PE20010825A1 - A PHARMACEUTICAL COMPOSITION THAT HAS GREAT PERMEABILITY THROUGH THE CELLULAR MEMBRANE - Google Patents

A PHARMACEUTICAL COMPOSITION THAT HAS GREAT PERMEABILITY THROUGH THE CELLULAR MEMBRANE

Info

Publication number
PE20010825A1
PE20010825A1 PE2000001154A PE0011542000A PE20010825A1 PE 20010825 A1 PE20010825 A1 PE 20010825A1 PE 2000001154 A PE2000001154 A PE 2000001154A PE 0011542000 A PE0011542000 A PE 0011542000A PE 20010825 A1 PE20010825 A1 PE 20010825A1
Authority
PE
Peru
Prior art keywords
pth
pharmaceutical composition
cellular membrane
composition
great permeability
Prior art date
Application number
PE2000001154A
Other languages
Spanish (es)
Inventor
Michael Terrence Kuhfeld
Ovidio Varga
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20010825A1 publication Critical patent/PE20010825A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE REFIERE A UNA COMPOSICION QUE COMPRENDE a)HORMONA PARATIROIDEA (PTH); b)UN TENSIOACTIVO DE UN ACIDO DE ION BIPOLAR BETAINICO TAL COMO PROPILBETAINA, LAURAMIDOPROPILBETAINA; QUE AUMENTA LA BIODISPONIBILIDAD DE LA PTH SIENDO LA RELACION PONDERAL DE PTH A PROPILBETAINA DE 0,05:100 A 10:100 Y DE PTH A LAURAMIDOPROPILBETAINA ES DE 0,031:1 A 1:23. TAMBIEN SE REFIERE AL USO DE LA COMPOSICION CON RALOXIFENO EN FORMA SIMULTANEA, SECUENCIAL O DENTRO DE UN INTERVALO TERAPEUTICAMENTE EFICAZ. LA COMPOSICION PUEDE SER UTIL PARA EL TRATAMIENTO DE LA PERDIDA DE MASA OSEAIT REFERS TO A COMPOSITION INCLUDING a) PARATHYROID HORMONE (PTH); b) A TENSIOACTIVE OF A BIPOLAR ION BETAINIC ACID SUCH AS PROPILBETAINE, LAURAMIDOPROPILBETAINE; WHICH INCREASES THE BIOAVAILABILITY OF PTH BEING THE PONDERAL RATIO OF PTH TO PROPILBETAINE FROM 0.05: 100 TO 10: 100 AND OF PTH TO LAURAMIDOPROPILBETAINE IS FROM 0.031: 1 TO 1:23. IT ALSO REFERS TO THE USE OF THE COMPOSITION WITH RALOXIFENE SIMULTANEOUSLY, SEQUENTIAL OR WITHIN A THERAPEUTICALLY EFFECTIVE INTERVAL. THE COMPOSITION MAY BE USEFUL FOR THE TREATMENT OF LOSS OF BONE MASS

PE2000001154A 1999-10-29 2000-10-27 A PHARMACEUTICAL COMPOSITION THAT HAS GREAT PERMEABILITY THROUGH THE CELLULAR MEMBRANE PE20010825A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16255799P 1999-10-29 1999-10-29

Publications (1)

Publication Number Publication Date
PE20010825A1 true PE20010825A1 (en) 2001-08-13

Family

ID=22586144

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000001154A PE20010825A1 (en) 1999-10-29 2000-10-27 A PHARMACEUTICAL COMPOSITION THAT HAS GREAT PERMEABILITY THROUGH THE CELLULAR MEMBRANE

Country Status (3)

Country Link
AU (1) AU1189301A (en)
PE (1) PE20010825A1 (en)
WO (1) WO2001032201A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002344371B2 (en) 2001-06-01 2006-06-29 Novartis Ag Orally administering parathyroid hormone and calcitonin
CA2782640A1 (en) 2009-12-07 2011-06-16 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
CN118001411A (en) * 2024-04-09 2024-05-10 深圳奥礼生物科技有限公司 Intestinal tract absorption composition

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524557B1 (en) * 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
JPH11292787A (en) * 1995-08-15 1999-10-26 Asahi Chem Ind Co Ltd Transucosal preparation containing physiologically active peptide
DE19538687A1 (en) * 1995-10-17 1997-04-24 Boehringer Mannheim Gmbh Stable pharmaceutical dosage forms containing parathyroid hormone

Also Published As

Publication number Publication date
AU1189301A (en) 2001-05-14
WO2001032201A2 (en) 2001-05-10
WO2001032201A3 (en) 2001-09-27

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Legal Events

Date Code Title Description
FD Application declared void or lapsed