PE20090066A1 - Composiciones farmaceuticas en base a granulos de un derivado de azidocitidina y un copolimero de bloques y procedimiento de preparacion - Google Patents
Composiciones farmaceuticas en base a granulos de un derivado de azidocitidina y un copolimero de bloques y procedimiento de preparacionInfo
- Publication number
- PE20090066A1 PE20090066A1 PE2008000545A PE2008000545A PE20090066A1 PE 20090066 A1 PE20090066 A1 PE 20090066A1 PE 2008000545 A PE2008000545 A PE 2008000545A PE 2008000545 A PE2008000545 A PE 2008000545A PE 20090066 A1 PE20090066 A1 PE 20090066A1
- Authority
- PE
- Peru
- Prior art keywords
- pharmaceutical compositions
- preparation procedure
- granules
- azidocitidine
- derivative
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
SE REFIERE A COMPOSICIONES FARMACEUTICAS QUE COMPRENDEN: a)GRANULOS QUE CONTIENEN, 50-70% (w/w) DE SAL CLORHIDRATO DE ISOBUTIRATO DE (2R,3S, -4R,5R)-5-(4-AMINO-2-OXO-2H-PIRIMIDIN-1-IL)-2-AZIDO-3,4-bis-ISOBUTIRILOXI-TETRAHIDRO-FURAN-2-ILMETILO Y 5-20% (w/w) DE UN POLOXAMERO 188; OPTENIDO POR GRANULACION HUMEDA; b)UN COPOLIMERO DE BLOQUES DE POLIETILENGLICOL (PEG)/POLIPROPILENGLICOL (PPG); c)UN DILUYENTE, TAL COMO MANITA O CELULOSA MICROCRISTALINA; DESINTEGRANTE, TAL COMO CROSCARMELOSA; UN LUBRICANTE, TAL COMO ESTERATO DE MAGNESIO Y UN MATERIAL DE RECUBRIMIENTO, TAL COMO OPADRY. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION. DICHA COMPOSICION SOLIDA TIENE UN PESO TOTAL DE 100 Y 1200 mg
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92058607P | 2007-03-29 | 2007-03-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090066A1 true PE20090066A1 (es) | 2009-02-13 |
Family
ID=39541351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008000545A PE20090066A1 (es) | 2007-03-29 | 2008-03-26 | Composiciones farmaceuticas en base a granulos de un derivado de azidocitidina y un copolimero de bloques y procedimiento de preparacion |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7893037B2 (es) |
| EP (1) | EP2142178B1 (es) |
| JP (1) | JP2010522705A (es) |
| CN (1) | CN101668515B (es) |
| AR (1) | AR065853A1 (es) |
| AT (1) | ATE540672T1 (es) |
| CA (1) | CA2682638C (es) |
| CL (1) | CL2008000861A1 (es) |
| ES (1) | ES2377760T3 (es) |
| PE (1) | PE20090066A1 (es) |
| TW (1) | TW200909006A (es) |
| WO (1) | WO2008119659A2 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2455068A1 (en) * | 2010-11-09 | 2012-05-23 | F. Hoffmann-La Roche AG | Pharmaceutical composition for treating HCV infections |
| US8889159B2 (en) * | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
| KR20230130175A (ko) | 2014-12-26 | 2023-09-11 | 에모리 유니버시티 | Ｎ4-하이드록시시티딘, 이와 관련된 유도체 및 이의 항 바이러스적 용도 |
| AU2018378832B9 (en) * | 2017-12-07 | 2021-05-27 | Emory University | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
| CN112957335B (zh) * | 2021-02-23 | 2022-10-04 | 上海纳为生物技术有限公司 | 一种乙酰氨基葡萄糖口腔崩解片及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ230497A (en) * | 1988-09-02 | 1992-05-26 | Du Pont | Layered, granular water-soluble or water-dispersible pesticide |
| AU2256702A (en) * | 2000-12-01 | 2002-06-11 | Kyowa Hakko Kogyo Kk | Composition improved in solubility or oral absorbability |
| TWI332507B (en) * | 2002-11-19 | 2010-11-01 | Hoffmann La Roche | Antiviral nucleoside derivatives |
| EP1664074A2 (en) * | 2003-09-11 | 2006-06-07 | F.Hoffmann-La Roche Ag | Polymorphic nucleoside compounds |
| EP1701704A2 (en) * | 2003-12-31 | 2006-09-20 | Pfizer Products Inc. | Solid compositions of low-solubility drugs and poloxamers |
| ATE482690T1 (de) * | 2005-12-14 | 2010-10-15 | Hoffmann La Roche | Hcv-prodrug-formulierung |
-
2008
- 2008-03-18 EP EP08717935A patent/EP2142178B1/en not_active Not-in-force
- 2008-03-18 CN CN2008800098977A patent/CN101668515B/zh not_active Expired - Fee Related
- 2008-03-18 AT AT08717935T patent/ATE540672T1/de active
- 2008-03-18 CA CA2682638A patent/CA2682638C/en not_active Expired - Fee Related
- 2008-03-18 JP JP2010500212A patent/JP2010522705A/ja active Pending
- 2008-03-18 WO PCT/EP2008/053202 patent/WO2008119659A2/en active Application Filing
- 2008-03-18 ES ES08717935T patent/ES2377760T3/es active Active
- 2008-03-26 PE PE2008000545A patent/PE20090066A1/es not_active Application Discontinuation
- 2008-03-26 CL CL2008000861A patent/CL2008000861A1/es unknown
- 2008-03-26 TW TW097110880A patent/TW200909006A/zh unknown
- 2008-03-27 AR ARP080101246A patent/AR065853A1/es unknown
- 2008-03-28 US US12/079,715 patent/US7893037B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2142178B1 (en) | 2012-01-11 |
| CN101668515B (zh) | 2013-03-20 |
| EP2142178A2 (en) | 2010-01-13 |
| CA2682638A1 (en) | 2008-10-09 |
| CA2682638C (en) | 2012-07-17 |
| CL2008000861A1 (es) | 2008-11-07 |
| US20080260826A1 (en) | 2008-10-23 |
| AR065853A1 (es) | 2009-07-08 |
| WO2008119659A2 (en) | 2008-10-09 |
| ATE540672T1 (de) | 2012-01-15 |
| CN101668515A (zh) | 2010-03-10 |
| US7893037B2 (en) | 2011-02-22 |
| JP2010522705A (ja) | 2010-07-08 |
| TW200909006A (en) | 2009-03-01 |
| ES2377760T3 (es) | 2012-03-30 |
| WO2008119659A3 (en) | 2009-03-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |