PE20100146A1 - NEW COMPOUNDS USEFUL IN PAIN THERAPY - Google Patents

NEW COMPOUNDS USEFUL IN PAIN THERAPY

Info

Publication number
PE20100146A1
PE20100146A1 PE2009000754A PE2009000754A PE20100146A1 PE 20100146 A1 PE20100146 A1 PE 20100146A1 PE 2009000754 A PE2009000754 A PE 2009000754A PE 2009000754 A PE2009000754 A PE 2009000754A PE 20100146 A1 PE20100146 A1 PE 20100146A1
Authority
PE
Peru
Prior art keywords
pyridin
compounds useful
new compounds
pain therapy
trifluoroetoxy
Prior art date
Application number
PE2009000754A
Other languages
Spanish (es)
Inventor
Per I Arvidsson
Yevgeni Besidski
Lars Sandberg
Gabor Csjernyik
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20100146A1 publication Critical patent/PE20100146A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DE FORMULA (I), DONDE R1 ES H, ALQUILO C1-C3, ALCOXI C1-C3, CIANO, ENTRE OTROS; m ES 1-3; Het ES HETEROARILO C5-C6 SUSTITUIDO CON 1-2 R2; R2 ES ALQUILO C1-C4, HALOALQUILO C1-C4, HALOALCOXI C1-C4, ENTRE OTROS; D ES HETEROARILO C5-C6, HETEROCICLOALQUILO C5-C7; L1 ES ALQUILENO C1-C4, UN ENLACE; L2 ES ALQUILENO C1-C3. SON COMPUESTOS SELECCIONADOS: 3-OXO-2-(2-PIRIDIN-2-PIRIDIN-2-ILETIL)-N-[[6-(2,2,2-TRIFLUOROETOXI)PIRIDIN-3-IL]METIL]-1H-ISOINDOL-1-CARBOXAMIDA; 2-(OXAN-4-IL)-3-OXO-N-[[6-(2,2,2-TRIFLUOROETOXI)PIRIDIN-3-IL]METIL]-1H-ISOINDOL-1-CARBOXAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE LO CONTIENE. DICHO COMPUESTO TIENE ACTIVIDAD SOBRE EL CANAL DE SODIO NaV1,7, SIENDO DE UTILIDAD EN EL TRATAMIENTO DEL DOLORREFERS TO COMPOUNDS OF FORMULA (I), WHERE R1 IS H, C1-C3 ALKYL, C1-C3 ALCOXY, CYANE, AMONG OTHERS; m IS 1-3; Het IS C5-C6 HETEROARYL SUBSTITUTE WITH 1-2 R2; R2 IS C1-C4 ALKYL, C1-C4 HALOALKYL, C1-C4 HALOALCOXY, AMONG OTHERS; D IS C5-C6 HETEROARYL, C5-C7 HETERO CYCLOALKYL; L1 IS C1-C4 ALKYLENE, A LINK; L2 IS C1-C3 ALKYLENE. SELECTED COMPOUNDS ARE: 3-OXO-2- (2-PYRIDIN-2-PYRIDIN-2-ILEYL) -N - [[6- (2,2,2-TRIFLUOROETOXY) PYRIDIN-3-IL] METHYL] -1H- ISOINDOL-1-CARBOXAMIDE; 2- (OXAN-4-IL) -3-OXO-N - [[6- (2,2,2-TRIFLUOROETOXY) PYRIDIN-3-IL] METHYL] -1H-ISOINDOL-1-CARBOXAMIDE; AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION THAT CONTAINS IT. SAID COMPOUND HAS ACTIVITY ON THE NaV1,7 SODIUM CHANNEL, BEING USEFUL IN THE TREATMENT OF PAIN

PE2009000754A 2008-05-30 2009-05-29 NEW COMPOUNDS USEFUL IN PAIN THERAPY PE20100146A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5730408P 2008-05-30 2008-05-30

Publications (1)

Publication Number Publication Date
PE20100146A1 true PE20100146A1 (en) 2010-03-21

Family

ID=41377345

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000754A PE20100146A1 (en) 2008-05-30 2009-05-29 NEW COMPOUNDS USEFUL IN PAIN THERAPY

Country Status (6)

Country Link
AR (1) AR071953A1 (en)
CL (1) CL2009001327A1 (en)
PE (1) PE20100146A1 (en)
TW (1) TW201000462A (en)
UY (1) UY31855A (en)
WO (1) WO2009145720A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3108792A1 (en) 2018-09-10 2020-03-19 Kaken Pharmaceutical Co., Ltd. Novel heteroaromatic amide derivative and medicament containing the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200613272A (en) * 2004-08-13 2006-05-01 Astrazeneca Ab Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
TW200804281A (en) * 2006-02-16 2008-01-16 Astrazeneca Ab New metabotropic glutamate receptor-potentiating isoindolones
TW200812962A (en) * 2006-07-12 2008-03-16 Astrazeneca Ab New compounds I/418
WO2008008020A1 (en) * 2006-07-12 2008-01-17 Astrazeneca Ab 3-oxoisoindoline-1-carboxamide derivatives as analgesic agents

Also Published As

Publication number Publication date
UY31855A (en) 2010-01-05
AR071953A1 (en) 2010-07-28
CL2009001327A1 (en) 2010-01-15
WO2009145720A1 (en) 2009-12-03
TW201000462A (en) 2010-01-01

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