EA200300206A1 - PHENOXYBENZYLAMINE DERIVATIVES AS A SEROTONIN REPEATED ABSORPTION INHIBITORS - Google Patents
PHENOXYBENZYLAMINE DERIVATIVES AS A SEROTONIN REPEATED ABSORPTION INHIBITORSInfo
- Publication number
- EA200300206A1 EA200300206A1 EA200300206A EA200300206A EA200300206A1 EA 200300206 A1 EA200300206 A1 EA 200300206A1 EA 200300206 A EA200300206 A EA 200300206A EA 200300206 A EA200300206 A EA 200300206A EA 200300206 A1 EA200300206 A1 EA 200300206A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- heterocyclic ring
- serotonin
- general formula
- phenoxybenzylamine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/39—Heterocyclic compounds having sulfur as a ring hetero atom having oxygen in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/06—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Abstract
Соединение общей формулы (I), где Rи Rпредставляют собой H, C-Cалкил или (CH)(C-Cциклоалкил), где d = 0, 1, 2 или 3; или Rи Rвместе с атомом азота, к которому они присоединены, образуют азетидиновое кольцо; один из Z и Y представляет собой -SR, а другой представляет собой галоген или -R; где Rнезависимо представляет собой C-Cалкил, необязательно замещенный фтором; при условии, что Rне является CF; или Z и Y соединены так, что вместе с соединяющими их атомами образуют конденсированное 5-7-членное карбоциклическое или гетероциклическое кольцо, и когда Z и Y образуют гетероциклическое кольцо, оно помимо атомов углерода содержит один или два гетероатома, независимо выбранных из кислорода, серы и азота; Rи R, которые могут быть одинаковыми или разными, представляют собой A-X, где A = -CH=CH- или -(CH)-, где p равно 0, 1 или 2; X представляет собой водород, F, Cl, Br, I, CONRR, SONRR, SONHC(=O)R, OH, Cалкокси, NRSOR, NO, NRR, CN, COR, CHO, SR, S(O)Rили SORили 5- или 6-членное гетероциклическое кольцо, содержащее 1, 2 или 3 гетероатома, выбранных из N, S и O, и необязательно независимо замещенное одним или несколькими R; где Rпредставляет собой гидроксильную группу, C-Cалкоксигруппу, F, C-Cалкил, галогеналкил, галогеналкоксигруппу, -NH, -NH(C-Cалкил) или -N(C-Cалкил). Соединения общей формулы (I) ингибируют повторное поглощение моноаминов, в частности, проявляют активность в качестве ингибиторов повторного поглощения серотонина.Международная заявка была опубликована вместе с отчетом о международном поиске.The compound of general formula (I), where R 1 and R 5 is H, C 1 -C 6 alkyl or (CH) (C 1 -C 5 cycloalkyl), where d = 0, 1, 2 or 3; or R and R together with the nitrogen atom to which they are attached, form an azetidine ring; one of Z and Y is -SR, and the other is halogen or -R; wherein R independently is C 1 -C 6 alkyl optionally substituted with fluorine; with the proviso that R is not CF; or Z and Y are connected so that together with the atoms connecting them form a fused 5-7-membered carbocyclic or heterocyclic ring, and when Z and Y form a heterocyclic ring, it contains, in addition to carbon atoms, one or two heteroatoms independently selected from oxygen, sulfur and nitrogen; R and R, which may be the same or different, are A-X, where A = -CH = CH- or - (CH) -, where p is 0, 1 or 2; X represents hydrogen, F, Cl, Br, I, CONRR, SONRR, SONHC (= O) R, OH, Salkoxy, NRSOR, NO, NRR, CN, COR, CHO, SR, S (O) R or SOR or 5- or a 6-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, S and O, and optionally independently substituted with one or more R; where R 1 is a hydroxyl group, a C 1 -C 6 alkoxy group, F, C 1 -C 6 alkyl, haloalkyl, a halogenoalkoxy group, -NH, -NH (C 1 -C 6 alkyl) or -N (C 1 -C 6 alkyl). The compounds of general formula (I) inhibit the reuptake of monoamines, in particular, are active as serotonin reuptake inhibitors. The international application was published along with an international search report.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0021593A GB0021593D0 (en) | 2000-08-31 | 2000-08-31 | Diphenyl ether compounds useful in therapy |
GB0107116A GB0107116D0 (en) | 2001-03-21 | 2001-03-21 | Novel compounds |
PCT/IB2001/001521 WO2002018333A1 (en) | 2000-08-31 | 2001-08-22 | Phenoxybenzylamine derivatives as selective serotonin re-uptake inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200300206A1 true EA200300206A1 (en) | 2003-06-26 |
Family
ID=26244953
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200300206A EA200300206A1 (en) | 2000-08-31 | 2001-08-22 | PHENOXYBENZYLAMINE DERIVATIVES AS A SEROTONIN REPEATED ABSORPTION INHIBITORS |
Country Status (32)
Country | Link |
---|---|
EP (1) | EP1313701A1 (en) |
JP (1) | JP2004507523A (en) |
KR (1) | KR20030029889A (en) |
CN (1) | CN1449380A (en) |
AP (1) | AP2001002265A0 (en) |
AR (1) | AR031867A1 (en) |
AU (1) | AU2001278650A1 (en) |
BG (1) | BG107544A (en) |
BR (1) | BR0113610A (en) |
CA (1) | CA2420969A1 (en) |
CZ (1) | CZ2003467A3 (en) |
DO (1) | DOP2001000242A (en) |
DZ (1) | DZ3414A1 (en) |
EA (1) | EA200300206A1 (en) |
EE (1) | EE200300084A (en) |
HN (1) | HN2001000191A (en) |
HR (1) | HRP20030141A2 (en) |
HU (1) | HUP0303385A2 (en) |
IL (1) | IL154343A0 (en) |
IS (1) | IS6704A (en) |
MA (1) | MA26945A1 (en) |
MX (1) | MXPA03001848A (en) |
NO (1) | NO20030842L (en) |
NZ (1) | NZ523951A (en) |
OA (1) | OA12372A (en) |
PA (1) | PA8526701A1 (en) |
PE (1) | PE20020346A1 (en) |
PL (1) | PL360743A1 (en) |
SK (1) | SK2012003A3 (en) |
TN (1) | TNSN01131A1 (en) |
UY (1) | UY26924A1 (en) |
WO (1) | WO2002018333A1 (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6403597B1 (en) * | 1997-10-28 | 2002-06-11 | Vivus, Inc. | Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation |
US6436938B1 (en) * | 2001-01-22 | 2002-08-20 | Pfizer Inc. | Combination treatment for depression |
US20020107244A1 (en) * | 2001-02-02 | 2002-08-08 | Howard Harry R. | Combination treatment for depression |
US20020183306A1 (en) * | 2001-05-30 | 2002-12-05 | Pfizer Inc. | Combination treatment for sleep disorders including sleep apnea |
GB0318706D0 (en) * | 2003-08-08 | 2003-09-10 | Pfizer Ltd | Selective serotonin reuptake inhibitors in the treatment of disease |
AP2006003700A0 (en) | 2004-02-13 | 2006-08-31 | Warner Lambert Co | Androgen receptor modulators |
BRPI0509759A (en) | 2004-04-13 | 2007-10-16 | Warner Lambert Co | androgen modulators |
EP1740533A1 (en) | 2004-04-22 | 2007-01-10 | Warner-Lambert Company LLC | Androgen modulators |
CA2570047C (en) | 2004-07-08 | 2010-09-28 | Warner-Lambert Company Llc | 4-cycloalkoxy benzonitriles as androgen modulators |
JP2008509983A (en) * | 2004-08-18 | 2008-04-03 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | Androgen modulator |
BRPI0514675A (en) * | 2004-09-10 | 2008-06-17 | Pfizer Prod Inc | therapeutic diphenyl ether binders |
TW200724139A (en) | 2005-05-05 | 2007-07-01 | Warner Lambert Co | Androgen modulators |
WO2007010350A1 (en) * | 2005-07-19 | 2007-01-25 | Pfizer Products Inc. | Synthesis of therapeutic diphenyl ethers |
EP1943226A2 (en) | 2005-10-13 | 2008-07-16 | Smithkline Beecham Corporation | Phenol ethers as modulators of the opioid receptors |
WO2007076875A2 (en) * | 2006-01-06 | 2007-07-12 | Aarhus Universitet | Compounds acting on the serotonin transporter |
CN101511785A (en) * | 2006-06-29 | 2009-08-19 | 詹森药业有限公司 | Substituted benzyl amine compounds |
AU2007265239A1 (en) | 2006-06-29 | 2008-01-03 | Janssen Pharmaceutica N.V. | Butyl and butynyl benzyl amine compounds |
AU2007265240A1 (en) * | 2006-06-29 | 2008-01-03 | Janssen Pharmaceutica N.V. | Substituted aminomethyl benzamide compounds |
US8642583B2 (en) | 2008-10-30 | 2014-02-04 | Janssen Pharmaceutica Nv | Serotonin receptor modulators |
WO2010059390A1 (en) | 2008-10-30 | 2010-05-27 | Janssen Pharmaceutica Nv | Modulators of serotonin receptor |
KR101043200B1 (en) * | 2010-11-08 | 2011-06-21 | 성시민 | Air charging device for respiration air tank |
DE112011104795T5 (en) | 2011-01-27 | 2013-10-31 | Hewlett-Packard Development Company, L.P. | Computer apparatus for connection to a portable device |
KR20210135521A (en) | 2019-03-06 | 2021-11-15 | 다이이찌 산쿄 가부시키가이샤 | pyrrolopyrazole derivatives |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA923283B (en) * | 1991-05-29 | 1993-01-27 | Akzo Nv | Phenoxyphenyl derivatives |
JPH09501920A (en) * | 1993-08-19 | 1997-02-25 | ワーナー−ランバート・コンパニー | Non-peptide endothelin antagonist ▲ I ▼ |
CZ293595A3 (en) * | 1995-11-09 | 1999-12-15 | Farmak A. S. | Derivatives of n,n-dimethyl-2-(arylthio)benzylamine, their salts, processes of their preparation and their use in medicaments |
EP1071648A2 (en) * | 1998-03-13 | 2001-01-31 | Merck Frosst Canada & Co. | Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment |
AP2001002252A0 (en) * | 1999-02-23 | 2001-09-30 | Pfizer Prod Inc | Monoamine reuptake inhibitors for treatment of CNS disorders. |
GB0007884D0 (en) * | 2000-03-31 | 2000-05-17 | Pfizer Ltd | Diphenyl ether compounds useful in therapy |
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2001
- 2001-08-22 CA CA002420969A patent/CA2420969A1/en not_active Abandoned
- 2001-08-22 KR KR10-2003-7003011A patent/KR20030029889A/en not_active Application Discontinuation
- 2001-08-22 EE EEP200300084A patent/EE200300084A/en unknown
- 2001-08-22 EP EP01956734A patent/EP1313701A1/en not_active Withdrawn
- 2001-08-22 CN CN01814846A patent/CN1449380A/en active Pending
- 2001-08-22 JP JP2002523451A patent/JP2004507523A/en active Pending
- 2001-08-22 HU HU0303385A patent/HUP0303385A2/en unknown
- 2001-08-22 MX MXPA03001848A patent/MXPA03001848A/en active IP Right Grant
- 2001-08-22 BR BR0113610-0A patent/BR0113610A/en not_active IP Right Cessation
- 2001-08-22 OA OA1200300056A patent/OA12372A/en unknown
- 2001-08-22 CZ CZ2003467A patent/CZ2003467A3/en unknown
- 2001-08-22 AP APAP/P/2001/002265A patent/AP2001002265A0/en unknown
- 2001-08-22 AU AU2001278650A patent/AU2001278650A1/en not_active Abandoned
- 2001-08-22 WO PCT/IB2001/001521 patent/WO2002018333A1/en not_active Application Discontinuation
- 2001-08-22 SK SK201-2003A patent/SK2012003A3/en unknown
- 2001-08-22 PL PL36074301A patent/PL360743A1/en not_active Application Discontinuation
- 2001-08-22 NZ NZ523951A patent/NZ523951A/en unknown
- 2001-08-22 IL IL15434301A patent/IL154343A0/en unknown
- 2001-08-22 DZ DZ013414A patent/DZ3414A1/en active
- 2001-08-22 EA EA200300206A patent/EA200300206A1/en unknown
- 2001-08-24 PA PA20018526701A patent/PA8526701A1/en unknown
- 2001-08-28 HN HN2001000191A patent/HN2001000191A/en unknown
- 2001-08-28 PE PE2001000862A patent/PE20020346A1/en not_active Application Discontinuation
- 2001-08-29 DO DO2001000242A patent/DOP2001000242A/en unknown
- 2001-08-29 AR ARP010104114A patent/AR031867A1/en unknown
- 2001-08-30 TN TNTNSN01131A patent/TNSN01131A1/en unknown
- 2001-08-31 UY UY26924A patent/UY26924A1/en not_active Application Discontinuation
-
2003
- 2003-01-30 IS IS6704A patent/IS6704A/en unknown
- 2003-02-07 BG BG107544A patent/BG107544A/en unknown
- 2003-02-21 MA MA27049A patent/MA26945A1/en unknown
- 2003-02-24 NO NO20030842A patent/NO20030842L/en not_active Application Discontinuation
- 2003-02-26 HR HR20030141A patent/HRP20030141A2/en not_active Application Discontinuation
Also Published As
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DOP2001000242A (en) | 2002-05-15 |
PE20020346A1 (en) | 2002-05-08 |
IS6704A (en) | 2003-01-30 |
BR0113610A (en) | 2003-06-24 |
AP2001002265A0 (en) | 2001-09-30 |
SK2012003A3 (en) | 2004-06-08 |
UY26924A1 (en) | 2002-03-22 |
HN2001000191A (en) | 2002-03-11 |
HRP20030141A2 (en) | 2003-04-30 |
EE200300084A (en) | 2005-02-15 |
AR031867A1 (en) | 2003-10-08 |
TNSN01131A1 (en) | 2005-11-10 |
MXPA03001848A (en) | 2003-06-04 |
IL154343A0 (en) | 2003-09-17 |
MA26945A1 (en) | 2004-12-20 |
PA8526701A1 (en) | 2003-07-28 |
BG107544A (en) | 2003-10-31 |
KR20030029889A (en) | 2003-04-16 |
NZ523951A (en) | 2004-09-24 |
DZ3414A1 (en) | 2002-03-07 |
PL360743A1 (en) | 2004-09-20 |
NO20030842D0 (en) | 2003-02-24 |
HUP0303385A2 (en) | 2004-03-01 |
CZ2003467A3 (en) | 2004-04-14 |
JP2004507523A (en) | 2004-03-11 |
OA12372A (en) | 2006-04-17 |
NO20030842L (en) | 2003-04-28 |
WO2002018333A1 (en) | 2002-03-07 |
AU2001278650A1 (en) | 2002-03-13 |
CA2420969A1 (en) | 2002-03-07 |
EP1313701A1 (en) | 2003-05-28 |
CN1449380A (en) | 2003-10-15 |
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