PE20061162A1 - COMPOUNDS OLEFINIC DERIVATIVES OF 8-AZONIABICICLO [3.2.1] OCTANES - Google Patents

COMPOUNDS OLEFINIC DERIVATIVES OF 8-AZONIABICICLO [3.2.1] OCTANES

Info

Publication number
PE20061162A1
PE20061162A1 PE2005001395A PE2005001395A PE20061162A1 PE 20061162 A1 PE20061162 A1 PE 20061162A1 PE 2005001395 A PE2005001395 A PE 2005001395A PE 2005001395 A PE2005001395 A PE 2005001395A PE 20061162 A1 PE20061162 A1 PE 20061162A1
Authority
PE
Peru
Prior art keywords
endo
dimethyl
octane
bromide
azoniabiciclo
Prior art date
Application number
PE2005001395A
Other languages
Spanish (es)
Inventor
Dramane Ibrahim Laine
Michael R Palovich
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PE20061162A1 publication Critical patent/PE20061162A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE R2 Y R3 SON ALQUILO(C1-C6), CICLOALQUILO(C5-C6), 2-TIENILO, 2-PIRIDILO, ENTRE OTROS; X- ES UN ANION ASOCIADO CON LA CARGA POSITIVA DEL ATOMO DE N TAL COMO CLORURO, BROMURO, YODURO, SULFATO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: BROMURO DE (3-ENDO)-3-(2,2-DI-2-TIENILETENIL)-8,8-DIMETIL-8-AZONIABICICLO[3.2.1]OCTANO, BROMURO DE (3-ENDO)-3-(2,2DIFENILETENIL)-8,8-DIMETIL-8-AZONIABICICLO[3.2.1]OCTANO, 4-METILBENCENOSULFONATO DE (3-ENDO)-3-(2,2-DIFENILETENIL)-8,8-DIMETIL-8-AZONIABICICLO[3.2.1]OCTANO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE ADEMAS CONTIENE UN AGONISTA DEL ADRENORECEPTOR ß2, UN ANTIHISTAMINICO, UN ANTIALERGICO O UN ANTIINFLAMATORIO. DICHOS COMPUESTOS INHIBEN LA UNION DE ACETILCOLINA A SUS RECEPTORES MUSCARINICOS SIENDO UTILES EN EL TRATAMIENTO DE ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA, BRONQUITIS CRONICA, ASMA, FIBROSIS PULMONAR, ENFISEMA PULMONARREFERS TO A COMPOUND OF FORMULA (I) WHERE R2 AND R3 ARE ALKYL (C1-C6), CYCLOALKYL (C5-C6), 2-THENYL, 2-PYRIDYL, AMONG OTHERS; X- IS AN ANION ASSOCIATED WITH THE POSITIVE CHARGE OF THE N ATOM SUCH AS CHLORIDE, BROMIDE, IODIDE, SULPHATE, AMONG OTHERS. THE PREFERRED COMPOUNDS ARE: (3-ENDO) -3- (2,2-DI-2-THYENYLETHENYL) -8,8-DIMETHYL-8-AZONIABYCLE [3.2.1] OCTANE BROMIDE, (3-ENDO) BROMIDE - 3- (2,2-DIPHENYLETHENYL) -8,8-DIMETHYL-8-AZONIABICYCLO [3.2.1] OCTANE, (3-ENDO) -3- (2,2-DIPHENYLETHENYL) -8,8-DIMETHYL- 4-METHYLBENZENOSULPHONATE 8-AZONIABICICLO [3.2.1] OCTANE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION THAT ALSO CONTAINS A ß2-ADRENORECEPTOR AGONIST, AN ANTIHISTAMINE, AN ANTI-ALLERGIC OR AN ANTI-INFLAMMATORY. SUCH COMPOUNDS INHIBIT THE BINDING OF ACETYLCHOLINE TO ITS MUSCARINAL RECEPTORS, BEING USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, CHRONIC BRONCHITIS, ASTHMA, PULMONARY FIBROSIS, PULMONARY EMPHYSEMA

PE2005001395A 2004-12-06 2005-12-01 COMPOUNDS OLEFINIC DERIVATIVES OF 8-AZONIABICICLO [3.2.1] OCTANES PE20061162A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63366904P 2004-12-06 2004-12-06

Publications (1)

Publication Number Publication Date
PE20061162A1 true PE20061162A1 (en) 2006-10-14

Family

ID=36578446

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005001395A PE20061162A1 (en) 2004-12-06 2005-12-01 COMPOUNDS OLEFINIC DERIVATIVES OF 8-AZONIABICICLO [3.2.1] OCTANES

Country Status (5)

Country Link
AR (1) AR054411A1 (en)
PE (1) PE20061162A1 (en)
TW (1) TW200633706A (en)
UY (1) UY29244A1 (en)
WO (1) WO2006062883A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200519108A (en) 2003-07-17 2005-06-16 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists
TW200811171A (en) 2003-10-14 2008-03-01 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists
OA13270A (en) 2003-10-17 2007-01-31 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists.
TW200524577A (en) 2003-11-04 2005-08-01 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists
WO2005095407A1 (en) 2004-03-17 2005-10-13 Glaxo Group Limited M3 muscarinic acetylcholine receptor antagonists
TWI363759B (en) 2004-04-27 2012-05-11 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists
WO2005112644A2 (en) 2004-05-13 2005-12-01 Glaxo Group Limited Muscarinic acetylcholine receptor antagonists
JP2008520579A (en) 2004-11-15 2008-06-19 グラクソ グループ リミテッド Novel M3 muscarinic acetylcholine receptor antagonist
US7767691B2 (en) 2005-08-18 2010-08-03 Glaxo Group Limited Muscarinic acetylcholine receptor antagonists containing an azoniabiocyclo[2.2.1] heptane ring system
UY31635A1 (en) 2008-02-06 2009-08-31 DUE PHARMACOPHORS-MUSCARINIC ANTAGONISTS OF PDE4
UY31637A1 (en) 2008-02-06 2009-08-03 DUE PHARMACOPHORES-MUSCARINIC ANTAGONISTS OF PDE4
AR070563A1 (en) 2008-02-06 2010-04-21 Glaxo Group Ltd COMPOSITE OF A CONDENSED BICYCLE PIRAZOL-PIRIDIN-AMINA, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND ITS USE TO PREPARE A USEFUL MEDICATION FOR THE TREATMENT OF RESPIRATORY DISEASES.
EP3578169B1 (en) 2009-02-26 2024-06-26 Glaxo Group Limited Pharmaceutical formulations comprising 4-{(1 r)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol
GB0921075D0 (en) 2009-12-01 2010-01-13 Glaxo Group Ltd Novel combination of the therapeutic agents
KR20140147891A (en) 2012-04-13 2014-12-30 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 Aggregate particles
GB201222679D0 (en) * 2012-12-17 2013-01-30 Glaxo Group Ltd Pharmaceutical combination products

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2800478A (en) * 1955-07-01 1957-07-23 Smith Kline French Lab 3-substituted-8-alkylnortropanes and the acid and quaternary ammonium salts thereof
GB1273823A (en) * 1968-10-22 1972-05-10 Soc Ind Fab Antibiotiques Sifa New tropane derivatives their salts and process for preparation thereof
IL104068A (en) * 1991-12-12 1998-10-30 Glaxo Group Ltd Surfactant-free pharmaceutical aerosol formulation comprising 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoro-n- propane as propellant
US6624167B1 (en) * 2000-08-04 2003-09-23 Targacept, Inc. Pharmaceutical compositions and methods for use

Also Published As

Publication number Publication date
TW200633706A (en) 2006-10-01
UY29244A1 (en) 2006-05-31
WO2006062883A2 (en) 2006-06-15
WO2006062883A3 (en) 2007-03-29
AR054411A1 (en) 2007-06-27

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