PE20000430A1 - Proceso para preparar 4-sustituido-1h-indol-3-glioxamidas - Google Patents
Proceso para preparar 4-sustituido-1h-indol-3-glioxamidasInfo
- Publication number
- PE20000430A1 PE20000430A1 PE1999000312A PE00031299A PE20000430A1 PE 20000430 A1 PE20000430 A1 PE 20000430A1 PE 1999000312 A PE1999000312 A PE 1999000312A PE 00031299 A PE00031299 A PE 00031299A PE 20000430 A1 PE20000430 A1 PE 20000430A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- compound
- halo
- forming
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
SE REFIERE A UN PROCEDIMIENTO PARA PREPARAR 1H-INDOL-3-GLIOXAMIDAS DE FORMULA I, DONDE R1 ES ALQUILO C7-C20, GRUPO a, b, c; R10 ES HALO, ALQUILO C1-C10, ENTRE OTROS; t ES 0-5; R2 ES H, HALO, ALQUILO C1-C3, ENTRE OTROS; R4 ES -CO2H, SO3H, PO(OH)2; R5 ES H, ALQUILO C1-C6, ALCOXI C1-C6, ENTRE OTROS; QUE COMPRENDE HALOGENAR R8-O-C(=O)-CH2-C(=O)-R2; R8 ES ALQUILO C1-C6, ARILO, HET; CON SO2Cl2 Y FORMAR R8-O-(C=O)-CH(Cl)-C(=O)-R2; LUEGO HIDROLIZAR, DESCARBOXILAR Y FORMAR Cl-CH2-C(=O)-R2; ALQUILIZAR UN COMPUESTO VII CON Cl-CH2-C(=O)-R2; PARA FORMAR UN COMPUESTO VI LUEGO AMINAR Y DESHIDRATAR CON UNA AMINA R1NH2, EN PRESENCIA DE UN SOLVENTE QUE FORMA UN AZEOTROPO EN AGUA PARA FORMAR UN COMPUESTO V; LUEGO OXIDAR CALENTANDO CON UNA BASE Y UN REACTIVO SULFINIZANTE RSOX; R ES -ALQUILO C1-C6, ARILO; X ES -ALCOXI C1-C6, HALO, -OCO2(ALQUILO C1-C6) Y FORMAR UN COMPUESTO IV; LUEGO ALQUILAR CON XCH2R4a; X ES UN GRUPO SALIENTE, R4a ES -CO2R4b, -SO3R4b, -P(O)(OR4b)2, -P(O)(OR4b)H; R4b ES UN GRUPO ACIDO PROTECTOR Y FORMAR UN GRUPO III, QUE REACCIONA CON CLORURO DE OXALILO, AMONIACO Y FORMAR UN COMPUESTO II; LUEGO HIDROLIZAR Y FORMAR EL COMPUESTO I EL QUE ES UN INHIBIDOR DE LA LIBERACION DE ACIDOS GRASOS OCASIONADA POR sPLA2 Y PUEDE SER UTIL PARA TRATAR SHOCK SEPTICO, PANCREATITIS, TRAUMA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8211098P | 1998-04-17 | 1998-04-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20000430A1 true PE20000430A1 (es) | 2000-05-24 |
Family
ID=22169126
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1999000312A PE20000430A1 (es) | 1998-04-17 | 1999-04-15 | Proceso para preparar 4-sustituido-1h-indol-3-glioxamidas |
Country Status (27)
Country | Link |
---|---|
US (1) | US6265591B1 (es) |
EP (1) | EP1071663A4 (es) |
JP (1) | JP2002512225A (es) |
KR (1) | KR20010042741A (es) |
CN (1) | CN1305459A (es) |
AR (1) | AR015767A1 (es) |
AU (1) | AU750368B2 (es) |
BR (1) | BR9909697A (es) |
CA (1) | CA2326515A1 (es) |
CO (1) | CO5080803A1 (es) |
DZ (1) | DZ2770A1 (es) |
EA (1) | EA003582B1 (es) |
EG (1) | EG22139A (es) |
HK (1) | HK1039120A1 (es) |
HR (1) | HRP20000685A2 (es) |
HU (1) | HUP0101344A3 (es) |
ID (1) | ID26021A (es) |
IL (1) | IL138827A0 (es) |
NO (1) | NO20005148L (es) |
NZ (1) | NZ507175A (es) |
PE (1) | PE20000430A1 (es) |
PL (1) | PL343487A1 (es) |
SK (1) | SK15372000A3 (es) |
SV (1) | SV1999000043A (es) |
TR (1) | TR200002999T2 (es) |
WO (1) | WO1999054300A1 (es) |
ZA (1) | ZA200005294B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1071661A4 (en) * | 1998-04-17 | 2001-08-22 | Lilly Co Eli | METHOD FOR PRODUCING 4-HYDROXYINDOL, INDAZOL AND CARBAZOL COMPOUNDS |
US6407261B1 (en) | 1998-04-17 | 2002-06-18 | Eli Lilly And Company | Process for preparing 4-hdyroxy indole, indazole and carbazole compounds |
DE19962300A1 (de) * | 1999-12-23 | 2001-06-28 | Asta Medica Ag | Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung |
US20030225149A1 (en) * | 2002-04-30 | 2003-12-04 | Blazecka Peter G. | Process for preparing highly functionalized gamma-butyrolactams and gamma-amino acids |
NZ624963A (en) | 2009-04-29 | 2016-07-29 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
AR088377A1 (es) | 2011-10-20 | 2014-05-28 | Siena Biotech Spa | Proceso para la preparacion de 6-cloro-2,3,4,9-tetrahidro-1h-carbazol-1-carboxamida y compuestos intermedios de esta |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY112897A (en) | 1994-04-01 | 2001-10-31 | Lilly Co Eli | Ih-indole-3-glyoxylamide spla2 inhibitors |
EP1071661A4 (en) * | 1998-04-17 | 2001-08-22 | Lilly Co Eli | METHOD FOR PRODUCING 4-HYDROXYINDOL, INDAZOL AND CARBAZOL COMPOUNDS |
-
1999
- 1999-04-14 DZ DZ990070A patent/DZ2770A1/xx active
- 1999-04-15 US US09/647,471 patent/US6265591B1/en not_active Expired - Fee Related
- 1999-04-15 PL PL99343487A patent/PL343487A1/xx not_active Application Discontinuation
- 1999-04-15 BR BR9909697-8A patent/BR9909697A/pt not_active IP Right Cessation
- 1999-04-15 AU AU35648/99A patent/AU750368B2/en not_active Ceased
- 1999-04-15 WO PCT/US1999/008332 patent/WO1999054300A1/en not_active Application Discontinuation
- 1999-04-15 EA EA200001076A patent/EA003582B1/ru not_active IP Right Cessation
- 1999-04-15 KR KR1020007011468A patent/KR20010042741A/ko not_active Application Discontinuation
- 1999-04-15 CN CN99807248A patent/CN1305459A/zh active Pending
- 1999-04-15 EP EP99917556A patent/EP1071663A4/en not_active Withdrawn
- 1999-04-15 HU HU0101344A patent/HUP0101344A3/hu unknown
- 1999-04-15 TR TR2000/02999T patent/TR200002999T2/xx unknown
- 1999-04-15 EG EG104099D patent/EG22139A/xx active
- 1999-04-15 CA CA002326515A patent/CA2326515A1/en not_active Abandoned
- 1999-04-15 SV SV1999000043A patent/SV1999000043A/es not_active Application Discontinuation
- 1999-04-15 AR ARP990101753A patent/AR015767A1/es not_active Application Discontinuation
- 1999-04-15 JP JP2000544641A patent/JP2002512225A/ja not_active Withdrawn
- 1999-04-15 ID IDW20002058A patent/ID26021A/id unknown
- 1999-04-15 NZ NZ507175A patent/NZ507175A/xx unknown
- 1999-04-15 PE PE1999000312A patent/PE20000430A1/es not_active Application Discontinuation
- 1999-04-15 SK SK1537-2000A patent/SK15372000A3/sk unknown
- 1999-04-15 IL IL13882799A patent/IL138827A0/xx unknown
- 1999-04-16 CO CO99022895A patent/CO5080803A1/es unknown
-
2000
- 2000-09-29 ZA ZA200005294A patent/ZA200005294B/en unknown
- 2000-10-13 NO NO20005148A patent/NO20005148L/no not_active Application Discontinuation
- 2000-10-17 HR HR20000685A patent/HRP20000685A2/hr not_active Application Discontinuation
-
2002
- 2002-01-23 HK HK02100522.5A patent/HK1039120A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
ZA200005294B (en) | 2001-10-01 |
HRP20000685A2 (en) | 2001-10-31 |
SV1999000043A (es) | 2000-05-02 |
CA2326515A1 (en) | 1999-10-28 |
EG22139A (en) | 2002-08-30 |
WO1999054300A1 (en) | 1999-10-28 |
EA200001076A1 (ru) | 2001-04-23 |
CN1305459A (zh) | 2001-07-25 |
PL343487A1 (en) | 2001-08-27 |
EP1071663A1 (en) | 2001-01-31 |
AU3564899A (en) | 1999-11-08 |
BR9909697A (pt) | 2000-12-19 |
NO20005148D0 (no) | 2000-10-13 |
EA003582B1 (ru) | 2003-06-26 |
AR015767A1 (es) | 2001-05-16 |
AU750368B2 (en) | 2002-07-18 |
IL138827A0 (en) | 2001-10-31 |
TR200002999T2 (tr) | 2001-01-22 |
KR20010042741A (ko) | 2001-05-25 |
DZ2770A1 (fr) | 2003-12-01 |
NO20005148L (no) | 2000-11-09 |
EP1071663A4 (en) | 2002-06-19 |
HUP0101344A2 (hu) | 2001-09-28 |
CO5080803A1 (es) | 2001-09-25 |
NZ507175A (en) | 2002-12-20 |
US6265591B1 (en) | 2001-07-24 |
HUP0101344A3 (en) | 2002-12-28 |
ID26021A (id) | 2000-11-16 |
JP2002512225A (ja) | 2002-04-23 |
HK1039120A1 (zh) | 2002-04-12 |
SK15372000A3 (sk) | 2001-08-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA199900093A1 (ru) | Новые ингибиторы нитрификации и применение поликислот для обработки минеральных удобрений, содержащих ингибитор нитрификации | |
MXPA04000306A (es) | Aditivos para inhibir la formacion de hidratos de gas. | |
AR008583A1 (es) | Composicion acida acuosa que contiene un ester de betaina de un alcohol activo y procedimiento para prerarar dicha composicion | |
PE20000430A1 (es) | Proceso para preparar 4-sustituido-1h-indol-3-glioxamidas | |
MY131271A (en) | Liquid detergents with an aryl boronic acid for inhibition of proteolytic enzyme | |
KR960000311B1 (ko) | 급수 시스템에서 망간에 의한 스케일 형성 및 부식을 아미노포스폰산으로 억제하는 방법 | |
MX9800882A (es) | Lubricantes transportadores de alquil eter amina que contienen inhibidores de corrosion. | |
ES2189412T3 (es) | Composiciones colectoras de minerales de acido graso hidroxamico mezcladas con un aceite y procedimiento para fabricar las mismas. | |
BRPI0505310A (pt) | processo para a preparação de soluções aquosas fluxìveis, altamente concentradas, de betaìnas | |
MX173360B (es) | Procedimiento para la produccion de fenil-4,5,6,7-tetrahidro-2h-isoindol-1,3-dionas 2-substituidas | |
PE20000476A1 (es) | Compuestos triciclicos sustituidos | |
ATE533571T1 (de) | Verbesserte wässrige zusammensetzungen zum abbeizen und reinigen | |
KR880007547A (ko) | O-인산의 직접적인 에스테르화 방법 | |
CA2944676A1 (en) | Process for acidizing using retarded acid formulations | |
NO320397B1 (no) | Kvaternaere ammoniumforbindelser som er nyttige for inhibering av metallkorrosjon | |
BRPI0511109A (pt) | método fácil para sintetizar compostos de baccatin iii | |
BR9914474A (pt) | Composição e processo para remoção de gases ácidos | |
ES480226A1 (es) | Procedimiento para la preparacion de amidas de acidos carbo-xilicos,sustituidas en n,insaturadas en &,b. | |
HUP0102657A2 (hu) | Eljárás orto-alkilezett benzoesav-származékok, mint intermedierek és hatóanyagok előállítására | |
ATE518T1 (de) | Korrosionsinhibitoren fuer saure loesungen. | |
PE84199A1 (es) | Procedimiento para la preparacion de 4-sustituido-1h-indol-3-glioxamidas | |
NZ520569A (en) | Composition comprising water, a polyether nonionic emulsifier or an amine oxide emulsifier, an alkylaminophosphonic acid or a hydroxyalkylphosphonic acid or an alkylphosphonic acid carboxylic acid chelating agent, a mineral acid and a tetraalkylammonium surfactant | |
PE20000429A1 (es) | Proceso para preparar 4-sustituido-1h-indol-3-glioxamidas | |
DE69933030D1 (de) | Verfahren zur hemmung von korrosion unter verwendung von isomeren des chlormethylbenzotriazols | |
HRP20020860B1 (en) | Novel method for synthesis of n-[(s)-1-carboxybutyl]-(s)-alanine esters and use in synthesis perindopril |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |