PE14996A1 - NEW AMINO ACID DERIVATIVES, PROCEDURE FOR THE PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINED IN THESE COMPOUNDS - Google Patents

NEW AMINO ACID DERIVATIVES, PROCEDURE FOR THE PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINED IN THESE COMPOUNDS

Info

Publication number
PE14996A1
PE14996A1 PE1995267931A PE26793195A PE14996A1 PE 14996 A1 PE14996 A1 PE 14996A1 PE 1995267931 A PE1995267931 A PE 1995267931A PE 26793195 A PE26793195 A PE 26793195A PE 14996 A1 PE14996 A1 PE 14996A1
Authority
PE
Peru
Prior art keywords
amino acid
compounds
acid derivatives
procedure
preparation
Prior art date
Application number
PE1995267931A
Other languages
Spanish (es)
Inventor
Horst Dollinger
Gerd Schnorrenberg
Franz Esser
Birgit Jung
Erich Burger
Georg Speck
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of PE14996A1 publication Critical patent/PE14996A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A DERIVADOS DE AMINOACIDOS DE FORMULA GENERAL (I): R1-R11-A1-B. DONDE B ES EL GRUPO A2-NR2R3 o R5; R1 ES UN ANILLO DE SEIS ESLABONES, SATURADO O PARCIALMENTE SATURADO DE CINCO O SEIS ATOMOS DE CARBONO Y ATOMOS DE OXIGENO Y NITROGENO, QUE EN POSICION 2 o 3 CON RESPECTO A R11 LLEVA UNA FUNCION CON OXIGENO QUE ES =O, -OH o -O-(ALQUILO DE C1-C4); R11 SIGNIFICA -C(O)-, -CH2-C(O)-,-SO2- o -CH2-SO2-, DE PREFERENCIA -C(0) Y -CH2SO2-; A1 SIGNIFICA D o L-ALANINA, D o L-VALINA, D o L-LEUCINA ENTRE OTROS; A2 ES UN O-AMINOACIDO LIPOFILICO QUE CONTIENE UN GRUPO FENILO, HETEROARILO, CICLOHEXILO ENTRE OTROS; R2 Y R3 INDEPENDIENTEMENTE UNO DE OTRO SIGNIFICAN ALQUILO, ARILALQUILO, HETEROARILO ENTRE OTROS; R5 REPRESENTA UNA AMINA. ESTOS COMPUESTOS SE CARACTERIZAN PORQUE DE ACUERDO A LOS METODOS CONOCIDOS, SE CONDENSAN ESCALONADAMENTE LOS AMINOACIDOS O SECUENCIAS PARCIALES DE DERIVADOS PEPTIDICOS, AMINOACIDOS Y AMINAS; EL COMPUESTO ASI OBTENIDO SE AISLA EN FORMA LIBRE O EN FORMA DE SAL. SE USA EN TERAPIA Y PROFILAXIS FRENTE A ENFERMEDADES MEDIADAS POR NEUROQUININA TAL COMO LAS INFLAMATORIAS Y ALERGICAS DE LAS VIAS RESPIRATORIAS, DEL TRACTO GASTROINTESTINAL Y DEL SISTEMA NERVIOSO CENTRAL ENTRE OTRASREFERS TO AMINO ACID DERIVATIVES OF GENERAL FORMULA (I): R1-R11-A1-B. WHERE B IS GROUP A2-NR2R3 or R5; R1 IS A SIX LINK RING, SATURATED OR PARTIALLY SATURATED OF FIVE OR SIX CARBON ATOMS AND OXYGEN AND NITROGEN ATOMS, WHICH IN POSITION 2 OR 3 WITH RESPECT TO R11 CARRIES A FUNCTION WITH OXYGEN THAT IS = O, -OH or - O- (C1-C4 ALKYL); R11 MEANS -C (O) -, -CH2-C (O) -, - SO2- or -CH2-SO2-, OF PREFERENCE -C (0) AND -CH2SO2-; A1 MEANS D or L-ALANINE, D or L-VALINE, D or L-LEUCINE AMONG OTHERS; A2 IS A LIPOPHILIC O-AMINO ACID CONTAINING A PHENYL GROUP, HETEROARYL, CYCLOHEXYL AMONG OTHERS; R2 AND R3 INDEPENDENTLY ONE OF THE OTHER MEAN ALKYL, ARYLALKYL, HETEROARYL AMONG OTHERS; R5 REPRESENTS AN AMINE. THESE COMPOUNDS ARE CHARACTERIZED BECAUSE ACCORDING TO THE KNOWN METHODS, THE AMINO ACIDS OR PARTIAL SEQUENCES OF PEPTIDIC DERIVATIVES, AMINO ACIDS AND AMINES ARE CONDENSED IN A STAGED BASIS; THE SO-OBTAINED COMPOUND IS ISOLATED FREE OR IN THE FORM OF SALT. IT IS USED IN THERAPY AND PROPHYLAXIS AGAINST NEUROQUININE MEDIATED DISEASES SUCH AS THE INFLAMMATORY AND ALLERGIC DISEASES OF THE RESPIRATORY TRACT, THE GASTROINTESTINAL TRACT AND THE CENTRAL NERVOUS SYSTEM BETWEEN OTHERS

PE1995267931A 1994-05-07 1995-05-05 NEW AMINO ACID DERIVATIVES, PROCEDURE FOR THE PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINED IN THESE COMPOUNDS PE14996A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4416255 1994-05-07
DE4445939A DE4445939A1 (en) 1994-05-07 1994-12-22 Novel amino acid derivatives, process for their preparation and pharmaceutical compositions containing them (II)

Publications (1)

Publication Number Publication Date
PE14996A1 true PE14996A1 (en) 1996-05-08

Family

ID=6517628

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1995267931A PE14996A1 (en) 1994-05-07 1995-05-05 NEW AMINO ACID DERIVATIVES, PROCEDURE FOR THE PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINED IN THESE COMPOUNDS

Country Status (6)

Country Link
KR (1) KR970702876A (en)
CO (1) CO4960643A1 (en)
DE (1) DE4445939A1 (en)
PE (1) PE14996A1 (en)
YU (1) YU28495A (en)
ZA (1) ZA953628B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19541283A1 (en) * 1995-11-06 1997-05-07 Boehringer Ingelheim Kg Novel amino acid derivatives, processes for their preparation and pharmaceutical compositions containing these compounds

Also Published As

Publication number Publication date
KR970702876A (en) 1997-06-10
ZA953628B (en) 1995-11-07
CO4960643A1 (en) 2000-09-25
DE4445939A1 (en) 1995-11-09
YU28495A (en) 1998-05-15

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