UY32055A - Substituted derivatives of 5-Halo-N2- [substituted] (1-methyl-1H-imidazol-4-yl) pyrimidin-2, -diamine and its pharmaceutically acceptable salts, preparation processes, compositions and applications. - Google Patents

Substituted derivatives of 5-Halo-N2- [substituted] (1-methyl-1H-imidazol-4-yl) pyrimidin-2, -diamine and its pharmaceutically acceptable salts, preparation processes, compositions and applications.

Info

Publication number
UY32055A
UY32055A UY0001032055A UY32055A UY32055A UY 32055 A UY32055 A UY 32055A UY 0001032055 A UY0001032055 A UY 0001032055A UY 32055 A UY32055 A UY 32055A UY 32055 A UY32055 A UY 32055A
Authority
UY
Uruguay
Prior art keywords
substituted
imidazol
pyrimidin
halo
diamine
Prior art date
Application number
UY0001032055A
Other languages
Spanish (es)
Inventor
Almeida Lynsie
Claudio Edmundo Chuaqui
Peng Bo
Guan Amy
Ioannidis Stephanos
Lamb Michelle
Su Qibin
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of UY32055A publication Critical patent/UY32055A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a compuestos de Fórmula (I): y a sus sales, composiciones farmacéuticas, métodos de uso, y métodos para su preparación. Estos compuestos proporcionan tratamiento para los trastornos mieloproliferativos y el cáncer.The present invention relates to compounds of Formula (I): and their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds provide treatment for myeloproliferative disorders and cancer.

UY0001032055A 2008-08-19 2009-08-18 Substituted derivatives of 5-Halo-N2- [substituted] (1-methyl-1H-imidazol-4-yl) pyrimidin-2, -diamine and its pharmaceutically acceptable salts, preparation processes, compositions and applications. UY32055A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9012208P 2008-08-19 2008-08-19

Publications (1)

Publication Number Publication Date
UY32055A true UY32055A (en) 2010-03-26

Family

ID=41226923

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001032055A UY32055A (en) 2008-08-19 2009-08-18 Substituted derivatives of 5-Halo-N2- [substituted] (1-methyl-1H-imidazol-4-yl) pyrimidin-2, -diamine and its pharmaceutically acceptable salts, preparation processes, compositions and applications.

Country Status (4)

Country Link
AR (1) AR073047A1 (en)
TW (1) TW201011017A (en)
UY (1) UY32055A (en)
WO (1) WO2010020810A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2554544A1 (en) * 2011-08-01 2013-02-06 Almirall, S.A. Pyridin-2(1h)-one derivatives as jak inhibitors
US20160123982A1 (en) 2013-02-04 2016-05-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for assaying jak2 activity in red blood cells and uses thereof
EP3359154B1 (en) * 2015-10-08 2021-05-26 Suzhou Yunxuan Yiyao Keji Youxian Gongsi Wnt signaling pathway inhibitors and therapeutic applications thereof
PE20190971A1 (en) 2016-06-13 2019-07-09 Glaxosmithkline Ip Dev Ltd CHEMICAL COMPOUNDS
KR20190026902A (en) 2016-07-14 2019-03-13 화이자 인코포레이티드 Novel pyrimidinecarboxamide as an inhibitor of vanin-1 enzyme
WO2018167283A1 (en) 2017-03-17 2018-09-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma associated neural remodeling
WO2018189335A1 (en) 2017-04-13 2018-10-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma
WO2020092015A1 (en) 2018-11-02 2020-05-07 University Of Rochester Therapeutic mitigation of epithelial infection
CN112094227B (en) * 2020-05-29 2021-04-16 凯美克(上海)医药科技有限公司 Synthesis method of 1- (5-chloro-3-fluoropyridin-2-yl) ethylamine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2375735T3 (en) * 2005-02-04 2012-03-05 Astrazeneca Ab USEFUL PIRAZOLILAMINOPIRIDINE DERIVATIVES AS QUINASE INHIBITORS.
WO2007031745A1 (en) * 2005-09-16 2007-03-22 Astrazeneca Ab Pyrimidine derivatives for the inhibition of igf-ir tyrosine kinase activity
EP2388259A1 (en) * 2005-10-28 2011-11-23 AstraZeneca AB 4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer
WO2008117050A1 (en) * 2007-03-27 2008-10-02 Astrazeneca Ab Pyrazolyl-amino-substituted pyrazines and their use for the treatment of cancer

Also Published As

Publication number Publication date
TW201011017A (en) 2010-03-16
AR073047A1 (en) 2010-10-06
WO2010020810A1 (en) 2010-02-25

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Effective date: 20130124