PE20091945A1 - 3-OXOISOINDOLIN-1-CARBOXAMIDE DERIVATIVES - Google Patents

3-OXOISOINDOLIN-1-CARBOXAMIDE DERIVATIVES

Info

Publication number
PE20091945A1
PE20091945A1 PE2009000756A PE2009000756A PE20091945A1 PE 20091945 A1 PE20091945 A1 PE 20091945A1 PE 2009000756 A PE2009000756 A PE 2009000756A PE 2009000756 A PE2009000756 A PE 2009000756A PE 20091945 A1 PE20091945 A1 PE 20091945A1
Authority
PE
Peru
Prior art keywords
carboxamide
oxo
oxoisoindolin
compounds
isoindol
Prior art date
Application number
PE2009000756A
Other languages
Spanish (es)
Inventor
Per I Arvidsson
Yevgeni Besidski
Gabor Csjernyik
Istvan Macsari
Linda I Nilsson
Tim Lange
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20091945A1 publication Critical patent/PE20091945A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE 3-OXOISOINDOLIN-1-CARBOXAMIDA DE FORMULA (I) DONDE R1 ES H, ALQUILO(C1-C3), ALCOXI(C1-C3), CN, ENTRE OTROS; m ES 1 O 2; R2 Y R3 SON CADA UNO H, HALOALQUILO(C1-C4), HALOALCOXI(C1-C4), HALO, ENTRE OTROS; HET ES PIRIDINILO, PIRAZINILO, ISOXAZOLILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS CON X4, DONDE X4 ES HALO, CN, ALQUILO(C1-C3), ENTRE OTROS; L1 ES ALQUILENO(C1-C4) OPCIONALMENTE FLUORADO O HIDROXILADO; L2 ES ALQUILENO(C1-C3). SON COMPUESTOS PREFERIDOS: 3-OXO-2-(PIRIDIN-3-ILETIL)-N-[[4-(TRIFLUOROMETOXI)FENIL]METIL]-1H-ISOINDOL-1-CARBOXAMIDA, N-[(4-CLOROFENIL)METIL]-3-OXO-2-(2-PIRAZIN-2-ILETIL)-1H-ISOINDOL-1-CARBOXAMIDA, 4-HIDROXI-3-OXO-2-(2-(PIRIDIN-2-IL)ETIL)-N-(4-(TRIFLUOROMETOXI)BENCIL)ISOINDOLIN-1-CARBOXAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LOS CANALES DE SODIO NaV1.7 SIENDO UTILES EN EL TRATAMIENTO DEL DOLORREFERS TO COMPOUNDS DERIVED FROM 3-OXOISOINDOLIN-1-CARBOXAMIDE OF FORMULA (I) WHERE R1 IS H, ALKYL (C1-C3), ALCOXY (C1-C3), CN, AMONG OTHERS; m IS 1 O 2; R2 AND R3 ARE EACH H, HALOALKYL (C1-C4), HALOALCOXY (C1-C4), HALO, AMONG OTHERS; HET IS PYRIDINYL, PYRAZINIL, ISOXAZOLYL, AMONG OTHERS, OPTIONALLY SUBSTITUTED WITH X4, WHERE X4 IS HALO, CN, ALKYL (C1-C3), AMONG OTHERS; L1 IS ALKYLENE (C1-C4) OPTIONALLY FLUORATED OR HYDROXYLATED; L2 IS ALKYLENE (C1-C3). PREFERRED COMPOUNDS ARE: 3-OXO-2- (PYRIDIN-3-ILEYL) -N - [[4- (TRIFLUOROMETOXY) PHENYL] METHYL] -1H-ISOINDOL-1-CARBOXAMIDE, N - [(4-CHLOROPHENYL) METHYL] -3-OXO-2- (2-PIRAZIN-2-ILETIL) -1H-ISOINDOL-1-CARBOXAMIDE, 4-HYDROXY-3-OXO-2- (2- (PYRIDIN-2-IL) ETHYL) -N- (4- (TRIFLUOROMETOXI) BENZYL) ISOINDOLIN-1-CARBOXAMIDE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE INHIBITORS OF NaV1.7 SODIUM CHANNELS, BEING USEFUL IN THE TREATMENT OF PAIN

PE2009000756A 2008-05-30 2009-05-29 3-OXOISOINDOLIN-1-CARBOXAMIDE DERIVATIVES PE20091945A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5731508P 2008-05-30 2008-05-30

Publications (1)

Publication Number Publication Date
PE20091945A1 true PE20091945A1 (en) 2010-01-28

Family

ID=41377343

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000756A PE20091945A1 (en) 2008-05-30 2009-05-29 3-OXOISOINDOLIN-1-CARBOXAMIDE DERIVATIVES

Country Status (6)

Country Link
AR (1) AR071955A1 (en)
CL (1) CL2009001329A1 (en)
PE (1) PE20091945A1 (en)
TW (1) TW201000461A (en)
UY (1) UY31852A (en)
WO (1) WO2009145718A1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200613272A (en) * 2004-08-13 2006-05-01 Astrazeneca Ab Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
TW200812962A (en) * 2006-07-12 2008-03-16 Astrazeneca Ab New compounds I/418
US20090291983A1 (en) * 2006-07-12 2009-11-26 Astrazeneca Ab 3-Oxoisoindoline-1-Carboxamide Derivatives as Analgesic Agents
GB0705882D0 (en) * 2007-03-27 2007-05-02 Glaxo Group Ltd Novel compounds

Also Published As

Publication number Publication date
WO2009145718A1 (en) 2009-12-03
TW201000461A (en) 2010-01-01
UY31852A (en) 2010-01-05
CL2009001329A1 (en) 2010-01-04
AR071955A1 (en) 2010-07-28

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Legal Events

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