CO5261532A1 - SILILATED HETEROCICLIC COMPOUNDS, PROCEDURE FOR THE PREPARATION OF THESE AND PHARMACEUTICAL COMPOSITION CONTAINING THEM - Google Patents
SILILATED HETEROCICLIC COMPOUNDS, PROCEDURE FOR THE PREPARATION OF THESE AND PHARMACEUTICAL COMPOSITION CONTAINING THEMInfo
- Publication number
- CO5261532A1 CO5261532A1 CO00084393A CO00084393A CO5261532A1 CO 5261532 A1 CO5261532 A1 CO 5261532A1 CO 00084393 A CO00084393 A CO 00084393A CO 00084393 A CO00084393 A CO 00084393A CO 5261532 A1 CO5261532 A1 CO 5261532A1
- Authority
- CO
- Colombia
- Prior art keywords
- preparation
- pharmaceutical composition
- composition containing
- carbon atoms
- sililated
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se relaciona con un compuesto de la fórmula I:<EMI FILE="00084393_1" ID="1" IMF=JPEG >en donde X es CH2 u O, R1 es hidrógeno, alquilo (de 1 a 4 átomos de carbono), alquenilo (de 3 a 5 átomos de carbono) en donde el doble enlace no está adyacente al átomo de nitrógeno, o bencilo, R2 es hidroxilo o alcoxilo (de 1 a 4 átomos de carbono), y R3, R4, y R5, son independientemente alquilo (de 1 a 4 átomos de carbono), en forma de base libre o de sal de adición de ácido. Igualmente, se refiere al proceso para la preparación de dicho compuesto y a una composición farmacéutica que lo contiene.The present invention relates to a compound of the formula I: <EMI FILE = "00084393_1" ID = "1" MFI = JPEG> wherein X is CH2 or O, R1 is hydrogen, alkyl (from 1 to 4 carbon atoms ), alkenyl (3 to 5 carbon atoms) where the double bond is not adjacent to the nitrogen atom, or benzyl, R2 is hydroxyl or alkoxy (1 to 4 carbon atoms), and R3, R4, and R5 , are independently alkyl (from 1 to 4 carbon atoms), in the form of free base or acid addition salt. It also refers to the process for the preparation of said compound and a pharmaceutical composition containing it.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19954847 | 1999-11-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5261532A1 true CO5261532A1 (en) | 2003-03-31 |
Family
ID=7929072
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO00084393A CO5261532A1 (en) | 1999-11-15 | 2000-11-07 | SILILATED HETEROCICLIC COMPOUNDS, PROCEDURE FOR THE PREPARATION OF THESE AND PHARMACEUTICAL COMPOSITION CONTAINING THEM |
Country Status (6)
Country | Link |
---|---|
AR (1) | AR026451A1 (en) |
AU (1) | AU2356301A (en) |
CO (1) | CO5261532A1 (en) |
EC (1) | ECSP003761A (en) |
PE (1) | PE20011023A1 (en) |
WO (1) | WO2001036428A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20200092955A (en) | 2017-11-24 | 2020-08-04 | 하. 룬드벡 아크티에셀스카브 | New catecholamine prodrug for use in the treatment of Parkinson's disease |
US11111263B2 (en) | 2019-05-20 | 2021-09-07 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
US11104697B2 (en) | 2019-05-20 | 2021-08-31 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
US11130775B2 (en) | 2019-05-20 | 2021-09-28 | H. Lundbeck A/S | Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
US11168056B2 (en) | 2019-05-20 | 2021-11-09 | H. Lundbeck A/S | Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2689892A1 (en) * | 1992-04-09 | 1993-10-15 | Rhone Poulenc Rorer Sa | New 4-substd. 1,4-di:phenyl-1-sila:cyclopentane derivs. - used as serotonin antagonists e.g. for treating anxiety, migraine, asthma or hypertension |
US6210705B1 (en) * | 1997-12-15 | 2001-04-03 | Noven Pharmaceuticals, Nc. | Compositions and methods for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate |
-
2000
- 2000-11-07 CO CO00084393A patent/CO5261532A1/en not_active Application Discontinuation
- 2000-11-10 EC EC2000003761A patent/ECSP003761A/en unknown
- 2000-11-13 WO PCT/EP2000/011203 patent/WO2001036428A1/en active Application Filing
- 2000-11-13 AR ARP000105976A patent/AR026451A1/en unknown
- 2000-11-13 PE PE2000001209A patent/PE20011023A1/en not_active Application Discontinuation
- 2000-11-13 AU AU23563/01A patent/AU2356301A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ECSP003761A (en) | 2002-06-26 |
AR026451A1 (en) | 2003-02-12 |
AU2356301A (en) | 2001-05-30 |
WO2001036428A1 (en) | 2001-05-25 |
PE20011023A1 (en) | 2001-09-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Application withdrawn |