PE20060870A1 - TOPICAL COMPOSITIONS OF VITRONECTIN RECEPTOR ANTAGONISTS - Google Patents

TOPICAL COMPOSITIONS OF VITRONECTIN RECEPTOR ANTAGONISTS

Info

Publication number
PE20060870A1
PE20060870A1 PE2006000024A PE2006000024A PE20060870A1 PE 20060870 A1 PE20060870 A1 PE 20060870A1 PE 2006000024 A PE2006000024 A PE 2006000024A PE 2006000024 A PE2006000024 A PE 2006000024A PE 20060870 A1 PE20060870 A1 PE 20060870A1
Authority
PE
Peru
Prior art keywords
vitronectin receptor
receptor antagonists
topical compositions
heteroaryl
alkyl
Prior art date
Application number
PE2006000024A
Other languages
Spanish (es)
Inventor
Simon M Blake
William Henry Miller
H Jeffrey Wilkens
Amyn Sayani
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PE20060870A1 publication Critical patent/PE20060870A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Birds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R ES H, ALQUILO C1-C6, HETEROARILO, ARILALQUILO C1-C6; R1 ES A-ALQUILO C0-C4, A-ALQUENILO C2-C4, A-OXOALQUENILO C3-C4, ENTRE OTROS; A ES H, CICLCOALQUILO C3-C6, HETEROARILO, ARILO; R2 ES DE PREFERENCIA 2-PROPILAMINOPIRIDINA, 7-ETIL-1,2,3,4-TETRAHIDRO-1,8-NAFTIRIDINA. SE REFIERE TAMBIEN A FORMULACIONES FARMACEUTICAS DE ADMINISTRACION TOPICA TALES COMO CREMAS, POMADAS. DICHOS COMPUESTOS SON AGONISTAS DEL RECEPTOR DE VITRONECTINA UTILES EN LA PREVENCION DE CICATRIZACION EXCESIVA DE LA PIELREFERS TO A COMPOUND OF FORMULA I, WHERE R IS H, C1-C6 ALKYL, HETEROARYL, C1-C6 ARYLALKYL; R1 IS A-C0-C4 ALKYL, A-C2-C4 ALKENYL, A-C3-C4 A-OXOALKENYL, AMONG OTHERS; A IS H, C3-C6 CYCLCOALKYL, HETEROARYL, ARYL; R2 IS PREFERRED 2-PROPYLAMINOPYRIDINE, 7-ETHYL-1,2,3,4-TETRAHYDRO-1,8-NAPHTHYRIDINE. IT ALSO REFERS TO TOPICAL PHARMACEUTICAL ADMINISTRATION FORMULATIONS SUCH AS CREAMS, OINTS. SUCH COMPOUNDS ARE USEFUL VITRONECTIN RECEPTOR AGONISTS IN THE PREVENTION OF EXCESSIVE SKIN HEALING

PE2006000024A 2004-12-21 2006-01-03 TOPICAL COMPOSITIONS OF VITRONECTIN RECEPTOR ANTAGONISTS PE20060870A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63782404P 2004-12-21 2004-12-21

Publications (1)

Publication Number Publication Date
PE20060870A1 true PE20060870A1 (en) 2006-08-16

Family

ID=36602271

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000024A PE20060870A1 (en) 2004-12-21 2006-01-03 TOPICAL COMPOSITIONS OF VITRONECTIN RECEPTOR ANTAGONISTS

Country Status (6)

Country Link
EP (1) EP1841406A4 (en)
JP (1) JP2008524334A (en)
AR (1) AR052823A1 (en)
PE (1) PE20060870A1 (en)
TW (1) TW200635902A (en)
WO (1) WO2006069079A2 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA60311C2 (en) * 1996-10-02 2003-10-15 Смітклайн Бічам Корпорейшн Vitronectin receptor antagonists
UA71586C2 (en) * 1998-12-04 2004-12-15 Smithkline Beecham Corp A vitronectin receptor antagonist
WO2000046215A1 (en) * 1999-02-03 2000-08-10 Merck & Co., Inc. Benzazepine derivatives as alpha-v integrin receptor antagonists
EP1385504B1 (en) * 2001-04-10 2008-12-17 SmithKline Beecham Corporation Method of inhibiting adhesion formation

Also Published As

Publication number Publication date
AR052823A1 (en) 2007-04-04
WO2006069079A2 (en) 2006-06-29
EP1841406A2 (en) 2007-10-10
JP2008524334A (en) 2008-07-10
EP1841406A4 (en) 2008-06-25
TW200635902A (en) 2006-10-16
WO2006069079A3 (en) 2007-04-19

Similar Documents

Publication Publication Date Title
CL2012000925A1 (en) Compounds derived from tetrahydrocyclohepta [b] pyridinyl, antagonist of the cgrp receptor; pharmaceutical composition comprising it; and its use in the treatment of migraine, headache, diabetes, cancer, among others.
CL2008001667A1 (en) Compounds derived from 5- (1,2,4-oxadiazol-5-yl) -2,3-dihydro-isoindol-1-one, modulator of the metabotropic glutamate receptor mglur2; pharmaceutical composition; and its use in the treatment of neurological and psychiatric disorders such as cerebral ischemia, trauma to the spinal cord, pain, depression, and sleep disorders.
SV2001000020A (en) DERIVATIVES OF QUINOLINE-2-ONE SUBSTITUTED FOR HETEROARYL USEFUL AS ANTI-CANCER AGENT REF.PC10198 / 82888 / BB
CR9098A (en) 3-PHENYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEIVER USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
AR078507A1 (en) LIPID COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, USES AND PREPARATION METHOD
AR065622A1 (en) DERIVATIVES OF 3-CIANO -4- (4-PHENYL- PIPERIDIN -1- IL) PIRIDIN -2- ONA
ATE411296T1 (en) IMIDAZOLINE DERIVATIVES WITH CB1 ANTAGONISTIC EFFECT
AR054786A1 (en) (6-FLUOR-BENZOL (1,3) DIOXOLIL) -MORFOLIN-4-IL-METANOMAS, CB1 RECEIVER MODULATORS
AR050952A1 (en) INDAZOLONA DERIVATIVES; PROCESSES FOR OBTAINING; PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE IN THE MANUFACTURE OF MEDICINES FOR THE TREATMENT OF DISEASES MEDIATED BY THE INHIBITION OF ENZYME 11BETA - HSD1.
UY32978A (en) CHROMENONE DERIVATIVES
CL2009000127A1 (en) [Indole, azaindole] -2-carboxamide derivative compounds substituted with a silanyl group; preparation procedure; intermediate compounds; pharmaceutical composition; and its use in the treatment of pain, inflammation, metabolic disorders, among other diseases mediated by modulation of the trpv1 receptor.
MX2010007023A (en) C20-c21 substituted glucocorticoid receptor agonists.
UY31885A (en) DERIVED FROM THE 1, 3, 5-TRIAZINA-2, 4-DIAMINAS-6-SUBSTITUTED-N-SUBSTITUTED AND PHARMACEUTICALLY ACCEPTABLE SALTS OF THE SAME, COMPOSITIONS AND APPLICATIONS.
MX2011010311A (en) Pharmaceutical formulations comprising nitrocatechol derivatives and methods of making the same.
MX340360B (en) Pharmaceutical formulations comprising nitrocatechol derivatives and methods of making thereof.
PE20090890A1 (en) COMPOUNDS DERIVED FROM 1- (2,3-DIHIDROBENZO [1,4] DIOXIN-2-ILMETIL) AZACICLOS AS ANTAGONISTS OF SUPTIPO ADRENORECEPTOR ALFA2C
GEP20135744B (en) Quinuclidine carbonate derivatives and medicinal compositions containing the same
AR050914A1 (en) PEPTIDIC VASOPRESINE RECEPTOR AGONIST
ATE530187T1 (en) PHARMACEUTICAL PREPARATIONS CONTAINING NK1 RECEPTOR ANTAGONISTS AND SODIUM CHANNEL BLOCKERS
AR054508A1 (en) BENCILPIPERAZINE COMPOSITE, ITS USE TO PREPARE A MEDICINAL PRODUCT, PROCEDURES FOR THE PREPARATION OF SUCH COMPOUND AND INTERMEDIATE COMPOUNDS, SUCH INTERMEDIARY COMPOUNDS, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND PROCEDURE TO PREPARE IT
AR079957A1 (en) DERIVATIVES OF FATTY ACIDS OF SALICILATOS PHARMACEUTICAL COMPOSITIONS AND USE OF THE SAME
CY1113759T1 (en) HIGHLY DISTRIBUTED DOPAMINE COMPETITORS 2
AR074353A1 (en) NAFTALEN-2-IL-ACETIC ACIDS SUBSTITUTED, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND USE OF THE SAME IN THE TREATMENT OF ALLERGIC DISEASES, SUCH AS RHINITIS, ASTHMA AND ATOPIC DERMATITITIS.
UY32055A (en) Substituted derivatives of 5-Halo-N2- [substituted] (1-methyl-1H-imidazol-4-yl) pyrimidin-2, -diamine and its pharmaceutically acceptable salts, preparation processes, compositions and applications.
PE20150629A1 (en) ETHINYL DERIVATIVES AS MODULATORS OF MGLUR5 RECEPTOR ACTIVITY

Legal Events

Date Code Title Description
FA Abandonment or withdrawal