PE20000879A1 - METHOD TO CRYSTALLIZE A ß-LACTAMIC ANTIBIOTIC - Google Patents

METHOD TO CRYSTALLIZE A ß-LACTAMIC ANTIBIOTIC

Info

Publication number
PE20000879A1
PE20000879A1 PE1999000315A PE00031599A PE20000879A1 PE 20000879 A1 PE20000879 A1 PE 20000879A1 PE 1999000315 A PE1999000315 A PE 1999000315A PE 00031599 A PE00031599 A PE 00031599A PE 20000879 A1 PE20000879 A1 PE 20000879A1
Authority
PE
Peru
Prior art keywords
acid
lactam
crystallize
alcoxy
glycin
Prior art date
Application number
PE1999000315A
Other languages
Spanish (es)
Inventor
Der Does Thomas Van
Rienk Hendrik Kuipers
Original Assignee
Dsm Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Nv filed Critical Dsm Nv
Publication of PE20000879A1 publication Critical patent/PE20000879A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE REFIERE A UN METODO PARA CRISTALIZAR UNA ß-LACTAMA DE FORMULA I, QUE COMPRENDE LA CRISTALIZACION DE UNA ß-LACTAMA A PARTIR DE UNA SOLUCION DE ACIDO NITRICO DE pH 0.5 A 2; A UNA CONCENTRACION MAYOR DE 0,4 moles/L; MEDIANTE LA ADICION DE UNA SOLUCION ALCALINA DE AMONIACO O SAL DE HIDROXIDO; DONDE: R0 ES H, ALCOXI C1-C3; R1 ES H, DERIVADO DE ACIDO ORGANICO; Y ES CH2, O, S; Z ES UN GRUPO a, -CH2-C(-R2)=, -CH=C(R2)-, -CH2-C(=CH2)-; R2 ES H, OH, HALOGENO, ALCOXI C1-C3, ALQUILO C1-C5, CICLOALQUILO C5-C8; EL NUCLEO ß-LACTAMICO SE UNE A UN AMINOACIDO POR LA CADENA LATERAL QUE PUEDE SER D-(-)-FENILGLICINA, D-(-)-4-HIDROXIFENILGLICINA, D-(-)-2,5-DIHIDROXIFENILGLICINA, ACIDO 2-TIENILACETICO, ACIDO 2-(2-AMINO-4-TIAZOLIL)-2-METOXIIMINOACETICO, ENTRE OTROS; LA ß-LACTAMA PUEDE SER AMOXICILINA, AMPICILINA, CEFALEXINA, CEFACLOR, CEFADROXIL, CEFADRINA, EPICILINA, CEFAMANDOL, CEFOTAXIME, CEFDINIR, CEFPROZIL, CEFUROXIM, CEFEPIME, CEFIBUTEN, LORACARBEF Y SE PUEDE OBTENER DE MANERA ENZIMATICAREFERS TO A METHOD TO CRYSTALLIZE A ß-LACTAM OF FORMULA I, WHICH INCLUDES THE CRYSTALLIZATION OF A ß-LACTAM FROM A NITRIC ACID SOLUTION OF pH 0.5 TO 2; AT A CONCENTRATION GREATER THAN 0.4 moles / L; THROUGH THE ADDITION OF AN AMMONIA ALKALINE OR HYDROXIDE SALT SOLUTION; WHERE: R0 IS H, C1-C3 ALCOXY; R1 IS H, DERIVED FROM ORGANIC ACID; Y IS CH2, O, S; Z IS A GROUP a, -CH2-C (-R2) =, -CH = C (R2) -, -CH2-C (= CH2) -; R2 IS H, OH, HALOGEN, C1-C3 ALCOXY, C1-C5 ALKYL, C5-C8 CYCLOALKYL; THE ß-LACTAMIC NUCLEUM JOINES AN AMINO ACID THROUGH THE SIDE CHAIN WHICH MAY BE D - (-) - PHENYLGLYCIN, D - (-) - 4-HYDROXYPHENYL GLYCIN, D - (-) - 2,5-DIHYDROXYPHENYL GLYCIN, ACID 2- THYENILACETICO, 2- (2-AMINO-4-THIAZOLIL) -2-METOXYIMINOACETICO ACID, AMONG OTHERS; Ss-LACTAM MAY BE AMOXICILLIN, AMPICILLIN, CEFALEXIN, CEFACLOR, CEFADROXYL, CEFADRIN, EPICILLIN, CEFAMANDOL, CEFOTAXIME, CEFDINIR, CEFPROZIL, CEFUROXIM, CEFEPIMERA OBEFARBUTENE, CEFEDIBARUTENE OBEPIME, CEFEDIBARUTEN DE MANZENE

PE1999000315A 1998-04-29 1999-04-16 METHOD TO CRYSTALLIZE A ß-LACTAMIC ANTIBIOTIC PE20000879A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98201398 1998-04-29

Publications (1)

Publication Number Publication Date
PE20000879A1 true PE20000879A1 (en) 2000-09-23

Family

ID=8233663

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000315A PE20000879A1 (en) 1998-04-29 1999-04-16 METHOD TO CRYSTALLIZE A ß-LACTAMIC ANTIBIOTIC

Country Status (9)

Country Link
EP (1) EP1075479A1 (en)
KR (1) KR20010043038A (en)
CN (1) CN1298408A (en)
AU (1) AU3539599A (en)
BR (1) BR9910085A (en)
ID (1) ID26418A (en)
PE (1) PE20000879A1 (en)
TR (1) TR200003131T2 (en)
WO (1) WO1999055710A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1842852A1 (en) 2002-08-13 2007-10-10 Sandoz AG A cefdinir intermediate
US7534781B2 (en) * 2003-03-21 2009-05-19 Dsm Ip Assets B.V. Crystalline amoxicillin trihydrate powder
ZA200507748B (en) * 2003-03-24 2007-03-28 Acs Dobfar Spa Novel crystal of 7-[2-(2-aminothiazole-4-yl)-2-hydroxyimino-acetamido-3-vinyl-3-cephem-4-carboxylic acid (syn isomer) and method for preparation thereof
WO2006059753A1 (en) 2004-11-30 2006-06-08 Astellas Pharma Inc. Novel oral pharmaceutical suspension of cefdinir crystal
KR101420451B1 (en) * 2006-05-19 2014-07-16 디에스엠 시노켐 파마슈티칼스 네덜란드 비.브이. Process for the crystallisation of cefadroxil
CN103145733B (en) * 2013-03-20 2014-02-26 四川省惠达药业有限公司 Amoxicillin compound and pharmaceutical composition of amoxicillin compound and potassium clavulanate
CN104059086B (en) * 2014-06-19 2016-04-13 河南牧翔动物药业有限公司 A kind of amoxycilline Trihydrate bp crystal and preparation method thereof
CN104830523B (en) * 2015-05-15 2018-01-09 湖北民族学院 A kind of No-harmful apple orchard device of high-quality vegetable oil and the method for producing vegetable oil
CN106397455B (en) * 2016-08-30 2018-08-31 山东罗欣药业集团恒欣药业有限公司 A kind of anti-infectives Ceftibuten crystalline compounds and combinations thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE465649A (en) * 1944-06-19
JPS6379888A (en) * 1986-09-24 1988-04-09 Tanabe Seiyaku Co Ltd Stable hydrate of penicillin derivative
RU2024851C1 (en) * 1992-07-22 1994-12-15 Шорманов Владимир Камбулатович Method for determination of sodium 6-(d-aminophenylacetamido)-penicillanate
BE1009264A3 (en) * 1995-03-31 1997-01-07 Dsm Nv Process for the extraction of ampicillin.
AU1234999A (en) * 1997-11-10 1999-05-31 Gist-Brocades B.V. Crystallization of beta-lactam compounds

Also Published As

Publication number Publication date
AU3539599A (en) 1999-11-16
BR9910085A (en) 2000-12-26
EP1075479A1 (en) 2001-02-14
KR20010043038A (en) 2001-05-25
WO1999055710A1 (en) 1999-11-04
CN1298408A (en) 2001-06-06
ID26418A (en) 2000-12-21
TR200003131T2 (en) 2001-01-22

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