU2013302469A1 (en) 2015-02-26
BR112015003328A2 (en) 2017-07-04
JP2015524851A (en) 2015-08-27
EP2885279A1 (en) 2015-06-24
CN105189464B (en) 2017-12-12
EA201590382A1 (en) 2015-08-31
CA2882042A1 (en) 2014-02-20
CN105189464A (en) 2015-12-23
HK1217690A1 (en) 2017-01-20
AU2013302469B2 (en) 2017-08-24
CL2015000357A1 (en) 2015-06-12
KR20150042270A (en) 2015-04-20
SG11201501140RA (en) 2015-04-29
ZA201501746B (en) 2017-08-30
PH12015500314A1 (en) 2015-03-30
ECSP15009830A (en) 2015-12-31
MX2015002037A (en) 2016-01-22
IL237189A0 (en) 2015-04-30
US8853418B2 (en) 2014-10-07
US20140051660A1 (en) 2014-02-20
JP6262231B2 (en) 2018-01-17

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