PE20061453A1 - 2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZODIAZEPIN-3-IL-PIPERIDINES DERIVED COMPOUNDS AS CGPR ANTAGONISTS - Google Patents

2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZODIAZEPIN-3-IL-PIPERIDINES DERIVED COMPOUNDS AS CGPR ANTAGONISTS

Info

Publication number
PE20061453A1
PE20061453A1 PE2006000336A PE2006000336A PE20061453A1 PE 20061453 A1 PE20061453 A1 PE 20061453A1 PE 2006000336 A PE2006000336 A PE 2006000336A PE 2006000336 A PE2006000336 A PE 2006000336A PE 20061453 A1 PE20061453 A1 PE 20061453A1
Authority
PE
Peru
Prior art keywords
oxo
piperidin
benzodiazepin
tetrahydro
benzyl
Prior art date
Application number
PE2006000336A
Other languages
Spanish (es)
Inventor
Stephan Georg Mueller
Klaus Rudolf
Dirk Stenkamp
Kirsten Arndt
Henri Doods
Fabio Paleari
Marco Santagostino
Gerhard Schaenzle
Alexander Dreyer
Philipp Lustenberger
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ARP050101139A external-priority patent/AR049625A1/en
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Priority to PE2006000336A priority Critical patent/PE20061453A1/en
Publication of PE20061453A1 publication Critical patent/PE20061453A1/en

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE B ES SELECCIONADO DE 3,5-BIS-TRIFLUOROMETIL-BENCIL, 4-AMINO-3,5-DIMETIL-BENCIL, 4-BENZOIL-3,5-DIMETIL-FENIL, ENTRE OTROS; R1 Y R2 JUNTO CON EL ATOMO DE NITROGENO SON UN RADICAL DE FORMULA (II) DONDE Y1 ES C O N; R3 ES CICLOPENTILO, MORFOLIN-4-ILO, PIPERIDIN-1-ILO, ENTRE OTROS; R4 ES H O UN PAR DE ELECTRONES LIBRES. SON COMPUESTOS PREFERIDOS: ESTER (R)-2-[4-(4-METIL-PIPERAZIN-1-IL)-PIPERIDIN-1-IL]-2-OXO-1-(3-TRIFLUOROMETIL-BENCIL)-ETILICO DE ACIDO 4-(2-OXO-1,2,4,5-TETRAHIDRO-1,3-BENZODIAZEPIN-3-IL)-PIPERIDIN-1-CARBOXILICO, ESTER (R)-2-[4-(4-METIL-PIPERAZIN-1-IL)-PIPERIDIN-1-IL]-2-OXO-1-(3-METIL-BENCIL)-ETILICO DE ACIDO 4-(2-OXO-1,2,4,5-TETRAHIDRO-1,3-BENZODIAZEPIN-3-IL)-PIPERIDIN-1-CARBOXILICO, ESTER (R)-1-(3,5-BIS-TRIFLUOROMETIL-BENCIL)-2-(1'-ETOXICARBONILMETIL-4,4'-BIPIPERIDINIL-1-IL)-2-OXO-ETILICO DE ACIDO 4-(2-OXO-1,2,4,5-TETRAHIDRO-1,3-BENZODIAZEPIN-3-IL)-PIPERIDIN-1-CARBOXILICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON ANTAGONISTAS DE CGPR UTILES EN EL TRATAMIENTO DE DOLORES DE CABEZA, DIABETES MELLITUS, ENFERMEDADES CARDIOVASCULARES, ENFERMEDADES DE LA PIEL, RINITIS ALERGICAREFERS TO A COMPOUND OF FORMULA (I) WHERE B IS SELECTED FROM 3,5-BIS-TRIFLUOROMETHYL-BENZYL, 4-AMINO-3,5-DIMETHYL-BENZYL, 4-BENZOYL-3,5-DIMETHYL-PHENYL, BETWEEN OTHERS; R1 AND R2 TOGETHER WITH THE NITROGEN ATOM ARE A RADICAL OF FORMULA (II) WHERE Y1 IS C O N; R3 IS CYCLOPENTILO, MORFOLIN-4-ILO, PIPERIDIN-1-ILO, AMONG OTHERS; R4 IS H OR A PAIR OF FREE ELECTRONS. PREFERRED COMPOUNDS ARE: ESTER (R) -2- [4- (4-METHYL-PIPERAZIN-1-IL) -PIPERIDIN-1-IL] -2-OXO-1- (3-TRIFLUOROMETHYL-BENZYL) -ETHYL ACID 4- (2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZODIAZEPIN-3-IL) -PIPERIDIN-1-CARBOXILICO, ESTER (R) -2- [4- (4-METTIL-PIPERAZIN -1-IL) -PIPERIDIN-1-IL] -2-OXO-1- (3-METHYL-BENZYL) -ETHYL ACID 4- (2-OXO-1,2,4,5-TETRAHYDRO-1,3 -BENZODIAZEPIN-3-IL) -PIPERIDIN-1-CARBOXYL, ESTER (R) -1- (3,5-BIS-TRIFLUOROMETHYL-BENZYL) -2- (1'-ETOXICARBONYLMETHYL-4,4'-BIPIPERIDINYL-1- IL) -2-OXO-ETHYL ACID 4- (2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZODIAZEPIN-3-IL) -PIPERIDIN-1-CARBOXILICO, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. SUCH COMPOUNDS ARE USEFUL ANTAGONISTS OF CGPR IN THE TREATMENT OF HEADACHES, DIABETES MELLITUS, CARDIOVASCULAR DISEASES, SKIN DISEASES, ALLERGIC RHINITIS

PE2006000336A 2005-03-23 2006-03-23 2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZODIAZEPIN-3-IL-PIPERIDINES DERIVED COMPOUNDS AS CGPR ANTAGONISTS PE20061453A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PE2006000336A PE20061453A1 (en) 2005-03-23 2006-03-23 2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZODIAZEPIN-3-IL-PIPERIDINES DERIVED COMPOUNDS AS CGPR ANTAGONISTS

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ARP050101139A AR049625A1 (en) 2004-03-29 2005-03-23 CGRP ANTAGONISTS, PROCEDURE FOR PREPARATION AS WELL AS ITS USE AS A MEDICINAL PRODUCT
PE2005000336A PE20060150A1 (en) 2004-03-29 2005-03-23 SELECTED CGRP ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS AND PROCEDURE FOR THEIR PREPARATION
PCT/EP2005/003094 WO2005092880A1 (en) 2004-03-29 2005-03-23 Selected cgrp antagonists, methods for the production thereof and their use as medicaments
PE2006000336A PE20061453A1 (en) 2005-03-23 2006-03-23 2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZODIAZEPIN-3-IL-PIPERIDINES DERIVED COMPOUNDS AS CGPR ANTAGONISTS

Publications (1)

Publication Number Publication Date
PE20061453A1 true PE20061453A1 (en) 2007-01-19

Family

ID=43298656

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000336A PE20061453A1 (en) 2005-03-23 2006-03-23 2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZODIAZEPIN-3-IL-PIPERIDINES DERIVED COMPOUNDS AS CGPR ANTAGONISTS

Country Status (1)

Country Link
PE (1) PE20061453A1 (en)

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