PE20020576A1 - DRUG COMPOSITIONS BASED ON ANTICHOLINERGIC AND CORTICOSTEROID AGENTS - Google Patents

DRUG COMPOSITIONS BASED ON ANTICHOLINERGIC AND CORTICOSTEROID AGENTS

Info

Publication number
PE20020576A1
PE20020576A1 PE2001001073A PE2001001073A PE20020576A1 PE 20020576 A1 PE20020576 A1 PE 20020576A1 PE 2001001073 A PE2001001073 A PE 2001001073A PE 2001001073 A PE2001001073 A PE 2001001073A PE 20020576 A1 PE20020576 A1 PE 20020576A1
Authority
PE
Peru
Prior art keywords
agents
holyphole
hiphole
sulphonate
vitamin
Prior art date
Application number
PE2001001073A
Other languages
Spanish (es)
Inventor
Michel Pairet
Michael P Pieper
Christopher John Montague Meade
Richard Reichl
Christel Schmelzer
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10062712A external-priority patent/DE10062712A1/en
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of PE20020576A1 publication Critical patent/PE20020576A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

SE REFIERE A UN MEDICAMENTO QUE COMPRENDE 1)AGENTES ANTICOLINERGICOS COMO TIOTROPIO, OXITROPIO, IPRATROPIO SUS SALES COMO CLORURO, BROMURO, YODURO, METANO-SULFONATO, SULFATO, PARATOLUENO-SULFONATO; 2)ESTEROIDES COMO FLUNISOLIDA, BECLOMETASONA, TRIAMCINOLONA, BUDESONIDA, FLUTICASONA, MOMETASONA, CICLESONIDA, ROFLEPONIDA, DEXAMETASONA; SIENDO LA RELACION DE 1 Y 2 DE1:300 A 50:1; UTILIZANDOSE DE 0,01µg A 10000µg; SIENDO LA FORMA DE PRESENTACION a)POLVOS PARA INHALACION QUE ADEMAS CONTIENE MEZCLAS CON SUSTANCIAS AUXILIARES FISIOLOGICAMENTE INOCUAS COMO MONOSACARIDOS, DISACARIDOS, OLIGO O POLISACARIDOS, POLIALCOHOLES CARACTERIZADA POR SU TAMANO DE PARTICULAS DE HASTA 250µm, b)AEROSOLES DOSIFICABLES CON UN CONTENIDO DE GAS PROPULSOR (n-PROPANO, n-BUTANO, ISOBUTANO, ENTRE OTROS) QUE CONTIENE LAS SUSTANCIAS ACTIVAS EN FORMA DISUELTA O DISPERSA Y c)SOLUCIONES O SUSPENSIONES PARA INHALACION EXENTAS DE GAS PROPULSOR QUE CONTIENE COMO DISOLVENTE AGUA, ETANOL; CODISOLVENTES COMO ALCOHOL ISOPROPILICO, GLICOLES, POLIOXIETILEN ALCOHOLES; AGENTE FORMADOR DE COMPLEJO COMO ACIDO ETIDINICO; AGENTES ANTIOXIDANTES COMO ACIDO ASCORBICO, VITAMINA A, VITAMINA E, TOCOFEROLES; AGENTES DE CONSERVACION COMO CETIL PIRIDINIO, CLORURO DE BENZALCONIO CON UN pH DE 2-7 QUE SE AJUSTA ADICIONANDO ACIDO. LA COMPOSICION PUEDE SER UTIL PARA EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS U OBSTRUCTIVAS DE LAS VIAS RESPIRATORIASIT REFERS TO A MEDICINAL PRODUCT THAT INCLUDES 1) ANTICHOLINERGIC AGENTS SUCH AS THYOTROPE, OXITROPE, IPRATROPE, ITS SALTS SUCH AS CHLORIDE, BROMIDE, IODIDE, METHANE-SULPHONATE, SULPHATE, PARATOLUENE-SULPHONATE; 2) STEROIDS LIKE FLUNISOLIDE, BECLOMETASONE, TRIAMCINOLONE, BUDESONIDE, FLUTICASONE, MOMETASONE, CYCLESONIDE, ROFLEPONIDE, DEXAMETASONE; BEING THE RATIO OF 1 AND 2 FROM 1: 300 TO 50: 1; USING FROM 0.01µg TO 10000µg; BEING THE FORM OF PRESENTATION a) INHALATION POWDERS THAT ALSO CONTAIN MIXTURES WITH PHYSIOLOGICALLY HARMFUL AUXILIARY SUBSTANCES SUCH AS MONOSACCHARIDS, DISACCHARIDES, OLIGO OR POLYSACCHARIDES, POLYALCOHOLS CHARACTERIZED BY ITS SIZE OF PARTICULAR HOLYPHOLE HOLYPHOLE GULF 250 µS, CONTAINED BY ITS SIZE OF HIPHOLE HIPHOLE GOLM. n-PROPANE, n-BUTANE, ISOBUTANE, AMONG OTHERS) CONTAINING THE ACTIVE SUBSTANCES IN DISSOLVED OR DISPERSED FORM AND c) SOLUTIONS OR SUSPENSIONS FOR INHALATION FREE FROM PROPULSOR GAS CONTAINING ETHANOL AS A SOLVENT WATER; CODISOLVENTS SUCH AS ISOPROPYL ALCOHOL, GLYCOLS, POLYOXYETHYLENE ALCOHOLS; COMPLEX FORMING AGENT LIKE ETIDINIC ACID; ANTIOXIDANT AGENTS LIKE ASCORBIC ACID, VITAMIN A, VITAMIN E, TOCOPHEROLS; PRESERVATION AGENTS SUCH AS CETIL PYRIDINIUM, BENZALCONIUM CHLORIDE WITH A pH OF 2-7 THAT IS ADJUSTED BY ADDING ACID. THE COMPOSITION MAY BE USEFUL FOR THE TREATMENT OF INFLAMMATORY OR OBSTRUCTIVE DISEASES OF THE RESPIRATORY TRACT

PE2001001073A 2000-10-31 2001-10-29 DRUG COMPOSITIONS BASED ON ANTICHOLINERGIC AND CORTICOSTEROID AGENTS PE20020576A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10054042 2000-10-31
DE10062712A DE10062712A1 (en) 2000-12-15 2000-12-15 New drug compositions based on anticholinergics and corticosteroids

Publications (1)

Publication Number Publication Date
PE20020576A1 true PE20020576A1 (en) 2002-08-09

Family

ID=26007540

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001001073A PE20020576A1 (en) 2000-10-31 2001-10-29 DRUG COMPOSITIONS BASED ON ANTICHOLINERGIC AND CORTICOSTEROID AGENTS

Country Status (8)

Country Link
EP (1) EP1333830A2 (en)
JP (1) JP2004512359A (en)
AU (1) AU2002210575A1 (en)
CA (2) CA2733294C (en)
MX (1) MXPA03003751A (en)
PE (1) PE20020576A1 (en)
UY (1) UY26992A1 (en)
WO (1) WO2002036106A2 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2165768B1 (en) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa NEW DERIVATIVES OF QUINUCLIDINE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
US7214687B2 (en) 1999-07-14 2007-05-08 Almirall Ag Quinuclidine derivatives and medicinal compositions containing the same
US7311894B2 (en) 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
DE10214263A1 (en) * 2002-03-28 2003-10-16 Boehringer Ingelheim Pharma HFA suspension formulations containing an anticholinergic
US7244415B2 (en) 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
US7084153B2 (en) 2002-04-12 2006-08-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising steroids and a novel anticholinergic
DE10216429A1 (en) * 2002-04-12 2003-10-23 Boehringer Ingelheim Pharma Synergistic medicaments for treating inflammatory or obstructive respiratory tract diseases, containing quaternized scopine ester anticholinergic agent and steroid, e.g. budesonide
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
US20040102469A1 (en) * 2002-09-13 2004-05-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for reducing the mortality rate
ES2257152B1 (en) 2004-05-31 2007-07-01 Laboratorios Almirall S.A. COMBINATIONS THAT INCLUDE ANTIMUSCARINIC AGENTS AND BETA-ADRENERGIC AGONISTS.
PL1891974T3 (en) 2004-05-31 2010-12-31 Almirall Sa Combinations comprising antimuscarinic agents and PDE4 inhibitors
CA2568834A1 (en) * 2004-06-29 2006-01-12 Boehringer Ingelheim International Gmbh Medicaments for inhalation comprising steroids and an anticholinergic
GB0523653D0 (en) * 2005-11-21 2005-12-28 Novartis Ag Organic compounds
ES2298049B1 (en) 2006-07-21 2009-10-20 Laboratorios Almirall S.A. PROCEDURE FOR MANUFACTURING BROMIDE OF 3 (R) - (2-HIDROXI-2,2-DITIEN-2-ILACETOXI) -1- (3-PHENOXIPROPIL) -1-AZONIABICICLO (2.2.2) OCTANO.
EP2124915A2 (en) 2007-02-19 2009-12-02 Cipla Limited Pharmaceutical combinations of at least two bronchodilators or of a bronchodilator with a corticosteroid
EP2100598A1 (en) * 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
TR200909793A2 (en) * 2009-12-25 2011-07-21 Bi̇lgi̇ç Mahmut Combination of dry powder containing a combination of tiotropium, mometasone and a chromoglycic acid derivative.
TR200909789A2 (en) * 2009-12-25 2011-07-21 Bi̇lgi̇ç Mahmut Dry powder combination containing tiotropium, budesonide and a chromoglycic acid derivative combination
US8834931B2 (en) 2009-12-25 2014-09-16 Mahmut Bilgic Dry powder formulation containing tiotropium for inhalation
TR200909792A2 (en) * 2009-12-25 2011-07-21 Bi̇lgi̇ç Mahmut Dry powder combination containing tiotropium, corticosteroid and a combination of chromoglycic acid derivative
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
MX2023001201A (en) 2020-07-31 2023-05-03 Chemo Res S L Combination therapy for inhalation administration.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0504112A3 (en) * 1991-03-14 1993-04-21 Ciba-Geigy Ag Pharmaceutical aerosol formulations
DE19835346A1 (en) * 1998-08-05 2000-02-10 Boehringer Ingelheim Pharma Two-part capsule for pharmaceutical preparations for powder inhalers
GB0009606D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Therapeutic combinations
GB0009592D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Respiratory combinations
GB0009605D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Medicaments

Also Published As

Publication number Publication date
EP1333830A2 (en) 2003-08-13
CA2436540C (en) 2008-01-29
MXPA03003751A (en) 2004-10-15
WO2002036106A2 (en) 2002-05-10
AU2002210575A1 (en) 2002-05-15
WO2002036106A3 (en) 2002-09-19
CA2733294A1 (en) 2002-05-10
JP2004512359A (en) 2004-04-22
UY26992A1 (en) 2002-06-20
CA2733294C (en) 2011-12-20
CA2436540A1 (en) 2002-05-10

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