PE20061445A1 - PIRAZOLE COMPOUNDS AS INHIBITORS OF HEPATIC GLUCOGEN PHOSPHORYLASE - Google Patents

PIRAZOLE COMPOUNDS AS INHIBITORS OF HEPATIC GLUCOGEN PHOSPHORYLASE

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Publication number
PE20061445A1
PE20061445A1 PE2006000537A PE2006000537A PE20061445A1 PE 20061445 A1 PE20061445 A1 PE 20061445A1 PE 2006000537 A PE2006000537 A PE 2006000537A PE 2006000537 A PE2006000537 A PE 2006000537A PE 20061445 A1 PE20061445 A1 PE 20061445A1
Authority
PE
Peru
Prior art keywords
alkyl
hepatic
difluoro
pyridin
chloro
Prior art date
Application number
PE2006000537A
Other languages
Spanish (es)
Inventor
Masaki Takagi
Takeshi Nakamura
Isamu Matsuda
Kenji Fukuda
Koichi Ozawa
Nobuhisa Ueda
Kaoru Sakata
Yukihiro Nomura
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of PE20061445A1 publication Critical patent/PE20061445A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE PIRAZOL DE FORMULA (I) DONDE R1 ES H, HALOGENO, ALQUILO(C1-C6), ALCOXI(C1-C6); R2 ES HALOGENO, ALQUILO(C1-C6), ALCOXI(C1-C6), O UN GRUPO AZIDO; R3 ES HALOGENO, HIDROXILO, ALQUILO(C1-C6), ENTRE OTROS; R4 Y R5 SON INDEPENDIENTEMENTE H, ALQUILO(C1-C6), ALQUENILO(C2-C6), ENTRE OTROS; Q ES ARILO O HETEROAROMATICO. SON PREFERIDOS: (PIRIDIN-3-ILMETIL)-AMIDA DE ACIDO 5-(2-CLORO-4,5-DIFLUORO-BENZOILAMINO)-1H-PIRAZOL-3-CARBOXILICO, (PIRIDIN-3-ILMETIL)-AMIDA DICLORHIDRATO DE ACIDO 5-(2-CLORO-4,5-DIFLUORO-BENZOILAMINO)-1H-PIRAZOL-3-CARBOXILICO, (PIRIDIN-3-ILMETIL)-AMIDA-CLORHIDRATO DE ACIDO 5-(2-CLORO-4,5-DIFLUORO-BENZOILAMINO)-1H-PIRAZOL-3-CARBOXILICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS TIENEN ACTIVIDAD INHIBITORIA DE LA FOSFORILASA DEL GLUCOGENO HEPATICO Y QUE RESULTA UTIL COMO UN AGENTE TERAPEUTICO O PROFILACTICO PARA COMBATIR LA DIABETESREFERS TO COMPOUNDS DERIVED FROM PIRAZOLE OF FORMULA (I) WHERE R1 IS H, HALOGEN, ALKYL (C1-C6), ALCOXY (C1-C6); R2 IS HALOGEN, (C1-C6) ALKYL, (C1-C6) ALCOXY, OR A AZIDO GROUP; R3 IS HALOGEN, HYDROXYL, ALKYL (C1-C6), AMONG OTHERS; R4 AND R5 ARE INDEPENDENTLY H, ALKYL (C1-C6), ALKENYL (C2-C6), AMONG OTHERS; Q IS ARYLUS OR HETEROAROMATIC. THE PREFERRED ARE: (PYRIDIN-3-ILMETHYL) -AMIDE OF ACID 5- (2-CHLORO-4,5-DIFLUORO-BENZOYLAMINO) -1H-PIRAZOL-3-CARBOXILICO, (PYRIDIN-3-ILMETIL) -AMIDE DICHLORO-ACIDO 5- (2-CHLORO-4,5-DIFLUORO-BENZOYLAMINE) -1H-PYRAZOL-3-CARBOXYL, (PYRIDIN-3-ILMETHYL) -AMIDE-ACID HYDROCHLORIDE 5- (2-CHLORO-4,5-DIFLUORO- BENZOYLAMINE) -1H-PIRAZOL-3-CARBOXYL, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. THESE COMPOUNDS HAVE INHIBITORY ACTIVITY OF HEPATIC GLUCOGEN PHOSPHORYLASE AND THAT IS USEFUL AS A THERAPEUTIC OR PROPHYLACTIC AGENT TO FIGHT DIABETES

PE2006000537A 2005-05-23 2006-05-22 PIRAZOLE COMPOUNDS AS INHIBITORS OF HEPATIC GLUCOGEN PHOSPHORYLASE PE20061445A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005148847 2005-05-23
JP2005367286 2005-12-20

Publications (1)

Publication Number Publication Date
PE20061445A1 true PE20061445A1 (en) 2007-01-24

Family

ID=38134441

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000537A PE20061445A1 (en) 2005-05-23 2006-05-22 PIRAZOLE COMPOUNDS AS INHIBITORS OF HEPATIC GLUCOGEN PHOSPHORYLASE

Country Status (4)

Country Link
JP (1) JPWO2006126695A1 (en)
AR (1) AR054194A1 (en)
PE (1) PE20061445A1 (en)
TW (1) TWI322688B (en)

Also Published As

Publication number Publication date
TW200719887A (en) 2007-06-01
AR054194A1 (en) 2007-06-06
TWI322688B (en) 2010-04-01
JPWO2006126695A1 (en) 2008-12-25

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FD Application declared void or lapsed