PE20061445A1 - PIRAZOLE COMPOUNDS AS INHIBITORS OF HEPATIC GLUCOGEN PHOSPHORYLASE - Google Patents
PIRAZOLE COMPOUNDS AS INHIBITORS OF HEPATIC GLUCOGEN PHOSPHORYLASEInfo
- Publication number
- PE20061445A1 PE20061445A1 PE2006000537A PE2006000537A PE20061445A1 PE 20061445 A1 PE20061445 A1 PE 20061445A1 PE 2006000537 A PE2006000537 A PE 2006000537A PE 2006000537 A PE2006000537 A PE 2006000537A PE 20061445 A1 PE20061445 A1 PE 20061445A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- hepatic
- difluoro
- pyridin
- chloro
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE PIRAZOL DE FORMULA (I) DONDE R1 ES H, HALOGENO, ALQUILO(C1-C6), ALCOXI(C1-C6); R2 ES HALOGENO, ALQUILO(C1-C6), ALCOXI(C1-C6), O UN GRUPO AZIDO; R3 ES HALOGENO, HIDROXILO, ALQUILO(C1-C6), ENTRE OTROS; R4 Y R5 SON INDEPENDIENTEMENTE H, ALQUILO(C1-C6), ALQUENILO(C2-C6), ENTRE OTROS; Q ES ARILO O HETEROAROMATICO. SON PREFERIDOS: (PIRIDIN-3-ILMETIL)-AMIDA DE ACIDO 5-(2-CLORO-4,5-DIFLUORO-BENZOILAMINO)-1H-PIRAZOL-3-CARBOXILICO, (PIRIDIN-3-ILMETIL)-AMIDA DICLORHIDRATO DE ACIDO 5-(2-CLORO-4,5-DIFLUORO-BENZOILAMINO)-1H-PIRAZOL-3-CARBOXILICO, (PIRIDIN-3-ILMETIL)-AMIDA-CLORHIDRATO DE ACIDO 5-(2-CLORO-4,5-DIFLUORO-BENZOILAMINO)-1H-PIRAZOL-3-CARBOXILICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS TIENEN ACTIVIDAD INHIBITORIA DE LA FOSFORILASA DEL GLUCOGENO HEPATICO Y QUE RESULTA UTIL COMO UN AGENTE TERAPEUTICO O PROFILACTICO PARA COMBATIR LA DIABETESREFERS TO COMPOUNDS DERIVED FROM PIRAZOLE OF FORMULA (I) WHERE R1 IS H, HALOGEN, ALKYL (C1-C6), ALCOXY (C1-C6); R2 IS HALOGEN, (C1-C6) ALKYL, (C1-C6) ALCOXY, OR A AZIDO GROUP; R3 IS HALOGEN, HYDROXYL, ALKYL (C1-C6), AMONG OTHERS; R4 AND R5 ARE INDEPENDENTLY H, ALKYL (C1-C6), ALKENYL (C2-C6), AMONG OTHERS; Q IS ARYLUS OR HETEROAROMATIC. THE PREFERRED ARE: (PYRIDIN-3-ILMETHYL) -AMIDE OF ACID 5- (2-CHLORO-4,5-DIFLUORO-BENZOYLAMINO) -1H-PIRAZOL-3-CARBOXILICO, (PYRIDIN-3-ILMETIL) -AMIDE DICHLORO-ACIDO 5- (2-CHLORO-4,5-DIFLUORO-BENZOYLAMINE) -1H-PYRAZOL-3-CARBOXYL, (PYRIDIN-3-ILMETHYL) -AMIDE-ACID HYDROCHLORIDE 5- (2-CHLORO-4,5-DIFLUORO- BENZOYLAMINE) -1H-PIRAZOL-3-CARBOXYL, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. THESE COMPOUNDS HAVE INHIBITORY ACTIVITY OF HEPATIC GLUCOGEN PHOSPHORYLASE AND THAT IS USEFUL AS A THERAPEUTIC OR PROPHYLACTIC AGENT TO FIGHT DIABETES
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005148847 | 2005-05-23 | ||
JP2005367286 | 2005-12-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20061445A1 true PE20061445A1 (en) | 2007-01-24 |
Family
ID=38134441
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006000537A PE20061445A1 (en) | 2005-05-23 | 2006-05-22 | PIRAZOLE COMPOUNDS AS INHIBITORS OF HEPATIC GLUCOGEN PHOSPHORYLASE |
Country Status (4)
Country | Link |
---|---|
JP (1) | JPWO2006126695A1 (en) |
AR (1) | AR054194A1 (en) |
PE (1) | PE20061445A1 (en) |
TW (1) | TWI322688B (en) |
-
2006
- 2006-05-22 JP JP2007517929A patent/JPWO2006126695A1/en active Pending
- 2006-05-22 AR ARP060102078 patent/AR054194A1/en unknown
- 2006-05-22 PE PE2006000537A patent/PE20061445A1/en not_active Application Discontinuation
- 2006-05-23 TW TW95118217A patent/TWI322688B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
TW200719887A (en) | 2007-06-01 |
AR054194A1 (en) | 2007-06-06 |
TWI322688B (en) | 2010-04-01 |
JPWO2006126695A1 (en) | 2008-12-25 |
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Legal Events
Date | Code | Title | Description |
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FG | Grant, registration | ||
FD | Application declared void or lapsed |