PE20041058A1 - DERIVATIVES OF PHENYLALANINE AS INHIBITORS OF DIPEPTIDYLPEPTIDASE - Google Patents
DERIVATIVES OF PHENYLALANINE AS INHIBITORS OF DIPEPTIDYLPEPTIDASEInfo
- Publication number
- PE20041058A1 PE20041058A1 PE2004000012A PE2004000012A PE20041058A1 PE 20041058 A1 PE20041058 A1 PE 20041058A1 PE 2004000012 A PE2004000012 A PE 2004000012A PE 2004000012 A PE2004000012 A PE 2004000012A PE 20041058 A1 PE20041058 A1 PE 20041058A1
- Authority
- PE
- Peru
- Prior art keywords
- oxobutanil
- amino
- dipeptidylpeptidase
- inhibitors
- fluoropyrrolidine
- Prior art date
Links
Abstract
SE REFIERE A DERIVADOS DE FENILALANINA DE FORMULA I DONDE X ES CH2, S, CHF, CHF2; R2 ES METILO, ETILO, CH2-CICLOPROPILO, COOH, CONH2, ENTRE OTROS; R4 ES 4-FLUOROFENILO, 2,4-DIFLUOROFENILO, 3,4-DIFLUOROFENILO, 2-FLUOROFENILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (3S)-1-[(2S,3S)-2-AMINO-3-(4'-FLUORO-1,1-BIFENIL-4-IL)-1-OXOBUTANIL]-3-FLUOROPIRROLIDINA SAL DEL ACIDO TRIFLUOROACETICO, (3S)-1-[(2S,3S)-2-AMINO-3-[4-(6-OXO-1.6-DIHIDROPIRIDIN-3-IL)-1-OXOBUTANIL]-3-FLUOROPIRROLIDINA CLORHIDRATO, (3S)-1-[(2S,3S)-2-AMINO-3-[4-(1-METIL-6-OXO-1.6-DIHIDROPIRIDIN-3-IL)FENIL]-1-OXOBUTANIL]-3-FLUOROPIRROLIDINA, SAL DEL ACIDO TRIFLUOROACETICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE LA DIPEPTIDILPEPTIDASA Y SON UTILES PARA EL TRATAMIENTO DE DIABETESREFERS TO PHENYLALANINE DERIVATIVES OF FORMULA I WHERE X IS CH2, S, CHF, CHF2; R2 IS METHYL, ETHYL, CH2-CYCLOPROPYL, COOH, CONH2, AMONG OTHERS; R4 IS 4-FLUOROPHENYL, 2,4-DIFLUOROPHENYL, 3,4-DIFLUOROPHENYL, 2-FLUOROPHENYL, AMONG OTHERS. PREFERRED COMPOUNDS ARE: (3S) -1 - [(2S, 3S) -2-AMINO-3- (4'-FLUORO-1,1-BIPHENYL-4-IL) -1-OXOBUTANIL] -3-FLUOROPYRROLIDINE SALT TRIFLUOROACETIC ACID, (3S) -1 - [(2S, 3S) -2-AMINO-3- [4- (6-OXO-1,6-DIHYDROPYRIDIN-3-IL) -1-OXOBUTANIL] -3-FLUOROPYRROLIDINE HYDROCHLORIDE, ( 3S) -1 - [(2S, 3S) -2-AMINO-3- [4- (1-METHYL-6-OXO-1,6-DIHYDROPYRIDIN-3-IL) PHENYL] -1-OXOBUTANIL] -3-FLUOROPYRROLIDINE, SALT OF TRIFLUOROACETIC ACID, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. THE MENTIONED COMPOUNDS ARE INHIBITORS OF DIPEPTIDYLPEPTIDASE AND ARE USEFUL FOR THE TREATMENT OF DIABETES
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50123203P | 2003-06-19 | 2003-06-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20041058A1 true PE20041058A1 (en) | 2005-02-07 |
Family
ID=40261513
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2004000012A PE20041058A1 (en) | 2003-06-19 | 2004-01-05 | DERIVATIVES OF PHENYLALANINE AS INHIBITORS OF DIPEPTIDYLPEPTIDASE |
Country Status (4)
Country | Link |
---|---|
AR (1) | AR042654A1 (en) |
CL (1) | CL2003002751A1 (en) |
PE (1) | PE20041058A1 (en) |
TW (1) | TW200500338A (en) |
-
2003
- 2003-12-22 AR ARP030104780 patent/AR042654A1/en not_active Application Discontinuation
- 2003-12-24 TW TW092136707A patent/TW200500338A/en unknown
- 2003-12-24 CL CL2003002751A patent/CL2003002751A1/en unknown
-
2004
- 2004-01-05 PE PE2004000012A patent/PE20041058A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TW200500338A (en) | 2005-01-01 |
CL2003002751A1 (en) | 2005-04-08 |
AR042654A1 (en) | 2005-06-29 |
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