NZ588686A - Injectable composition comprising an NSAID and an antibiotic in a non-aqueous solvent for treating a microbial infection in a mammary gland - Google Patents

Injectable composition comprising an NSAID and an antibiotic in a non-aqueous solvent for treating a microbial infection in a mammary gland

Info

Publication number
NZ588686A
NZ588686A NZ588686A NZ58868611A NZ588686A NZ 588686 A NZ588686 A NZ 588686A NZ 588686 A NZ588686 A NZ 588686A NZ 58868611 A NZ58868611 A NZ 58868611A NZ 588686 A NZ588686 A NZ 588686A
Authority
NZ
New Zealand
Prior art keywords
antibiotic
nsaid
aqueous solvent
carrier
composition
Prior art date
Application number
NZ588686A
Inventor
Fadil Al Alawi
Wayne Frederick Leech
Karthigeyan Nanjan
Original Assignee
Bayer New Zealand Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46515931&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ588686(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer New Zealand Ltd filed Critical Bayer New Zealand Ltd
Priority to NZ588686A priority Critical patent/NZ588686A/en
Priority to AU2012207698A priority patent/AU2012207698A1/en
Priority to MX2013008407A priority patent/MX353876B/en
Priority to BR112013018557-0A priority patent/BR112013018557B1/en
Priority to KR1020137021988A priority patent/KR101905173B1/en
Priority to PE2013001576A priority patent/PE20140035A1/en
Priority to PCT/NZ2012/000003 priority patent/WO2012099479A1/en
Priority to CN201280005989.4A priority patent/CN103327984B/en
Priority to NI201300063A priority patent/NI201300063A/en
Priority to GT201300182A priority patent/GT201300182A/en
Priority to IL227540A priority patent/IL227540A/en
Priority to CL2013002086A priority patent/CL2013002086A1/en
Publication of NZ588686A publication Critical patent/NZ588686A/en
Priority to ZA2013/05780A priority patent/ZA201305780B/en
Priority to CO13186092A priority patent/CO6801732A2/en
Priority to CR20130401A priority patent/CR20130401A/en
Priority to AU2015268626A priority patent/AU2015268626C1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

ABSTRACT - 588686 The disclosure relates to an injectable composition for the treatment of a microbial infection in a mammary gland of an animal, wherein the composition includes: (a) a non-steroidal anti-inflammatory drug (NSAID); (b) an antibiotic selected from the group consisting of a beta lactam antibiotic and macrolide antibiotic; (c) a carrier, characterised in that the composition includes at least two non-aqueous solvents, wherein at least one non-aqueous solvent is a solubilising agent, preferably selected from N-Methyl-2-Pyrrolidone (NMP), glycerine formal, and benzyl alcohol; and at least one non-aqueous solvent is a carrier, preferably propylene glycol, wherein the amount of carrier in the composition is more than the amount of solubilising agent in the composition; wherein the solubilising agent has the property of dissolving the NSAID and/or antibiotic more readily than a carrier; and wherein the NSAID and antibiotic are dissolved in the at least two non-aqueous solvents.
NZ588686A 2011-01-20 2011-01-20 Injectable composition comprising an NSAID and an antibiotic in a non-aqueous solvent for treating a microbial infection in a mammary gland NZ588686A (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
NZ588686A NZ588686A (en) 2011-01-20 2011-01-20 Injectable composition comprising an NSAID and an antibiotic in a non-aqueous solvent for treating a microbial infection in a mammary gland
CN201280005989.4A CN103327984B (en) 2011-01-20 2012-01-20 Be included in NSAID and the antibiotic Injectable composition that is used for the treatment of mastitis in non-aqueous solvent
PCT/NZ2012/000003 WO2012099479A1 (en) 2011-01-20 2012-01-20 Injectable compositions for mastitis comprising an nsaid and an antibiotic in a non-aqueous solvent
MX2013008407A MX353876B (en) 2011-01-20 2012-01-20 Injectable compositions for mastitis comprising an nsaid and an antibiotic in a non-aqueous solvent.
BR112013018557-0A BR112013018557B1 (en) 2011-01-20 2012-01-20 INJECTABLE COMPOSITION, ITS USE AND METHOD OF PREPARATION
KR1020137021988A KR101905173B1 (en) 2011-01-20 2012-01-20 Injectable compositions for mastitis comprising an NSAID and an antibiotic in a non-aqueous solvent
PE2013001576A PE20140035A1 (en) 2011-01-20 2012-01-20 INJECTABLE COMPOSITION INCLUDING A NON-STEROID ANTI-INFLAMMATORY AND AN ANTIBIOTIC
AU2012207698A AU2012207698A1 (en) 2011-01-20 2012-01-20 Injectable compositions for mastitis comprising an NSAID and an antibiotic in a non-aqueous solvent
GT201300182A GT201300182A (en) 2011-01-20 2013-07-17 METHOD FOR THE TREATMENT OF AN INFECTION
NI201300063A NI201300063A (en) 2011-01-20 2013-07-17 METHOD FOR THE TREATMENT OF AN INFECTION
IL227540A IL227540A (en) 2011-01-20 2013-07-18 Injectible compositions comprising an nsaid and an antibiotic in a non-aqueous solvent and uses thereof
CL2013002086A CL2013002086A1 (en) 2011-01-20 2013-07-19 Injectable composition for treating microbial infection comprising a non-steroidal anti-inflammatory drug (aine), a beta-lactam or macrolide antibiotic and a vehicle
ZA2013/05780A ZA201305780B (en) 2011-01-20 2013-07-31 Injectable compositions for mastitis comprising an nsaid and an antibiotic in a non-aqueaous solvent
CO13186092A CO6801732A2 (en) 2011-01-20 2013-08-05 Injectable compositions for mastitis comprising an aine and an antibiotic in a non-aqueous solvent
CR20130401A CR20130401A (en) 2011-01-20 2013-08-19 INJECTABLE COMPOSITIONS FOR MASTITIS THAT INCLUDES A NON-STEROID ANTI-INFLAMMATORY (NSAID) AND AN ANTIBIOTIC IN A NON-WATER SOLVENT
AU2015268626A AU2015268626C1 (en) 2011-01-20 2015-12-10 Injectable compositions for mastitis comprising an NSAID and an antibiotic in a non-aqueous solvent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NZ588686A NZ588686A (en) 2011-01-20 2011-01-20 Injectable composition comprising an NSAID and an antibiotic in a non-aqueous solvent for treating a microbial infection in a mammary gland

Publications (1)

Publication Number Publication Date
NZ588686A true NZ588686A (en) 2013-07-26

Family

ID=46515931

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ588686A NZ588686A (en) 2011-01-20 2011-01-20 Injectable composition comprising an NSAID and an antibiotic in a non-aqueous solvent for treating a microbial infection in a mammary gland

Country Status (15)

Country Link
KR (1) KR101905173B1 (en)
CN (1) CN103327984B (en)
AU (1) AU2012207698A1 (en)
BR (1) BR112013018557B1 (en)
CL (1) CL2013002086A1 (en)
CO (1) CO6801732A2 (en)
CR (1) CR20130401A (en)
GT (1) GT201300182A (en)
IL (1) IL227540A (en)
MX (1) MX353876B (en)
NI (1) NI201300063A (en)
NZ (1) NZ588686A (en)
PE (1) PE20140035A1 (en)
WO (1) WO2012099479A1 (en)
ZA (1) ZA201305780B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2995297A1 (en) * 2014-09-09 2016-03-16 Ceva Sante Animale Parenteral compositions and uses thereof
AR102172A1 (en) 2015-10-05 2017-02-08 Química Luar S R L A BACTERICIDE AND VIRUCIDE PHARMACEUTICAL COMPOSITION
CN105663037A (en) * 2016-01-27 2016-06-15 成都乾坤动物药业有限公司 Amoxicillin solution as well as preparation method and application thereof
CN112472667B (en) * 2019-08-23 2022-11-15 北京欧博方医药科技有限公司 Retxib long-acting injection and preparation method and application thereof
CN111035614B (en) * 2019-12-20 2024-02-02 北京喜禽药业有限公司 High-content terramycin injection and preparation method thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6787568B1 (en) 2000-11-27 2004-09-07 Phoenix Scientific, Inc. Antibiotic/analgesic formulation and a method of making this formulation
CN1297319C (en) * 2003-09-22 2007-01-31 王玉万 Preparing pharmaceutics of medication containing antimicrobials by using silicone oil as medium
EP1677781A4 (en) 2003-10-29 2008-11-19 Idexx Lab Inc Salts of pharmacologically active compounds
DE102004025324A1 (en) * 2004-05-19 2005-12-08 Boehringer Ingelheim Vetmedica Gmbh Liquid preparation for veterinary medicine, process for their preparation and their use

Also Published As

Publication number Publication date
WO2012099479A1 (en) 2012-07-26
NI201300063A (en) 2014-05-23
GT201300182A (en) 2014-07-28
MX2013008407A (en) 2013-09-26
AU2012207698A1 (en) 2013-04-18
KR101905173B1 (en) 2018-11-28
IL227540A (en) 2017-12-31
IL227540A0 (en) 2013-09-30
MX353876B (en) 2018-02-01
PE20140035A1 (en) 2014-02-16
CO6801732A2 (en) 2013-11-29
KR20140012646A (en) 2014-02-03
BR112013018557B1 (en) 2021-11-03
BR112013018557A2 (en) 2016-11-22
CR20130401A (en) 2014-02-04
CN103327984B (en) 2016-08-17
ZA201305780B (en) 2014-04-30
CL2013002086A1 (en) 2014-07-25
CN103327984A (en) 2013-09-25

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Legal Events

Date Code Title Description
ASS Change of ownership

Owner name: BAYER NEW ZEALAND LIMITED, NZ

Free format text: OLD OWNER(S): BOMAC RESEARCH LIMITED

ERR Error or correction

Free format text: THE FILED DATE HAS BEEN CORRECTED TO 20/01/2011

Effective date: 20130716