PE20030758A1 - 1,3-DIARYLPROP-2-EN-1-ONAS, COMPOSITIONS CONTAINING THEM AND THEIR USE - Google Patents

1,3-DIARYLPROP-2-EN-1-ONAS, COMPOSITIONS CONTAINING THEM AND THEIR USE

Info

Publication number
PE20030758A1
PE20030758A1 PE2002001118A PE2002001118A PE20030758A1 PE 20030758 A1 PE20030758 A1 PE 20030758A1 PE 2002001118 A PE2002001118 A PE 2002001118A PE 2002001118 A PE2002001118 A PE 2002001118A PE 20030758 A1 PE20030758 A1 PE 20030758A1
Authority
PE
Peru
Prior art keywords
phenyl
propenone
amino
trimetoxifenil
trimetoxy
Prior art date
Application number
PE2002001118A
Other languages
Spanish (es)
Inventor
Patrick Mailliet
Thomas Caulfield
Marie-Christine Bissery
Cecile Combeau
Marie-Pierre Cherrier
Gilles Tiraboschi
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0115739A external-priority patent/FR2833008B1/en
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of PE20030758A1 publication Critical patent/PE20030758A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/30—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to nitro or nitroso groups
    • C07C279/32—N-nitroguanidines
    • C07C279/36—Substituted N-nitroguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Abstract

SE REFIERE A DERIVADOS DE 1,3-DIARILPROP-2-EN-1-ONAS DE FORMULA I DONDE Y ES HALOGENO, ALQUILO, CICLOALQUILO, NH2, CONH2, ENTRE OTROS; Ar2 ES EL GRUPO FORMADO POR LA REACCION DE UN GRUPO ARILO CON SUSTITUYENTES R1 Y R2 DONDE R1 Y R2 SON NH2, NH2.HZ, NCH(O)-ACIDO AMINADO, ENTRE OTROS; HZ ES UN ACIDO ORGANICO O MINERAL; X ES O, NOH, NO(R3) DONDE R3 ES H, ALQUILO, CICLOALQUILO, ENTRE OTROS; Ar SE SELECCIONA DE 2,5-DIMETOXIFENILO, 2,3,4-TRIMETOXIFENILO, 3,4,5-TRIMETOXIFENILO, 2,3,5-TRIMETOXIFENILO, ENTRE OTROS; Y ES Cl, Br, CH3, CH2CH3, ENTRE OTROS. SON COMPUESTOS PREFERIDOS E-3-(3-AMINO-4-METOXI-FENIL)-2-METIL-1-(3,4,5-TRIMETOXI-FENIL)-PROPENONA, E-3-(4-AMINO-3-METOXI-FENIL)-2-METIL-1-(3,4,5-TRIMETOXI-FENIL)-PROPENONA, CLORHIDRATO DE E-3-(3-AMINO-4-METOXI-FENIL)-2-METIL-1-(2,5-DIMETOXI-FENIL)-PROPENONA, E-3-(3-AMINO-4-METOXI-FENIL)-2-BROMO-1-(3,4,5-TRIMETOXI-FENIL)-PROPENONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS INHIBEN LA POLIMERIZACION DE LA TUBULINA Y SON UTILES PARA EL TRATAMIENTO DE NECROSIS TUMORALREFERS TO DERIVATIVES OF 1,3-DIARYLPROP-2-IN-1-ONAS OF FORMULA I WHERE AND IS HALOGEN, ALKYL, CYCLOALKYL, NH2, CONH2, AMONG OTHERS; Ar2 IS THE GROUP FORMED BY THE REACTION OF AN ARYL GROUP WITH SUBSTITUENTS R1 AND R2 WHERE R1 AND R2 ARE NH2, NH2.HZ, NCH (O) -AMINATED ACID, AMONG OTHERS; HZ IS AN ORGANIC OR MINERAL ACID; X IS O, NOH, NO (R3) WHERE R3 IS H, ALKYL, CYCLOALKYL, AMONG OTHERS; Ar IS SELECTED FROM 2,5-DIMETOXYPHENYL, 2,3,4-TRIMETOXIFENIL, 3,4,5-TRIMETOXIFENIL, 2,3,5-TRIMETOXIFENIL, AMONG OTHERS; Y IS Cl, Br, CH3, CH2CH3, AMONG OTHERS. PREFERRED COMPOUNDS ARE E-3- (3-AMINO-4-METOXY-PHENYL) -2-METHYL-1- (3,4,5-TRIMETOXY-PHENYL) -PROPENONE, E-3- (4-AMINO-3- METHOXY-PHENYL) -2-METHYL-1- (3,4,5-TRIMETOXY-PHENYL) -PROPENONE, E-3- (3-AMINO-4-METOXY-PHENYL) -2-METHYL-1- ( 2,5-DIMETOXY-PHENYL) -PROPENONE, E-3- (3-AMINO-4-METOXY-PHENYL) -2-BROMO-1- (3,4,5-TRIMETOXY-PHENYL) -PROPENONE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. THE MENTIONED COMPOUNDS INHIBIT THE POLYMERIZATION OF TUBULIN AND ARE USEFUL FOR THE TREATMENT OF TUMOR NECROSIS

PE2002001118A 2001-12-05 2002-11-21 1,3-DIARYLPROP-2-EN-1-ONAS, COMPOSITIONS CONTAINING THEM AND THEIR USE PE20030758A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0115739A FR2833008B1 (en) 2001-12-05 2001-12-05 1,3-DIARYLPROP-2-IN-1-ONES, COMPOSITIONS CONTAINING THEM, AND USE
FR0214217 2002-11-14

Publications (1)

Publication Number Publication Date
PE20030758A1 true PE20030758A1 (en) 2003-10-07

Family

ID=26213287

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002001118A PE20030758A1 (en) 2001-12-05 2002-11-21 1,3-DIARYLPROP-2-EN-1-ONAS, COMPOSITIONS CONTAINING THEM AND THEIR USE

Country Status (23)

Country Link
EP (1) EP1453790A2 (en)
JP (1) JP2005531494A (en)
KR (1) KR20050044712A (en)
CN (1) CN1612856A (en)
AR (1) AR037479A1 (en)
AU (1) AU2002365644A1 (en)
BR (1) BR0214694A (en)
CA (1) CA2469193A1 (en)
CO (1) CO5580759A2 (en)
EA (1) EA006803B1 (en)
HR (1) HRP20040508A2 (en)
HU (1) HUP0500100A2 (en)
IL (1) IL162223A0 (en)
MA (1) MA27351A1 (en)
MX (1) MXPA04005226A (en)
NZ (1) NZ533224A (en)
PA (1) PA8558501A1 (en)
PE (1) PE20030758A1 (en)
PL (1) PL370676A1 (en)
RS (1) RS47804A (en)
SV (1) SV2003001422A (en)
TW (1) TW200300685A (en)
WO (1) WO2003048106A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2854399B1 (en) * 2003-04-30 2006-11-17 Aventis Pharma Sa 1-ARYL-3- (INDOL-5-YL) -PROP-2-EN-1-ONES, COMPOSITIONS CONTAINING SAME AND USE THEREOF
EP1598353A1 (en) * 2004-05-17 2005-11-23 Boehringer Ingelheim International GmbH Pyrrolobenzimidazolones and their use as antiproliferative agents
WO2017103637A1 (en) 2015-12-18 2017-06-22 Blirt S.A. Diphenylpropane compounds and their cytotoxic activity
CN109467549B (en) * 2018-12-07 2021-02-09 中国药科大学 Quinoline-substituted chalcone compound, preparation method and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4904697A (en) * 1987-04-09 1990-02-27 Merrell Dow Pharmaceuticals Inc. Controlling the growth of certain tumor tissue with chalcone derivatives
JPH08277242A (en) * 1995-02-08 1996-10-22 Kyowa Hakko Kogyo Co Ltd Propenone derivative
ATE259353T1 (en) * 1995-12-01 2004-02-15 Kyowa Hakko Kogyo Kk PROPENONE DERIVATIVES
WO1999000114A2 (en) * 1997-06-26 1999-01-07 Statens Serum Institut Biologically active 1,3-bis-aromatic-prop-2-en-1-ones, 1,3-bis-aromatic-propan-1-ones, and 1,3-bis-aromatic-prop-2-yn-1-ones

Also Published As

Publication number Publication date
EA006803B1 (en) 2006-04-28
AU2002365644A1 (en) 2003-06-17
HRP20040508A2 (en) 2005-08-31
HUP0500100A2 (en) 2005-05-30
EA200400764A1 (en) 2004-12-30
CA2469193A1 (en) 2003-06-12
IL162223A0 (en) 2005-11-20
PA8558501A1 (en) 2003-09-05
CO5580759A2 (en) 2005-11-30
NZ533224A (en) 2006-03-31
WO2003048106A3 (en) 2004-03-25
WO2003048106A2 (en) 2003-06-12
RS47804A (en) 2006-12-15
AR037479A1 (en) 2004-11-10
MXPA04005226A (en) 2004-10-11
MA27351A1 (en) 2005-06-01
CN1612856A (en) 2005-05-04
JP2005531494A (en) 2005-10-20
SV2003001422A (en) 2003-07-10
KR20050044712A (en) 2005-05-12
BR0214694A (en) 2004-12-14
TW200300685A (en) 2003-06-16
EP1453790A2 (en) 2004-09-08
PL370676A1 (en) 2005-05-30

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