PE20040774A1 - COMBINACION DE UN INHIBIDOR DEL FACTOR Xa Y CLOPIDOGREL - Google Patents

COMBINACION DE UN INHIBIDOR DEL FACTOR Xa Y CLOPIDOGREL

Info

Publication number
PE20040774A1
PE20040774A1 PE2003000998A PE2003000998A PE20040774A1 PE 20040774 A1 PE20040774 A1 PE 20040774A1 PE 2003000998 A PE2003000998 A PE 2003000998A PE 2003000998 A PE2003000998 A PE 2003000998A PE 20040774 A1 PE20040774 A1 PE 20040774A1
Authority
PE
Peru
Prior art keywords
combination
trombolytic
clopidogrel
agents
trombine
Prior art date
Application number
PE2003000998A
Other languages
English (en)
Inventor
Pancras Wong
Robert Knabb
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20040774A1 publication Critical patent/PE20040774A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A UNA COMBINACION DE UNA SAL DEL ACIDO 1-(3'-AMINOBENCISOXAZOL-5'-IL)-3-TRIFLUOROMETIL-5-[[4-[(2'-DIMETILAMINOMETIL)IMIDAZOL-1'-IL]-2-FLUOROFENIL]AMINOCARBONIL]PIRAZOL-CLORHIDRICO (COMPUESTO A) O EN FORMA DE SAL Y b) UN SEGUNDO AGENTE TERAPEUTICO SELECCIONADO DE CLOPIDOGREL. SE REFIERE TAMBIEN A UN METODO DONDE AL MENOS UNO DE LOS DOS COMPONENTES ES ADMINISTRADO EN UNA DOSIFICACION SUB-TERAPEUTICA SIMULTANEAMENTE O CONSECUTIVAMENTE. LA COMBINACION PUEDE CONTENER UN TERCER AGENTE TERAPEUTICO SELECCIONADO DE AGENTES ANTICOAGULANTES, AGENTES INHIBIDORES DE LAS PLAQUETAS, INHIBIDORES DE TROMBINA, AGENTES TROMBOLITICOS, FIBRINOLITICOS SELECCIONADOS DE ASPIRINA, PRAVASTATINA ENTRE OTROS Y SON UTILES PARA EL TRATAMIENTO DE TRASTORNOS TROMBOEMBOLICOS
PE2003000998A 2002-10-02 2003-10-02 COMBINACION DE UN INHIBIDOR DEL FACTOR Xa Y CLOPIDOGREL PE20040774A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41537202P 2002-10-02 2002-10-02

Publications (1)

Publication Number Publication Date
PE20040774A1 true PE20040774A1 (es) 2004-11-06

Family

ID=32069844

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000998A PE20040774A1 (es) 2002-10-02 2003-10-02 COMBINACION DE UN INHIBIDOR DEL FACTOR Xa Y CLOPIDOGREL

Country Status (6)

Country Link
US (2) US20040067995A1 (es)
AR (1) AR041455A1 (es)
AU (1) AU2003270861A1 (es)
PE (1) PE20040774A1 (es)
TW (1) TW200500064A (es)
WO (1) WO2004031143A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2301562B1 (en) * 1994-12-12 2013-04-17 Omeros Corporation Irrigation solution and method for inhibition of pain, inflammation and spasm
SE9904377D0 (sv) * 1999-12-01 1999-12-01 Astra Pharma Prod Pharmaceutical combinations
GB0306615D0 (en) * 2003-03-22 2003-04-30 Astrazeneca Ab New use
WO2006044548A2 (en) * 2004-10-14 2006-04-27 Dr. Reddy's Laboratories Ltd. Clopidogrel compositions
US9532945B2 (en) * 2006-04-04 2017-01-03 Kg Acquisition Llc Oral dosage forms including an antiplatelet agent and an enterically coated acid inhibitor
KR20150105419A (ko) * 2006-04-04 2015-09-16 케이지 액퀴지션 엘엘씨 항혈소판제와 산 억제제를 포함하는 경구 투여 형태
DE102006051625A1 (de) 2006-11-02 2008-05-08 Bayer Materialscience Ag Kombinationstherapie substituierter Oxazolidinone
EP2591783A1 (en) * 2007-04-13 2013-05-15 Millennium Pharmaceuticals, Inc. Combination anticoagulant therapy with a compound that acts as a factor Xa inhibitor
CA2685331C (en) 2007-04-27 2016-07-05 Cydex Pharmaceuticals, Inc. Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use
KR20110115578A (ko) 2008-12-30 2011-10-21 트롬보로직 에이피에스 장기 부전이 발달할 증가된 위험이 있는 중증 질환 환자의 확인 방법 및 이의 치료를 위한 화합물
KR20190071006A (ko) 2009-05-13 2019-06-21 사이덱스 파마슈티칼스, 인크. 프라수그렐 및 사이클로덱스트린 유도체를 포함하는 약학 조성물 및 그의 제조 및 사용 방법
KR101935147B1 (ko) 2017-04-28 2019-01-04 가톨릭대학교 산학협력단 프라바스타틴(pravastatin) 및 항혈소판제를 유효성분으로 함유하는 신장 질환 예방 또는 치료용 조성물
KR20200024413A (ko) * 2018-08-28 2020-03-09 에이치케이이노엔 주식회사 항혈소판제와 산 분비 억제제를 포함하는 약학 조성물
US11654036B2 (en) 2020-05-26 2023-05-23 Elixir Medical Corporation Anticoagulant compounds and methods and devices for their use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2530247B1 (fr) * 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
US5576328A (en) * 1994-01-31 1996-11-19 Elf Sanofi Method for the secondary prevention of ischemic events
FR2744918B1 (fr) * 1996-02-19 1998-05-07 Sanofi Sa Nouvelles associations de principes actifs contenant un derive de thieno(3,2-c)pyridine et un antithrombotique
FR2764511B1 (fr) 1997-06-13 2000-09-08 Sanofi Sa Compositions pour le traitement et la prevention de la thrombose arterielle et utilisation d'un inhibiteur du facteur xa seul et/ou en combinaison avec un antiagregant plaquettaire
ZA985247B (en) * 1997-06-19 1999-12-17 Du Pont Merck Pharma Guanidine mimics as factor Xa inhibitors.
US6339099B1 (en) * 1997-06-20 2002-01-15 Dupont Pharmaceuticals Company Guanidine mimics as factor Xa inhibitors
FR2779726B1 (fr) * 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
US6541639B2 (en) * 2000-07-26 2003-04-01 Bristol-Myers Squibb Pharma Company Efficient ligand-mediated Ullmann coupling of anilines and azoles
MXPA03002493A (es) * 2000-09-22 2004-09-10 Bristol Myers Squibb Pharma Co Proceso eficiente para preparacion de un inhibidor del factor xa.
TW200303309A (en) * 2001-12-04 2003-09-01 Bristol Myers Squibb Co Novel n-[4-(1h-imidazol-1-yl)-2-fluorophenyl]-3-trifluoromethyl)-1h-pyrazole-5-carboxamides as factor Xa inhibitors

Also Published As

Publication number Publication date
AU2003270861A8 (en) 2004-04-23
TW200500064A (en) 2005-01-01
AR041455A1 (es) 2005-05-18
AU2003270861A1 (en) 2004-04-23
US7018990B2 (en) 2006-03-28
WO2004031143A2 (en) 2004-04-15
US20040067995A1 (en) 2004-04-08
WO2004031143A3 (en) 2004-05-27
US20050043382A1 (en) 2005-02-24

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