PA8526701A1 - PHENOXIBENCILAMINE DERIVATIVES AS SSRI - Google Patents

PHENOXIBENCILAMINE DERIVATIVES AS SSRI

Info

Publication number
PA8526701A1
PA8526701A1 PA20018526701A PA8526701A PA8526701A1 PA 8526701 A1 PA8526701 A1 PA 8526701A1 PA 20018526701 A PA20018526701 A PA 20018526701A PA 8526701 A PA8526701 A PA 8526701A PA 8526701 A1 PA8526701 A1 PA 8526701A1
Authority
PA
Panama
Prior art keywords
rent
ring
independently
zey
alcoxi
Prior art date
Application number
PA20018526701A
Other languages
Spanish (es)
Inventor
Mark Leonard Elliott
Mark David Andrews
David Hepworth
Donald Stuart Middleton
Alan Stobie
Mavis Diane Adam
Harry Ralph Howard Jr
Geoffrey Edward Gymer
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0021593A external-priority patent/GB0021593D0/en
Priority claimed from GB0107116A external-priority patent/GB0107116D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of PA8526701A1 publication Critical patent/PA8526701A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62Benzothiazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/39Heterocyclic compounds having sulfur as a ring hetero atom having oxygen in the same ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/74Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87Benzo [c] furans; Hydrogenated benzo [c] furans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D327/00Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06Six-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/72Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)

Abstract

UN COMPUESTO DE FORMULA GENERAL (I) EN LA QUE R1 Y R2 SON H, ALQUILO C1-C6 O (CH2)d-(CICLOALQUILO C3-C6), DONDE d ES 0, 1, 2 O 3; O R1 Y R2 JUNTO CON EL NITROGENO AL QUE ESTAN UNIDOS FORMAN UN ANILLO DE AZETIDINA; UNO DE Z O Y ES -SR3 Y EL OTRO DE Z O Y ES HALOGENO O -R3; DONDE R3 ES INDEPENDIENTEMENTE ALQUILO C1-C4 OPCIONALMENTE SUSTITUIDO CON FLUOR; EXCEPTO QUE R3 NO ES CF3; O Z E Y ESTAN UNIDOS DE MANERA QUE, JUNTO CON LOS ATOMOS DE INTERCONEXION, Z E Y FORMAN UN ANILLO CARBOCICLICO O HETEROCICLICO DE 5 A 7 MIEMBROS, CONDENSADO, Y DONDE, CUANDO Z E Y FORMAN UN ANILLO HETEROCICLICO, ADEMAS DE ATOMOS DE CARBONO, EL ENLACE CONTIENE UNO O DOS HETEROATOMOS SELECCIONADOS INDEPENDIENTEMENTE ENTRE OXIGENO, AZUFRE Y NITROGENO; R4 Y R5, QUE PUEDEN SER IGUALES O DIFERENTES, SON: A-X, DONDE A ES -CH=CH- O -(CH2)P-, DONDE P ES O,1 O 2; X ES HIDROGENO, F, CL, BR, I, CONR6R7, SO2NR6R7, SO2NHC (=O)R6, OH, ALCOXI C1-4, NR8SO2R9, NO2, NROR11, CN, CO2R10, CHO, SR10, S(O)R9 O SO2R10; O UN ANILLO HETEROCICLICO DE 5 O 6 MIEMBROS QUE CONTIENE 1, 2, O 3 HETEROATOMOS SELECCIONADOS ENTRE N, S Y O, OPCIONALMENTE SUSTITUIDO INDEPENDIENTEMENTE CON UNO O MAS R13; DONDE R13 ES HIDROXI, ALCOXI C1-C4, F, ALQUILO C1-C6, HALOALQUILO, HALOALCOXI, -NH2, -NH(ALQUILO C1-C6) O -N(ALQUILO C1-C6)2.A COMPOSITE OF GENERAL FORMULA (I) IN WHICH R1 AND R2 ARE H, I RENT C1-C6 OR (CH2) d- (CYCLEALKYL C3-C6), WHERE d IS 0, 1, 2 OR 3; OR R1 AND R2 TOGETHER WITH THE NITROGEN TO WHICH THEY ARE UNITED, FORM AN AZETIDINE RING; ONE OF Z O AND IS -SR3 AND THE OTHER OF Z O Y IS HALOGEN OR -R3; WHERE R3 IS INDEPENDENTLY RENT C1-C4 OPTIONALLY REPLACED WITH FLUOR; EXCEPT THAT R3 IS NOT CF3; OZEY ARE UNITED IN A WAY THAT, WITH THE INTERCONNECTION ATOMS, ZEY FORMS A CARBOCICLIC OR HETEROCICLICAL RING OF 5 TO 7 MEMBERS, CONDENSED, AND WHERE, WHEN ZEY FORM A HETEROCICLICAL RING, IN ADDITION TO CARBONET OTHERS TWO SELECTED HETEROATOMOS INDEPENDENTLY BETWEEN OXYGEN, SULFUR AND NITROGEN; R4 AND R5, WHICH CAN BE EQUAL OR DIFFERENT, ARE: A-X, WHERE TO ES -CH = CH- O - (CH2) P-, WHERE P IS O, 1 OR 2; X ES HYDROGEN, F, CL, BR, I, CONR6R7, SO2NR6R7, SO2NHC (= O) R6, OH, ALCOXI C1-4, NR8SO2R9, NO2, NROR11, CN, CO2R10, CHO, SR10, S (O) R9 O SO2R10; OR A HETEROCICLIC RING OF 5 OR 6 MEMBERS CONTAINING 1, 2, OR 3 SELECTED HETEROATOMES BETWEEN N, S AND O, OPTIONALLY REPLACED INDEPENDENTLY WITH ONE OR MORE R13; WHERE R13 IS HYDROXI, ALCOXI C1-C4, F, RENT C1-C6, HALOALQUILO, HALOALCOXI, -NH2, -NH (RENT C1-C6) OR -N (RENT C1-C6) 2.

PA20018526701A 2000-08-31 2001-08-24 PHENOXIBENCILAMINE DERIVATIVES AS SSRI PA8526701A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0021593A GB0021593D0 (en) 2000-08-31 2000-08-31 Diphenyl ether compounds useful in therapy
GB0107116A GB0107116D0 (en) 2001-03-21 2001-03-21 Novel compounds

Publications (1)

Publication Number Publication Date
PA8526701A1 true PA8526701A1 (en) 2003-07-28

Family

ID=26244953

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20018526701A PA8526701A1 (en) 2000-08-31 2001-08-24 PHENOXIBENCILAMINE DERIVATIVES AS SSRI

Country Status (32)

Country Link
EP (1) EP1313701A1 (en)
JP (1) JP2004507523A (en)
KR (1) KR20030029889A (en)
CN (1) CN1449380A (en)
AP (1) AP2001002265A0 (en)
AR (1) AR031867A1 (en)
AU (1) AU2001278650A1 (en)
BG (1) BG107544A (en)
BR (1) BR0113610A (en)
CA (1) CA2420969A1 (en)
CZ (1) CZ2003467A3 (en)
DO (1) DOP2001000242A (en)
DZ (1) DZ3414A1 (en)
EA (1) EA200300206A1 (en)
EE (1) EE200300084A (en)
HN (1) HN2001000191A (en)
HR (1) HRP20030141A2 (en)
HU (1) HUP0303385A2 (en)
IL (1) IL154343A0 (en)
IS (1) IS6704A (en)
MA (1) MA26945A1 (en)
MX (1) MXPA03001848A (en)
NO (1) NO20030842L (en)
NZ (1) NZ523951A (en)
OA (1) OA12372A (en)
PA (1) PA8526701A1 (en)
PE (1) PE20020346A1 (en)
PL (1) PL360743A1 (en)
SK (1) SK2012003A3 (en)
TN (1) TNSN01131A1 (en)
UY (1) UY26924A1 (en)
WO (1) WO2002018333A1 (en)

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GB0318706D0 (en) * 2003-08-08 2003-09-10 Pfizer Ltd Selective serotonin reuptake inhibitors in the treatment of disease
AP2006003700A0 (en) 2004-02-13 2006-08-31 Warner Lambert Co Androgen receptor modulators
US7507860B2 (en) 2004-04-13 2009-03-24 Pfizer Inc. Androgen modulators
CA2562672C (en) 2004-04-22 2009-09-29 Warner-Lambert Company Llc 4-cyano-phenoxy derivatives as androgen modulators
BRPI0513020A (en) 2004-07-08 2008-04-22 Warner Lambert Co androgen modulators, their uses, pharmaceutical composition, topical pharmaceutical formulation and article of manufacture
WO2006018723A2 (en) * 2004-08-18 2006-02-23 Warner-Lambert Company Llc Androgen modulators
MX2007002732A (en) * 2004-09-10 2007-04-24 Pfizer Prod Inc Therapeutic diphenyl ether ligands.
TW200724139A (en) 2005-05-05 2007-07-01 Warner Lambert Co Androgen modulators
WO2007010350A1 (en) * 2005-07-19 2007-01-25 Pfizer Products Inc. Synthesis of therapeutic diphenyl ethers
EP1943226A2 (en) 2005-10-13 2008-07-16 Smithkline Beecham Corporation Phenol ethers as modulators of the opioid receptors
WO2007076875A2 (en) * 2006-01-06 2007-07-12 Aarhus Universitet Compounds acting on the serotonin transporter
CA2656083A1 (en) * 2006-06-29 2008-01-03 Janssen Pharmaceutica N.V. Substituted aminomethyl benzamide compounds
CA2656089A1 (en) 2006-06-29 2008-01-03 Janssen Pharmaceutica N.V. Substituted benzyl amine compounds
WO2008002817A1 (en) * 2006-06-29 2008-01-03 Janssen Pharmaceutica N.V. Butyl and butynyl benzyl amine compounds
US8642583B2 (en) 2008-10-30 2014-02-04 Janssen Pharmaceutica Nv Serotonin receptor modulators
WO2010059390A1 (en) 2008-10-30 2010-05-27 Janssen Pharmaceutica Nv Modulators of serotonin receptor
KR101043200B1 (en) * 2010-11-08 2011-06-21 성시민 Air charging device for respiration air tank
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JP7413346B2 (en) 2019-03-06 2024-01-15 第一三共株式会社 Pyrrolopyrazole derivative

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ZA923283B (en) * 1991-05-29 1993-01-27 Akzo Nv Phenoxyphenyl derivatives
KR960703901A (en) * 1993-08-19 1996-08-31 로즈 암스트롱 Substituted 2 (5H) furanone, 2 (5H) thiophenone and 2 (5H) pyrrolone derivatives, methods for their preparation and their use as endothelin antagonists (Substituted 2 (5H) Furanone, 2 (5H) Thiophenone and 2 (5H) Pyrrolone Derivatives, Their Preparation and Their Use as Endothelin antagonists)
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WO1999047497A2 (en) * 1998-03-13 1999-09-23 Merck Frosst Canada & Co. Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
YU56301A (en) * 1999-02-23 2004-05-12 Pfizer Products Inc. Monoamine reuptake inhibitors for treatment of cns disorders
GB0007884D0 (en) * 2000-03-31 2000-05-17 Pfizer Ltd Diphenyl ether compounds useful in therapy

Also Published As

Publication number Publication date
NO20030842L (en) 2003-04-28
UY26924A1 (en) 2002-03-22
EE200300084A (en) 2005-02-15
HUP0303385A2 (en) 2004-03-01
WO2002018333A1 (en) 2002-03-07
EP1313701A1 (en) 2003-05-28
DZ3414A1 (en) 2002-03-07
CN1449380A (en) 2003-10-15
MA26945A1 (en) 2004-12-20
NO20030842D0 (en) 2003-02-24
OA12372A (en) 2006-04-17
DOP2001000242A (en) 2002-05-15
IS6704A (en) 2003-01-30
PL360743A1 (en) 2004-09-20
JP2004507523A (en) 2004-03-11
BR0113610A (en) 2003-06-24
PE20020346A1 (en) 2002-05-08
HN2001000191A (en) 2002-03-11
KR20030029889A (en) 2003-04-16
TNSN01131A1 (en) 2005-11-10
SK2012003A3 (en) 2004-06-08
CZ2003467A3 (en) 2004-04-14
IL154343A0 (en) 2003-09-17
HRP20030141A2 (en) 2003-04-30
MXPA03001848A (en) 2003-06-04
EA200300206A1 (en) 2003-06-26
BG107544A (en) 2003-10-31
AR031867A1 (en) 2003-10-08
CA2420969A1 (en) 2002-03-07
AU2001278650A1 (en) 2002-03-13
AP2001002265A0 (en) 2001-09-30
NZ523951A (en) 2004-09-24

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