PE20041058A1 - DERIVATIVES OF PHENYLALANINE AS INHIBITORS OF DIPEPTIDYLPEPTIDASE - Google Patents

DERIVATIVES OF PHENYLALANINE AS INHIBITORS OF DIPEPTIDYLPEPTIDASE

Info

Publication number
PE20041058A1
PE20041058A1 PE2004000012A PE2004000012A PE20041058A1 PE 20041058 A1 PE20041058 A1 PE 20041058A1 PE 2004000012 A PE2004000012 A PE 2004000012A PE 2004000012 A PE2004000012 A PE 2004000012A PE 20041058 A1 PE20041058 A1 PE 20041058A1
Authority
PE
Peru
Prior art keywords
oxobutanil
amino
dipeptidylpeptidase
inhibitors
fluoropyrrolidine
Prior art date
Application number
PE2004000012A
Other languages
Spanish (es)
Inventor
Jinyou Xu
Vincent J Colandrea
Robert J Mathvink
Ann E Weber
Anthony Mastracchio
Scott D Edmonson
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of PE20041058A1 publication Critical patent/PE20041058A1/en

Links

Abstract

SE REFIERE A DERIVADOS DE FENILALANINA DE FORMULA I DONDE X ES CH2, S, CHF, CHF2; R2 ES METILO, ETILO, CH2-CICLOPROPILO, COOH, CONH2, ENTRE OTROS; R4 ES 4-FLUOROFENILO, 2,4-DIFLUOROFENILO, 3,4-DIFLUOROFENILO, 2-FLUOROFENILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (3S)-1-[(2S,3S)-2-AMINO-3-(4'-FLUORO-1,1-BIFENIL-4-IL)-1-OXOBUTANIL]-3-FLUOROPIRROLIDINA SAL DEL ACIDO TRIFLUOROACETICO, (3S)-1-[(2S,3S)-2-AMINO-3-[4-(6-OXO-1.6-DIHIDROPIRIDIN-3-IL)-1-OXOBUTANIL]-3-FLUOROPIRROLIDINA CLORHIDRATO, (3S)-1-[(2S,3S)-2-AMINO-3-[4-(1-METIL-6-OXO-1.6-DIHIDROPIRIDIN-3-IL)FENIL]-1-OXOBUTANIL]-3-FLUOROPIRROLIDINA, SAL DEL ACIDO TRIFLUOROACETICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE LA DIPEPTIDILPEPTIDASA Y SON UTILES PARA EL TRATAMIENTO DE DIABETESREFERS TO PHENYLALANINE DERIVATIVES OF FORMULA I WHERE X IS CH2, S, CHF, CHF2; R2 IS METHYL, ETHYL, CH2-CYCLOPROPYL, COOH, CONH2, AMONG OTHERS; R4 IS 4-FLUOROPHENYL, 2,4-DIFLUOROPHENYL, 3,4-DIFLUOROPHENYL, 2-FLUOROPHENYL, AMONG OTHERS. PREFERRED COMPOUNDS ARE: (3S) -1 - [(2S, 3S) -2-AMINO-3- (4'-FLUORO-1,1-BIPHENYL-4-IL) -1-OXOBUTANIL] -3-FLUOROPYRROLIDINE SALT TRIFLUOROACETIC ACID, (3S) -1 - [(2S, 3S) -2-AMINO-3- [4- (6-OXO-1,6-DIHYDROPYRIDIN-3-IL) -1-OXOBUTANIL] -3-FLUOROPYRROLIDINE HYDROCHLORIDE, ( 3S) -1 - [(2S, 3S) -2-AMINO-3- [4- (1-METHYL-6-OXO-1,6-DIHYDROPYRIDIN-3-IL) PHENYL] -1-OXOBUTANIL] -3-FLUOROPYRROLIDINE, SALT OF TRIFLUOROACETIC ACID, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. THE MENTIONED COMPOUNDS ARE INHIBITORS OF DIPEPTIDYLPEPTIDASE AND ARE USEFUL FOR THE TREATMENT OF DIABETES

PE2004000012A 2003-06-19 2004-01-05 DERIVATIVES OF PHENYLALANINE AS INHIBITORS OF DIPEPTIDYLPEPTIDASE PE20041058A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50123203P 2003-06-19 2003-06-19

Publications (1)

Publication Number Publication Date
PE20041058A1 true PE20041058A1 (en) 2005-02-07

Family

ID=40261513

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004000012A PE20041058A1 (en) 2003-06-19 2004-01-05 DERIVATIVES OF PHENYLALANINE AS INHIBITORS OF DIPEPTIDYLPEPTIDASE

Country Status (4)

Country Link
AR (1) AR042654A1 (en)
CL (1) CL2003002751A1 (en)
PE (1) PE20041058A1 (en)
TW (1) TW200500338A (en)

Also Published As

Publication number Publication date
TW200500338A (en) 2005-01-01
CL2003002751A1 (en) 2005-04-08
AR042654A1 (en) 2005-06-29

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