PE20011023A1 - SILILATED HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF DEPRESSION AND ATTENTION DEFICIENT HYPERACTIVITY DISORDERS - Google Patents
SILILATED HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF DEPRESSION AND ATTENTION DEFICIENT HYPERACTIVITY DISORDERSInfo
- Publication number
- PE20011023A1 PE20011023A1 PE2000001209A PE0012092000A PE20011023A1 PE 20011023 A1 PE20011023 A1 PE 20011023A1 PE 2000001209 A PE2000001209 A PE 2000001209A PE 0012092000 A PE0012092000 A PE 0012092000A PE 20011023 A1 PE20011023 A1 PE 20011023A1
- Authority
- PE
- Peru
- Prior art keywords
- depression
- treatment
- heterocyclic compounds
- compound
- sililated
- Prior art date
Links
- 208000020401 Depressive disease Diseases 0.000 title abstract 2
- 150000002391 heterocyclic compounds Chemical class 0.000 title abstract 2
- 230000002950 deficient Effects 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 208000013403 hyperactivity Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 102000040125 5-hydroxytryptamine receptor family Human genes 0.000 abstract 1
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 abstract 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical group ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical group [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- 239000011630 iodine Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000004031 partial agonist Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS HETEROCICLICOS SILILADOS, DONDE: X ES CH2, O; R1 ES H, ALQUILO C1-C4, ALQUENILO C3-C5, EL DOBLE ENLACE NO ES ADYACENTE AL N; R2 ES HIDROXILO, ALCOXILO C1-C4; R3, R4 Y R5 SON ALQUILO C1-C4. UN COMPUESTO PREFERIDO ES (-)-(4aR,10aR)-9-METOXI-N-METIL-1,2,3,4,4a,5-10,10a,-OCTAHIDRO-6-TRIMETILSILIL-BENZO[g]QUINOLINA. TAMBIEN SE REFIERE A UN PROCESO PARA LA PREPARACION QUE INCLUYE EL PASO DE SUSTITUIR EL HALOGENO EN UN COMPUESTO DE FORMULA II; R6 ES CLORO, BROMO, IODO; POR UN GRUPO TRIALQUILSILILO Y RECUPERAR EL COMPUESTO. EL COMPUESTO ES UN AGONISTA PARCIAL DEL ADRENORECEPTOR -1A Y AGONISTAS DEL RECEPTOR DE SEROTONINA Y PUEDE SER UTIL PARA EL TRATAMIENTO DE DEPRESION Y DESORDENES DE HIPERACTIVIDAD CON DEFICIT DE ATENCIONREFERS TO SILYLATED HETEROCYCLIC COMPOUNDS, WHERE: X IS CH2, O; R1 IS H, C1-C4 ALKYL, C3-C5 ALKYL, THE DOUBLE BONDING IS NOT ADJACENT TO N; R2 IS HYDROXYL, C1-C4 ALCOXYL; R3, R4 AND R5 ARE C1-C4 ALKYL. A PREFERRED COMPOUND IS (-) - (4aR, 10aR) -9-METHOXY-N-METHYL-1,2,3,4,4a, 5-10,10a, -OCTAHYDRO-6-TRIMETHYLSILYL-BENZO [g] QUINOLINE . IT ALSO REFERS TO A PROCESS FOR THE PREPARATION THAT INCLUDES THE STEP OF SUBSTITUTING THE HALOGEN IN A COMPOUND OF FORMULA II; R6 IS CHLORINE, BROMINE, IODINE; BY A TRIALKYLSILYL GROUP AND RECOVER THE COMPOUND. THE COMPOUND IS A PARTIAL AGONIST OF THE -1A ADRENORECEPTOR AND AGONISTS OF THE SEROTONIN RECEPTOR AND MAY BE USEFUL FOR THE TREATMENT OF DEPRESSION AND ATTENTION-DEFICIT HYPERACTIVITY DISORDERS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19954847 | 1999-11-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20011023A1 true PE20011023A1 (en) | 2001-09-27 |
Family
ID=7929072
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2000001209A PE20011023A1 (en) | 1999-11-15 | 2000-11-13 | SILILATED HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF DEPRESSION AND ATTENTION DEFICIENT HYPERACTIVITY DISORDERS |
Country Status (6)
Country | Link |
---|---|
AR (1) | AR026451A1 (en) |
AU (1) | AU2356301A (en) |
CO (1) | CO5261532A1 (en) |
EC (1) | ECSP003761A (en) |
PE (1) | PE20011023A1 (en) |
WO (1) | WO2001036428A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112019014981A2 (en) | 2017-11-24 | 2020-04-07 | H Lundbeck As | compound, pharmaceutically acceptable salt, use of them and pharmaceutical composition |
US11104697B2 (en) | 2019-05-20 | 2021-08-31 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
US11168056B2 (en) | 2019-05-20 | 2021-11-09 | H. Lundbeck A/S | Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol |
US11111263B2 (en) | 2019-05-20 | 2021-09-07 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
US11130775B2 (en) | 2019-05-20 | 2021-09-28 | H. Lundbeck A/S | Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2689892A1 (en) * | 1992-04-09 | 1993-10-15 | Rhone Poulenc Rorer Sa | New 4-substd. 1,4-di:phenyl-1-sila:cyclopentane derivs. - used as serotonin antagonists e.g. for treating anxiety, migraine, asthma or hypertension |
US6210705B1 (en) * | 1997-12-15 | 2001-04-03 | Noven Pharmaceuticals, Nc. | Compositions and methods for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate |
-
2000
- 2000-11-07 CO CO00084393A patent/CO5261532A1/en not_active Application Discontinuation
- 2000-11-10 EC EC2000003761A patent/ECSP003761A/en unknown
- 2000-11-13 AR ARP000105976A patent/AR026451A1/en unknown
- 2000-11-13 AU AU23563/01A patent/AU2356301A/en not_active Abandoned
- 2000-11-13 PE PE2000001209A patent/PE20011023A1/en not_active Application Discontinuation
- 2000-11-13 WO PCT/EP2000/011203 patent/WO2001036428A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
CO5261532A1 (en) | 2003-03-31 |
AR026451A1 (en) | 2003-02-12 |
ECSP003761A (en) | 2002-06-26 |
AU2356301A (en) | 2001-05-30 |
WO2001036428A1 (en) | 2001-05-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |