PE20140391A1 - 1H-PIRAZOLE-5-SODIUM OLATE SUBSTITUTE - Google Patents
1H-PIRAZOLE-5-SODIUM OLATE SUBSTITUTEInfo
- Publication number
- PE20140391A1 PE20140391A1 PE2013000943A PE2013000943A PE20140391A1 PE 20140391 A1 PE20140391 A1 PE 20140391A1 PE 2013000943 A PE2013000943 A PE 2013000943A PE 2013000943 A PE2013000943 A PE 2013000943A PE 20140391 A1 PE20140391 A1 PE 20140391A1
- Authority
- PE
- Peru
- Prior art keywords
- pirazole
- compound
- sodium
- substitute
- morfolin
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
REFERIDA AL COMPUESTO 1- 6- MORFOLIN-4-IL PIRIMIDIN-4-IL -4- 1H-1,2,3-TRIAZOL-1-IL -1H-PIRAZOL-5-OLATO SODICO DE FORMULA (II) EN SU FORMA CRISTALINA. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION QUE CONSISTE EN HACER REACCIONAR EL COMPUESTO 1-[6-(MORFOLIN-4-IL)PIRIMIDIN-4-IL]-4-(1H-1,2,3-TRIAZOL-1-IL)-1H-PIRAZOL-5-OL EN UN DISOLVENTE CON HIDROXIDO DE SODIO O SODA CAUSTICA ACUOSA O UNA SAL SODICA, CON LA ADICION DE UNA BASE TAL COMO TRIETILAMINA. DICHO COMPUESTO ES UTIL EN EL TRATAMIENTO DE ENFERMEDADES CARDIO-CIRCULATORIAS, ANEMIA, ENFERMEDADES RENALES CRONICAS E INSUFECIENCIA RENALREFERRING TO THE COMPOUND 1- 6- MORFOLIN-4-IL PYRIMIDIN-4-IL -4- 1H-1,2,3-TRIAZOL-1-IL-1H-PIRAZOLE-5-OLATE SODIUM OF FORMULA (II) IN ITS FORM CRYSTAL. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND TO A PREPARATION PROCEDURE WHICH CONSISTS OF REACTING THE COMPOUND 1- [6- (MORFOLIN-4-IL) PIRIMIDIN-4-IL] -4- (1H-1,2,3-TRIAZOLE -1-IL) -1H-PIRAZOL-5-OL IN A SOLVENT WITH SODIUM HYDROXIDE OR AQUEOUS CAUSTIC SODA OR A SODIUM SALT, WITH THE ADDITION OF A BASE SUCH AS TRIETILAMINE. SAID COMPOUND IS USEFUL IN THE TREATMENT OF CARDIO-CIRCULATORY DISEASES, ANEMIA, CHRONIC KIDNEY DISEASES AND KIDNEY INSUFFICIENCY
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102010044131A DE102010044131A1 (en) | 2010-11-18 | 2010-11-18 | Substituted sodium 1H-pyrazole-5-olate |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20140391A1 true PE20140391A1 (en) | 2014-03-29 |
Family
ID=44999768
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2013000943A PE20140391A1 (en) | 2010-11-18 | 2011-11-15 | 1H-PIRAZOLE-5-SODIUM OLATE SUBSTITUTE |
PE2017002012A PE20180324A1 (en) | 2010-11-18 | 2011-11-15 | 1H-PIRAZOLE-5-SODIUM OLATE SUBSTITUTE |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2017002012A PE20180324A1 (en) | 2010-11-18 | 2011-11-15 | 1H-PIRAZOLE-5-SODIUM OLATE SUBSTITUTE |
Country Status (45)
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102006050516A1 (en) | 2006-10-26 | 2008-04-30 | Bayer Healthcare Ag | New pyrazol-3-one compounds are hypoxia-inducible transcription factor-prolyl-4-hydroxylase inhibitors useful e.g. to treat and/or prophylaxis heart-circulation diseases, heart failure, anemia, chronic kidney diseases and renal failure |
DE102010044131A1 (en) * | 2010-11-18 | 2012-05-24 | Bayer Schering Pharma Aktiengesellschaft | Substituted sodium 1H-pyrazole-5-olate |
MY184577A (en) * | 2012-05-08 | 2021-04-06 | Bayer Pharma AG | Method for the preparation of triazole compounds |
MX2016004628A (en) * | 2013-10-17 | 2016-08-01 | Bayer Pharma AG | Pharmaceutical dosage forms containing sodium-1-[6-(morpholin-4-y l)pyrimidin-4-yl]-4-(1h-1,2,3-triazol-1-yl)-1h-pyrazol-5-olate. |
EP3197442B1 (en) | 2014-09-26 | 2019-07-03 | The Cleveland Clinic Foundation | Treating and preventing disease with tma and tmao lowering agents |
CL2015003047A1 (en) * | 2015-10-15 | 2016-06-17 | Univ Chile | Ex vivo method to detect acute renal injury early in critically ill patients, which includes mediciom in a sample of three proteins as biomarkers, fibroblastic growth factor 23, klotho and erythropoietin |
WO2018149929A1 (en) * | 2017-02-16 | 2018-08-23 | Bayer Pharma Aktiengesellschaft | Combination of reporter gene assays and transcriptional analysis |
EP3888684A1 (en) * | 2020-03-31 | 2021-10-06 | Bayer Animal Health GmbH | Composition having improved voluntary acceptance |
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US4663327A (en) | 1984-05-23 | 1987-05-05 | Bayer Aktiengesellschaft | 1-heteroaryl-4-aryl-pyrazolin-5-ones |
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UY27813A1 (en) * | 2002-05-31 | 2003-12-31 | Smithkline Beecham Corp | PEPTIDE-DISFORMILASE INHIBITORS |
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CA2614068A1 (en) | 2004-06-29 | 2006-08-24 | Massachusetts Institute Of Technology | Methods and compositions related to the modulation of intercellular junctions |
DE102008020113A1 (en) | 2008-04-23 | 2009-10-29 | Bayer Schering Pharma Aktiengesellschaft | Substituted dihydropyrazolones and their use |
MX2007011280A (en) | 2005-03-16 | 2007-11-15 | Aventis Pharma Inc | Dipyrazoles as central nervous system agents. |
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WO2007008541A2 (en) | 2005-07-08 | 2007-01-18 | Kalypsys, Inc. | Cellular cholesterol absorption modifiers |
WO2007121687A1 (en) | 2006-04-26 | 2007-11-01 | Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China | 4-methyl-1h-diaryl pyrazole derivatives and their uses as medicament |
DE102006050513A1 (en) | 2006-10-26 | 2008-04-30 | Bayer Healthcare Ag | New substituted dihydropyrazolone derivatives are hypoxia-inducible transcription factor-prolyl-4-hydroxylase inhibitors useful to treat/prevent e.g. cardiovascular diseases, heart-circulation diseases, heart failure and anemia |
DE102006050515A1 (en) | 2006-10-26 | 2008-04-30 | Bayer Healthcare Ag | New substituted dipyridiyl-dihydropyrazolone derivatives are hypoxia-inducible transcription factor-prolyl-4-hydroxylase inhibitors useful to treat/prevent e.g. cardiovascular diseases, heart-circulation diseases, heart failure and anemia |
DE102006050516A1 (en) | 2006-10-26 | 2008-04-30 | Bayer Healthcare Ag | New pyrazol-3-one compounds are hypoxia-inducible transcription factor-prolyl-4-hydroxylase inhibitors useful e.g. to treat and/or prophylaxis heart-circulation diseases, heart failure, anemia, chronic kidney diseases and renal failure |
DE102010044131A1 (en) * | 2010-11-18 | 2012-05-24 | Bayer Schering Pharma Aktiengesellschaft | Substituted sodium 1H-pyrazole-5-olate |
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2010
- 2010-11-18 DE DE102010044131A patent/DE102010044131A1/en not_active Withdrawn
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2011
- 2011-11-08 US US13/291,271 patent/US8653074B2/en active Active
- 2011-11-15 PE PE2013000943A patent/PE20140391A1/en active IP Right Grant
- 2011-11-15 LT LTEP11784992.7T patent/LT2640718T/en unknown
- 2011-11-15 TR TR2018/06652T patent/TR201806652T4/en unknown
- 2011-11-15 KR KR1020137012680A patent/KR101984317B1/en active IP Right Grant
- 2011-11-15 UA UAA201307718A patent/UA112422C2/en unknown
- 2011-11-15 HU HUE11784992A patent/HUE038024T2/en unknown
- 2011-11-15 EA EA201390703A patent/EA023103B1/en not_active IP Right Cessation
- 2011-11-15 BR BR112013012223-4A patent/BR112013012223B1/en active IP Right Grant
- 2011-11-15 JP JP2013539223A patent/JP5918779B2/en active Active
- 2011-11-15 SG SG2013030887A patent/SG189975A1/en unknown
- 2011-11-15 MX MX2013004797A patent/MX347670B/en active IP Right Grant
- 2011-11-15 PT PT117849927T patent/PT2640718T/en unknown
- 2011-11-15 RS RS20180749A patent/RS57599B1/en unknown
- 2011-11-15 CA CA2818002A patent/CA2818002C/en active Active
- 2011-11-15 ES ES11784992.7T patent/ES2675580T3/en active Active
- 2011-11-15 AP AP2013006922A patent/AP3429A/en active
- 2011-11-15 AU AU2011331305A patent/AU2011331305B2/en active Active
- 2011-11-15 KR KR1020187005194A patent/KR20180023043A/en not_active Application Discontinuation
- 2011-11-15 PL PL11784992T patent/PL2640718T3/en unknown
- 2011-11-15 WO PCT/EP2011/070099 patent/WO2012065967A1/en active Application Filing
- 2011-11-15 MY MYPI2013700801A patent/MY167219A/en unknown
- 2011-11-15 PE PE2017002012A patent/PE20180324A1/en unknown
- 2011-11-15 NZ NZ610614A patent/NZ610614A/en unknown
- 2011-11-15 SI SI201131516T patent/SI2640718T1/en unknown
- 2011-11-15 US US13/988,141 patent/US9533972B2/en active Active
- 2011-11-15 CN CN201180055239.3A patent/CN103270031B/en active Active
- 2011-11-15 DK DK11784992.7T patent/DK2640718T3/en active
- 2011-11-15 CN CN201510059285.0A patent/CN104650047A/en active Pending
- 2011-11-15 EP EP11784992.7A patent/EP2640718B8/en active Active
- 2011-11-15 AR ARP110104269A patent/AR083887A1/en not_active Application Discontinuation
- 2011-11-16 UY UY0001033736A patent/UY33736A/en active IP Right Grant
- 2011-11-17 JO JOP/2011/0347A patent/JOP20110347B1/en active
- 2011-11-17 TW TW100141958A patent/TWI516485B/en active
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2013
- 2013-04-30 CO CO13109274A patent/CO6741155A2/en not_active Application Discontinuation
- 2013-05-02 CR CR20130196A patent/CR20130196A/en unknown
- 2013-05-03 DO DO2013000096A patent/DOP2013000096A/en unknown
- 2013-05-07 IL IL226192A patent/IL226192A/en active IP Right Grant
- 2013-05-15 GT GT201300125A patent/GT201300125A/en unknown
- 2013-05-16 CU CU2013000072A patent/CU20130072A7/en unknown
- 2013-05-16 CL CL2013001390A patent/CL2013001390A1/en unknown
- 2013-05-16 MA MA35911A patent/MA34671B1/en unknown
- 2013-05-16 EC ECSP13012627 patent/ECSP13012627A/en unknown
- 2013-05-17 TN TNP2013000215A patent/TN2013000215A1/en unknown
- 2013-06-14 ZA ZA2013/04430A patent/ZA201304430B/en unknown
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2014
- 2014-02-26 HK HK14101861.8A patent/HK1188782A1/en unknown
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2015
- 2015-11-23 HK HK15111529.0A patent/HK1210776A1/en unknown
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2018
- 2018-06-27 HR HRP20180993TT patent/HRP20180993T1/en unknown
- 2018-06-28 CY CY20181100675T patent/CY1120375T1/en unknown
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