PE20140381A1 - SOLID DISPERSIONS EXTRUDED BY FUSION CONTAINING AN APOPTOSIS-INDUCING AGENT - Google Patents
SOLID DISPERSIONS EXTRUDED BY FUSION CONTAINING AN APOPTOSIS-INDUCING AGENTInfo
- Publication number
- PE20140381A1 PE20140381A1 PE2013000918A PE2013000918A PE20140381A1 PE 20140381 A1 PE20140381 A1 PE 20140381A1 PE 2013000918 A PE2013000918 A PE 2013000918A PE 2013000918 A PE2013000918 A PE 2013000918A PE 20140381 A1 PE20140381 A1 PE 20140381A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- heterociclic
- apoptosis
- extruded
- iloxi
- Prior art date
Links
- 239000007962 solid dispersion Substances 0.000 title abstract 3
- 230000004927 fusion Effects 0.000 title 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 abstract 4
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 4
- GEAXLHPORCRESC-UHFFFAOYSA-N chlorocyclohexatriene Chemical class ClC1=CC=C=C[CH]1 GEAXLHPORCRESC-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical class [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 abstract 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 2
- 239000004094 surface-active agent Substances 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 102000051485 Bcl-2 family Human genes 0.000 abstract 1
- 108700038897 Bcl-2 family Proteins 0.000 abstract 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229920001531 copovidone Polymers 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 229950008882 polysorbate Drugs 0.000 abstract 1
- 229920000136 polysorbate Polymers 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 229940069328 povidone Drugs 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Inorganic Chemistry (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
REFERIDA A UNA DISPERSION SOLIDA QUE COMPRENDE UN COMPUESTO HETEROCICLICO DE FORMULA (I) DISPERSADO EN UNA MATRIZ SOLIDA QUE COMPRENDE UN VEHICULO POLIMERICO SOLUBLE EN AGUA Y UN SURFACTANTE, DONDE R0 ES HALO; R1 Y R2 SON H, METILO O METOXI; R3 Y R4 SON METILO O METOXI; A1 Y A2 SON CH O N; R5 ES ALQUILO C1-C4, HALO, NITRO, CIANO, ENTRE OTROS; X ES O O NH; Y ES -(CH2)n-; n ES 0, 1 2 O 3; R6 ES UN ANILLO CARBOCICLICO O HETEROCICLICO DE 3 A 7 MIEMBROS OPCIONALMENTE SUSTITUIDO CON NR7R8; R7 Y R8 SON H O R9-(CH2)m; R9 ES UN ANILLO CARBOCICLICO O HETEROCICLICO DE 3 A 7 MIEMBROS. SON COMPUESTOS PREFERIDOS DE FORMULA (I): 4-(4-{[2-(4-CLOROFENIL)-4,4-DIMETILCICLOHEX-1-EN-1-IL]METIL}PIPERAZIN-1-IL)-2-(1H-INDOL-5-ILOXI)-N-({3-NITRO-4-[(1-TETRAHIDRO-2H-PIRAN-4-ILPIPERIDIN-4-IL)AMINO]FENIL}SULFONIL)BENZAMIDA, 4-(4-{[2-(4-CLOROFENIL)-4,4-DIMETILCICLOHEX-1-EN-1-IL]METIL}PIPERAZIN-1-IL)-2-(1H-INDOL-5-ILOXI)-N-({4-[(4-METILPIPERAZIN-1-IL)AMINO]-3-NITROFENIL}SULFONIL)BENZAMIDA, ENTRE OTROS. EL VEHICULO POLIMERICO ES UNA POVIDONA, COPOVIDONA, ENTRE OTROS Y EL SURFACTANTE ES UN POLISORBATO. DICHA DISPERSION SOLIDA SE ADMINISTRA VIA ORAL Y ES UTIL EN EL TRATAMIENTO DE UNA ENFERMEDAD EN LA QUE SE SOBREEXPRESA UNA O MAS PROTEINAS ANTIAPOPTOTICAS DE LA FAMILIA Bcl-2 TALES COMO EL CANCER O UNA ENFERMEDAD AUTOINMUNE O INMUNEREFERRED TO A SOLID DISPERSION THAT INCLUDES A HETEROCICLIC COMPOUND OF FORMULA (I) DISPERSED IN A SOLID MATRIX THAT INCLUDES A POLYMERIC VEHICLE SOLUBLE IN WATER AND A SURFACTANT, WHERE R0 IS HALO; R1 AND R2 ARE H, METHYL, OR METHOXY; R3 AND R4 ARE METHYL OR METHOXY; A1 AND A2 ARE CH O N; R5 IS C1-C4 ALKYL, HALO, NITRO, CYANE, AMONG OTHERS; X IS O O NH; Y IS - (CH2) n-; n IS 0, 1 2 O 3; R6 IS A CARBOCYCLIC OR HETEROCICLIC RING OF 3 TO 7 MEMBERS OPTIONALLY REPLACED WITH NR7R8; R7 AND R8 ARE H O R9- (CH2) m; R9 IS A CARBOCYCLIC OR HETEROCICLIC RING OF 3 TO 7 MEMBERS. PREFERRED COMPOUNDS OF FORMULA (I) ARE: 4- (4 - {[2- (4-CHLOROPHENYL) -4,4-DIMETHYL CYCLOHEX-1-EN-1-IL] METHYL} PIPERAZIN-1-IL) -2- ( 1H-INDOL-5-ILOXI) -N - ({3-NITRO-4 - [(1-TETRAHYDRO-2H-PYRAN-4-ILPIPERIDIN-4-IL) AMINO] PHENYL} SULFONYL) BENZAMIDE, 4- (4- {[2- (4-CHLOROPHENYL) -4,4-DIMETHYL CYCLOHEX-1-EN-1-IL] METHYL} PIPERAZIN-1-IL) -2- (1H-INDOL-5-ILOXI) -N - ({4 - [(4-METHYLPIPERAZIN-1-IL) AMINO] -3-NITROPHENIL} SULFONIL) BENZAMIDE, AMONG OTHERS. THE POLYMERIC VEHICLE IS A POVIDONE, COPOVIDONE, AMONG OTHERS AND THE SURFACTANT IS A POLYSORBATE. SAID SOLID DISPERSION IS ADMINISTERED BY THE ORAL ROUTE AND IS USEFUL IN THE TREATMENT OF A DISEASE IN WHICH ONE OR MORE ANTIAPOPTIC PROTEINS OF THE Bcl-2 FAMILY IS OVER EXPRESSED, SUCH AS CANCER OR AN AUTOIMMUNE OR IMMUNE DISEASE
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40852710P | 2010-10-29 | 2010-10-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20140381A1 true PE20140381A1 (en) | 2014-04-21 |
Family
ID=44903438
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2017001230A PE20171242A1 (en) | 2010-10-29 | 2011-10-05 | SOLID DISPERSIONS EXTRUDED BY FUSION CONTAINING AN APOPTOSIS-INDUCING AGENT |
PE2013000918A PE20140381A1 (en) | 2010-10-29 | 2011-10-05 | SOLID DISPERSIONS EXTRUDED BY FUSION CONTAINING AN APOPTOSIS-INDUCING AGENT |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2017001230A PE20171242A1 (en) | 2010-10-29 | 2011-10-05 | SOLID DISPERSIONS EXTRUDED BY FUSION CONTAINING AN APOPTOSIS-INDUCING AGENT |
Country Status (40)
Country | Link |
---|---|
US (2) | US20120108590A1 (en) |
EP (3) | EP2613769B1 (en) |
JP (2) | JP5902187B2 (en) |
KR (2) | KR101836820B1 (en) |
CN (2) | CN103282025B (en) |
AR (2) | AR083656A1 (en) |
AU (1) | AU2011361704B2 (en) |
BR (1) | BR112013010524A8 (en) |
CA (1) | CA2813985C (en) |
CL (1) | CL2013001120A1 (en) |
CO (1) | CO6781472A2 (en) |
CR (2) | CR20180289A (en) |
CY (1) | CY1119993T1 (en) |
DK (1) | DK2613769T3 (en) |
DO (2) | DOP2013000092A (en) |
EC (2) | ECSP13012647A (en) |
ES (1) | ES2647583T3 (en) |
GT (1) | GT201300102A (en) |
HK (1) | HK1243761A1 (en) |
HR (1) | HRP20171884T1 (en) |
HU (1) | HUE035169T2 (en) |
IL (2) | IL226215A (en) |
LT (1) | LT2613769T (en) |
ME (1) | ME02942B (en) |
MX (2) | MX345603B (en) |
MY (1) | MY189224A (en) |
NO (1) | NO2613769T3 (en) |
NZ (1) | NZ608907A (en) |
PE (2) | PE20171242A1 (en) |
PL (1) | PL2613769T3 (en) |
PT (1) | PT2613769T (en) |
RS (1) | RS56718B1 (en) |
RU (2) | RU2633353C1 (en) |
SG (2) | SG2014015077A (en) |
SI (1) | SI2613769T1 (en) |
TW (2) | TWI648261B (en) |
UA (1) | UA113500C2 (en) |
UY (3) | UY33692A (en) |
WO (1) | WO2012121758A1 (en) |
ZA (2) | ZA201302669B (en) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20220315555A1 (en) | 2009-05-26 | 2022-10-06 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
US8546399B2 (en) | 2009-05-26 | 2013-10-01 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
US9034875B2 (en) | 2009-05-26 | 2015-05-19 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
UA113500C2 (en) | 2010-10-29 | 2017-02-10 | MEL EXTRUSION SOLID DISPERSIONS CONTAINING AN APOPTOSIS-INDUCING AGENT | |
JP6068352B2 (en) | 2010-10-29 | 2017-01-25 | アッヴィ・インコーポレイテッド | Solid dispersion containing apoptosis inducer |
BR112013012740A2 (en) | 2010-11-23 | 2016-09-13 | Abbvie Inc | salts and crystalline forms of an apoptosis inducing agent |
SG190399A1 (en) | 2010-11-23 | 2013-06-28 | Abbvie Inc | Methods of treatment using selective bcl-2 inhibitors |
US20140189897A1 (en) | 2011-06-21 | 2014-07-03 | Mayo Foundation For Medical Education And Research | Transgenic animals capable of being induced to delete senescent cells |
US20140335074A1 (en) | 2011-12-13 | 2014-11-13 | Buck Institute For Research On Aging | Methods for improving medical therapies |
WO2013158664A2 (en) | 2012-04-17 | 2013-10-24 | Kythera Biopharmaceuticals, Inc. | Use of engineered viruses to specifically kill senescent cells |
US9901080B2 (en) | 2012-08-23 | 2018-02-27 | Buck Institute For Research On Aging | Transgenic mouse having a transgene that converts a prodrug into a cytotoxic compound in senescent cells |
US9901081B2 (en) | 2012-08-23 | 2018-02-27 | Buck Institute For Research On Aging | Transgenic mouse for determining the role of senescent cells in cancer |
WO2014039855A1 (en) | 2012-09-07 | 2014-03-13 | Genentech, Inc. | Combination therapy of a type ii anti-cd20 antibody with a selective bcl-2 inhibitor |
WO2014048782A1 (en) * | 2012-09-27 | 2014-04-03 | Basf Se | A storage-stable dust-free homogeneous particulate formulation comprising at least one water-soluble vitamin e-derivative and at least one hydrophilic polymer |
CN107721851B (en) | 2013-03-13 | 2021-06-25 | 艾伯维公司 | Method for preparing apoptosis inducer |
US9006438B2 (en) | 2013-03-13 | 2015-04-14 | Abbvie Inc. | Processes for the preparation of an apoptosis-inducing agent |
US20140275082A1 (en) | 2013-03-14 | 2014-09-18 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
US20170216286A1 (en) | 2014-01-28 | 2017-08-03 | Mayo Foundation For Medical Education And Research | Killing senescent cells and treating senescence-associated conditions using a src inhibitor and a flavonoid |
US10328058B2 (en) | 2014-01-28 | 2019-06-25 | Mayo Foundation For Medical Education And Research | Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques |
IL311537A (en) | 2014-01-28 | 2024-05-01 | Mayo Found Medical Education & Res | Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders |
EP3102564A4 (en) | 2014-02-05 | 2017-10-18 | Merck Sharp & Dohme Corp. | Tablet formulation for cgrp-active compounds |
US9238652B2 (en) | 2014-03-04 | 2016-01-19 | Abbvie Inc. | Processes for the preparation of an apoptosis-inducing agent |
EP3179991B1 (en) | 2014-08-11 | 2021-10-06 | Acerta Pharma B.V. | Therapeutic combinations of a btk inhibitor and a bcl-2 inhibitor |
CN106793821B (en) * | 2014-08-29 | 2021-05-07 | 花王株式会社 | Method for producing solid dispersion containing hardly soluble polyphenol |
CN104586770A (en) * | 2014-12-30 | 2015-05-06 | 山东博迈康药物研究有限公司 | Hot-melt extrusion preparation of pazopanib hydrochloride and preparation method of hot-melt extrusion preparation |
GB201502073D0 (en) * | 2015-02-09 | 2015-03-25 | Cubic Pharmaceuticals Ltd And Delta Pharmaceuticals Ltd | HDEG technology |
US10195213B2 (en) | 2015-03-13 | 2019-02-05 | Unity Biotechnology, Inc. | Chemical entities that kill senescent cells for use in treating age-related disease |
EP3370775B1 (en) | 2015-11-03 | 2023-04-19 | Genentech, Inc. | Combination of bcl-2 inhibitor and mek inhibitor for the treatment of cancer |
CN106957315B (en) * | 2016-01-08 | 2019-08-13 | 中国人民解放军第二军医大学 | N- replaces benzenesulfonyl-azaindole oxybenzamide class compound and its prepares the purposes of drug |
US11001582B2 (en) | 2016-03-10 | 2021-05-11 | Assia Chemical Industries Ltd. | Solid state forms of Venetoclax and processes for preparation of Venetoclax |
US10779980B2 (en) | 2016-04-27 | 2020-09-22 | Synerz Medical, Inc. | Intragastric device for treating obesity |
RU2018146513A (en) * | 2016-06-09 | 2020-07-09 | Др. Редди'С Лабораторис Лимитед | SOLID FORMS OF VENETO-KLAX AND METHODS FOR PRODUCING A VENETO-KLAX |
WO2018009444A1 (en) * | 2016-07-06 | 2018-01-11 | Concert Pharmaceuticals, Inc. | Deuterated venetoclax |
CN107648185A (en) * | 2016-07-25 | 2018-02-02 | 常州爱诺新睿医药技术有限公司 | A kind of unformed Venetoclax and pharmaceutic adjuvant solid dispersions and preparation method thereof |
WO2018069941A2 (en) | 2016-10-14 | 2018-04-19 | Mylan Laboratories Limited | Polymorphic forms of venetoclax |
EP3333167A1 (en) * | 2016-12-09 | 2018-06-13 | LEK Pharmaceuticals d.d. | Solid forms of venetoclax |
EP3565815B1 (en) * | 2017-01-07 | 2024-03-13 | Fochon Pharmaceuticals, Ltd. | Compounds as bcl-2-selective apoptosis-inducing agents |
EP4119560B1 (en) | 2017-04-18 | 2024-06-05 | Fochon Pharmaceuticals, Ltd. | Apoptosis-inducing agents |
CA3073446A1 (en) | 2017-08-23 | 2019-02-28 | Newave Pharmaceutical Inc. | Bcl-2 inhibitors |
WO2019135253A1 (en) | 2018-01-02 | 2019-07-11 | Mylan Laboratories Limited | Polymorphic forms of venetoclax |
MX2020007392A (en) | 2018-01-10 | 2020-10-14 | Recurium Ip Holdings Llc | Benzamide compounds. |
WO2020023435A1 (en) | 2018-07-24 | 2020-01-30 | Albany Molecular Research, Inc. | Venetoclax basic salts and processes for the purification of venetoclax |
US20210315904A1 (en) | 2018-08-22 | 2021-10-14 | Newave Pharmaceutical Inc. | Bcl-2 inhibitors |
EP4031136A1 (en) | 2019-09-18 | 2022-07-27 | Aprea Therapeutics AB | Combination treatment with a p53 reactivator and an inhibitor of an antiapoptotic bcl-2 family protein |
IL295803A (en) * | 2020-02-24 | 2022-10-01 | Newave Pharmaceutical Inc | Hot melt extruded solid dispersions containing a bcl2 inhibitor |
CN114533677A (en) * | 2020-11-25 | 2022-05-27 | 苏州亚盛药业有限公司 | Solid dispersion, preparation method and application thereof |
MX2023007575A (en) | 2020-12-22 | 2023-09-21 | Allergan Pharmaceuticals Int Ltd | Treatment of migraine. |
Family Cites Families (131)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5665379A (en) | 1990-09-28 | 1997-09-09 | Pharmacia & Upjohn Aktiebolag | Lipid particle forming matrix, preparation and use thereof |
MY115155A (en) | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
US5536729A (en) | 1993-09-30 | 1996-07-16 | American Home Products Corporation | Rapamycin formulations for oral administration |
IL111004A (en) | 1993-09-30 | 1998-06-15 | American Home Prod | Oral rapamycin formulations |
JPH09510182A (en) | 1993-11-17 | 1997-10-14 | エルディーエス・テクノロジーズ・インコーポレーテッド | Encapsulated transparent liquid for drug delivery |
US5759548A (en) | 1993-11-30 | 1998-06-02 | Lxr Biotechnology Inc. | Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof |
GB9405304D0 (en) | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
US5538737A (en) | 1994-11-30 | 1996-07-23 | Applied Analytical Industries, Inc. | Oral compositions of H2 -antagonists |
FR2736550B1 (en) | 1995-07-14 | 1998-07-24 | Sandoz Sa | PHARMACEUTICAL COMPOSITION IN THE FORM OF A SOLID DISPERSION COMPRISING A MACROLIDE AND A VEHICLE |
ES2214546T3 (en) | 1995-09-15 | 2004-09-16 | PHARMACIA & UPJOHN COMPANY | N-OXIDES OF AMINOARILOXAZOLIDINONA. |
US6964946B1 (en) | 1995-10-26 | 2005-11-15 | Baker Norton Pharmaceuticals, Inc. | Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same |
DE122004000004I1 (en) | 1996-02-09 | 2004-08-12 | Abott Biotechnology Ltd | Human antibodies that bind to human TNFalpha. |
US5891469A (en) | 1997-04-02 | 1999-04-06 | Pharmos Corporation | Solid Coprecipitates for enhanced bioavailability of lipophilic substances |
US20030220234A1 (en) | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
BE1011899A6 (en) | 1998-04-30 | 2000-02-01 | Ucb Sa | PHARMACEUTICAL USE gelling. |
GEP20033114B (en) | 1998-07-06 | 2003-11-25 | Bristol Myers Squibb Co | Biphenyl Sulfonamides as Dual Angiotensin Endothelin Receptor Antagonists, Method for Their Production and Pharmaceutical Compositions Containing the Same |
US6267985B1 (en) | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
US6294192B1 (en) | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
DE19913692A1 (en) | 1999-03-25 | 2000-09-28 | Basf Ag | Mechanically stable pharmaceutical dosage forms containing liquid or semi-solid surface-active substances |
DE19929361A1 (en) | 1999-06-25 | 2001-01-04 | Basf Ag | Mechanically stable pharmaceutical dosage forms containing liquid or semi-solid surface-active substances |
US20030236236A1 (en) | 1999-06-30 | 2003-12-25 | Feng-Jing Chen | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
US6309663B1 (en) | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
GB9918037D0 (en) | 1999-07-30 | 1999-09-29 | Biochemie Gmbh | Organic compounds |
ES2246922T3 (en) | 1999-12-28 | 2006-03-01 | Eisai Co., Ltd. | HETEROCICLICAL COMPOUNDS THAT HAVE SULFONAMIDE GROUPS. |
US20060183776A9 (en) | 2000-03-03 | 2006-08-17 | Eisai Co., Ltd. | Liquid dosage formulations of donepezil |
UY26942A1 (en) | 2000-09-20 | 2002-04-26 | Abbott Lab | PROMOTING N-ACILSULFONAMIDS OF APOPTOSIS |
US20020055631A1 (en) | 2000-09-20 | 2002-05-09 | Augeri David J. | N-acylsulfonamide apoptosis promoters |
US6720338B2 (en) | 2000-09-20 | 2004-04-13 | Abbott Laboratories | N-acylsulfonamide apoptosis promoters |
US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
CN1527830A (en) | 2001-01-31 | 2004-09-08 | �Ʒ� | Ether derivatives useful as inhibitors of PDE4 isozymes |
US6927009B2 (en) | 2001-05-22 | 2005-08-09 | Fuji Photo Film Co., Ltd. | Positive photosensitive composition |
CZ20033296A3 (en) | 2001-06-06 | 2004-04-14 | Eli Lilly And Company | Benzoyl sulfonamides and sulfonyl benzamidines functioning as antineoplastic compounds |
GB0123400D0 (en) | 2001-09-28 | 2001-11-21 | Novartis Ag | Organic compounds |
ATE464880T1 (en) | 2002-02-04 | 2010-05-15 | Elan Pharma Int Ltd | MEDICINAL NANOPARTICLES WITH LYSOZYME SURFACE STABILIZER |
KR20040086452A (en) | 2002-02-26 | 2004-10-08 | 아스트라제네카 아베 | Novel crystalline forms of the anti-cancer compound zd1839 |
MY135609A (en) | 2002-02-26 | 2008-05-30 | Astrazeneca Ab | Pharmaceutical formulation of iressa comprising a water-soluble cellulose derivative |
FR2836914B1 (en) | 2002-03-11 | 2008-03-14 | Aventis Pharma Sa | SUBSTITUTED INDAZOLES, COMPOSITIONS CONTAINING SAME, METHOD OF MANUFACTURE AND USE |
MY129850A (en) | 2002-04-29 | 2007-05-31 | Merck Sharp & Dohme | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
US20060177430A1 (en) | 2002-12-20 | 2006-08-10 | Chakshu Research Inc | Treatment of ocular disorders with ophthalmic formulations containing methylsulfonylmethane as a transport enhancer |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
US20050048112A1 (en) | 2003-08-28 | 2005-03-03 | Jorg Breitenbach | Solid pharmaceutical dosage form |
WO2005024636A1 (en) | 2003-09-04 | 2005-03-17 | Hitachi Ulsi Systems Co., Ltd. | Semiconductor device |
WO2005049593A2 (en) | 2003-11-13 | 2005-06-02 | Abbott Laboratories | N-acylsulfonamide apoptosis promoters |
US7973161B2 (en) | 2003-11-13 | 2011-07-05 | Abbott Laboratories | Apoptosis promoters |
US8614318B2 (en) | 2003-11-13 | 2013-12-24 | Abbvie Inc. | Apoptosis promoters |
US7767684B2 (en) | 2003-11-13 | 2010-08-03 | Abbott Laboratories | Apoptosis promoters |
US7642260B2 (en) | 2003-11-13 | 2010-01-05 | Abbott Laboratories, Inc. | Apoptosis promoters |
US7790190B2 (en) | 2004-03-20 | 2010-09-07 | Yasoo Health, Inc. | Aqueous emulsions of lipophile solubilized with vitamin E TPGS and linoleic acid |
PL1737850T3 (en) | 2004-04-19 | 2008-02-29 | Symed Labs Ltd | A novel process for the preparation of linezolid and related compounds |
US7318503B2 (en) | 2004-04-26 | 2008-01-15 | Akebono Corporation (North America) | Pad retaining clips |
US20070237823A1 (en) | 2004-05-04 | 2007-10-11 | Thomas Bock | Solid Pharmaceutical Form Comprising and Ltb4 Antagonist |
ATE429423T1 (en) | 2004-07-20 | 2009-05-15 | Symed Labs Ltd | NEW INTERMEDIATE PRODUCTS FOR LINEZOLID AND RELATED COMPOUNDS |
MY191349A (en) * | 2004-08-27 | 2022-06-17 | Bayer Pharmaceuticals Corp | New pharmaceutical compositions for the treatment of hyper-proliferative disorders |
CA2578442A1 (en) | 2004-08-27 | 2006-03-09 | Bayer Pharmaceuticals Corporation | Pharmaceutical compositions comprising 4{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-phenoxy}-pyridine-2-carboxylic acid methyl amide for the treatment of cancer |
FR2875409B1 (en) | 2004-09-17 | 2010-05-07 | Sanofi Aventis | PHARMACEUTICAL COMPOSITION COMPRISING A SOLID POLYMERIC MATRIX DISPERSION COMPRISING A CONTINUOUS PHASE OF POLYDEXTROSE AND A CONTINUOUS PHASE OF A POLYMER OTHER THAN POLYDEXTROSE |
US7511013B2 (en) | 2004-09-29 | 2009-03-31 | Amr Technology, Inc. | Cyclosporin analogues and their pharmaceutical uses |
PL2757099T3 (en) | 2005-05-12 | 2018-02-28 | Abbvie Bahamas Limited | Apoptosis promoters |
US8624027B2 (en) | 2005-05-12 | 2014-01-07 | Abbvie Inc. | Combination therapy for treating cancer and diagnostic assays for use therein |
AU2006247322A1 (en) | 2005-05-16 | 2006-11-23 | Irm Llc | Pyrrolopyridine derivatives as protein kinase inhibitors |
CN1706371B (en) | 2005-05-27 | 2010-11-10 | 沈阳药科大学 | Efficient sword-like iris seed preparation and its preparation process |
TW200716636A (en) | 2005-05-31 | 2007-05-01 | Speedel Experimenta Ag | Heterocyclic spiro-compounds |
CN102603581B (en) | 2005-06-22 | 2015-06-24 | 普莱希科公司 | Pyrrolo[2,3-b] pyridine derivatives as protein kinase inhibitors |
US7514068B2 (en) | 2005-09-14 | 2009-04-07 | Concert Pharmaceuticals Inc. | Biphenyl-pyrazolecarboxamide compounds |
CN101325944B (en) | 2005-10-11 | 2013-01-16 | 耶路撒冷希伯来大学伊萨姆研究开发公司 | Compositions for nasal delivery |
JP2009513642A (en) | 2005-10-25 | 2009-04-02 | アボット・ラボラトリーズ | Formulation containing drug with low water solubility and method of using the same |
US7151188B1 (en) | 2005-11-16 | 2006-12-19 | General Electric Company | Process for the production of mercaptoalkylalkoxysilanes |
WO2007133796A2 (en) | 2006-05-15 | 2007-11-22 | Encysive Pharmaceuticals, Inc. | Methods and compositions for treatment of sleep apnea comprising administration of an endothelin antagonist |
JP2009542664A (en) | 2006-06-30 | 2009-12-03 | シェーリング コーポレイション | Methods of use of substituted piperidines that increase P53 activity |
JP5320291B2 (en) | 2006-07-14 | 2013-10-23 | ケモセントリックス, インコーポレイテッド | Triazolylpyridylbenzenesulfonamides |
EP1880715A1 (en) | 2006-07-19 | 2008-01-23 | Abbott GmbH & Co. KG | Pharmaceutically acceptable solubilizing composition and pharmaceutical dosage form containing same |
US7799790B2 (en) | 2006-07-20 | 2010-09-21 | Helm Ag | Amorphous aripiprazole and process for the preparation thereof |
KR101462693B1 (en) | 2006-08-16 | 2014-11-17 | 노파르티스 아게 | Method for making solid dispersions of highly crystalline therapeutic compounds |
CA2662320C (en) | 2006-09-05 | 2014-07-22 | Abbott Laboratories | Bcl inhibitors treating platelet excess |
US8796267B2 (en) | 2006-10-23 | 2014-08-05 | Concert Pharmaceuticals, Inc. | Oxazolidinone derivatives and methods of use |
MX2009004861A (en) | 2006-11-09 | 2009-05-21 | Abbott Gmbh & Co Kg | Pharmaceutical dosage form for oral administration of tyrosine kinase inhibitor. |
CA2669938C (en) * | 2006-11-15 | 2016-01-05 | Abbott Laboratories | Solid pharmaceutical dosage formulations |
US20080182845A1 (en) | 2006-11-16 | 2008-07-31 | Abbott Laboratories | Method of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection |
KR101335845B1 (en) | 2007-02-15 | 2013-12-02 | 에프. 호프만-라 로슈 아게 | 2-aminooxazolines as taar1 ligands |
RU2351352C2 (en) | 2007-04-09 | 2009-04-10 | Закрытое акционерное общество "Санкт-Петербургский институт фармации" | Solid nanocomposition for delivery of biologically active substances |
WO2008124878A1 (en) | 2007-04-13 | 2008-10-23 | Cryptopharma Pty Ltd | Non-steroidal compounds |
WO2008131259A1 (en) | 2007-04-19 | 2008-10-30 | Concert Pharmaceuticals Inc. | Deuterated morpholinyl compounds |
US7531685B2 (en) | 2007-06-01 | 2009-05-12 | Protia, Llc | Deuterium-enriched oxybutynin |
US20090131485A1 (en) | 2007-09-10 | 2009-05-21 | Concert Pharmaceuticals, Inc. | Deuterated pirfenidone |
US20090118238A1 (en) | 2007-09-17 | 2009-05-07 | Protia, Llc | Deuterium-enriched alendronate |
US20090082471A1 (en) | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched fingolimod |
US20090088416A1 (en) | 2007-09-26 | 2009-04-02 | Protia, Llc | Deuterium-enriched lapaquistat |
AU2008307565A1 (en) | 2007-10-01 | 2009-04-09 | The Johns Hopkins University | Methods of treating neurological autoimmune disorders with cyclophosphamide |
EP2209774A1 (en) | 2007-10-02 | 2010-07-28 | Concert Pharmaceuticals Inc. | Pyrimidinedione derivatives |
US10736848B2 (en) | 2007-10-12 | 2020-08-11 | Massachusetts Institute Of Technology | Vaccine nanotechnology |
US20090105338A1 (en) | 2007-10-18 | 2009-04-23 | Protia, Llc | Deuterium-enriched gabexate mesylate |
US8410124B2 (en) | 2007-10-18 | 2013-04-02 | Concert Pharmaceuticals Inc. | Deuterated etravirine |
CA2703591C (en) | 2007-10-26 | 2013-05-07 | Concert Pharmaceuticals, Inc. | Deuterated darunavir |
EP2231159A1 (en) | 2007-11-16 | 2010-09-29 | Abbott Laboratories | Method of treating arthritis |
CA2708223A1 (en) | 2007-12-06 | 2009-06-11 | Andrew Krivoshik | Oral compositions of abt-263 for treating cancer |
EP2784089A1 (en) | 2008-01-15 | 2014-10-01 | AbbVie Inc. | Improved mammalian expression vectors and uses thereof |
CN101220008B (en) | 2008-01-21 | 2011-04-27 | 中国科学院广州生物医药与健康研究院 | Synthesis of compound ABT-263 |
US20090203709A1 (en) | 2008-02-07 | 2009-08-13 | Abbott Laboratories | Pharmaceutical Dosage Form For Oral Administration Of Tyrosine Kinase Inhibitor |
CN101548960B (en) | 2008-04-01 | 2012-11-07 | 沈阳药科大学 | High-dissolution oral bifendate capsule and preparation method thereof |
US8168784B2 (en) | 2008-06-20 | 2012-05-01 | Abbott Laboratories | Processes to make apoptosis promoters |
JP5524220B2 (en) | 2008-10-07 | 2014-06-18 | アストラゼネカ・ユーケイ・リミテッド | Pharmaceutical formulation 514 |
US20100160322A1 (en) * | 2008-12-04 | 2010-06-24 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
UA108193C2 (en) * | 2008-12-04 | 2015-04-10 | APOPTOZINDUCE FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTO-IMMUNE DISEASES | |
US8557983B2 (en) | 2008-12-04 | 2013-10-15 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
PT2376480T (en) * | 2008-12-05 | 2016-10-26 | Abbvie Inc | Sulfonamide derivatives as bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
US8563735B2 (en) * | 2008-12-05 | 2013-10-22 | Abbvie Inc. | Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
US8586754B2 (en) | 2008-12-05 | 2013-11-19 | Abbvie Inc. | BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
US20110245156A1 (en) | 2008-12-09 | 2011-10-06 | Cytokine Pharmasciences, Inc. | Novel antiviral compounds, compositions, and methods of use |
US8959548B2 (en) * | 2008-12-22 | 2015-02-17 | Verizon Patent And Licensing Inc. | Presenting advertisements with video program descriptions |
WO2010072734A2 (en) | 2008-12-23 | 2010-07-01 | The Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | Targeting prodrugs and compositions for the treatment of gastrointestinal diseases |
CN102282129A (en) * | 2009-01-19 | 2011-12-14 | 雅培制药有限公司 | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
ES2593427T3 (en) | 2009-01-19 | 2016-12-09 | Abbvie Inc. | Agents inducing apoptosis for the treatment of cancer and autoimmune and immune diseases |
US8362013B2 (en) | 2009-04-30 | 2013-01-29 | Abbvie Inc. | Salt of ABT-263 and solid-state forms thereof |
US8728516B2 (en) | 2009-04-30 | 2014-05-20 | Abbvie Inc. | Stabilized lipid formulation of apoptosis promoter |
US20100297194A1 (en) | 2009-04-30 | 2010-11-25 | Nathaniel Catron | Formulation for oral administration of apoptosis promoter |
US20100278921A1 (en) | 2009-04-30 | 2010-11-04 | Fischer Cristina M | Solid oral formulation of abt-263 |
US20100280031A1 (en) | 2009-04-30 | 2010-11-04 | Paul David | Lipid formulation of apoptosis promoter |
US8546399B2 (en) | 2009-05-26 | 2013-10-01 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
RU2535347C3 (en) * | 2009-05-26 | 2019-05-14 | ЭббВи Айэленд Анлимитед Компани | Inducing apoptosis means for the treatment of malignant tumors and immune and autoimmune diseases |
TWI471321B (en) | 2009-06-08 | 2015-02-01 | Abbott Gmbh & Co Kg | Pharmaceutical dosage form for oral administration of a bcl-2 family inhibitor |
TWI532484B (en) | 2009-06-08 | 2016-05-11 | 艾伯維有限公司 | Solid dispersions containing an apoptosis-promoting agent |
DK2455376T3 (en) | 2009-06-11 | 2015-03-02 | Abbvie Bahamas Ltd | Heterocyclic compounds as inhibitors of hepatitis C virus (HCV) |
CA2764187A1 (en) | 2009-06-18 | 2010-12-23 | Abbott Laboratories | Stable nanoparticulate drug suspension |
MX2012003408A (en) | 2009-09-20 | 2012-08-03 | Abbott Lab | Abt-263 crystalline forms and solvates for use in treating bcl-2 protein related diseases. |
CN101798292A (en) | 2010-03-29 | 2010-08-11 | 无锡好芳德药业有限公司 | Method for preparing novel Bc1-2 protein inhibitor derived from ABT-263 |
TWI520960B (en) | 2010-05-26 | 2016-02-11 | 艾伯維有限公司 | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
UA113500C2 (en) | 2010-10-29 | 2017-02-10 | MEL EXTRUSION SOLID DISPERSIONS CONTAINING AN APOPTOSIS-INDUCING AGENT | |
JP6068352B2 (en) | 2010-10-29 | 2017-01-25 | アッヴィ・インコーポレイテッド | Solid dispersion containing apoptosis inducer |
BR112013012740A2 (en) | 2010-11-23 | 2016-09-13 | Abbvie Inc | salts and crystalline forms of an apoptosis inducing agent |
SG190399A1 (en) | 2010-11-23 | 2013-06-28 | Abbvie Inc | Methods of treatment using selective bcl-2 inhibitors |
JP6095678B2 (en) | 2011-11-11 | 2017-03-15 | エスアイオーツー・メディカル・プロダクツ・インコーポレイテッド | Passivation, pH protection or slippery coatings for pharmaceutical packages, coating processes and equipment |
-
2011
- 2011-05-10 UA UAA201306667A patent/UA113500C2/en unknown
- 2011-10-05 DK DK11770975.8T patent/DK2613769T3/en active
- 2011-10-05 MX MX2013004843A patent/MX345603B/en active IP Right Grant
- 2011-10-05 PT PT117709758T patent/PT2613769T/en unknown
- 2011-10-05 SG SG2014015077A patent/SG2014015077A/en unknown
- 2011-10-05 NZ NZ608907A patent/NZ608907A/en unknown
- 2011-10-05 AU AU2011361704A patent/AU2011361704B2/en active Active
- 2011-10-05 LT LTEP11770975.8T patent/LT2613769T/en unknown
- 2011-10-05 CN CN201180063724.5A patent/CN103282025B/en active Active
- 2011-10-05 SI SI201131373T patent/SI2613769T1/en unknown
- 2011-10-05 WO PCT/US2011/054959 patent/WO2012121758A1/en active Application Filing
- 2011-10-05 EP EP11770975.8A patent/EP2613769B1/en active Active
- 2011-10-05 EP EP23152636.9A patent/EP4218731A3/en active Pending
- 2011-10-05 RS RS20171320A patent/RS56718B1/en unknown
- 2011-10-05 KR KR1020137013700A patent/KR101836820B1/en active Protection Beyond IP Right Term
- 2011-10-05 US US13/253,727 patent/US20120108590A1/en not_active Abandoned
- 2011-10-05 JP JP2013536646A patent/JP5902187B2/en active Active
- 2011-10-05 KR KR1020187005383A patent/KR101957137B1/en active IP Right Grant
- 2011-10-05 PL PL11770975T patent/PL2613769T3/en unknown
- 2011-10-05 HU HUE11770975A patent/HUE035169T2/en unknown
- 2011-10-05 RU RU2016104763A patent/RU2633353C1/en active
- 2011-10-05 ES ES11770975.8T patent/ES2647583T3/en active Active
- 2011-10-05 MX MX2017001658A patent/MX362113B/en unknown
- 2011-10-05 CR CR20180289A patent/CR20180289A/en unknown
- 2011-10-05 BR BR112013010524A patent/BR112013010524A8/en not_active Application Discontinuation
- 2011-10-05 NO NO11770975A patent/NO2613769T3/no unknown
- 2011-10-05 ME MEP-2017-299A patent/ME02942B/en unknown
- 2011-10-05 CA CA2813985A patent/CA2813985C/en active Active
- 2011-10-05 SG SG2013029913A patent/SG189477A1/en unknown
- 2011-10-05 MY MYPI2018001778A patent/MY189224A/en unknown
- 2011-10-05 EP EP17169667.7A patent/EP3219308A1/en not_active Withdrawn
- 2011-10-05 CN CN201711309600.6A patent/CN108175749B/en active Active
- 2011-10-05 PE PE2017001230A patent/PE20171242A1/en unknown
- 2011-10-05 RU RU2013124823/04A patent/RU2577859C2/en active
- 2011-10-05 PE PE2013000918A patent/PE20140381A1/en active IP Right Grant
- 2011-10-21 TW TW105108567A patent/TWI648261B/en active
- 2011-10-21 TW TW100138348A patent/TWI535699B/en active
- 2011-10-27 UY UY0001033692A patent/UY33692A/en active IP Right Grant
- 2011-10-27 UY UY0001039192A patent/UY39192A/en not_active Application Discontinuation
- 2011-10-28 AR ARP110104026A patent/AR083656A1/en not_active Application Discontinuation
-
2013
- 2013-04-12 ZA ZA2013/02669A patent/ZA201302669B/en unknown
- 2013-04-22 GT GT201300102A patent/GT201300102A/en unknown
- 2013-04-24 CL CL2013001120A patent/CL2013001120A1/en unknown
- 2013-04-26 DO DO2013000092A patent/DOP2013000092A/en unknown
- 2013-05-07 IL IL226215A patent/IL226215A/en active IP Right Grant
- 2013-05-15 CR CR20130224A patent/CR20130224A/en unknown
- 2013-05-17 CO CO13122333A patent/CO6781472A2/en not_active Application Discontinuation
- 2013-05-29 EC ECSP13012647 patent/ECSP13012647A/en unknown
- 2013-12-20 HK HK18103255.4A patent/HK1243761A1/en unknown
-
2014
- 2014-02-25 ZA ZA2014/01440A patent/ZA201401440B/en unknown
- 2014-07-24 US US14/340,435 patent/US11369599B2/en active Active
-
2016
- 2016-03-08 JP JP2016044090A patent/JP6153638B2/en active Active
-
2017
- 2017-01-05 DO DO2017000003A patent/DOP2017000003A/en unknown
- 2017-04-24 IL IL251877A patent/IL251877B/en active IP Right Grant
- 2017-07-13 UY UY0001037326A patent/UY37326A/en active IP Right Grant
- 2017-12-05 HR HRP20171884TT patent/HRP20171884T1/en unknown
- 2017-12-20 CY CY20171101338T patent/CY1119993T1/en unknown
-
2021
- 2021-05-10 AR ARP210101264A patent/AR122475A2/en unknown
-
2022
- 2022-11-10 EC ECSENADI202286925A patent/ECSP22086925A/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20140381A1 (en) | SOLID DISPERSIONS EXTRUDED BY FUSION CONTAINING AN APOPTOSIS-INDUCING AGENT | |
PE20130221A1 (en) | APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | |
PE20120119A1 (en) | APOPTOSIS INDUCING AGENTS WITH Bcl-2 SELECTIVITY | |
PE20141824A1 (en) | THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE | |
PE20191147A1 (en) | CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR MODULATOR, PHARMACEUTICAL COMPOSITIONS, TREATMENT METHODS AND PROCESS TO PRODUCE THE MODULATOR | |
PE20170268A1 (en) | HETEROARYL COMPOUNDS FOR KINASE INHIBITION | |
PE20160891A1 (en) | ROR GAMMA MODULATORS (RORY) | |
AR083849A1 (en) | ESPIRO-OXINDOL MDM2 ANTAGONISTS | |
AR071385A1 (en) | COMPOUNDS OF 2-IMINO-3-METHYL PIRROLOPIRIMIDINONE REPLACED WITH THIOPHENYLL, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND USE OF THE SAME FOR THE TREATMENT OF PATHOLOGIES ASSOCIATED WITH THE BETA AMYLOID PROTEIN, SUCH AS ALZHEIMAS DE OMOSTER DE OMOS. | |
PE20211700A1 (en) | HETEROCICLIC COMPOUND AND ITS USE | |
PE20141700A1 (en) | 2- (2,4,5-ANILINE SUBSTITUTED) PYRIMIDINE COMPOUNDS | |
PE20151555A1 (en) | APOPTOSIS INDUCING AGENTS TO TREAT CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | |
PE20061150A1 (en) | DERIVATIVES OF N- (N-SULFONYLAMINOARILMETIL) CYCLOPROPANOCARBOXAMIDE SUBSTITUTED AS ANTAGONISTS OF THE VAINILLOID RECEPTOR TYPE 1 (VDR1) | |
PE20120345A1 (en) | DERIVATIVES OF 2- (1H-PIRROLO [2,3-B] PYRIDIN-5-ILOXI) -N-FENYLSULFONYLBENZAMIDE AS INHIBITORS OF ANTI-APOPTOTIC PROTEINS | |
PE20110285A1 (en) | SULFONAMIDOPHENYL PROPIONAMIDE DERIVATIVES AS LIGANDS OF THE VANILOID RECEPTOR SUBTYPE 1 | |
PE20080552A1 (en) | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYLENE ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | |
PE20121050A1 (en) | N- (1- (4- (1H-PYRAZOLE-5-IL) FTALAZIN-1-IL) PIPERIDIN-4-IL) -BENZAMIDE COMPOUNDS SUBSTITUTE AS ANTAGONISTS IN THE HEDGEHOG TRAJECTORY | |
CL2015000578A1 (en) | Compound n- (2- (6-fluoro-1-h-indol-3-yl) ethyl) -3- (2,2,3,3-tetrafluoropropoxy) benzylamine or its salt, 5-ht6 receptor antagonist; pharmaceutical composition; Use in the treatment of Alzheimer's disease. | |
AR059957A1 (en) | DERIVATIVES OF SPIROINDOLINONE, METHODS FOR THEIR PREPARATION, A PHARMACEUTICAL COMPOSITION CONTAINING THEM AND THEIR USE IN THE MANUFACTURE OF MEDICINES FOR THE TREATMENT OF CANCER. | |
PE20080409A1 (en) | COMPOUNDS THAT MODULATE IN THE CB2 RECEIVER | |
PE20151794A1 (en) | 1,3-OXAZIN-2-AMINE COMPOUNDS FUSED WITH PERFLUORATED CYCLOPROPYL AS BETA-SECRETASE INHIBITORS AND METHODS OF USE | |
UY32409A (en) | FUSIONED RING COMPOUND AND ITS USE | |
AR079690A1 (en) | PIRROL HETEROCICLIC DERIVATIVES [2,3-B] PIRIDINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PROCEDURE TO PREPARE THEM, AND USE OF THE SAME AS ANTICANCER AGENTS. | |
SI2989100T1 (en) | Naphthyridine derivatives useful as alpha-v-beta-6 integrin antagonists | |
CL2013000488A1 (en) | Co-crystals of compounds derived from (2r) -5-oxo-1- (benzylpiperidin-4-yl) -n- (pyridin-2-yl) pyrrolidin-2-carboxamide and a co-crystal forming agent; salts of the compounds; intermediary compounds; pharmaceutical composition; and its use for the treatment of inflammatory and infectious diseases. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration |