PE20000633A1 - THERAPEUTIC COMBINATIONS FOR MUSCULOSKELETAL FRAGILITY - Google Patents
THERAPEUTIC COMBINATIONS FOR MUSCULOSKELETAL FRAGILITYInfo
- Publication number
- PE20000633A1 PE20000633A1 PE1999000522A PE00052299A PE20000633A1 PE 20000633 A1 PE20000633 A1 PE 20000633A1 PE 1999000522 A PE1999000522 A PE 1999000522A PE 00052299 A PE00052299 A PE 00052299A PE 20000633 A1 PE20000633 A1 PE 20000633A1
- Authority
- PE
- Peru
- Prior art keywords
- etil
- pyridin
- oxo
- tartrate
- salt
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE a)UN MODULADOR SELECTIVO DEL RECEPTOR DE ESTROGENOS (SERM) TAL COMO (-)-CIS-6-FENIL-5-(4-(2-PIRROLIDIN-1-IL-ETOXI)-FENIL)-5,6,7,8-TETRAHIDRONAFTALENO-2-OL O SU SAL D-TARTRATO; b)UN SECRETAGOGO DE LA HORMONA DE CRECIMIENTO TAL COMO 2-AMINO-N-(1(R)-(2,4-DIFLUORO-BENCILOXIMETIL)-2-OXO-2-(3-OXO-3a(R)-PIRIDIN-2-ILMETIL)-2-(2,2,2-TRIFLUORO-ETIL)-2,3,3a,4,6,7-HEXAHIDRO-PIRAZOLO[4,3-c]PIRIDIN-5-IL)-ETIL)-2-METIL-PROPIONAMIDA O SU SAL L-TARTRATO. LA COMPOSICION PUEDE SER UTIL PARA EL TRATAMIENTO DE LA FRAGILIDAD MUSCULOESQUELETICA, OSTEOPOROSIS, OSTEOTOMIA, PERDIDA OSEA IDIOPATICA INFANTIL, PERDIDA OSEA ASOCIADA CON PERIODONTITIS, CURACION DE HUESO DESPUES DE UNA RECONSTRUCCION FACIAL, RECONSTRUCCION MAXILAR, RECONSTRUCCION MANDIBULARREFERS TO A PHARMACEUTICAL COMPOSITION INCLUDING a) A SELECTIVE MODULATOR OF THE ESTROGEN RECEPTOR (SERM) SUCH AS (-) - CIS-6-PHENYL-5- (4- (2-PYRROLIDIN-1-IL-ETOXY) -PHENIL ) -5,6,7,8-TETRAHYDRONAPHTHALENE-2-OL OR ITS D-TARTRATE SALT; b) A SECRETAGOG OF GROWTH HORMONE SUCH AS 2-AMINO-N- (1 (R) - (2,4-DIFLUORO-BENZYLOXIMETHYL) -2-OXO-2- (3-OXO-3a (R) -PYRIDIN -2-ILMETIL) -2- (2,2,2-TRIFLUORO-ETIL) -2,3,3a, 4,6,7-HEXAHIDRO-PIRAZOLO [4,3-c] PYRIDIN-5-IL) -ETIL ) -2-METHYL-PROPIONAMIDE OR ITS SALT L-TARTRATE. THE COMPOSITION MAY BE USEFUL FOR THE TREATMENT OF MUSCULOSKELETAL FRAGILITY, OSTEOPOROSIS, OSTEOTOMY, CHILDHOOD IDIOPATIC BONE LOSS, BONE LOSS ASSOCIATED WITH PERIODONTITIS, BONE HEALING AFTER MAXIMUM RECONSTRUCTION, FACIAL RECONSTRUCTION
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8942498P | 1998-06-16 | 1998-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20000633A1 true PE20000633A1 (en) | 2000-07-26 |
Family
ID=22217565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000522A PE20000633A1 (en) | 1998-06-16 | 1999-06-11 | THERAPEUTIC COMBINATIONS FOR MUSCULOSKELETAL FRAGILITY |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP1085867A1 (en) |
| JP (1) | JP2002518328A (en) |
| KR (1) | KR20010052817A (en) |
| CN (1) | CN1305378A (en) |
| AP (1) | AP9901581A0 (en) |
| AR (1) | AR018868A1 (en) |
| AU (1) | AU3342099A (en) |
| BG (1) | BG105128A (en) |
| BR (1) | BR9911357A (en) |
| CA (1) | CA2335112A1 (en) |
| CO (1) | CO5070586A1 (en) |
| EA (1) | EA200001189A1 (en) |
| GT (1) | GT199900083A (en) |
| HR (1) | HRP20000857A2 (en) |
| HU (1) | HUP0102395A2 (en) |
| ID (1) | ID26726A (en) |
| IL (1) | IL139587A0 (en) |
| IS (1) | IS5727A (en) |
| MA (1) | MA26648A1 (en) |
| NO (1) | NO20006381D0 (en) |
| OA (1) | OA11569A (en) |
| PA (1) | PA8472101A1 (en) |
| PE (1) | PE20000633A1 (en) |
| PL (1) | PL345064A1 (en) |
| SK (1) | SK18902000A3 (en) |
| TN (1) | TNSN99118A1 (en) |
| UY (1) | UY25557A1 (en) |
| WO (1) | WO1999065488A1 (en) |
| ZA (1) | ZA993973B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1004306A3 (en) * | 1998-08-06 | 2000-06-07 | Pfizer Products Inc. | Estrogen agonists/antagonists |
| BR0113626A (en) * | 2000-08-30 | 2003-06-17 | Pfizer Prod Inc | Sustained-Release Formulations for Growth Hormone Secretors |
| IL145106A0 (en) * | 2000-08-30 | 2002-06-30 | Pfizer Prod Inc | Intermittent administration of a geowth hormone secretagogue |
| CN100548283C (en) * | 2001-11-29 | 2009-10-14 | Gtx公司 | Osteoporosis prevention that androgen-deprivation causes and treatment |
| US7524866B2 (en) | 2001-11-29 | 2009-04-28 | Gtx, Inc. | Prevention and treatment of androgen—deprivation induced osteoporosis |
| US7476653B2 (en) | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
| CU23558A1 (en) | 2006-02-28 | 2010-07-20 | Ct Ingenieria Genetica Biotech | COMPOUNDS ANALOG TO THE PEPTIDIC SECRETAGOGS OF THE GROWTH HORMONE |
| EP2644618B1 (en) | 2007-02-09 | 2016-08-17 | Ocera Therapeutics, Inc. | tether intermediates for the synthesis of macrocyclic ghrelin receptor modulators |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA51676C2 (en) * | 1995-11-02 | 2002-12-16 | Пфайзер Інк. | (-)cis-6(S)-phenyl-5(R)-[4-(2-pyrrolidin-I-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol D-tartrate, a method of its preparation, method of THE treatment OF diseases medicated by agonists of estrogen and a pharmaceutical composition |
| TW432073B (en) * | 1995-12-28 | 2001-05-01 | Pfizer | Pyrazolopyridine compounds |
| HN1996000101A (en) * | 1996-02-28 | 1997-06-26 | Inc Pfizer | COMBINED THERAPY FOR OSTEOPOROSIS |
-
1999
- 1999-05-03 ID IDW20002604A patent/ID26726A/en unknown
- 1999-05-03 EA EA200001189A patent/EA200001189A1/en unknown
- 1999-05-03 PL PL99345064A patent/PL345064A1/en unknown
- 1999-05-03 OA OA1200000346A patent/OA11569A/en unknown
- 1999-05-03 BR BR9911357-0A patent/BR9911357A/en not_active Application Discontinuation
- 1999-05-03 JP JP2000554368A patent/JP2002518328A/en active Pending
- 1999-05-03 CN CN99807381A patent/CN1305378A/en active Pending
- 1999-05-03 SK SK1890-2000A patent/SK18902000A3/en unknown
- 1999-05-03 AU AU33420/99A patent/AU3342099A/en not_active Abandoned
- 1999-05-03 HU HU0102395A patent/HUP0102395A2/en unknown
- 1999-05-03 WO PCT/IB1999/000796 patent/WO1999065488A1/en not_active Application Discontinuation
- 1999-05-03 EP EP99914723A patent/EP1085867A1/en not_active Withdrawn
- 1999-05-03 CA CA002335112A patent/CA2335112A1/en not_active Abandoned
- 1999-05-03 KR KR1020007014140A patent/KR20010052817A/en not_active Application Discontinuation
- 1999-05-03 IL IL13958799A patent/IL139587A0/en unknown
- 1999-05-07 PA PA19998472101A patent/PA8472101A1/en unknown
- 1999-06-10 AP APAP/P/1999/001581A patent/AP9901581A0/en unknown
- 1999-06-11 UY UY25557A patent/UY25557A1/en not_active Application Discontinuation
- 1999-06-11 PE PE1999000522A patent/PE20000633A1/en not_active Application Discontinuation
- 1999-06-14 GT GT199900083A patent/GT199900083A/en unknown
- 1999-06-15 ZA ZA9903973A patent/ZA993973B/en unknown
- 1999-06-15 AR ARP990102847A patent/AR018868A1/en not_active Application Discontinuation
- 1999-06-15 TN TNTNSN99118A patent/TNSN99118A1/en unknown
- 1999-06-15 MA MA25622A patent/MA26648A1/en unknown
- 1999-06-16 CO CO99037624A patent/CO5070586A1/en unknown
-
2000
- 2000-11-24 IS IS5727A patent/IS5727A/en unknown
- 2000-12-14 HR HR20000857A patent/HRP20000857A2/en not_active Application Discontinuation
- 2000-12-14 NO NO20006381A patent/NO20006381D0/en not_active Application Discontinuation
-
2001
- 2001-01-08 BG BG105128A patent/BG105128A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TNSN99118A1 (en) | 2005-11-10 |
| EA200001189A1 (en) | 2001-06-25 |
| MA26648A1 (en) | 2004-12-20 |
| HRP20000857A2 (en) | 2001-10-31 |
| PL345064A1 (en) | 2001-11-19 |
| CA2335112A1 (en) | 1999-12-23 |
| AU3342099A (en) | 2000-01-05 |
| ID26726A (en) | 2001-02-01 |
| PA8472101A1 (en) | 2000-09-29 |
| BR9911357A (en) | 2001-03-13 |
| OA11569A (en) | 2004-07-01 |
| BG105128A (en) | 2001-11-30 |
| CN1305378A (en) | 2001-07-25 |
| AR018868A1 (en) | 2001-12-12 |
| AP9901581A0 (en) | 1999-06-30 |
| WO1999065488A1 (en) | 1999-12-23 |
| GT199900083A (en) | 2000-12-05 |
| EP1085867A1 (en) | 2001-03-28 |
| JP2002518328A (en) | 2002-06-25 |
| SK18902000A3 (en) | 2001-12-03 |
| NO20006381L (en) | 2000-12-14 |
| ZA993973B (en) | 2000-12-15 |
| NO20006381D0 (en) | 2000-12-14 |
| UY25557A1 (en) | 2001-01-31 |
| HUP0102395A2 (en) | 2001-11-28 |
| CO5070586A1 (en) | 2001-08-28 |
| IL139587A0 (en) | 2002-02-10 |
| IS5727A (en) | 2000-11-24 |
| KR20010052817A (en) | 2001-06-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ECSP066315A (en) | DERIVATIVES OF PIRIDAZINE AND ITS USE AS THERAPEUTIC AGENTS | |
| AR023130A1 (en) | COMPOSITIONS TO PROMOTE GROWTH | |
| IL154888A (en) | Non-aqueous pharmaceutical gel composition containing at least one vitamin d or one vitamin d analogue and at least one corticosteroid and its use in the manufacture of a medicament for treatment of psoriasis | |
| EA200100154A1 (en) | Benzo-cycloheptenes, method of their production, containing their pharmaceutical preparations and their use for the preparation of drugs | |
| ATE257386T1 (en) | PHARMACEUTICAL COMPOSITIONS CONTAINING A MIXTURE OF SELF-CROSS-LINKED AND NON-SELF-CROSS-LINKED HYALURONIC ACID FOR THE TREATMENT OF ARTHROPATHIES | |
| MXPA02005173A (en) | Remedies for diseases in association with decrease in bone mass. | |
| BR0100558A (en) | Compositions and methods for treating osteoporosis | |
| ATE112684T1 (en) | USE OF IGF-II TO TREAT BONE DISEASES. | |
| AR013001A1 (en) | DERIVATIVES OF PIPERAZINE, PROCEDURES TO PREPARE THEM, THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM, THEIR USE AS A MEDICINAL PRODUCT AND THE METHOD FOR TREATING DISEASES MEDIATED BY TACHININ. | |
| BRPI0417621A (en) | continuous combination therapy with selective prostaglandin ep4 receptor agonists and an estrogen for the treatment of conditions with low bone mass | |
| BR0310087A (en) | Hyaluronic acid injectable solid carriers for application of osteogenic proteins | |
| PE20000644A1 (en) | THERAPEUTIC COMBINATIONS INCLUDING A SELECTIVE ESTROGEN RECEPTOR MODULATOR AND PARATHYROID HORMONE | |
| BR0012951A (en) | Selective retinoid agonists | |
| ECSP044961A (en) | ACID N- (5-CHLOROSALICILOIL) -8-AMINOCAPRILICO AS AN ORAL SUPPLY AGENT FOR PARTIROID HORMONE FRAGMENTS | |
| PE20000633A1 (en) | THERAPEUTIC COMBINATIONS FOR MUSCULOSKELETAL FRAGILITY | |
| IT1170214B (en) | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF PERIPHERAL ARTERIOPATHIES | |
| AU2284001A (en) | Substituted aminoalkylamide derivatives as antagonists of follicle stimulating hormone | |
| BRPI0407178A (en) | Osteogenic Pharmaceutical Composition | |
| AR048672A1 (en) | DISINTEGRATION TABLETS THAT INCLUDE LICARBAZEPINA | |
| PE20000646A1 (en) | COMBINATION THERAPY FOR MUSCULOSKELETAL FRAGILITY | |
| PL1638582T3 (en) | Use of hyaluronic acid for preparing compositions for treating recurrent oral cavity aphthas | |
| BR0213878A (en) | Process for the formation of ibuprofen solids | |
| MXPA03010679A (en) | Compositions for promoting healing of bone fracture. | |
| BRPI0409881A (en) | compounds, pharmaceutical compositions, method for the treatment or prophylaxis of diseases, and uses of compounds and one or more compounds in combination with other pharmacologically active compounds | |
| BR0013582A (en) | Selective retinoid agonists for rar |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |