PE20140035A1 - INJECTABLE COMPOSITION INCLUDING A NON-STEROID ANTI-INFLAMMATORY AND AN ANTIBIOTIC - Google Patents

INJECTABLE COMPOSITION INCLUDING A NON-STEROID ANTI-INFLAMMATORY AND AN ANTIBIOTIC

Info

Publication number
PE20140035A1
PE20140035A1 PE2013001576A PE2013001576A PE20140035A1 PE 20140035 A1 PE20140035 A1 PE 20140035A1 PE 2013001576 A PE2013001576 A PE 2013001576A PE 2013001576 A PE2013001576 A PE 2013001576A PE 20140035 A1 PE20140035 A1 PE 20140035A1
Authority
PE
Peru
Prior art keywords
antibiotic
composition including
injectable composition
steroid anti
inflammatory
Prior art date
Application number
PE2013001576A
Other languages
Spanish (es)
Inventor
Fadil Al Alawi
Wayne Frederick Leech
Karthigeyan Nanjan
Original Assignee
Bayer New Zealand Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46515931&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20140035(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer New Zealand Ltd filed Critical Bayer New Zealand Ltd
Publication of PE20140035A1 publication Critical patent/PE20140035A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UNA COMPOSICION INYECTABLE QUE COMPRENDE: A) UN FARMACO ANTIINFLAMATORIO NO ESTEROIDEO (AINE) TAL COMO FLUNIXINA, MELOXICAM, CARPROFENO O KETOPROFENO, EN UNA CANTIDAD DE 1 A 15% P/V; B) UN ANTIBIOTICO MACROLIDO TAL COMO TILOSINA Y UN ANTIBIOTICO BETALACTAMICO TAL COMO PENETAMATO, EN UNA CANTIDAD DE 10 A 35% P/V; C) DOS DISOLVENTES NO ACUOSOS QUE ACTUAN COMO UN AGENTE SOLUBILIZADOR Y UN VEHICULO, EN EL QUE EL PRIMER DISOLVENTE NO ACUOSO ES GLICERINA FORMALDEHIDO O N-METIL-2-PIRROLIDONA (NMP) Y EL SEGUNDO DISOLVENTE NO ACUOSO ES PROPILENGLICOL; Y D) UN ANTIOXIDANTE TAL COMO SULFOXILATO FORMALDEHIDO DE SODIO O TOLUENO HIDROXIBUTILADO (BHT) EN UNA CANTIDAD DE 0,01 A 0,3% P/V; EN DONDE LA PROPORCION ENTRE EL AINE Y ANTIBIOTICO ES 1:3 P/V. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DE UNA INFECCION MICROBIANA EN LA GLANDULA MAMARIA DE UN ANIMALIT REFERS TO AN INJECTABLE COMPOSITION INCLUDING: A) A NON-STEROID ANTI-INFLAMMATORY DRUG (NSAID) SUCH AS FLUNIXIN, MELOXICAM, CARPROPHENE OR KETOPROPHEN, IN AN AMOUNT OF 1 TO 15% w / V; B) A MACROLIDE ANTIBIOTIC SUCH AS TYLOSIN AND A BETHALACTAMIC ANTIBIOTIC SUCH AS PENETAMATE, IN A QUANTITY OF 10 TO 35% P / V; C) TWO NON-AQUEOUS SOLVENTS THAT ACT AS A SOLUBILIZING AGENT AND A VEHICLE, IN WHICH THE FIRST NON-AQUEOUS SOLVENT IS GLYCERIN FORMALDEHYDE OR N-METHYL-2-PYRROLIDONE (NMP) AND THE SECOND NON-AQUEOUS SOLVENT IS PROPYLENE GLYCOL; AND D) AN ANTIOXIDANT SUCH AS SODIUM FORMALDEHYDE SULFOXYLATE OR HYDROXIBUTYLED TOLUENE (BHT) IN AN AMOUNT OF 0.01 TO 0.3% W / V; WHERE THE RATIO BETWEEN THE NSAID AND ANTIBIOTIC IS 1: 3 P / V. SUCH COMPOSITION IS USEFUL IN THE TREATMENT OF A MICROBIAL INFECTION IN THE MAMMARY GLAND OF AN ANIMAL

PE2013001576A 2011-01-20 2012-01-20 INJECTABLE COMPOSITION INCLUDING A NON-STEROID ANTI-INFLAMMATORY AND AN ANTIBIOTIC PE20140035A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NZ588686A NZ588686A (en) 2011-01-20 2011-01-20 Injectable composition comprising an NSAID and an antibiotic in a non-aqueous solvent for treating a microbial infection in a mammary gland

Publications (1)

Publication Number Publication Date
PE20140035A1 true PE20140035A1 (en) 2014-02-16

Family

ID=46515931

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2013001576A PE20140035A1 (en) 2011-01-20 2012-01-20 INJECTABLE COMPOSITION INCLUDING A NON-STEROID ANTI-INFLAMMATORY AND AN ANTIBIOTIC

Country Status (15)

Country Link
KR (1) KR101905173B1 (en)
CN (1) CN103327984B (en)
AU (1) AU2012207698A1 (en)
BR (1) BR112013018557B1 (en)
CL (1) CL2013002086A1 (en)
CO (1) CO6801732A2 (en)
CR (1) CR20130401A (en)
GT (1) GT201300182A (en)
IL (1) IL227540A (en)
MX (1) MX353876B (en)
NI (1) NI201300063A (en)
NZ (1) NZ588686A (en)
PE (1) PE20140035A1 (en)
WO (1) WO2012099479A1 (en)
ZA (1) ZA201305780B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2995297A1 (en) * 2014-09-09 2016-03-16 Ceva Sante Animale Parenteral compositions and uses thereof
AR102172A1 (en) 2015-10-05 2017-02-08 Química Luar S R L A BACTERICIDE AND VIRUCIDE PHARMACEUTICAL COMPOSITION
CN105663037A (en) * 2016-01-27 2016-06-15 成都乾坤动物药业有限公司 Amoxicillin solution as well as preparation method and application thereof
CN112472667B (en) * 2019-08-23 2022-11-15 北京欧博方医药科技有限公司 Retxib long-acting injection and preparation method and application thereof
CN111035614B (en) * 2019-12-20 2024-02-02 北京喜禽药业有限公司 High-content terramycin injection and preparation method thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6787568B1 (en) * 2000-11-27 2004-09-07 Phoenix Scientific, Inc. Antibiotic/analgesic formulation and a method of making this formulation
CN1297319C (en) * 2003-09-22 2007-01-31 王玉万 Preparing pharmaceutics of medication containing antimicrobials by using silicone oil as medium
EP1677781A4 (en) 2003-10-29 2008-11-19 Idexx Lab Inc Salts of pharmacologically active compounds
DE102004025324A1 (en) * 2004-05-19 2005-12-08 Boehringer Ingelheim Vetmedica Gmbh Liquid preparation for veterinary medicine, process for their preparation and their use

Also Published As

Publication number Publication date
MX2013008407A (en) 2013-09-26
CN103327984B (en) 2016-08-17
AU2012207698A1 (en) 2013-04-18
ZA201305780B (en) 2014-04-30
CN103327984A (en) 2013-09-25
NZ588686A (en) 2013-07-26
GT201300182A (en) 2014-07-28
KR101905173B1 (en) 2018-11-28
BR112013018557A2 (en) 2016-11-22
IL227540A (en) 2017-12-31
CL2013002086A1 (en) 2014-07-25
IL227540A0 (en) 2013-09-30
CR20130401A (en) 2014-02-04
CO6801732A2 (en) 2013-11-29
KR20140012646A (en) 2014-02-03
WO2012099479A1 (en) 2012-07-26
NI201300063A (en) 2014-05-23
MX353876B (en) 2018-02-01
BR112013018557B1 (en) 2021-11-03

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