PA8526701A1 - PHENOXIBENCILAMINE DERIVATIVES AS SSRI - Google Patents

PHENOXIBENCILAMINE DERIVATIVES AS SSRI

Info

Publication number
PA8526701A1
PA8526701A1 PA20018526701A PA8526701A PA8526701A1 PA 8526701 A1 PA8526701 A1 PA 8526701A1 PA 20018526701 A PA20018526701 A PA 20018526701A PA 8526701 A PA8526701 A PA 8526701A PA 8526701 A1 PA8526701 A1 PA 8526701A1
Authority
PA
Panama
Prior art keywords
rent
ring
independently
zey
alcoxi
Prior art date
Application number
PA20018526701A
Other languages
Spanish (es)
Inventor
Mark Leonard Elliott
Mark David Andrews
David Hepworth
Donald Stuart Middleton
Alan Stobie
Mavis Diane Adam
Harry Ralph Howard Jr
Geoffrey Edward Gymer
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0021593A external-priority patent/GB0021593D0/en
Priority claimed from GB0107116A external-priority patent/GB0107116D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of PA8526701A1 publication Critical patent/PA8526701A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/39—Heterocyclic compounds having sulfur as a ring hetero atom having oxygen in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)

Abstract

UN COMPUESTO DE FORMULA GENERAL (I) EN LA QUE R1 Y R2 SON H, ALQUILO C1-C6 O (CH2)d-(CICLOALQUILO C3-C6), DONDE d ES 0, 1, 2 O 3; O R1 Y R2 JUNTO CON EL NITROGENO AL QUE ESTAN UNIDOS FORMAN UN ANILLO DE AZETIDINA; UNO DE Z O Y ES -SR3 Y EL OTRO DE Z O Y ES HALOGENO O -R3; DONDE R3 ES INDEPENDIENTEMENTE ALQUILO C1-C4 OPCIONALMENTE SUSTITUIDO CON FLUOR; EXCEPTO QUE R3 NO ES CF3; O Z E Y ESTAN UNIDOS DE MANERA QUE, JUNTO CON LOS ATOMOS DE INTERCONEXION, Z E Y FORMAN UN ANILLO CARBOCICLICO O HETEROCICLICO DE 5 A 7 MIEMBROS, CONDENSADO, Y DONDE, CUANDO Z E Y FORMAN UN ANILLO HETEROCICLICO, ADEMAS DE ATOMOS DE CARBONO, EL ENLACE CONTIENE UNO O DOS HETEROATOMOS SELECCIONADOS INDEPENDIENTEMENTE ENTRE OXIGENO, AZUFRE Y NITROGENO; R4 Y R5, QUE PUEDEN SER IGUALES O DIFERENTES, SON: A-X, DONDE A ES -CH=CH- O -(CH2)P-, DONDE P ES O,1 O 2; X ES HIDROGENO, F, CL, BR, I, CONR6R7, SO2NR6R7, SO2NHC (=O)R6, OH, ALCOXI C1-4, NR8SO2R9, NO2, NROR11, CN, CO2R10, CHO, SR10, S(O)R9 O SO2R10; O UN ANILLO HETEROCICLICO DE 5 O 6 MIEMBROS QUE CONTIENE 1, 2, O 3 HETEROATOMOS SELECCIONADOS ENTRE N, S Y O, OPCIONALMENTE SUSTITUIDO INDEPENDIENTEMENTE CON UNO O MAS R13; DONDE R13 ES HIDROXI, ALCOXI C1-C4, F, ALQUILO C1-C6, HALOALQUILO, HALOALCOXI, -NH2, -NH(ALQUILO C1-C6) O -N(ALQUILO C1-C6)2.A COMPOSITE OF GENERAL FORMULA (I) IN WHICH R1 AND R2 ARE H, I RENT C1-C6 OR (CH2) d- (CYCLEALKYL C3-C6), WHERE d IS 0, 1, 2 OR 3; OR R1 AND R2 TOGETHER WITH THE NITROGEN TO WHICH THEY ARE UNITED, FORM AN AZETIDINE RING; ONE OF Z O AND IS -SR3 AND THE OTHER OF Z O Y IS HALOGEN OR -R3; WHERE R3 IS INDEPENDENTLY RENT C1-C4 OPTIONALLY REPLACED WITH FLUOR; EXCEPT THAT R3 IS NOT CF3; OZEY ARE UNITED IN A WAY THAT, WITH THE INTERCONNECTION ATOMS, ZEY FORMS A CARBOCICLIC OR HETEROCICLICAL RING OF 5 TO 7 MEMBERS, CONDENSED, AND WHERE, WHEN ZEY FORM A HETEROCICLICAL RING, IN ADDITION TO CARBONET OTHERS TWO SELECTED HETEROATOMOS INDEPENDENTLY BETWEEN OXYGEN, SULFUR AND NITROGEN; R4 AND R5, WHICH CAN BE EQUAL OR DIFFERENT, ARE: A-X, WHERE TO ES -CH = CH- O - (CH2) P-, WHERE P IS O, 1 OR 2; X ES HYDROGEN, F, CL, BR, I, CONR6R7, SO2NR6R7, SO2NHC (= O) R6, OH, ALCOXI C1-4, NR8SO2R9, NO2, NROR11, CN, CO2R10, CHO, SR10, S (O) R9 O SO2R10; OR A HETEROCICLIC RING OF 5 OR 6 MEMBERS CONTAINING 1, 2, OR 3 SELECTED HETEROATOMES BETWEEN N, S AND O, OPTIONALLY REPLACED INDEPENDENTLY WITH ONE OR MORE R13; WHERE R13 IS HYDROXI, ALCOXI C1-C4, F, RENT C1-C6, HALOALQUILO, HALOALCOXI, -NH2, -NH (RENT C1-C6) OR -N (RENT C1-C6) 2.

PA20018526701A 2000-08-31 2001-08-24 PHENOXIBENCILAMINE DERIVATIVES AS SSRI PA8526701A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0021593A GB0021593D0 (en) 2000-08-31 2000-08-31 Diphenyl ether compounds useful in therapy
GB0107116A GB0107116D0 (en) 2001-03-21 2001-03-21 Novel compounds

Publications (1)

Publication Number Publication Date
PA8526701A1 true PA8526701A1 (en) 2003-07-28

Family

ID=26244953

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20018526701A PA8526701A1 (en) 2000-08-31 2001-08-24 PHENOXIBENCILAMINE DERIVATIVES AS SSRI

Country Status (32)

Country Link
EP (1) EP1313701A1 (en)
JP (1) JP2004507523A (en)
KR (1) KR20030029889A (en)
CN (1) CN1449380A (en)
AP (1) AP2001002265A0 (en)
AR (1) AR031867A1 (en)
AU (1) AU2001278650A1 (en)
BG (1) BG107544A (en)
BR (1) BR0113610A (en)
CA (1) CA2420969A1 (en)
CZ (1) CZ2003467A3 (en)
DO (1) DOP2001000242A (en)
DZ (1) DZ3414A1 (en)
EA (1) EA200300206A1 (en)
EE (1) EE200300084A (en)
HN (1) HN2001000191A (en)
HR (1) HRP20030141A2 (en)
HU (1) HUP0303385A2 (en)
IL (1) IL154343A0 (en)
IS (1) IS6704A (en)
MA (1) MA26945A1 (en)
MX (1) MXPA03001848A (en)
NO (1) NO20030842L (en)
NZ (1) NZ523951A (en)
OA (1) OA12372A (en)
PA (1) PA8526701A1 (en)
PE (1) PE20020346A1 (en)
PL (1) PL360743A1 (en)
SK (1) SK2012003A3 (en)
TN (1) TNSN01131A1 (en)
UY (1) UY26924A1 (en)
WO (1) WO2002018333A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403597B1 (en) * 1997-10-28 2002-06-11 Vivus, Inc. Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation
US6436938B1 (en) * 2001-01-22 2002-08-20 Pfizer Inc. Combination treatment for depression
US20020107244A1 (en) * 2001-02-02 2002-08-08 Howard Harry R. Combination treatment for depression
US20020183306A1 (en) * 2001-05-30 2002-12-05 Pfizer Inc. Combination treatment for sleep disorders including sleep apnea
GB0318706D0 (en) * 2003-08-08 2003-09-10 Pfizer Ltd Selective serotonin reuptake inhibitors in the treatment of disease
AP2006003700A0 (en) 2004-02-13 2006-08-31 Warner Lambert Co Androgen receptor modulators
US7507860B2 (en) 2004-04-13 2009-03-24 Pfizer Inc. Androgen modulators
CA2562672C (en) 2004-04-22 2009-09-29 Warner-Lambert Company Llc 4-cyano-phenoxy derivatives as androgen modulators
BRPI0513020A (en) 2004-07-08 2008-04-22 Warner Lambert Co androgen modulators, their uses, pharmaceutical composition, topical pharmaceutical formulation and article of manufacture
WO2006018723A2 (en) * 2004-08-18 2006-02-23 Warner-Lambert Company Llc Androgen modulators
MX2007002732A (en) * 2004-09-10 2007-04-24 Pfizer Prod Inc Therapeutic diphenyl ether ligands.
TW200724139A (en) 2005-05-05 2007-07-01 Warner Lambert Co Androgen modulators
WO2007010350A1 (en) * 2005-07-19 2007-01-25 Pfizer Products Inc. Synthesis of therapeutic diphenyl ethers
EP1943226A2 (en) 2005-10-13 2008-07-16 Smithkline Beecham Corporation Phenol ethers as modulators of the opioid receptors
WO2007076875A2 (en) * 2006-01-06 2007-07-12 Aarhus Universitet Compounds acting on the serotonin transporter
CA2656083A1 (en) * 2006-06-29 2008-01-03 Janssen Pharmaceutica N.V. Substituted aminomethyl benzamide compounds
CA2656089A1 (en) 2006-06-29 2008-01-03 Janssen Pharmaceutica N.V. Substituted benzyl amine compounds
WO2008002817A1 (en) * 2006-06-29 2008-01-03 Janssen Pharmaceutica N.V. Butyl and butynyl benzyl amine compounds
US8642583B2 (en) 2008-10-30 2014-02-04 Janssen Pharmaceutica Nv Serotonin receptor modulators
WO2010059390A1 (en) 2008-10-30 2010-05-27 Janssen Pharmaceutica Nv Modulators of serotonin receptor
KR101043200B1 (en) * 2010-11-08 2011-06-21 성시민 Air charging device for respiration air tank
DE112011104795T5 (en) 2011-01-27 2013-10-31 Hewlett-Packard Development Company, L.P. Computer apparatus for connection to a portable device
JP7413346B2 (en) 2019-03-06 2024-01-15 第一三共株式会社 Pyrrolopyrazole derivative

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA923283B (en) * 1991-05-29 1993-01-27 Akzo Nv Phenoxyphenyl derivatives
KR960703901A (en) * 1993-08-19 1996-08-31 로즈 암스트롱 Substituted 2 (5H) furanone, 2 (5H) thiophenone and 2 (5H) pyrrolone derivatives, methods for their preparation and their use as endothelin antagonists (Substituted 2 (5H) Furanone, 2 (5H) Thiophenone and 2 (5H) Pyrrolone Derivatives, Their Preparation and Their Use as Endothelin antagonists)
CZ293595A3 (en) * 1995-11-09 1999-12-15 Farmak A. S. Derivatives of n,n-dimethyl-2-(arylthio)benzylamine, their salts, processes of their preparation and their use in medicaments
WO1999047497A2 (en) * 1998-03-13 1999-09-23 Merck Frosst Canada & Co. Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
YU56301A (en) * 1999-02-23 2004-05-12 Pfizer Products Inc. Monoamine reuptake inhibitors for treatment of cns disorders
GB0007884D0 (en) * 2000-03-31 2000-05-17 Pfizer Ltd Diphenyl ether compounds useful in therapy

Also Published As

Publication number Publication date
NO20030842L (en) 2003-04-28
UY26924A1 (en) 2002-03-22
EE200300084A (en) 2005-02-15
HUP0303385A2 (en) 2004-03-01
WO2002018333A1 (en) 2002-03-07
EP1313701A1 (en) 2003-05-28
DZ3414A1 (en) 2002-03-07
CN1449380A (en) 2003-10-15
MA26945A1 (en) 2004-12-20
NO20030842D0 (en) 2003-02-24
OA12372A (en) 2006-04-17
DOP2001000242A (en) 2002-05-15
IS6704A (en) 2003-01-30
PL360743A1 (en) 2004-09-20
JP2004507523A (en) 2004-03-11
BR0113610A (en) 2003-06-24
PE20020346A1 (en) 2002-05-08
HN2001000191A (en) 2002-03-11
KR20030029889A (en) 2003-04-16
TNSN01131A1 (en) 2005-11-10
SK2012003A3 (en) 2004-06-08
CZ2003467A3 (en) 2004-04-14
IL154343A0 (en) 2003-09-17
HRP20030141A2 (en) 2003-04-30
MXPA03001848A (en) 2003-06-04
EA200300206A1 (en) 2003-06-26
BG107544A (en) 2003-10-31
AR031867A1 (en) 2003-10-08
CA2420969A1 (en) 2002-03-07
AU2001278650A1 (en) 2002-03-13
AP2001002265A0 (en) 2001-09-30
NZ523951A (en) 2004-09-24

Similar Documents

Publication Publication Date Title
PA8526701A1 (en) PHENOXIBENCILAMINE DERIVATIVES AS SSRI
SV2002000363A (en) DIFENILIC ETER COMPOUNDS USEFUL IN THERAPY REF. PCS10327ARCS / BB
ES2220529T3 (en) USEFUL DIBENZOPIRANS AS ANTAGONISTS OF THE GLUCOCORTICOID RECEPTOR, IN THE TREATMENT OF DIABETES.
AR039489A1 (en) DERIVATIVES OF TETRAHYDROPIRANIL CYCLOPENTIL TETRAHYDROPIRIDOPIRIDINE, MODULATORS OF ACTIVITY OF CYTOKIN RECEPTORS
ES2161231T3 (en) HETEROCICLICAL COMPOUNDS AS AN ANTIGONIST OF BRADIQUININA.
YU45293A (en) TYOMORPHOL MORPHOLIN TAHIKIN ANTAGONIST RECEPTORA
UY27457A1 (en) DERIVATIVES OF 1,8-NAFTIRIDINE AND ITS USE FOR THE TREATMENT OF DIABETES AND RELATED DISORDERS
CO4560411A1 (en) NEW SUBSTITUTED OXAZOLIDINONES
SV2006002126A (en) DERIVATIVES OF TETRAHYDROISOQUINOLILSULFONAMIDAS, ITS PREPARATION AND ITS USE IN THERAPEUTICS
ES2183905T3 (en) MATRIX METALOPROTEASE INHIBITORS.
ES2160106T3 (en) DERIVATIVES OF QUINAZOLINE.
TR199900486T2 (en) Azinyloxy and phenoxy-diaryl-carboxylic acid derivatives.
ES2159749T3 (en) DERIVATIVES OF BENCILAMINO-2-METHYL-PROPANAMIDS 2- (4-SUBSTITUTES).
DE602005024245D1 (en) TRICYCLIC BENZOPYRANE COMPOUNDS AS ANTIARRHYTHMIKA
ES2158840T3 (en) NEW USEFUL CARBOCICLIC ADENOSINE ANALOGS AS IMMUNOSUPPRESSORS.
PE16399A1 (en) GUANIDINYL HETERO-CYCLE COMPOUNDS USEFUL AS ALPHA-2 ADRENORECEPTOR AGONISTS
EP1229025A4 (en) Novel quinazoline derivatives
ES2164366T3 (en) DERIVED FROM THE DISTAMICINA ACRILOIL REPLACED, ASSOCIATED MANUFACTURING PROCEDURE AND ITS USE AS ANTITUMORAL AND ANTIVIRAL AGENTS.
EP1070715A4 (en) Arylpiperidine derivatives and use thereof
ES2158861T3 (en) 4-IMIDOMETIL-1- (2'-PHENYL-2'-OXOETIL) -PIPERIDINS AS INHIBITORS OF THE 5HT2 RECEPTORS OF THE SEROTONINE, ITS PREPARATION AND THERAPEUTIC APPLICATIONS.
ES2155660T3 (en) DERIVATIVES OF BENCIMIDAZOL, BENZOXAZOL AND BENZOTIAZOL, USED AS INHIBITORS OF INTERLEUQUINA 1BETA.
AR054121A1 (en) PHENYL PIRIDYL PIPERAZINE COMPOUNDS, PREPARATION PROCEDURE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PHARMACOLOGICAL USES AS ANTAGONIST OF HISTAMINERGIC RECEPTORS H3
AR037125A1 (en) REPLACED INDOLES
ES2132761T3 (en) DERIVATIVES OF THE ACID PIPERIDIN ACETICO USEFUL AS ANTAGONISTS OF THE FIBRINOGEN.
ES2188134T3 (en) CICLOHEXANDIOL DERIVATIVES.