PE20030933A1 - CINAMIC ACID SALTS, PROCEDURES FOR THEIR PREPARATION AND USE AS MEDICINES - Google Patents

CINAMIC ACID SALTS, PROCEDURES FOR THEIR PREPARATION AND USE AS MEDICINES

Info

Publication number
PE20030933A1
PE20030933A1 PE2003000197A PE2003000197A PE20030933A1 PE 20030933 A1 PE20030933 A1 PE 20030933A1 PE 2003000197 A PE2003000197 A PE 2003000197A PE 2003000197 A PE2003000197 A PE 2003000197A PE 20030933 A1 PE20030933 A1 PE 20030933A1
Authority
PE
Peru
Prior art keywords
benzenodimethanol
phenylbutoxy
hexyl
hydroxy
methyl
Prior art date
Application number
PE2003000197A
Other languages
Spanish (es)
Inventor
Rainer Soyka
Gunter Linz
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2002109243 external-priority patent/DE10209243A1/en
Priority claimed from DE2002116124 external-priority patent/DE10216124A1/en
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of PE20030933A1 publication Critical patent/PE20030933A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A SALES DEL ACIDO CINAMICO DEL SALMETEROL DE FORMULA I; CARACTERIZADA POR EL ALTO GRADO DE COMPATIBILIDAD LOCAL, DONDE R1 Y R2 SON H, ALQUILO, ALCOXI, HALOGENO, CF3, FENILO; SI R1 Y R2 ESTAN CONTIGUOS SON -CH=CH-CH=CH-; R3 ES H, ALQUILO, ALCOXI, HALOGENO, CF3. SON COMPUESTOS PREFERIDOS SAL 4-HIDROXI-O1-[[[6-(4-FENILBUTOXI)-HEXIL]-AMINO]-METIL]-1,3-BENCENODIMETANOL-4-FENILCINAMATO; SAL 4-HIDROXI-O1-[[[6-(4-FENILBUTOXI)-HEXIL]-AMINO]-METIL]-1,3-BENCENODIMETANOL-4-TRIFLUOROMETIL-CINAMATO; SAL 4-HIDROXI-O1-[[[6-(4-FENILBUTOXI)-HEXIL]-AMINO]-METIL]-1,3-BENCENODIMETANOL-4-BENCENODIEMTANOL-3,4-DICLORO-CINAMATO; ENTRE OTROS; EL COMPUESTO TIENE ACTIVIDAD BETAMINERGICA Y PUEDE SER UTIL PARA EL TRATAMIENTO DE ASMA, COPDREFERS TO SALTS OF FORMULA I SALMETEROL CINAMIC ACID; CHARACTERIZED BY THE HIGH DEGREE OF LOCAL COMPATIBILITY, WHERE R1 AND R2 ARE H, ALKYL, ALCOXY, HALOGEN, CF3, PHENYL; IF R1 AND R2 ARE CONTIGUOUS, THEY ARE -CH = CH-CH = CH-; R3 IS H, ALKYL, ALCOXY, HALOGEN, CF3. PREFERRED COMPOUNDS ARE SALT 4-HYDROXY-O1 - [[[6- (4-PHENYLBUTOXY) -HEXYL] -AMINO] -MEthyl] -1,3-BENZENODIMETHANOL-4-PHENYLZINAMATE; 4-HYDROXY-O1 SALT - [[[6- (4-PHENYLBUTOXY) -HEXYL] -AMINE] -MEthyl] -1,3-BENZENODIMETHANOL-4-TRIFLUOROMETHYL-CINAMATE; 4-HYDROXY-O1 SALT - [[[6- (4-PHENYLBUTOXY) -HEXYL] -AMINE] -MEthyl] -1,3-BENZENODIMETHANOL-4-BENZENODIEMTHANOL-3,4-DICHLORO-CINAMATE; AMONG OTHERS; THE COMPOUND HAS BETAMINERGIC ACTIVITY AND MAY BE USEFUL FOR THE TREATMENT OF ASTHMA, COPD

PE2003000197A 2002-03-04 2003-02-28 CINAMIC ACID SALTS, PROCEDURES FOR THEIR PREPARATION AND USE AS MEDICINES PE20030933A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2002109243 DE10209243A1 (en) 2002-03-04 2002-03-04 Synergistic, well tolerated medicament combination of tiotropium salt and sparingly water-soluble salmeterol salt, useful for treating asthma or chronic obstructive pulmonary disease
DE2002116124 DE10216124A1 (en) 2002-04-12 2002-04-12 New cinnamic acid salts of salmeterol useful for the treatment of e.g. chronic obstructive pulmonary disease

Publications (1)

Publication Number Publication Date
PE20030933A1 true PE20030933A1 (en) 2003-12-15

Family

ID=27789722

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000197A PE20030933A1 (en) 2002-03-04 2003-02-28 CINAMIC ACID SALTS, PROCEDURES FOR THEIR PREPARATION AND USE AS MEDICINES

Country Status (9)

Country Link
EP (1) EP1483231A1 (en)
JP (1) JP2005519110A (en)
AR (1) AR038622A1 (en)
AU (1) AU2003221482A1 (en)
CA (1) CA2477714C (en)
PE (1) PE20030933A1 (en)
TW (1) TW200404759A (en)
UY (1) UY27686A1 (en)
WO (1) WO2003074469A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2265276B1 (en) * 2005-05-20 2008-02-01 Laboratorios Almirall S.A. DERIVATIVES OF 4- (2-AMINO-1-HYDROXYETHYL) Phenol as agonists of the BETA2 ADRENERGIC RECEIVER.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8310477D0 (en) * 1983-04-18 1983-05-25 Glaxo Group Ltd Chemical compounds
ZW6584A1 (en) * 1983-04-18 1985-04-17 Glaxo Group Ltd Phenethanolamine derivatives
US4791108A (en) * 1987-04-13 1988-12-13 Syntex (U.S.A.) Inc. Sulfonyl-decahydro-8H-isoquino[2,1-G][1,6]-naphthyridines and related compounds useful as α2 -blockers
IL95590A (en) * 1989-09-08 1996-06-18 Glaxo Group Ltd Pharmaceutical compositions comprising salmeterol and fluticasone propionate
RU2081108C1 (en) * 1991-10-16 1997-06-10 Циба-Гейги АГ Additive salts of acids with the base and pharmaceutical composition showing antitumor activity

Also Published As

Publication number Publication date
EP1483231A1 (en) 2004-12-08
JP2005519110A (en) 2005-06-30
TW200404759A (en) 2004-04-01
AU2003221482A1 (en) 2003-09-16
AR038622A1 (en) 2005-01-19
WO2003074469A1 (en) 2003-09-12
CA2477714C (en) 2011-01-25
CA2477714A1 (en) 2003-09-12
UY27686A1 (en) 2003-10-31

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal