PE20020065A1 - DERIVATIVES OF 2-AMINOCARBONYL-9H-PURINE - Google Patents
DERIVATIVES OF 2-AMINOCARBONYL-9H-PURINEInfo
- Publication number
- PE20020065A1 PE20020065A1 PE2001000520A PE2001000520A PE20020065A1 PE 20020065 A1 PE20020065 A1 PE 20020065A1 PE 2001000520 A PE2001000520 A PE 2001000520A PE 2001000520 A PE2001000520 A PE 2001000520A PE 20020065 A1 PE20020065 A1 PE 20020065A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- amino
- carbonyl
- purine
- ilo
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A DERIVADOS DE 2-AMINOCARBONIL-9H-PURINA DE FORMULA I DONDE R1 ES H, ALQUILO C1-C6, FLUORENILO, SUSTITUIDO cON FENILO, NAFTILO, ENTRE OTROS; R2 ES H, ALQUILO C1-C6; R15 ES H, ALQUILO C1-C6; X ES i) ALQUILENO C2-C3 NO RAMIFICADO SUSTITUIDO CON ALQUILO C1-C6, CICLOALQUILO C3-C8, ii) UN GRUPO DE FORMULA -(CH2)n-W-(CH2)p DONDE W ES CICLOALQUILENO C5-C7 CON ALQUILO C1-C6; n Y p SON 0-1; R3 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C8, BENCILO; R4 ES AZETIDIN-3-ILO, PIRROLIDIN-3-ILO,PIPERIDIN 3-ILO, ENTRE OTROS; R3 Y R4 JUNTO A N FORMAN AZETIDINILO, PIRROLIDINILO, PIPERIDINILO, PIPERAZINILO, HOMOPIPERIDINILO, ENTRE OTROS; R5 ES CH2OH, CONR14R14; R6 Y R7 SON H, ALQUILO C1-C6 O JUNTO A N FORMAN AZETIDINILO, PIRROLIDINILO, ENTRE OTROS; R14 ES H, ALQUILO C1-C6; Y ES CO, CS, SO2, C=N(CN). SON COMPUESTOS PREFERIDOS 6-[(2,2-DIFENILETIL)AMINO]-9-{(2R,3R,4S,5S)-5-[(ETILAMINO)CARBONIL]-3,4-DIHIDROXITETRAHIDRO-2-FURANIL}-N-{2-[({[1-(2-PIRIDINIL)-4-PIPERIDINIL]AMINO}CARBONIL)AMINO]-ETIL}-9H-PURINA-2-CARBOXAMIDA, 4-[({[(2-{[(6-[(2,2-DIFENILETIL)AMINO]-9-{(2R,3R,4S,5S)-5-[(ETILAMINO)CARBONIL]-3,4-DIHIDRO-2-FURANIL}-9H-PURIN-2-IL)CARBONIL]AMINO}ETIL}AMINO]-CARBONIL}-AMINO)METIL]BENZOICO. SE REFIERE TAMBIEN A UN COMPOSICION FARMACEUTICA. LOS DERIVADOS DE 2-AMINOCARBONIL-9H-PURINA SON AGONISTAS DEL RECEPTOR A2a Y ACTUAN COMO AGENTES ANTIINFLAMATORIOREFERS TO 2-AMINOCARBONYL-9H-PURINE DERIVATIVES OF FORMULA I WHERE R1 IS H, C1-C6 ALKYL, FLUORENIL, SUBSTITUTED WITH PHENYL, NAPHTHYLL, AMONG OTHERS; R2 IS H, C1-C6 ALKYL; R15 IS H, C1-C6 ALKYL; X IS i) NON-BRANCHED C2-C3 ALKYLENE SUBSTITUTED WITH C1-C6 ALKYL, C3-C8 CYCLOALKYL, ii) A GROUP OF FORMULA - (CH2) nW- (CH2) p WHERE W IS C5-C7 CYCLOALKYLENE WITH C1-C6 ALKYL ; n and p ARE 0-1; R3 IS H, C1-C6 ALKYL, C3-C8 CYCLOALkyl, BENZYL; R4 IS AZETIDIN-3-ILO, PIRROLIDIN-3-ILO, PIPERIDIN 3-ILO, AMONG OTHERS; R3 AND R4 TOGETHER WITH N FORM AZETIDINYL, PYRROLIDINYL, PIPERIDINYL, PIPERAZINYL, HOMOPIPERIDINYL, AMONG OTHERS; R5 IS CH2OH, CONR14R14; R6 AND R7 ARE H, C1-C6 ALKYL OR TOGETHER WITH N FORMING AZETHYDINYL, PYRROLIDINYL, AMONG OTHERS; R14 IS H, C1-C6 ALKYL; Y IS CO, CS, SO2, C = N (CN). PREFERRED COMPOUNDS ARE 6 - [(2,2-DIPHENYLETHYL) AMINO] -9 - {(2R, 3R, 4S, 5S) -5 - [(ETHYLAMINE) CARBONYL] -3,4-DIHYDROXITETRAHYDRO-2-FURANIL} -N - {2 - [({[1- (2-PYRIDINYL) -4-PIPERIDINYL] AMINO} CARBONYL) AMINO] -ETHYL} -9H-PURINE-2-CARBOXAMIDE, 4 - [({[(2 - {[( 6 - [(2,2-DIPHENYLETHYL) AMINO] -9 - {(2R, 3R, 4S, 5S) -5 - [(ETHYLAMINE) CARBONYL] -3,4-DIHYDRO-2-FURANIL} -9H-PURIN- 2-IL) CARBONYL] AMINO} ETHYL} AMINO] -CARBONYL} -AMINE) METHYL] BENZOIC. ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. DERIVATIVES OF 2-AMINO CARBONYL-9H-PURINE ARE A2a RECEPTOR AGONISTS AND ACT AS ANTI-INFLUENCE AGENTS
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0014048A GB0014048D0 (en) | 2000-06-06 | 2000-06-06 | Purine derivatives |
| GB0018246A GB0018246D0 (en) | 2000-06-06 | 2000-07-25 | Purine derivatives |
| GB0024920A GB0024920D0 (en) | 2000-06-06 | 2000-10-11 | Purine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020065A1 true PE20020065A1 (en) | 2002-02-12 |
Family
ID=9893285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000520A PE20020065A1 (en) | 2000-06-06 | 2001-06-05 | DERIVATIVES OF 2-AMINOCARBONYL-9H-PURINE |
Country Status (15)
| Country | Link |
|---|---|
| CN (1) | CN100374454C (en) |
| AP (1) | AP2001002179A0 (en) |
| CR (1) | CR6829A (en) |
| DO (1) | DOP2001000182A (en) |
| EC (1) | ECSP024370A (en) |
| GB (2) | GB0014048D0 (en) |
| GE (1) | GEP20053513B (en) |
| GT (1) | GT200100105A (en) |
| IL (1) | IL152783A (en) |
| MY (1) | MY128457A (en) |
| PE (1) | PE20020065A1 (en) |
| SV (1) | SV2002000477A (en) |
| TN (1) | TNSN01083A1 (en) |
| YU (1) | YU82302A (en) |
| ZA (1) | ZA200209875B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105481861B (en) * | 2014-09-19 | 2018-04-17 | 北京普禄德医药科技有限公司 | A kind of platelet aggregation inhibitor and its preparation method and application |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1121372B1 (en) * | 1998-10-16 | 2006-06-28 | Pfizer Limited | Adenine derivatives |
-
2000
- 2000-06-06 GB GB0014048A patent/GB0014048D0/en not_active Ceased
- 2000-07-25 GB GB0018246A patent/GB0018246D0/en not_active Ceased
-
2001
- 2001-05-30 MY MYPI20012561 patent/MY128457A/en unknown
- 2001-05-31 AP APAP/P/2001/002179A patent/AP2001002179A0/en unknown
- 2001-06-01 DO DO2001000182A patent/DOP2001000182A/en unknown
- 2001-06-05 PE PE2001000520A patent/PE20020065A1/en not_active Application Discontinuation
- 2001-06-05 SV SV2001000477A patent/SV2002000477A/en not_active Application Discontinuation
- 2001-06-05 CN CNB2006100045883A patent/CN100374454C/en not_active Expired - Fee Related
- 2001-06-05 TN TNTNSN01083A patent/TNSN01083A1/en unknown
- 2001-06-05 YU YU82302A patent/YU82302A/en unknown
- 2001-06-05 GE GEAP2001004973 patent/GEP20053513B/en unknown
- 2001-06-05 GT GT200100105A patent/GT200100105A/en unknown
-
2002
- 2002-11-11 IL IL152783A patent/IL152783A/en not_active IP Right Cessation
- 2002-11-22 CR CR6829A patent/CR6829A/en not_active Application Discontinuation
- 2002-12-02 EC ECSP024370 patent/ECSP024370A/en unknown
- 2002-12-05 ZA ZA200209875A patent/ZA200209875B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN100374454C (en) | 2008-03-12 |
| DOP2001000182A (en) | 2002-08-30 |
| ECSP024370A (en) | 2003-03-10 |
| GB0014048D0 (en) | 2000-08-02 |
| IL152783A (en) | 2008-11-26 |
| CN1810822A (en) | 2006-08-02 |
| YU82302A (en) | 2005-11-28 |
| GEP20053513B (en) | 2005-05-10 |
| ZA200209875B (en) | 2003-12-05 |
| CR6829A (en) | 2004-03-11 |
| GT200100105A (en) | 2002-01-31 |
| MY128457A (en) | 2007-02-28 |
| AP2001002179A0 (en) | 2002-11-30 |
| SV2002000477A (en) | 2002-10-24 |
| GB0018246D0 (en) | 2000-09-13 |
| TNSN01083A1 (en) | 2005-11-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20030007A1 (en) | ALDOSA REDUCTASE INHIBITORS FROM THE PYRIDAZINONE GROUP | |
| PE20010039A1 (en) | CARBAMIC ACID ESTER DERIVATIVES AS AGONISTS AND / OR ANTAGONISTS OF THE METABOTROPIC GLUTAMATE RECEPTOR | |
| AR057107A2 (en) | USE OF USED PIPERAZINE DERIVED COMPOUNDS AS CCR5 ANTAGONISTS, FOR THE PREPARATION OF MEDICINES | |
| YU48854B (en) | Derivatives n-(4-piperidinyl) (dihydrobenzofurane or dihydro-2h-benzopyran)carboxamide or the procedure for obtaining thereof | |
| RU2009117701A (en) | PYRROLIDINE DERIVATIVES AS IAP INHIBITORS | |
| KR910006277A (en) | N-substituted-4-pyrimidineamines and pyrimidinediamines, methods for their preparation and their use as medicaments | |
| PE20000280A1 (en) | DERIVATIVES OF 2- (PURIN-9-IL) -TETRAHIDROFURAN-3,4-DIOL | |
| KR950321212A (en) | 4-amino-1-piperidylbenzoylguanidine | |
| PE20070189A1 (en) | AMINO-5-HETEROARYL COMPOUND (5 MEMBERS) IMIDAZOLONE AND ITS USE FOR ß-SECRETASE MODULATION | |
| PE20040647A1 (en) | TYROSINE KINE INHIBITORS | |
| KR920702223A (en) | 1-cycloalkylpiperidine as an antipsychotic | |
| RU2002121645A (en) | 2-AMINONICOTINAMIDE DERIVATIVES AND THEIR APPLICATION AS VEGF-TYROSINKINASE RECEPTOR INHIBITORS | |
| FR2662607B1 (en) | COMPOSITION FOR USE IN BRAKING HAIR LOSS AND INDUCING AND STIMULATING THEIR GROWTH, CONTAINING ALKYL-2 AMINO-4 (OR DIALKYL-2-4) PYRIMIDINE OXIDE-3 DERIVATIVES. | |
| PE20050018A1 (en) | HETEROAROMATIC PENTACYCLIC COMPOUND AS INHIBITOR OF PROTEIN TYROSINE PHOSPHATASE 1B (PTB1B) | |
| PE20040687A1 (en) | QUINOLINES SUBSTITUTED AS ANTAGONISTS OF THE CCR5 RECEPTOR | |
| HUP0102453A2 (en) | Adenosine derivatives, their use and pharmaceutical compositions containing the compounds | |
| OA09477A (en) | "Novel naphth-1-yl piperazine derivatives, their preparation process and pharmaceutical compositions which contain them". | |
| FR2677884B1 (en) | COMPOSITION FOR BRAKING HAIR LOSS BASED ON TRISUBSTITUTED N-OXIDE PYRIMIDINES OR THEIR SULFOCONJUGAL DERIVATIVES, NOVEL PYRIMIDINE N-OXIDE COMPOUNDS OR THEIR SULFOCONJUGAL DERIVATIVES. | |
| KR900003127A (en) | cardiac | |
| TR200000414T2 (en) | 2- (4-Aryl or heteroaryl-piperazin-1-ylmethyl) -1H-indole derivatives. | |
| KR920002588A (en) | Novel 3-arylindole and 3-aryridazole derivatives | |
| KR840006633A (en) | Method for preparing benzoxazolinone derivatives | |
| KR910004599A (en) | 1,3-dihydro-1- (pyridinylamino) -2H-indol-2-one, preparation method thereof and use thereof as a medicament | |
| JP2011510072A5 (en) | ||
| DE69828317D1 (en) | Process for the preparation of N - ((4-phenyl) methylphenyl) piperazines |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |