PE20030947A1 - USE OF LTB4 ANTAGONISTS IN VETERINARY MEDICINE - Google Patents

USE OF LTB4 ANTAGONISTS IN VETERINARY MEDICINE

Info

Publication number
PE20030947A1
PE20030947A1 PE2003000289A PE2003000289A PE20030947A1 PE 20030947 A1 PE20030947 A1 PE 20030947A1 PE 2003000289 A PE2003000289 A PE 2003000289A PE 2003000289 A PE2003000289 A PE 2003000289A PE 20030947 A1 PE20030947 A1 PE 20030947A1
Authority
PE
Peru
Prior art keywords
alkyl
aryl
phenyl
alcoxy
heteroaryl
Prior art date
Application number
PE2003000289A
Other languages
Spanish (es)
Inventor
Franz Birke
Kandace Matzek
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of PE20030947A1 publication Critical patent/PE20030947A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

COMPOSICION QUE CONTIENE AL MENOS UN ANTAGONISTA DE LTB4 DE FORMULA (I), DONDE A ES -O-CmH2m-O-(PHE)n-, DONDE m ES DE 2 A 6, n ES DE 0 o 1, PHE ES 1,4-FENILENO SUSTITUIDO EVENTUALMENTE CON UNO O DOS GRUPOS ALQUILO C1-C6; R1 ES H, OH, CN, COR10, COOR10CHO; R2 ES H, Br, Cl, F, CF3, CHF2, OH, HSO3-O-, ALQUILO(C1-C6), ALCOXI (C1-C6), CICLOALQUILO(C5-C7), CONR8R9, ARILO, O-ARILO, CH2-ARILO, CR5R6-ARILO o C(CH3)2-R7; R3 ES H O ALQUILO(C1-C6); R5 ES ALQUILO(C1-C4), CF3, CH2OH, COOH o COO-(ALQUILO(C1-C4)); R6 ES H, ALQUILO(C1-C4) o CF3; R7 ES CH2OH, COOH, COO(ALQUILO(C1-C4), CONR8R9 o CH2NR8R9; R8 ES H, ALQUILO (C1-C6), FENILO, FENIL-ALQUILO (C1-C6), COR10, COOR10, CHO, CONH2, CONHR10, SO2-ALQUILO (C1-C6), SO2-FENILO, PUDIENDO ESTAR SUSTITUIDO EL GRUPO FENILO, UNA O DOS VECES CON CL, F, CF3, ALQUILO (C1-C4), OH Y/o ALCOXI C1-C4; R9 ES H o ALQUILO C1-C6; o R8 Y R9 AMBOS SON UN GRUPO ALQUILENO C4-C6; R10 ES ALQUILO C1-C6, CICLOALQUILO C5-C7, ARILO, HETEROARILO, ARALQUILO O HETEROARIL-ALQUILO (C1-C6), DONDE LOS GRUPOS ARILO DE LOS RADICALES R2 A R10 SON FENILO O NAFTILO, LOS GRUPOS HETEROARILO SON PIRROL, PIRAZOL, IMIDAZOL, FURANILO, TIENILO, PIRIDINA O PIRIMIDINA, Y PUEDEN ESTAR SUSTITUIDOS EN CADA CASO, UNA O VARIAS VECES, CON Cl, F, CF3, ALQUILO(C1-C4), OH, HSO3-O- o ALCOXI C1-C4; ASI COMO SALES POR ADICION DE ACIDOS, GLUCOSIDOS Y O-SULFATOS, ASI COMO AL MENOS UN BETA-MIMETICO O UN ESTEROIDE. DE APLICACION EN EL TRATAMIENTO DE ENFERMEDADES RESPIRATORIAS EN ANIMALESCOMPOSITION CONTAINING AT LEAST ONE LTB4 ANTAGONIST OF FORMULA (I), WHERE A IS -O-CmH2m-O- (PHE) n-, WHERE m IS FROM 2 TO 6, n IS FROM 0 or 1, PHE IS 1, 4-PHENYLENE EVENTUALLY REPLACED WITH ONE OR TWO C1-C6 ALKYL GROUPS; R1 IS H, OH, CN, COR10, COOR10CHO; R2 IS H, Br, Cl, F, CF3, CHF2, OH, HSO3-O-, ALKYL (C1-C6), ALCOXY (C1-C6), CYCLOALKYL (C5-C7), CONR8R9, ARYL, O-ARYL, CH2-ARYL, CR5R6-ARYL or C (CH3) 2-R7; R3 IS H O ALKYL (C1-C6); R5 IS (C1-C4) ALKYL, CF3, CH2OH, COOH or COO- ((C1-C4) ALKYL); R6 IS H, (C1-C4) ALKYL or CF3; R7 IS CH2OH, COOH, COO (ALKYL (C1-C4), CONR8R9 or CH2NR8R9; R8 IS H, ALKYL (C1-C6), PHENYL, PHENYL-ALKYL (C1-C6), COR10, COOR10, CHO, CONH2, CONHR10 , SO2-ALKYL (C1-C6), SO2-PHENYL, THE PHENYL GROUP MAY BE SUBSTITUTED ONE OR TWICE WITH CL, F, CF3, ALKYL (C1-C4), OH AND / or C1-C4 ALCOXY; R9 IS H or C1-C6 ALKYL; or R8 AND R9 BOTH ARE A C4-C6 ALKYLENE GROUP; R10 IS C1-C6 ALKYL, C5-C7 CYCLOALKYL, ARYL, HETEROARYL, ARALKYL OR HETEROARYL-ALKYL (C1-C6), WHERE ARYL OF RADICALS R2 TO R10 ARE PHENYL OR NAPHTHYL, THE HETEROARYL GROUPS ARE PIRROL, PIRAZOL, IMIDAZOL, FURANIL, THENYL, PYRIDINE OR PYRIMIDINE, AND THEY MAY BE SUBSTITUTED IN EACH CASE, ONE OR SEVERAL TIMES, Cl3, Cl ALKYL (C1-C4), OH, HSO3-O- or ALCOXY C1-C4; AS WELL AS SALTS BY ADDITION OF ACIDS, GLUCOSIDES AND O-SULPHATES, AS WELL AS AT LEAST ONE BETA-MIMETIC OR A STEROID.APPLICATION IN THE TREATMENT OF RESPIRATORY DISEASES IN ANIMALS

PE2003000289A 2002-03-26 2003-03-24 USE OF LTB4 ANTAGONISTS IN VETERINARY MEDICINE PE20030947A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10213350A DE10213350A1 (en) 2002-03-26 2002-03-26 Use of LTB¶4¶ antagonists in veterinary medicine

Publications (1)

Publication Number Publication Date
PE20030947A1 true PE20030947A1 (en) 2004-01-13

Family

ID=28050833

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000289A PE20030947A1 (en) 2002-03-26 2003-03-24 USE OF LTB4 ANTAGONISTS IN VETERINARY MEDICINE

Country Status (10)

Country Link
EP (1) EP1490042A2 (en)
JP (1) JP2005529085A (en)
AR (1) AR039141A1 (en)
AU (1) AU2003212375A1 (en)
CA (1) CA2480032A1 (en)
DE (1) DE10213350A1 (en)
PE (1) PE20030947A1 (en)
TW (1) TW200407109A (en)
UY (1) UY27731A1 (en)
WO (1) WO2003080037A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018207950A1 (en) 2017-05-12 2018-11-15 横山　茂之 Class a gpcr-binding compound modifier

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5246965A (en) * 1991-06-11 1993-09-21 Ciba-Geigy Arylethers, their manufacture and methods of treatment
ATE163914T1 (en) * 1991-11-25 1998-03-15 Lilly Co Eli SUBSTITUTED PHENYLPHENOL LEUKOTRIEN ANTAGONISTS
DE19636689A1 (en) * 1996-09-10 1998-03-12 Boehringer Ingelheim Kg New benzamidine derivatives
US6291531B1 (en) * 1999-10-07 2001-09-18 Boehringer Ingelheim Pharma Kg LTB4 antagonist, processes for the preparation thereof and its use as a pharmaceutical composition

Also Published As

Publication number Publication date
AU2003212375A1 (en) 2003-10-08
WO2003080037A3 (en) 2004-06-10
AR039141A1 (en) 2005-02-09
DE10213350A1 (en) 2003-10-16
CA2480032A1 (en) 2003-10-02
WO2003080037A2 (en) 2003-10-02
TW200407109A (en) 2004-05-16
EP1490042A2 (en) 2004-12-29
UY27731A1 (en) 2003-10-31
JP2005529085A (en) 2005-09-29

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