AR071953A1 - DERIVATIVES OF ISOINDOLS AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM - Google Patents

DERIVATIVES OF ISOINDOLS AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM

Info

Publication number
AR071953A1
AR071953A1 ARP090101935A ARP090101935A AR071953A1 AR 071953 A1 AR071953 A1 AR 071953A1 AR P090101935 A ARP090101935 A AR P090101935A AR P090101935 A ARP090101935 A AR P090101935A AR 071953 A1 AR071953 A1 AR 071953A1
Authority
AR
Argentina
Prior art keywords
alkyl
optionally substituted
fluoro
alkoxy
isoindols
Prior art date
Application number
ARP090101935A
Other languages
Spanish (es)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR071953A1 publication Critical patent/AR071953A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Se reivindican compuestos de formula (1), en la que R1 es hidrogeno; alquilo C1-3, opcionalmente sustituido con uno o m s sustituyentes seleccionados independientemente de hidroxi, alcoxi C1-3 y fluoro; alcoxi C1-3, opcionalmente sustituido con uno o m s fluoro; ciano; hidroxi o halo; m es 1, 2 o 3; Het es heteroarilo C5-6 sustituido con 1 o 2 sustituyentes R2; R2 es alquilo C1-4, haloalquilo C1-4, haloalcoxi C1-4, halo; alcoxi C1-4 o cicloalquil C3-7-oxi, opcionalmente sustituido con uno o m s fluoro; D es heteroarilo C5-6 heterocicloalquilo C3-7 o cicloalquilo C3-7; en el que cada D puede estar opcionalmente sustituido con uno o m s X4; X4 es halo; o alquilo C1-3, opcionalmente sustituido con uno o m s fluoro; alquil C1-3-O-alquilo C1-3, opcionalmente sustituido con uno o m s fluoro; alcoxi C1-3, opcionalmente sustituido con uno o m s fluoro; ciano; hidroxi; oxo; R3O(C=O); o R4(C=O); R3 es alquilo alquilo C1-4; alquil C1-4-O-alquilo C1-4, cicloalquilo C5-6, arilo; o aril-alquilo C1-2; R4 es alquilo C1-4; o heteroarilo C5-6; L1 es alquileno C1-4, o un enlace; y L2 es alquileno C1-3. Los compuestos de la presente son utiles en terapia, tal como terapia contra el dolor.Compounds of formula (1) are claimed, wherein R1 is hydrogen; C1-3 alkyl, optionally substituted with one or more substituents independently selected from hydroxy, C1-3 alkoxy and fluoro; C1-3 alkoxy, optionally substituted with one or more fluoro; cyano; hydroxy or halo; m is 1, 2 or 3; Het is C5-6 heteroaryl substituted with 1 or 2 R2 substituents; R2 is C1-4 alkyl, C1-4 haloalkyl, C1-4 haloalkoxy, halo; C1-4 alkoxy or C3-7-oxycycloalkyl, optionally substituted with one or more fluoro; D is C5-6 heteroaryl C3-7 heterocycloalkyl or C3-7 cycloalkyl; wherein each D may be optionally substituted with one or more X4; X4 is halo; or C1-3 alkyl, optionally substituted with one or more fluoro; C1-3 alkyl-O-C1-3 alkyl, optionally substituted with one or more fluoro; C1-3 alkoxy, optionally substituted with one or more fluoro; cyano; hydroxy; oxo; R3O (C = O); or R4 (C = O); R3 is C1-4 alkyl; C 1-4 alkyl-C 1-4 alkyl, C 5-6 cycloalkyl, aryl; or aryl-C1-2 alkyl; R4 is C1-4 alkyl; or C5-6 heteroaryl; L1 is C1-4 alkylene, or a bond; and L2 is C1-3 alkylene. The compounds herein are useful in therapy, such as pain therapy.

ARP090101935A 2008-05-30 2009-05-29 DERIVATIVES OF ISOINDOLS AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM AR071953A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5730408P 2008-05-30 2008-05-30

Publications (1)

Publication Number Publication Date
AR071953A1 true AR071953A1 (en) 2010-07-28

Family

ID=41377345

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090101935A AR071953A1 (en) 2008-05-30 2009-05-29 DERIVATIVES OF ISOINDOLS AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM

Country Status (6)

Country Link
AR (1) AR071953A1 (en)
CL (1) CL2009001327A1 (en)
PE (1) PE20100146A1 (en)
TW (1) TW201000462A (en)
UY (1) UY31855A (en)
WO (1) WO2009145720A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3108792A1 (en) 2018-09-10 2020-03-19 Kaken Pharmaceutical Co., Ltd. Novel heteroaromatic amide derivative and medicament containing the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200613272A (en) * 2004-08-13 2006-05-01 Astrazeneca Ab Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
TW200804281A (en) * 2006-02-16 2008-01-16 Astrazeneca Ab New metabotropic glutamate receptor-potentiating isoindolones
TW200812962A (en) * 2006-07-12 2008-03-16 Astrazeneca Ab New compounds I/418
WO2008008020A1 (en) * 2006-07-12 2008-01-17 Astrazeneca Ab 3-oxoisoindoline-1-carboxamide derivatives as analgesic agents

Also Published As

Publication number Publication date
UY31855A (en) 2010-01-05
CL2009001327A1 (en) 2010-01-15
WO2009145720A1 (en) 2009-12-03
PE20100146A1 (en) 2010-03-21
TW201000462A (en) 2010-01-01

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