PE20061453A1 - 2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZODIAZEPIN-3-IL-PIPERIDINES DERIVED COMPOUNDS AS CGPR ANTAGONISTS - Google Patents
2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZODIAZEPIN-3-IL-PIPERIDINES DERIVED COMPOUNDS AS CGPR ANTAGONISTSInfo
- Publication number
- PE20061453A1 PE20061453A1 PE2006000336A PE2006000336A PE20061453A1 PE 20061453 A1 PE20061453 A1 PE 20061453A1 PE 2006000336 A PE2006000336 A PE 2006000336A PE 2006000336 A PE2006000336 A PE 2006000336A PE 20061453 A1 PE20061453 A1 PE 20061453A1
- Authority
- PE
- Peru
- Prior art keywords
- oxo
- piperidin
- benzodiazepin
- tetrahydro
- benzyl
- Prior art date
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE B ES SELECCIONADO DE 3,5-BIS-TRIFLUOROMETIL-BENCIL, 4-AMINO-3,5-DIMETIL-BENCIL, 4-BENZOIL-3,5-DIMETIL-FENIL, ENTRE OTROS; R1 Y R2 JUNTO CON EL ATOMO DE NITROGENO SON UN RADICAL DE FORMULA (II) DONDE Y1 ES C O N; R3 ES CICLOPENTILO, MORFOLIN-4-ILO, PIPERIDIN-1-ILO, ENTRE OTROS; R4 ES H O UN PAR DE ELECTRONES LIBRES. SON COMPUESTOS PREFERIDOS: ESTER (R)-2-[4-(4-METIL-PIPERAZIN-1-IL)-PIPERIDIN-1-IL]-2-OXO-1-(3-TRIFLUOROMETIL-BENCIL)-ETILICO DE ACIDO 4-(2-OXO-1,2,4,5-TETRAHIDRO-1,3-BENZODIAZEPIN-3-IL)-PIPERIDIN-1-CARBOXILICO, ESTER (R)-2-[4-(4-METIL-PIPERAZIN-1-IL)-PIPERIDIN-1-IL]-2-OXO-1-(3-METIL-BENCIL)-ETILICO DE ACIDO 4-(2-OXO-1,2,4,5-TETRAHIDRO-1,3-BENZODIAZEPIN-3-IL)-PIPERIDIN-1-CARBOXILICO, ESTER (R)-1-(3,5-BIS-TRIFLUOROMETIL-BENCIL)-2-(1'-ETOXICARBONILMETIL-4,4'-BIPIPERIDINIL-1-IL)-2-OXO-ETILICO DE ACIDO 4-(2-OXO-1,2,4,5-TETRAHIDRO-1,3-BENZODIAZEPIN-3-IL)-PIPERIDIN-1-CARBOXILICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON ANTAGONISTAS DE CGPR UTILES EN EL TRATAMIENTO DE DOLORES DE CABEZA, DIABETES MELLITUS, ENFERMEDADES CARDIOVASCULARES, ENFERMEDADES DE LA PIEL, RINITIS ALERGICAREFERS TO A COMPOUND OF FORMULA (I) WHERE B IS SELECTED FROM 3,5-BIS-TRIFLUOROMETHYL-BENZYL, 4-AMINO-3,5-DIMETHYL-BENZYL, 4-BENZOYL-3,5-DIMETHYL-PHENYL, BETWEEN OTHERS; R1 AND R2 TOGETHER WITH THE NITROGEN ATOM ARE A RADICAL OF FORMULA (II) WHERE Y1 IS C O N; R3 IS CYCLOPENTILO, MORFOLIN-4-ILO, PIPERIDIN-1-ILO, AMONG OTHERS; R4 IS H OR A PAIR OF FREE ELECTRONS. PREFERRED COMPOUNDS ARE: ESTER (R) -2- [4- (4-METHYL-PIPERAZIN-1-IL) -PIPERIDIN-1-IL] -2-OXO-1- (3-TRIFLUOROMETHYL-BENZYL) -ETHYL ACID 4- (2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZODIAZEPIN-3-IL) -PIPERIDIN-1-CARBOXILICO, ESTER (R) -2- [4- (4-METTIL-PIPERAZIN -1-IL) -PIPERIDIN-1-IL] -2-OXO-1- (3-METHYL-BENZYL) -ETHYL ACID 4- (2-OXO-1,2,4,5-TETRAHYDRO-1,3 -BENZODIAZEPIN-3-IL) -PIPERIDIN-1-CARBOXYL, ESTER (R) -1- (3,5-BIS-TRIFLUOROMETHYL-BENZYL) -2- (1'-ETOXICARBONYLMETHYL-4,4'-BIPIPERIDINYL-1- IL) -2-OXO-ETHYL ACID 4- (2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZODIAZEPIN-3-IL) -PIPERIDIN-1-CARBOXILICO, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. SUCH COMPOUNDS ARE USEFUL ANTAGONISTS OF CGPR IN THE TREATMENT OF HEADACHES, DIABETES MELLITUS, CARDIOVASCULAR DISEASES, SKIN DISEASES, ALLERGIC RHINITIS
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PE2006000336A PE20061453A1 (en) | 2005-03-23 | 2006-03-23 | 2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZODIAZEPIN-3-IL-PIPERIDINES DERIVED COMPOUNDS AS CGPR ANTAGONISTS |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ARP050101139A AR049625A1 (en) | 2004-03-29 | 2005-03-23 | CGRP ANTAGONISTS, PROCEDURE FOR PREPARATION AS WELL AS ITS USE AS A MEDICINAL PRODUCT |
PE2005000336A PE20060150A1 (en) | 2004-03-29 | 2005-03-23 | SELECTED CGRP ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS AND PROCEDURE FOR THEIR PREPARATION |
PCT/EP2005/003094 WO2005092880A1 (en) | 2004-03-29 | 2005-03-23 | Selected cgrp antagonists, methods for the production thereof and their use as medicaments |
PE2006000336A PE20061453A1 (en) | 2005-03-23 | 2006-03-23 | 2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZODIAZEPIN-3-IL-PIPERIDINES DERIVED COMPOUNDS AS CGPR ANTAGONISTS |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20061453A1 true PE20061453A1 (en) | 2007-01-19 |
Family
ID=43298656
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006000336A PE20061453A1 (en) | 2005-03-23 | 2006-03-23 | 2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZODIAZEPIN-3-IL-PIPERIDINES DERIVED COMPOUNDS AS CGPR ANTAGONISTS |
Country Status (1)
Country | Link |
---|---|
PE (1) | PE20061453A1 (en) |
-
2006
- 2006-03-23 PE PE2006000336A patent/PE20061453A1/en not_active Application Discontinuation
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Legal Events
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FG | Grant, registration | ||
FD | Application declared void or lapsed |