OA21195A

OA21195A - Synergistic pesticidal composition against sucking pests complex.

Info

Publication number: OA21195A
Application number: OA1202200511
Authority: OA
Inventors: Vimal Kumar; Raajan Kumar Ailawadhi; Ajit S Gujral
Original assignee: Best Agrolife Limited
Priority date: 2020-06-05
Filing date: 2021-06-12
Publication date: 2024-02-29

Abstract

A synergistic insecticidal composition comprising of bioactive amount of Diafenthiuron and Pyriproxyfen with at least one agro-chemically active insecticide selected from Thiamethoxam, Imidacloprid, Thiacloprid, Dinotefuran, Clothianidin, and Pymetrozine. The present invention further relates to process for preparing the said compositions in specific ratio. The present invention further relates to the process for preparing the said composition along with at least one inactive excipient; and formulations thereof. The present invention further relates to the synergistic insecticidal compositions, wherein active ingredient present in fixed ratio shows synergy in insecticidal activity and formulation thereof are stable in nature.

Description

SYNERGISTIC PESTICIDAL COMPOSITION AGAINST SUCKING PESTS COMPLEX

FIELD OF THE INVENTION:

The présent invention relates to synergistic pesticidal compositions against sucking pests complex. More particularly, the présent invention relates to a synergistic pesticidal composition comprising of bioactive amounts of Diafenthiuron; Pyriproxyfen; and at least one agro-chemically active insecticide selected from Thiamethoxam, Imidacloprid, Thiacloprid, Dinotefuran, Clothianidin, and Pymetrozine. The présent invention also relates to process for preparing such compositions.

BACKGROUND OF THE INVENTION:

Pesticides including insecticides are used widely and very frequently in commercial agriculture and hâve enabled an enormous increase in crop yields and product quality which ultimately increased the ease to farmers in term of économie advantage as well as ease of farming activities.

Insecticides are a type of pesticide that is used to specifically target and kill insects. Some insecticides include snail bait, ant killer, and wasp killer. An insecticide is a substance used to kill insects. They include ovicides and larvicides used against insect eggs and larvae, respectively. Insecticides are used in agriculture, medicine, industry and by consumers.

In general use, the pesticide actives are used in the form of a dilute aqueous composition because it can attain a good interaction with the target organism, such as plants, fungi and insects. However, most active pesticide compounds that are used as pesticides are only sparingly or even insoluble in water. The low solubility of such compounds présent the challenges and difficulties to formulator in formulating pesticide compounds in stable formulations that can be easily stored for a long time and which still hâve a high stability and effective activity until end use. This problem especially occurs and may get worsen if more than one active compound is présent in the composition.

Varions compositions hâve been developed to control insect-pests and in practice hâve been used as a single or mixed agent. Practical agricultural expérience has shown that the repeated and exclusive application of an individual active compound for the control of harmful insect-pests leads in many cases to a rapid sélection of those strains which hâve developed naturel or adapted résistance against the active compound in question. Effective control of such insect-pests with the active compound in question is very difficult in such cases.

To reduce the risk of the sélection strains, mixtures of different active compounds are employed for controlling insect-pests. It is possible to ensure successful control over a relatively long period of time by combining active compounds having different mechanisms of action.

Certain mixtures of active compounds are proposed for pest control in the earlier literature. U.S. Patent No.4,104,376 discloses a synergistic formulation for insect control comprised of a combination of phosphorodithioate and formamidine at a ratio of 1 to 0.1 - 1.0, preferably 1 to about 0.2 - 0.5.

U. S. Patent No.4,613,617 discloses synergistic compositions for insect control comprising dione esters and other insecticides, such as pyrethroids, carba- mates and organophosphates.

U.S. Patent No.4,767,773 discloses synergistic compositions for insect control comprising benzoyl ureas and pyrethroids, carbamates, and organophosphates.

U.S. Patent No.5,187,184 discloses that synergistic compositions for insect control comprising adding aryl nitro pyrrole or arylpyrrole- carbonitrile to a compositions of aryl pyrazole carboximide provides superior pest control at lower levels of the combined active ingrédients than may be achieved with the aryl nitro pyrrole or aryl pyrrole carbo nitrile or aryl pyrazole carboximide applied alone at equal or higher levels than the total amount of active agent used in the combination treatment.

U.S. Patent No.5,491,168 discloses synergistic compositions for insect control comprising propargite (tert. butyl phenoxy cyclohexyl propynyl sulfite) and a pyrethroid. Finally, JP Kokai (A) H8-198719 published August 6, 1996 discloses agricultural and horticultural fungicides comprised of a synergistic combination of a substance which inhibits the complex I enzyme reaction of the mitochondria électron transfer System (e.g., Pyridaben) and a substance which inhibits the complex III enzyme reaction of the mitochondria électron transfer System (e. g., kresoxim-methyl). (Entire content of ail these prior arts are expressly incorporated hereinto by reference).

753/MUM/2012 relates to a composition comprising an effective amount of lambda Cyhalothrin in the range of 0.5% to 12%; an effective amount of Diafenthiuron in the range of 15% to 70% wherein the ratio of Lambda Cyhalothrin to Diafenthiuron is in the range of 1:4 to 1:35; and at least one agrochemical excipient.

However, the biological properties of these mixtures of known compounds mentioned above are not completely satisfactory in the field of pest control.

Thus, there still exists a need to develop novel pesticidal compositions showing a broader scope of activity and a synergistic effect in order to avoid or to control the development of résistant strains to the active ingredients/compounds or to the mixtures of known active ingrédients used by farmer while minimizing the doses of Chemical products spread in the environment and reducing the cost of the treatment. A need also exists for synergistic pesticidal compositions which shall be physio-chemically compatible formulations in the form of storage stable, safely packed and ready to use formulation.

In particular, there exists a need for a synergistic composition of Diafenthiuron; Pyriproxyfen in combination with Neonicotinoid insecticides.

Diafenthiuron was fîrst disclosed in GB2060626. Diafenthiuron is chemically known as 1-tertbutyl-3-(2,6-di-isopropyl-4-phenoxyphenyl) thiourea or N-[2,6-bis(l-methylethyl)-4phenoxyphenyl]-N'-(l,ldimethyl- ethyl ) thiourea and having Chemical structure as below:

çh₃

CH,—CH S

Il ÇH₃ ^c\ I

N—C—CH₃

H CH₃ ch₃

Diafenthiuron is a broad spectrum insecticide having contact and stomach action. Diafenthiuron acts after conversion by either light, or in vivo, to the corresponding carbodiimide, which is an inhibitor of mitochondrial respiration. Mode of action as insecticide and acaricide which kills larvae, nymphs and adults is by contact and/or stomach action; also shows some ovicidal action. It is commonly used as insecticide and acaricide effective against phytophagous mites

(tetranychidae, tarsonemidae), aleyrodidae, aphididae and jassidae on cotton, varions field and fruit crops, omamentals and vegetables. The effect of Diafenthiuron is based on the inhibition of ATP synthesis. Diafenthiuron also Controls some leaf-feeding pests in cole crops (Plutellaxylostella), soya beans (Anticarsiagemmatalis) and cotton (Alabama argillacea).

Pyriproxyfen, is chemically known as 4-phenoxyphenyl (RS)-2-(2-pyridyloxy)propyl ether 2-[l(4-phenoxyphenoxy)propan-2-yloxy]pyridine and having Chemical structure as below:

Pyriproxyfen is a pyridine-based pesticide which is found to be effective against a variety of arthropoda. Pyriproxyfen is a solid (melting range 48-50°C) of low volatility and only slightly soluble in water. It was introduced to the US in 1996, to protect cotton crops against whitefly. It has also been found useful for protecting other crops. It is also used as prévention for fleas on household pets. Pyriproxyfen is a juvénile hormone analog and an insect growth regulator, preventing larvae from developing into adulthood and thus rendering them unable to reproduce.

Neonicotinoids being broad spectrum insecticides are a class of neuro-active insecticides chemically similar to nicotine. Neonicotinoids are neurotoxins that target the nicotinic acétylcholine receptor acting as agonists. Neonicotinoids also affects the CNS (central nervous System) of the insects as it binds agonistically to the post-synaptic nicotinic acétylcholine receptors that results in the spontaneous discharge of nerve impulses and eventual failure of the neuron to propagate any signal. Although they are effective as contact insecticides, it is the ability of these Chemicals to translocate from the soil into leaves as systemic insecticides that has been one of the primary reasons for their popularity. Neonicotinoids are used to protect a variety of vegetables, fruits, and major crops like corn, cotton, potato, rice, etc. against sucking insects like aphids, whiteflies, thrips, leaf- and plant hoppers. These insecticides are recommended for the control of sucking pests of cotton, as they are most effective against thrips, jassid, and whitefly.

Amongst the Chemical classification of Neonicotinoids, three categories hâve been identified, which are listed as under:

A. Chloropyridylmethyl/First-generation neonicotinoids

i. Imidacloprid ii. Thiacloprid iii. Acetamiprid iv. Nitenpyram

B. ChloroThiozolylmethyl/ Second-generation neonicotinoids

i. Thiamethoxam ii. Clothianidin

C. Tetrahydrofuranylmethyl/ Third-generation neonicotinoids

i. Dinotefuran ii. Cycloxaprid

Under the naturel law of sélection, in order to control one particular species of pest attacking the crop at a particular stage of the crop, combination of pesticides hâve been applied. Thus, by such application of combination of pesticides, naturel balance is maintained and nature pushes another species of pests to flourish and attack the crops thereby rendering the crops still vulnérable to the pest attack and hence fariner loses substantial part of its produce. To address this, it has been found by the inventors of the présent application that to the composition of Diafenthiuron; Pyriproxyfen, a third category of insecticides (sélective neonicotinoids) hâve been combined which provide a broad spectrum control over ail the sucking pests attacking the crops (including cotton) under the theory of naturel sélection mentioned herein.

Thus, there exists a need for a synergistic composition of Diafenthiuron; Pyriproxyfen in combination with at least one agro-chemically active insecticide. In particular, there exists a need for a synergistic composition of Diafenthiuron; Pyriproxyfen in combination with at least one agro-chemically active insecticide selected from Thiamethoxam, Imidacloprid, Thiacloprid, Dinotefuran, Clothianidin, and Pymetrozine, which overcomes some of the existing problems mentioned above and can be prepared easily without much complex manufacturing process.

Inventors of the présent invention hâve surprisingly found that the novel synergistic composition of Diafenthiuron; Pyriproxyfen; and an insecticide selected from Thiamethoxam, Imidacloprid, Thiacloprid, Dinotefuran, Clothianidin, and Pymetrozine provide solution to the above mentioned problems. Thus, the object is achieved according to the invention by providing the présent composition.

SUMMARY OF THE INVENTION

Accordingly, in a fîrst aspect, the présent invention provides a synergistic pesticidal composition comprising (A) Diafenthiuron (B) Pyriproxyfen (C) at least one insecticide selected from Thiamethoxam, Imidacloprid, Thiacloprid, Dinotefuran, Clothiamdin, and Pymetrozine and one or more inactive excipients.

Accordingly, in a further aspect, the présent invention provides a synergistic pesticidal composition comprising A) Diafenthiuron is présent in an amount in the range from 5.0 to 60%w/w; B) Pyriproxyfen is présent in an amount in the range from 1.0 to 25%w/w; C) at least one more insecticide selected from Thiamethoxam, Imidacloprid, Thiacloprid, Dinotefuran, Clothianidin, Pymetrozine, is présent in an amount in the range from 0.5 to 50% w/w.

Accordingly, in a further aspect, the présent invention provides a synergistic pesticidal composition comprising:

a) Diafenthiuron in an amount in the range from 15-35%w/w, Pyriproxyfen in an amount in the range from 5-25% w/w, Thiamethoxam in an amount in the range from 2.5-15 % w/w and one or more inactive excipients, or

b) Diafenthiuron in an amount in the range from 5-14% w/w, Pyriproxyfen in an amount in the range from 2.8-4% w/w, Thiamethoxam in an amount in the range from 15.1-35% w/w and one or more inactive excipients, or

c) Diafenthiuron in an amount in the range from 40-60% w/w, Pyriproxyfen in an amount in the range from 1-2.7% w/w, Thiamethoxam in an amount in the range from 35.1-50 % w/w and one or more inactive excipients, or

d) Diafenthiuron in an amount in the range from 15-35% w/w, Pyriproxyfen in an amount in the range from 5-25% w/w, Imidacloprid in an amount in the range from 5-15% w/w and one or more inactive excipients, or

e) Diafenthiuron in an amount in the range from 5-14% w/w, Pyriproxyfen in an amount in the range from 2.8-4.9% w/w, Imidacloprid in an amount in the range from 15.1-35% w/w and one or more inactive excipients, or

f) Diafenthiuron in an amount in the range from 40-60% w/w, Pyriproxyfen in an amount in the range from 1-2.7% w/w, Imidacloprid in an amount in the range from 35.1-50% w/w and one or more inactive excipients, or

g) Diafenthiuron in an amount in the range from 15-35% w/w, Pyriproxyfen in an amount in the range from 5-25% w/w, Thiacloprid in an amount in the range from 2.5-10% w/w and one or more inactive excipients, or

h) Diafenthiuron in an amount in the range from 5-14% w/w, Pyriproxyfen in an amount in the range from 2.8-4.9% w/w, Thiacloprid in an amount in the range from 10-20% w/w and one or more inactive excipients, or

i) Diafenthiuron in an amount in the range from 40-60% w/w, Pyriproxyfen in an amount in the range from 1-2.7% w/w, Thiacloprid in an amount in the range from 20.1-50% w/w and one or more inactive excipients, or

j) Diafenthiuron in an amount in the range from 15.0-35.0% w/w, Pyriproxyfen in an amount in the range from 5.0-25% w/w, Dinotefuran in an amount in the range from 0.5-15% w/w and one or more inactive excipients, or

k) Diafenthiuron in an amount in the range from 5.0-14% w/w, Pyriproxyfen in an amount in the range from 2.8-4.9% w/w, Dinotefuran in an amount in the range from 15.1-35% w/w and one or more inactive excipients, or

1) Diafenthiuron in an amount in the range from 40-60% w/w, Pyriproxyfen in an amount in the range from 1.0-2.7% w/w, Dinotefuran in an amount in the range from 35.1-50% w/w and one or more inactive excipients, or

m) Diafenthiuron in an amount in the range from 15-35% w/w, Pyriproxyfen in an amount in the range from 5-25% w/w, Clothianidin in an amount in the range from 2.5-15% w/w and one or more inactive excipients, or

n) Diafenthiuron in an amount in the range from 5-14% w/w, Pyriproxyfen in an amount in the range from 2.8-4.9% w/w, Clothianidin in an amount in the range from 15.1-25% w/w and one or more inactive excipients, or

o) Diafenthiuron in an amount in the range from 40-60% w/w, Pyriproxyfen in an amount in the range from 1-2.7% w/w, Clothianidin in an amount in the range from 25.1-40% w/w and one or more inactive excipients, or

p) Diafenthiuron in an amount in the range from 15-35% w/w, Pyriproxyfen in an amount in the range from 5-25% w/w, Pymetrozine in an amount in the range from 0.5-15% w/w and one or more inactive excipients, or

q) Diafenthiuron in an amount in the range from 5-14% w/w, Pyriproxyfen in an amount in the range from 2.8-4.9% w/w, Pymetrozine in an amount in the range from 15.1-35% w/w and one or more inactive excipients, or

r) Diafenthiuron in an amount in the range from 40-60% w/w, Pyriproxyfen in an amount in the range from 1-2.7% w/w, Pymetrozine in an amount in the range from 35.1-50% w/w and one or more inactive excipients

Accordingly, in a second aspect, the présent invention provides a method of preparing the synergistic pesticidal composition of Diafenthiuron, Pyriproxyfen along with at least one insecticide selected from Thiamethoxam, Imidacloprid, Thiacloprid, Dinotefuran, Clothianidin, and Pymetrozine and one or more inactive excipients.

Accordingly, in a further aspect, the présent invention provides a method of protecting a plant propagation material, a plant, parts of a plant and/or plant organs that grow at a later point in time against pathogenic damage or pest damage (including sucking pests complex) by applying to the plant propagation material a composition comprising a pesticidal composition defined in the fîrst and further aspects.

Accordingly, in a yet another aspect, the said pesticidal composition is formulation selected from Emulsifïable concentrate (EC), Emulsifiable granule (EG), Emulsion water-in-oil (EO), Emulsifiable powder (EP), Emulsion for seed treatment (ES), Emulsion oil-in-water (EW), Flowable Slurry (FS), Flowable Suspension(FS), Suspension Concentrate (SC), Suspension concentrate for direct application (SD), Suspo- émulsion (SE), Water soluble granule (SG), Soluble concentrate (SL), Water soluble powder (SP ), Water dispersible powder for slurry seed treatment (WS), Water dispersible granules (WDG),Wettable powders (WP), Water dispersible powder for slurry seed treatment (WS), Water dispersible tablet (WT), a mixed formulation of CS and SC (ZC) or A mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW) comprising (A) Diafenthiuron (B) Pyriproxyfen (C) at least one insecticide selected from Thiamethoxam, Imidacloprid, Thiacloprid, Dinotefuran, Clothianidin, and Pymetrozine and one or more inactive excipients such as a) dispersant b) wetting agent c) anti-foaming agent d) biocides/anti-bacterial e) anti-freezing agent f) suspending agent g)thickener h) coating agent and i) buffering agent and binders.

As per one embodiment, formulation for the pesticidal composition is selected from Flowable Slurry (FS), Flowable Suspension (FS), Suspension Concentrate (SC), Suspo- émulsion (SE), Water dispersible powder for slurry seed treatment (WS), Water dispersible granules (WDG) and Wettable powders (WP).

The remainder of the aqueous formulation is preferably wholly water but may comprise other materials, such as inorganic salts. The formulation is preferably, completely free from organic solvents.

Accordingly, in another aspect, the présent invention provides a pesticidal composition comprising (A) Diafenthiuron in an amount in the range from 5.0 to 60% w/w (B) Pyriproxyfen in an amount in the range from 1.0 to 25% w/w (C) at least one insecticide selected from Thiamethoxam, Imidacloprid, Thiacloprid, Dinotefiiran, Clothianidin, Pymetrozine, in an amount in the range from 0.5 to 50% w/w shows synergistic activity; and formulation thereof is stable in nature.

DETAILED DESCRIPTION OF THE INVENTION:

Discussed below are some représentative embodiments of the présent invention. The invention in its broader aspects is not limited to the spécifie details and représentative methods. The illustrative examples are described in this section in connection with the embodiments and methods provided. The invention according to its varions aspects is particularly pointed out and distinctly claimed in the appended daims read in view of this spécification and appropriate équivalents.

It is to be noted that, as used in the spécification and the appended daims, the singular forms a, an and the include plural referents unless the context clearly dictâtes otherwise. Thus, for example, reference to a composition containing “a compound” includes a mixture of two or more compounds. It should also be noted that the terni “or” is generally employed in its sense including “and/or” unless the content clearly dictâtes otherwise.

The expression of varions quantifies in ternis of “% w/w” or “%” means the percentage by weight, relative to the weight of the total solution or composition unless otherwise specified.

The term “active ingrédient” (a.i.) or “active agent” used herein refers to that component of the composition responsible for control of insects-pests or disease.

Bioactive amounts” as mentioned herein means that amount which, when applied treatment of crops, is sufïïcient to effect such treatment. The bioactive amount of the compositions will also vaiy according to the prevailing conditions such as desired pesticidal effect and duration, weather, target species, locus, mode of application, and the like.

As used herein, the term effective amount means the amount of the active substances in the compositions to achieve an observable effect on growth, including the effects of necrosis, death, retardation, prévention, and removal, destruction, or otherwise diminishing the occurrence and activity of the target organism.

As used herein, the term “Diafenthiuron” encompasses Diafenthiuron or its agrochemically acceptable salt(s), derivative(s) or any other modified form of Diafenthiuron.

As used herein, the term “Pyriproxyfen” encompasses Pyriproxyfen or its agrochemically acceptable salt(s), derivative(s) or any other modified form of Pyriproxyfen.

The présent invention provides a novel synergistic pesticidal composition comprising bioactive amounts of Diafenthiuron; Pyriproxyfen; and an at least one insecticide selected from Thiamethoxam, Imidacloprid, Thiacloprid, Dinotefiiran, Clothianidin, Pymetrozine; along with one or more inactive excipients.

The présent invention provides formulation for the aforesaid composition and method of préparation thereof.

The term synergistic, as used herein, refers the combined action of two or more active agents blended together and administered conjointly that is greater than the sum of their individual effects.

The présent invention relates to synergistic insecticidal compositions of comprising of bioactive amounts of Diafenthiuron; Pyriproxyfen; and at least one active ingrédients selected from Thiamethoxam, Imidacloprid, Thiacloprid, Dinotefiiran, Clothianidin, Pymetrozine.

Pymetrozine was fîrst disclosed in US4931439 and US4996325.Pymetrozinee is chemically known as (E)-4,5-dihydro-6-methyl-4-(3-pyridylmethyleneamino)-l,2,4- triazin-3(2H)-one and having Chemical structure as below:

The mode of action of Pymetrozine in insects has not been precisely determined biochemically, but it may involve effects on neuroregulation or nerve-muscle interaction. Physiologically, it appears to act by preventing these insects from inserting their Stylus in to the plant tissue.

As used herein, the term “Pymetrozine” encompasses Pymetrozine or its agrochemically acceptable salt(s), derivative(s) or any other modified form of Pymetrozine.

Imidacloprid is a neonicotinoid, which is a class of neuro-active insecticides modeled after nicotine. Imidacloprid is chemically known as a (NE)-N-[l-[(6-chloropyridin-3yl)methyl]imidazolidin-2-ylidene]nitramide and having Chemical structure as below:

Imidacloprid is a systemic insecticide that acts as an insect neurotoxin and belongs to a class of Chemicals called the neonicotinoids which act on the central nervous System of insects. The Chemical works by interfering with the transmission of stimuli in the insect nervous System.

As used herein, the term “Imidacloprid” encompasses Imidacloprid or its agrochemically acceptable salt(s), derivative(s) or any other modifïed form of Imidacloprid.

Thiacloprid is a nitrile that is cyanamide in which the hydrogens are replaced by a 1,3-thiazolidin2-ylidene group which in tum is substituted by a (6-chloropyridin-3-yl)methyl group at the ring nitrogen. It has a rôle as a xenobiotic, an environmental contaminant and a neonicotinoid insecticide. It is a member of thiazolidines, a nitrile and a monochloropyridine. It is derived from 2-chloropyridine and a cyanamide. Thiacloprid is chemically known as a [3-[(6-chloropyridin-3yl)methyl]-l,3-thiazolidin-2-ylidene]cyanamide and having Chemical structure as below:

Thiacloprid is an insecticide of the neonicotinoid class. Its mechanism of action is similar to other neonicotinoids and involves disruption of the insect's nervous System by stimulating nicotinic acétylcholine receptors.

As used herein, the term “Thiacloprid” encompasses Thiacloprid or its agrochemically acceptable salt(s), derivative(s) or any other modifïed form of Thiacloprid.

Dinotefuran is an insecticide of the neonicotinoid class for control of insect pests such as aphids, whiteflies, thrips, leafhoppers, leafininers, sawflies, mole cricket, white grubs, lacebugs, billbugs, beetles, mealybugs, and cockroaches on leafy vegetables, in residential and commercial buildings, and for professional turf management. Dinotefuran is chemically known as 2-methyl-l-nitro-3[(tetrahydro-3-furanyl) methyl] guanidine and having Chemical structure as below:

Its mechanism of action involves disruption of the insect's nervous System by inhibiting nicotinic acétylcholine receptors.

As used herein, the term “Dinotefuran” encompasses Dinotefuran or its agrochemically acceptable salt(s), derivative(s) or any other modified form of Dinotefuran.

Thiamethoxam is a neonicotinoid insecticide. It is an oxadiazane, a member of 1,3-thiazoles, an organochlorine compound and a 2-nitroguanidine dérivative. Thiamethoxam chemically known as N-[3-[(2-chloro-1,3-thiazol-5-yl)methyl]-5-methy 1-1,3,5-oxadiazinan-4-ylidene]nitramid and having Chemical structure as below:

Thiamethoxam is a broad-spectrum, systemic insecticide, which means it is absorbed quickly by plants and transported to ail of its parts, including pollen, where it acts to deter insect feeding. An insect can absorb it in its stomach after feeding, or through direct contact, including through its trachéal System. The compound gets in the way of information transfer between nerve cells by interfering with nicotinic acétylcholine receptors in the central nervous System, and eventually paralyzes the muscles of the insects.

As used herein, the term “Thiamethoxam” encompasses Thiamethoxam or its agrochemically acceptable salt(s), derivative(s) or any other modified form of Thiamethoxam.

Clothianidin is an insecticide belonging to neonicotinoid class of compounds. Neonicotinoids are a class of insecticides that are chemically similar to nicotine. Clothianidin is chemically known as l-(2-Chloro-l,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine and having Chemical structure as below:

Clothianidin and other neonicotinoids act on the central nervous System of insects as an agonist of acétylcholine, the neurotransmitter that stimulâtes nAChR, targeting the same receptor site (AChR) and activating post-synaptic acétylcholine receptors but not inhibiting AChE.

As used herein, the term “Clothianidin” encompasses Clothianidin or its agrochemically acceptable salt(s), derivative(s) or any other modified form of Clothianidin.

The présent invention also provides a process for preparing a synergistic pesticide composition of (A) Diafenthiuron (B) Pyriproxyfen (C) at least one insecticide wherein insecticide(s) is selected from Thiamethoxam, Imidacloprid, Thiacloprid, Dinotefuran, Clothianidin, Pymetrozine. A synergistically effective amount of Diafenthiuron is an amount preferably ranging from 5% to 60% by weight of the composition and Pyriproxyfen is an amount preferably ranging from 1 to 25% by weight of the composition. The Diafenthiuron Technical grade provided in a purity of 97% minimum and Pyriproxyfen, Technical grade provided in a purity of 98% minimum. The insecticide(s) selected from Thiamethoxam, Imidacloprid, Thiacloprid, Dinotefuran, Clothianidin, Pymetrozine compounds présent in an amount preferably ranging from 0.5 to 50% by weight of the composition Technical grade having a purity of 95% minimum.

In an embodiment of the invention, the présent invention provides a synergistic pesticidal composition comprising A) Diafenthiuron is présent in an amount in the range from 5.0 to 60%w/w; B) Pyriproxyfen is présent in an amount in the range from 1.0 to 25%w/w; C) at least one more insecticide selected from Thiamethoxam, Imidacloprid, Thiacloprid, Dinotefuran, Clothianidin, Pymetrozine, is présent in an amount in the range from 0.5 to 50% w/w.

In another embodiment, the présent invention provides a synergistic pesticidal composition comprising:

m) Diafenthiuron in an amount in the range from 15-35% w/w, Pyriproxyfen in an amount in the range from 5-25% w/w, Clothiamdin in an amount in the range from 2.5-15% w/w and one or more inactive excipients, or

o) Diafenthiuron in an amount in the range from 40-60% w/w, Pyriproxyfen in an amount in the range from 1-2.7% w/w, Clothiamdin in an amount in the range from 25.1-40% w/w and one or more inactive excipients, or

In a preferred embodiment, the synergistic pesticidal composition comprises of:

a) Diafenthiuron in an amount in the range from 15.0-35.0% w/w, Pyriproxyfen in an amount in the range from 5.0-25% w/w, Dinotefuran in an amount in the range from 0.5-15% w/w and one or more inactive excipients, or

b) Diafenthiuron in an amount in the range from 5.0-14% w/w, Pyriproxyfen in an amount in the range from 2.8-4.9% w/w, Dinotefuran in an amount in the range from 15.1-35% w/w and one or more inactive excipients, or

c) Diafenthiuron in an amount in the range from 40-60% w/w, Pyriproxyfen in an amount in the range from 1.0-2.7% w/w, Dinotefuran in an amount in the range from 35.1-50% w/w and one or more inactive excipients

In a more preferred embodiment, the synergistic pesticidal composition is a suspoemulsion (SE), formulation comprising of:

a) Pyriproxyfen in an amount of 8%w/w by weight of the composition;

b) Dinotefuran in an amount of 5% w/w by weight of the composition;

c) Diafenthiuron in an amount of 18% w/w by weight of the composition;

d) Emulsifier selected form Blend of anionic & Non-ionic;

e) Dispersing Agent selected form Tristyrylphenol Ethoxylate & craft polymer;

f) Propylene Glycol as Anti-freezing Agent

g) Sodium lauryl sulphate as Wetting Agent;

h) Siloxane polyalkyleneoxide as Antifoaming Agent;

i) Silicon Dioxide as thickener;

j) Benzisothiazolin-3-one as Anti-bacterial;

k) Xanthan Gum.

In a more preferred embodiment, the synergistic pesticidal composition is a wettable powder (WP) formulation comprising of:

a) Pyriproxyfen in an amount of8%w/w by weight of the composition;

b) Dinotefuran in an amount of 5% w/w by weight of the composition;

c) Diafenthiuron in an amount of 18% w/w by weight of the composition;

d) Dispersing Agent selected from Napthalene sulfonic acid branched and linear sodium sait;

e) Sodium disopropyl naphthalene sulfonate as Wetting Agent;

f) Siloxane polyalkyleneoxide as Antifoaming Agent;

g) Fillers.

In a more preferred embodiment, the synergistic pesticidal composition is a Water Dispersible Granules (WDG) formulation comprising of:

a) Pyriproxyfen in an amount of 8%w/w by weight of the composition;

b) Dinotefuran in an amount of 5% w/w by weight of the composition;

c) Diafenthiuron in an amount of 18% w/w by weight of the composition;

d) Dispersing Agent is selected from Methyl Napthalene sulfonic acid polymer with formaldéhyde sodium sait;

e) Sodium lauryl sulphate as Wetting Agent;

f) Siloxane polyalkyleneoxide as Antifoaming Agent;

g) Citric acid / Sod. Bicarbonate as Disintegration Agent;

h) Fillers.

The composition according to the invention can be applied to any and ail developmental stages of pests, in particular sucking pests, such as egg, nymph, larva, pupa, and adult. The pests may be controlled by contacting the target pest, its food supply, habitat, breeding ground or its locus with a pesticidally effective amount of the inventive composition.

The inventors of the présent invention hâve surprisingly found that the composition of the présent invention is synergetic in nature. The synergetic composition of the présent invention is more effective than their individual counterparts or when two actives are taken together. The synergetic composition of the présent invention also makes it possible to use markedly smaller quantifies of the active ingrédients as compared to their individual counterparts. This allows a substantial réduction in the application rates of each of these active ingrédients, while maintaining good efficacy. The decrease in application rates reduces treatment cost to the farmer and also eases the burden on the environment both from manufacturing waste and crop protection Chemical residues.

The synergistic pesticidal composition of présent invention provides a wide spectrum control of insect-pests, delays the emergence of the résistant strains, minimizing the risk of development of résistance, and achieves effective and economical control of undesired insect-pest.

The synergistic composition of the présent invention provides a number of other advantages:

• Increased efficacy in comparison to the other formulations tested during the trial.

• Economically bénéficiai to the farmers as it provides better yield of the crop with réduction in the number of sprays.

• Reduced possibility of hazards to the farmers due to occupational exposure because of réduction in the number of sprays.

• Is storage stable.

• Is non-phytotoxic.

• Environmental friendly

The novel active ingrédient composition has very advantageous curative, préventive and systemic pesticidal properties for protecting cultivated plants. As has been mentioned, said active ingrédient composition can be used to inhibit or destroy the pathogens that occur on plants or parts of plants (fruit, blossoms, leaves, stems, tubers, roots) of different crops or useful plants, while at the same time those parts of plants which grow later are also protected from attack by such pathogens. Active ingrédient composition has the spécial advantage of being highly active against diseases in the soil that mostly occur in the early stages of plant development.

The compositions of Diafenthiuron; Pyriproxyfen and at least agrochemically active ingrédients selected from Thiamethoxam, Imidacloprid, Thiacloprid, Dinotefuran, Clothianidin, and Pymetrozine are also suitable for controlling against many phytophagous insects pests likes; Aphid, Jassid, Thrips, Mealybugs, Scales, Leaf miner, Gall midges, shootfly, stemfly, stemborer, root borer, fruitborer. It Controls insects pests from the following orders: Lepidoptera, for example Agrotis ypsilon, Anticarsia gemmatalis, Chilo partellus, Cnaphalocrosis medinalis, Cydia pomonella, Diaphania nitidalis, , Earias insulana, Elasmopalpus lignosellus, Heliothis armigera, Heliothis virescens, Heliothis zea, Hellula undalis, Hyphantria cunea, Hyponomeuta malinellus, Leucoptera coffeella, Leucoptera scitella, Ostrinia nubilalis, Panolis flammea, Pectinophora gossypiella, Peridroma saucia, Phalera bucephala, Phthorimaea operculella, Phyllocnistis citrella, Pieris bras-sicae, Plutella xylostella, Sitotroga cerealella, Sesamia inferans, Sparganothis pilleriana, Spodoptera frugiperda, Spodoptera littoralis, Spodoptera litura, Thaumatopoea pityocampa, Tortrix viridana, Trichoplusia ni, beetles (Coleoptera), for example Agrilus sinuatus, Agriotes lineatus, Agriotes obscu-rus, Amphimallus solstitialis, Anisandrus dispar, Anthonomus grandis, Anthonomus pomorum, Aphthona euphoridae, Apogonia aerea, Athous haemorrhoidalis, Atomaria linearis, Blasto-phagus piniperda, Blitophaga undata, Brahmina coriacea , Bruchus rufimanus, Bruchus pisorum, Bruchus lentis, Byctiscus betulae, Cassida nebulosa, Cerotoma trifurcata, Cetonia aurata, Ceuthorrhynchus assimilis, Ceuthorrhynchus napi, Chaetocnema tibialis, Conoderus vespertinus, Crioceris asparagi, Ctenicera ssp., Diabrotica longicomis, Diabrotica semipunctata, Diabrotica 12-punctata Diabrotica speciosa, Diabrotica virgifera, Epilachna varivestis, Epitrix hirtipennis, Eutinobothrus brasiliensis, White grub species, Holotrichia consanguinea , Holotrichia serrata, Holotrichia longipennis, Hylobius abietis, Hypera brunneipennis, Hypera postica, Ips typographus, Lema bilineata, Lema melanopus, Lepidiota stigma, Leptinotarsa decemlineata, Limonius califomicus, Lissorhoptrus oryzophilus, Melanotus communis, Meligethes aeneus, Melolontha hippocastani, Melolontha melolontha, Oberea (Obereopsis) brevis, Ouléma oryzae, Ortiorrhynchus sulcatus, Otiorrhynchus ovatus, Phaedon cochleariae, Phyllobius pyri, Phyllotreta chrysocephala, Phyllophaga sp., Phyllopertha horticola, Phyllotreta nemorum, Phyllotreta striolata, Popillia japonica, Sitona lineatus and Sito-philus gran aria, flies, (Diptera), e.g. Atherigona orientalis, Atherigona soccata, Athalia lugen proxima, Dacus cucurbi-tae, Dacus oleae, Glossina palpalis, Haematobia irritans, Haplodiplosis equestris, Hippelates spp., Hylemyia platura, Hypoderma lineata, Leptoconops torrens, Leaf miner, Liriomyza sativae, Liriomyza trifolii, Lucilia caprina, Lucilia cuprina, Lucilia sericata, Lycoria pectoralis, Mansonia titillanus, Mayetiola destructor, Oscinella frit, Phorbia brassicae, Prosimulium mixtum, Rhagoletis cerasi, Sarcophaga sp., Simulium vittatum, Stomoxys calcitrans, Tabanus bovinus, Tabanus atratus, Tabanus lineola, and Tabanus similis, Tipula oleracea, and Tipula paludosa, thrips (Thysanoptera), e.g. Dichromothrips corbetti, Dichromothrips ssp , Frankliniella fusca, Frankliniella occidentalis, Frankliniella tritici, Scirtothrips citri, Scirtothrips dorsalis, Thrips oryzae, Thrips palmi and Thrips tabaci, termites (Isoptera), e.g. Calotermes flavicollis, Coptotermes formosanus, Heterotermes aureus, Leucotermes flavipes, Microtermes spp., Odontotermes, Reticulitermes flavipes, Reticulitermes virginicus, Reticulitermes lucifugus and Termes natalensis; true bugs (Hemiptera), e.g. Acrostemum hilare, Amrasca biguttula biguttula, Amrasca devastans, Blissus leucopterus, Dysdercus cingulatus, Eurygaster integriceps, Euschistus impictiventris, Leptoglossus phyllopus, Lygus lineolaris, Lygus pratensis, Nezara viridu-la, Piesma quadrata, Solubea insularis, Thyanta perditor, Acyrthosiphon onobrychis, Adelges laricis, Aphidula nasturtii, Aphis fabae, Aphis forbesi, Aphis pomi, Aphis gossypii, Aphis crassivora, Aphis grossulariae, Aphis schneideri, Aphis spiraecola, Aphis sambuci, Acyrtho-siphon pisum, Aulacorthum solani, Bemisia argentifolii, Bemisia tabaci, Brachycaudus cardui, Brachy-caudus helichrysi, Brachycaudus persicae, Brachycaudus prunicola, Brevicoryne brassicae, Capitophorus homi, Cerosipha gossypii, Chaetosiphon fragaefolii, Cryptomyzus ribis, Dreyfusia nordmannianae, Dreyfusia piceae, Dysaphis radicola, Dysaulacorthum pseudosolani, Dysaphis plantaginea, Dysaphis pyri, Empoasca fabae, Hyalopterus pruni, Hyperomyzus lactucae, Macrosiphum avenae, Macrosiphum euphorbiae, Ma-crosiphon rosae, Megoura viciae, Melanaphis pyrarius, Metopolophium dirhodum, My-zus persicae, Myzus ascalonicus, Myzus cerasi, Myzus varians, Nasonovia ribisnigri, Nilaparvata lugens, Pemphigus bursarius, Perkinsiella saccharicida, Phorodon humuli, Psylla mail, Psylla piri, Rhopalomyzus ascalonicus, Rhopalosiphum maidis, Rhopalosi-phum padi, Rhopalosiphum insertum, Sappaphis mala, Sappaphis mail, Schizaphis graminum, Schizoneura lanuginosa, Sitobion avenae, Trialeurodes vaporariorum, Toxoptera aurantiia d, Viteus vitifolii, Cimex lectularius, Cimex hemipterus, Reduvius senilis, Triatoma spp., and Arilus critatus, Trialeurodes vaporariorum, Amrasca biguttula, Empoasca spp., Myzus spp., Nephotettix spp., Nilaparvata spp., Planococcus spp., Pseudococcus spp., Psylla spp., Rhopalosiphum spp., Sitobion spp., Amritodus atkinsoni, Idioscopus spp., ants, bees, wasps, sawflies (Hymenoptera), e.g. Athalia rosae, Atta cephalotes, Atta capiguara, Atta cephalotes, Atta laevigata, Atta robusta, Atta sexdens, Atta texana, Crematogaster spp., Hoplocampa minuta,

Hoplocampa testudinea, Monomorium pha-raonis, Solenopsis geminata, Solenopsis invicta, Solenopsis richteri, Solenopsis xyloni, Pogonomyrmex barbatus, Pogonomyrmex californiens, Pheidole megacephala, Dasy-mutilla occidentalis, Bombus spp. Vespula squamosa, Paravespula vulgaris, Paraves-pula pennsylvanica, Paravespula germanica, Dolichovespula maculata, Vespa crabro, Polistes rubiginosa, Camponotus floridanus, and Linepithema humile, crickets, grasshoppers, locusts (Orthoptera), e.g. Acheta domestica, Gryllotalpa gryllo-talpa, Locusta migratoria, Melanoplus bivittatus, Melanoplus femurrubrum, Melanoplus mexicanus, Melanoplus sanguinipes, Melanoplus spretus, Nomadacris septemfasciata, Schistocerca americana, Schistocerca gregaria, Dociostaurus maroccanus, Tachycines asynamorus, Oedaleus senegalensis, Zonozerus variegatus, Hieroglyphus daganensis, Kraussaria angulifera, Calliptamus italicus, Chortoicetes terminifera, and Locustana pardalina, plant parasitic nematodes such as root-knot nematodes, Meloidogyne arenaria, Meloidogyne incognita, Meloidogyne javanica; cyst nematodes, Globodera rostochiensis, Heterodera avenae; seed gall nematodes, Anguina funesta, Anguina tritici and other Anguina species; stem and foliar nematodes, Aphelenchoides besseyi, sting nematodes, Belonolaimus longicaudatus and other plant parasitic nematode species.

Suitable targets for seed treatment are various crop seeds, fruit species, vegetables, spices and omamental seed, for example com/maize (sweet and fïeld), durum wheat, soybean, Groundnut, wheat, barley, oats, rye, triticale, bananas, rice, cotton, sunflower, potatoes, pasture, alfalfa, grasses, turf, sorghum, rapeseed, Brassica spp., sugar beet, egg-plants, tomato, lettuce, iceberg lettuce, pepper, cucumber, squash, melon, bean, dry-beans, peas, leek, garlic, onion, cabbage, carrot, tuber such as sugar cane, tobacco, coffee, turf and forage, cruciferous, cucurbits, grapevines, pepper, fodder beet, oil seed râpe, pansy, impatiens, pétunia and géranium.

The composition of the présent invention is effective for management of insect or pests in of Cotton (Gossypium spp.), Paddy (Oryza sativa), Wheat (Triticumaestavum), Barley (Hordeumvulgare), Maize (Zea mays), Sorghum (Sorghum bicolor), Sugarcane (Saccharumofficinarum) , Sugarbeet (Beta vulgaris), Soybean (Glycin max), Peanut (Arachishypogaea), Sunflower (Helianthus annuus) , Mustard (Brassica juncea), Râpe seed (Brassica napus), Linseed (Linumusitatissimum), Sesame (Sesamumindicum), Castor (Ricinuscommunis), Green gram (Vigna radiate), Black gram (Vignamungo), Chickpea (Ciceraritinum), Cowpea (Vignaunguiculata), Redgram (Cajanuscajan), Frenchbean (Phaseolus vulgaris), Indian bean (Lablab purpureus), Horse gram (Macrotylomauniflorum), Field pea (Pisumsativum), Cluster bean (Cyamopsistetragonoloba), Lentils (Lens culinaris), Brinjal (Solanum melongena), Cabbage (Brassica oleracea var. capitata), Cauliflower (Brassica oleracea var. botrytis), Okra (Abelmoschus esculentus) , Onion (Allium cepa L.), Tomato (Solanumlycopersicun) , Potato (Solanumtuberosum) , Sweet potato (Ipomoea batatas), Chilly (Capsicum annum), Garlic (Allium sativum), Cucumber (Cucumissativus), Muskmelons (Cucumismelo), Watermelon (Citrulluslanatus), Bottle gourd (Lagenariasiceraria), Bitter gourd (Momordicacharantia), Radish (Raphanussativus), Carrot (Dacuscarota subsp. sativus), Tumip (Brassica rapasubsprapa), Apple (Melusdomestica), Banana (Musa spp.), Citrus groups (Citrus spp.), Grape (Vitisvinifera), Guava (Psidiumguajava), Litchi (Litchi chinensis), Mango (Mangiferaindica), Papaya (Carica papaya), Pineapple (Ananascomosus), Pomegranate (Punicagranatum), Sapota (Manilkarazapota), Tea (Camellia sinensis), Coffea (Coffea Arabica), Turmeric (Curcuma longa), Ginger (Zingiberoffïcinale), Cumin (Cuminumcyminum), Fenugreek (Trigonellafoenum-graecum), Fennel (Foeniculumvulgare), Coriander (Coriandrumsativum), Ajwain (Trachyspermumammi), Psyllium (Plantage ovate), Black Pepper (Piper nigrum), Stevia (Stevia rebaudiana), Safedmusli (Chlorophytumtuberosum), Drum stick (Moringaoleifera), Coconut (Coco nucifera), Mentha ( Mendia spp.), Rose (Rosa spp.), Jasmine (Jasminum spp.), Marigold ( Tagetes spp.), Common daisy (Bellisperennis), Dahlia (Dahlia hortnesis), Gerbera ( Gerbera jamesonii), Carnation (Dianthus caryophyllus) or GMO form thereof.

The composition of the présent invention can be used to control the insects-pests belongs to Lepidopteran insects, Chilopartellus, Chilosuppressalis, Cydiapomonella, Plutellaxylostella, Peirisrapae, beetles (coleopteran), e.g. Dicladispaarmigera, Phyllotretanemorum, Phyllotretastriolata, flies (Diptera), e.g. Atherigonaorientalis, Dacuscucurbi-tae, Dacusoleae, Liriomyzasativae, Liriomyzatrifolii, Melanagromyza obtuse, Ophiomyiaphaseli, thrips (Thysanoptera), e.g. Frankliniellaoccidentalis, Scirtothripscitri, Scirtothrips dorsalis, Thrips oryzae, Thrips palmi and Thrips tabaci, true bugs (Hemiptera), e.g. Amrascabiguttulabiguttula, Amrascadevastans, Amritodusatkinsoni, Aphis fabae, Aphis pomi, Aphis gossypii, Aphis crassivora, Bemisiaargentifolii, Bemisiatabaci, Brevicorynebrassicae, Clavigrallagibbosa, Dysdercuscingulatus, Idioscopus spp., Leptocorisaacuta, Lyguslineolaris, Myzuspersicae, Nilaparvatalugens, Nephotettixvirescens, Nephotettixnigropictus, Planococcus spp., Pseudococcus spp., Pyrillaperpusilla, Psylla mail, Psyllapiri, Rhopalomyzusascalonicus, Rhopalosiphummaidis, Rhopalosi-phumpadi, Rhopalosiphuminsertum, Sappaphis mala, Sappaphis mail, Schizaphisgraminum, Schizoneuralanuginosa, Sitobionavenae, Sogatellafurcifera, Trialeurodesvaporariorum, Toxopteraaurantiia, Psylla spp., Rhopalosiphum spp., Sitobion spp., crickets, grasshoppers, locusts (Orthoptera), e.g. Gryllotalpagryllo-talpa, Locustamigratoria, Melanoplusbivittatus, Locustanapardalina., from the order Acarina, for example, Brevipalpus spp., Eriophyes spp., Olygonychuscoffeae, Panonychus spp., Polyphagotarsonemuslatus, Tarsonemus spp. and Tetranychus spp. (Tetranychusurticae, Tetranychuscinnabarinus, Tetranychustelarius).

The term seed treatment comprises ail suitable seed treatment techniques known in the art, such as, but not limited to, seed dressing, seed coating, seed dusting, seed soaking, seed film coating, seed multilayer coating, seed encrusting, seed dripping, and seed pelleting.

The active ingrédient composition according to the invention are especially advantageous for seed treatment of oil seed râpe, wheat, corn, rye, barley, oats, sorghum, sunflowers, rice, maize, turf and forage, sugar beet, beans, peas, soybeans, omamentals, and vegetables such as cucurbits, tomatoes, eggplant, potatoes, pepper, lettuce, cabbage, canots, cruciferous.

The terni health of a plant or plant health is defined as a condition of the plant and/or its products. As a resuit of the improved health, yield, plant vigor, quality and tolérance to abiotic or biotic stress are increased. Noteworthy, the health of a plant when applying the method according to the invention, is increased independently of the pesticidal properties of the active ingrédients used because the increase in health is not based upon the reduced pest pressure but instead on complex physiological and metabolic reactions which resuit for example in an activation of the plant's own natural defense System. As a resuit, the health of a plant is increased even in the absence of pest pressure. Accordingly, in an especially preferred embodiment of the method according to the invention, the health of a plant is increased both in the presence and absence of biotic or abiotic stress factors. The above identified indicators for the health condition of a plant may be interdependent or they may resuit from each other. An increase in plant vigor may for example resuit in an increased yield and/or tolérance to abiotic or biotic stress. One indicator for the condition of the plant is the yield. Yield is to be understood as any plant product of économie value that is produced by the plant such as grains, fruits in the proper sense, vegetables, nuts, grains, seeds, wood (e.g. in the case of silviculture plants) or even flowers (e.g. in the case of gardening plants, omamentals). The plant products may in addition be further utilized and/or processed after harvesting.

In an especially preferred embodiment of the invention, the yield of the treated plant is increased.

In another preferred embodiment of the invention, the yield of the plants treated according to the method of the invention, is increased synergistically.

According to the présent invention, increased yield of a plant, in particular of an agricultural, silvicultural and/or horticultural plant means that the yield of a product of the respective plant is increased by a measurable amount over the yield of the saine product of the plant produced under the same conditions, but without the application of the mixture according to the invention.

Increased yield can be characterized, among others, by the following improved proper-ties of the plant: increased plant, weight, increased plant height, increased

biomass such as higher overall fresh weight	(FW), increased number of flowers
per plant, higher grain yield, more tillers or	side shoots (branches), larger leaves,
increased shoot growth, increased protein	content, increased oil content,
increased starch content, increased pigment	content, increased leaf are index.
According to the présent invention, the yield is increased by at least 4 %,
préférable by 5 to 10 %, more préférable by	10 to 20 %, or even 20 to 30 %
compared to the untreated control plants or plants treated with pesticides in a way
different from the method according to the présent invention. In general, the yield

increase may even be higher.

A further indicator for the condition of the plant is the plant vigor. The plant vigor becomes manifest in several aspects such as the general visual appearance.

In another especially preferred embodiment of the invention, the plant vigor of the treated plant is increased. In another preferred embodiment of the invention, the plant vigor of the plants treated according to the method of the invention is increased synergistically. Improved plant vigor can be characterized, among others, by the following improved properties of the plant: improved vitality of the plant, improved plant growth, improved plant development, improved visual appearance, improved plant stand (less plant verse/lodging), improved emergence, enhanced root growth and/or more developed root System, enhanced nodulation, in particular rhizobial nodulation, bigger leaf blade, bigger size, increased plant weight, increased plant height, increased tiller number, increased number of side shoots, increased number of flowers per plant, increased shoot growth, increased root growth (extensive root System), increased yield when grown on poor soils or unfavorable climate, enhanced photo synthetic activity (e.g. based on increased stomatal conductance and/or increased C02 assimilation rate), increased stomatal conductance, increased C02 assimilation rate, enhanced pigment content (e.g. chlorophyll content), earlier flowering, earlier fruiting, 23 earlier and improved germination, earlier grain maturity, improved self-defence mechanisms, improved stress tolérance and résistance of the plants against biotic and abiotic stress factors such as fungi, bacteria, viruses, insects, heat stress, cold stress, drought stress, UV stress and/or sait stress, less non-productive tillers, less dead basal leaves, less input needed (such as fertilizers or water), greener leaves, complété maturation under shortened végétation periods, less fertilizers needed, less seeds needed, easier harvesting, faster and more uniform ripening, longer shelf-life, longer panicles, delay of senescence, stronger and/or more productive tillers, better extractability of ingrédients, improved quality of seeds (for being seeded in the following seasons for seed production), better nitrogen uptake, improved reproduction, reduced production of ethylene and/or the inhibition of its réception by the plant.

The improvement of the plant vigor according to the présent invention particularly means that the improvement of any one or several or ail of the above mentioned plant characteristics are improved independently of the pesticidal action of the mixture or active ingrédients (components).

Another indicator for the condition of the plant is the quality of a plant and/or its products.

In an especially preferred embodiment of the invention, the quality of the treated plant is increased.

In another preferred embodiment of the invention, the quality of the plants treated according to the method of the invention, is increased synergistically.

According to the présent invention, enhanced quality means that certain plant characteristics such as the content or composition of certain ingrédients are increased or improved by a measurable or noticeable amount over the same factor of the plant produced under the same conditions, but without the application of the mixtures of the présent invention. Enhanced quality can be characterized, among others, by following improved properties of the plant or its product:

increased nutrient content, increased protein content, increased content of fatty acids, increased métabolite content, increased carotenoid content, increased sugar content, increased amount of essential amino acids, improved nutrient composition, improved protein composition, improved composition of fatty acids, improved métabolite composition, improved carotenoid composition, improved sugar composition, improved amino acids composition, improved or optimal fruit color, improved leaf color, higher storage capacity, higher processability of the harvested products.

Another indicator for the condition of the plant is the plant's tolérance or résistance to biotic and/or abiotic stress factors. Biotic and abiotic stress, especially over longer terms, can hâve harmful effects on plants. Biotic stress is caused by living organisms while abiotic stress is caused for example by environmental extremes. According to the présent invention, enhanced tolérance or résistance to biotic and/or abiotic stress factors means (1.) that certain négative factors caused by biotic and/or abiotic stress are diminished in a measurable or noticeable amount as compared to plants exposed to the same conditions, but without being treated with a mixture according to the invention and (2.) that the négative effects are not diminished by a direct action of the mixture according to the invention on the stress factors, e.g. by its fiingicidal or 10 insecticidal action which directly destroys the microorganisms or pests, but rather by a stimulation of the plants' own défensive reactions against said stress factors.

Formulation of the présent invention can be in any of the formulations selected from Emulsifiable concentrate (EC), Emulsifiable granule (EG), Emulsion water-in-oil (EO), Emulsifiable powder (EP), Emulsion for seed treatment (ES), Emulsion oil-in-water (EW), Flowable Slurry (FS), Flowable Suspension(FS), Suspension Concentrate (SC), Suspension concentrate for direct application (SD), Suspo- émulsion (SE), Water soluble granule (SG), Soluble concentrate (SL), Water soluble powder (SP ), Water dispersible powder for slurry seed treatment (WS), Water dispersible granules (WDG),Wettable powders (WP), Water dispersible powder for slurry seed treatment (WS), Water dispersible tablet (WT), a mixed formulation of CS and SC (ZC) or A mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW) comprising (A) Diafenthiuron (B) Pyriproxyfen (C) at least one insecticide selected from Thiamethoxam, Imidacloprid, Thiacloprid, Dinotefuran, Clothianidin, and Pymetrozine and one or more inactive excipients such as a) dispersant b) wetting agent c) anti-foaming agent d) biocides/anti-bacterial e) anti-freezing agent f) suspending agent g)thickener h) coating agent and i) buffering agent and binders.

One or more of the active ingrédients is encapsulated for varions purposes, such as to increase the residual biological activity, or to reduce the acute toxicity, or to obtain a physical or chemically stable water-based formulation. The purpose détermines whether the “free” active ingrédient and the “release rate” are relevant properties of a spécifie product.

Diafenthiuron; Pyriproxyfen; and at least one insecticides selected from Thiamethoxam, Imidacloprid, Thiacloprid, Dinotefuran, Clothianidin, Pymetrozine ; which are bio active ingrédient for the présent composition are présent in spécifie fixed ratio.

The composition of the présent invention in addition to bioactive amounts of Diafenthiuron; Pyriproxyfen; and one more agrochemically active ingrédients selected from Thiamethoxam, Imidacloprid, Thiacloprid, Dinotefuran, Clothianidin, Pymetrozine; further comprises inactive excipients including but not limited to dispersant, anti-freezing agent, anti-foam agent, wetting agent, suspension aid, antimicrobial agent, thickener, quick coating agent or sticking agents (also referred to as “stickers” or “binders”) and buffering agent.

An agriculturally acceptable carrier may be solid, liquid or both. Solid cames are essentially: minerai earth such as silicas, silica gels, silicates, talc, kaolin, montmorillonite, attapulgite, pumice, sepiolite, bentonite, limestone, lime, chalk, bole, loes, clay, dolomite, diatomaceous earth, calcite, calcium sulfate, magnésium sulfate, magnésium sulfate, magnésium oxide, sand, ground plastics, ferilizers such as ammonium sulfate, ammonium phosphate, ammonium nitrate, ureas, and crushed products of vegetable origin such as cereal meal, tree bark meal, wood meal and nutshell meal, cellulose powders, or other solid carriers.

The synergistic composition of Diafenthiuron; Pyriproxyfen; and at least one agrochemically active ingrédients selected from Thiamethoxam, Imidacloprid, Thiacloprid, Dinotefuran, Clothianidin, Pymetrozine may optionally include surfactant(s) which are non-ionic, cationic and/or anionic in nature and surfactant mixtures which hâve good emulsifying, dispersing and wetting properties, depending on the nature of the active ingrédient to be formulated. Suitable anionic surfactants can be both so-called water-soluble soaps and water-soluble synthetic surfaceactive compounds. Soaps which may be included as a surfactant are the alkali métal, alkaline earth métal or substituted or unsubstituted ammonium salts of higher fatty acids (C10-C22), for example the sodium or potassium sait of oleic or stearic acid, or of natural fatty acid mixtures.

A dispersant is a substance which adsorbs onto the surface of particles and helps to preserve the state of dispersion of the particles and prevents them from re-aggregating. Dispersants are added to agrochemical formulations to facilitate dispersion and suspension during manufacture, and to ensure the particles re-disperse into water in a spray tank. They are widely used in wettable powders, suspension concentrâtes and water-dispersible granules. Surfactants that are used as dispersants hâve the ability to adsorb strongly onto a particle surface and provide a charged or steric barrier to reaggregation of particles. The most commonly used surfactants are anionic, nonionic, or mixtures of the two types. For wettable powder formulations, the most common dispersants are sodium lingo sulphonates. For suspension concentrâtes, very good adsorption and stabilization are obtained using polyelectrolytes, such as sodium naphthalene sulphonate formaldéhyde condensâtes. Tristyrylphenolethoxylate phosphate esters are also used. Nonionics such as alkyl aryl ethylene oxide condensâtes and EO-PO block copolymers are sometimes combined with anionics as dispersants for suspension concentrâtes. In recent years, new types of very high molecular weight polymeric surfactants hâve been developed as dispersants. These hâve very long hydrophobie ‘backbones’ and a large number of ethylene oxide chains forming the ‘teeth’ of a ‘comb’ surfactant. These high molecular weight polymers can give very good longterm stability to suspension concentrâtes because the hydrophobie backbones hâve many anchoring points onto the particle surfaces. Examples of dispersants used herein include but not limited to sodium lingo sulphonates; sodium naphthalene sulphonate formaldéhyde condensâtes; tristyryl phénol ethoxylate phosphate esters; aliphatic alcohol ethoxylates; alky ethoxylates; EOPO block copolymers; and graft copolymers or mixtures thereof.

Anti-freezing agent as used herein can be selected from the group consisting of polyethylene glycols, methoxy polyethylene glycols, polypropylene glycols, polybutylene glycols, glycerin and ethylene glycol. Water-based formulations often cause foam during mixing operations in production. In order to reduce the tendency to foam, anti-foam agents are often added either during the production stage or before filling into bottles. Generally, there are two types of antifoam agents, namely silicones and non-silicones. Silicones are usually aqueous émulsions of dimethyl poly siloxane while the non-silicone anti-foam agents are water- insoluble oils, such as octanol and nonanol, or silica. In both cases, the function of the anti-foam agent is to displace the surfactant from the air-water interface.

A wetting agent is a substance that when added to a liquid increases the spreading or pénétration power of the liquid by reducing the interfacial tension between the liquid and the surface on which it is spreading. Wetting agents are used for two main functions in agrochemical formulations: 27 during processing and manufacture to increase the rate of wetting of powders in water to make concentrâtes for soluble liquids or suspension concentrâtes; and during mixing of a product with water in a spray tank or other vessel to reduce the wetting time of wettable powders and to improve the pénétration of water into water-dispersible granules. Examples of wetting agents used in wettable powder, suspension concentrate, and water-dispersible granule formulations include but not limited to sodium lauryl sulphate; sodium dioctyl sulpho succinate; alkyl phénol ethoxylates; and aliphatic alcohol ethoxylates or mixtures thereof.

Suspension aid in the présent description dénotés a naturel or synthetic, organic or inorganic material with which the active substance is combined in order to facilitate its application to the plant, to the seeds or to the soil. This carrier is hence generally inert, and it must be agriculturally acceptable, in particular to the plant being treated. The carrier may be solid (clays, naturel or synthetic silicates, silica, resins, waxes, solid fertilizers, and the like or mixtures thereof) or liquid (water, alcohols, ketones, petroleum fractions, aromatic or parafïinic hydrocarbons, chlorinated hydrocarbons, liquefïed gases, and the like or mixtures thereof).

An emulsifier is a kind of surfactant. It helps to prevent the droplets of the dispersed phase of an émulsion from flocculating or coalescing in the émulsion. It can be or include a cationic, zwitterionic or a non-ionic emulsifier.

Biocides/Ant-bacterials: Microorganisms cause spoilage of formulated products. Therefore antimicrobial agents are used to eliminate or reduce their effect. Examples of such agents include, but are not limited to: propionic acid and its sodium sait; sorbic acid and its sodium or potassium salts; benzoic acid and its sodium sait; p-hydroxy benzoic acid sodium sait; methyl p-hydroxy benzoate; and biocide such as sodium benzoate, 1,2- benzisothiazoline-3-one, 2-methyl-4isothiazolin-3-one, 5-chloro-2-methyl-4- isothiazolin-3-one, potassium sorbate, para hydroxy benzoates or mixtures thereof.

Thickeners or gelling agents are used mainly in the formulation of suspension concentrâtes, émulsions and suspoemulsions to modify the rheology or flow properties of the liquid and to prevent séparation and settling of the dispersed particles or droplets. Thickening, gelling, and antisettling agents generally fall into two categories, namely water-insoluble particulates and watersoluble polymers. It is possible to produce suspension concentrate formulations using clays and silicas. Examples of these types of materials, include, but are limited to, montmorillonite, e.g. bentonite; magnésium aluminum silicate; and attapulgite. Water-soluble polysaccharides hâve been used as thickening-gelling agents for many years. The types of polysaccharides most commonly used are naturel extracts of seeds and seaweeds are synthetic dérivatives of cellulose or mixtures thereof. Examples of these types of materials include, but are not limited to, guar gum; locust bean gum; carrageenam; xanthan gum; alginates; methyl cellulose; sodium carboxymethyl cellulose (SCMC); hydroxyethyl cellulose (HEC) or mixtures thereof. Other types of anti-settling agents are based on modified starches, polyacrylates, polyvinyl alcohol and polyethylene oxide or mixtures.

The quick coating agent can be a conventionally available sticker, for example polyesters, polyamides, poly- carbonates, polyurea and polyuréthanes, acrylate polymers and copolymers, styrene copolymers, butadiene copolymers, polysaccharides such as starch and cellulose dérivatives, vinyl alcohol, vinyl acetate and vinyl pyrrolidone polymers and copolymers, polyethers, epoxy, phenolic and melamine resins, polyolefms and define copolymers and mixtures thereof. Examples of preferred polymers are acrylate polymers such as poly(methacrylate), poly(ethyl méthacrylate), poly(methyl méthacrylate), acrylate copoylmers and styrene-acrylic copolymers as defîned herein below, poly(styrene-co maleic anhydride), cellulosic polymers such as ethyl cellulose, cellulose acetate, cellulose acetatebutyrate, acetylated mono, di, and triglycérides, poly(vinyl pyrrolidone), vinyl acetate polymers and copolymers, poly(alkylene glycol), styrene butadiene copolymers, poly(ortho esters), alkyd resins, and mixtures of two or more of these.

Polymers that are biodégradable are also useful in the présent invention. As used herein, a polymer is biodégradable if is not water soluble, but is degraded over a period of several weeks when placed in an application environment. Examples of biodégradable polymers that are useful in the présent invention include biodégradable polyesters, starch, polylactic acid starch blends, polylactic acid, poly(lactic acid-glycolic acid) copolymers, polydioxanone, cellulose esters, ethyl cellulose, cellulose acetate butyrate, starch esters, starch ester aliphatic polyester blends, modified corn starch, poly capro lactone, poly(namylmethacrylate), wood rosin, poly anhydrides, poly vinyl alcohol, poly hydroxyl butyrate valerate, biodégradable aliphatic polyesters, and poly hydroxyl butyrate or mixtures thereof.

A defoamer, also called as anti-foaming agent, is generally added to the composition as foam formation prevents the efficient fïlling of a container. Suitable defoamer used herein, but not limited to, Siloxane polyalkylene oxide.

Buffering agent as used herein is selected from group consisting of calcium hydroxyapatite, Potassium Dihydrogen Phosphate, Sodium Hydroxide, carbonated apatite, calcium carbonate, sodium bicarbonate, tricalcium phosphate, calcium phosphates, carbonated calcium phosphates, amine monomers, lactate dehydrogenase and magnésium hydroxide.

The solvent for the formulation of the présent invention may include water, water soluble alcohols and dihydroxy alcohol ethers. The water-soluble alcohol which can be used in the présent invention may be lower alcohols or water-soluble macromolecular alcohols. The terni lower alcohol, as used herein, represents an alcohol having 1-4 carbon atoms, such as methanol, éthanol, n-propanol, isopropanol, n-butanol, tertbutanol, etc. Macromolecular alcohol is not limited, as long as it may be dissolved in water in a suitable amount range, e.g., polyethylene glycol, sorbitol, glucitol, etc. The examples of suitable dihydroxy alcohol ethers used in the présent invention may be dihydroxy alcohol alkyl ethers or dihydroxy alcohol aryl ethers. The examples of dihydroxy alcohol alkyl ether include ethylene glycol methyl ether, diethylene glycol methyl ether, propylene glycol methyl ether, dipropylene glycol methyl ether, ethylene glycol ethyl ether, diethylene glycol ethyl ether, propylene glycol ethyl ether, dipropylene glycol ethyl ether, etc. The examples of dihydroxy alcohol aiyl ethers include ethylene glycol phenyl ether, diethylene glycol phenyl ether, propylene glycol phenyl ether, dipropylene glycol phenyl ether, and the like. Any of the above mentioned solvent can be used either alone or in combination thereof.

The composition according to the présent invention may further comprises of additional components such as a surfactant, an agriculturally acceptable support, carrier or fîller, protective colloids, adhesives, thixotropic agents, pénétration agents, stabilisers, or sequestering agents.

In an embodiment, the présent invention provides a process for preparing the présent novel synergistic composition which may be modified accordingly by any person skilled in the art based on the knowledge of the manufacturing the formulation. However, ail such variations and modifications are still covered by the scope of présent invention.

Sr. No.

Raw Materials Details

% w/w

01	Pyriproxyfen Technical (97% basis)	08.25
02	Dinotefuran Technical (98% basis)	05.11
03	Diafenthiuron Technical (97.5% basis)	18.47
04	Surfactant/ Emulsifier - Blend of anionic & Non-ionic	10.50
05	Dispersing Agent- Ethoxylated Tristryl phénol Sulphate	01.10
06	Dispersing Agent- Tristyrylphenol Ethoxylate	01.50
07	Co-dispersing Agent-Acrylic polymer amine sait	00.50
08	Anti-freezing Agent -Mono Ethylene Glycol	02.50
09	Wetting Agent- Tristyrylphenol ethoxylate nonionic emulsifier	02.50
10	Antifoaming Agent-Siloxane polyalkyleneoxide	00.10
11	Thickener- Silicon Dioxide	00.40
12	Thickener- Clay	00.40
13	Anti-bacterial - Benzisothiazolin-3-one	00.10
14	Binder-Xanthan Gum	00.17
15	Demineralised(DM)Water	Q.S. to make 100%
	Total	100.00

These and other advantages of the invention may become more apparent from the examples set forth herein below. These examples are provided merely as illustrations of the invention and are not intended to be construed as a limitation thereof.

EXAMPLE-1

Préparation of a Synergistic Pesticidal Composition comprising Pyriproxyfen 8% + Dinotefuran 5% + Diafenthiuron 18% SC

Chemical Composition: 100% Basis

Sr. No.	Raw Materials Details	% w/w
01	Pyriproxyfen Technical (98% basis)	08.20
02	Dinotefuran Technical (99% basis)	05.05
03	Diafenthiuron Technical (97% basis)	18.56
04	Surfactant/ Emulsifier - Blend of anionic & Non-ionic	10.50
05	Dispersing Agent- Ethoxylated Tristryl phénol Sulphate	01.10
06	Dispersing Agent- Tristyrylphenol Ethoxylate	01.50
07	Co-dispersing Agent-Acrylic polymer amine sait	00.50
08	Anti-freezing Agent -Mono Ethylene Glycol	02.50
09	Wetting Agent- Tristyrylphenol ethoxylate nonionic emulsifier	02.50
10	Antifoaming Agent-Siloxane polyalkyleneoxide	00.10

11	Thickener- Silicon Dioxide	00.40
12	Thickener- Clay	00.40
13	Anti-bacterial - Benzisothiazolin-3-one	00.10
14	Xanthan Gum	00.17
15	DM Water	Q.S. to make 100%
	Total	100.00

EXAMPLE-2

Préparation of a Synergistic Pesticidal Composition comprising Pyriproxyfen +

Dinotefuran + Diafenthiuron SC

Chemical Composition: with Range of RM

Sr. No.	Raw Materials Details	% w/w
01	Pyriproxyfen Technical	01.0- 25.00
02	Dinotefuran Technical	00.50-50.00
03	Diafenthiuron Technical	01.00-85.00
04	Surfactant/ Emulsifier - Blend of anionic & Nonionic/Catanionic	01.00-10.00
05	Dispersing Agent- Tristyrylphenol Ethoxylate Amine sait of phosphate tristyryl phénol ethylated /Acrylic Copolymer/ Ethoxylated Tristryl phénol Sulphate	00.50- 10.00
06	Anti-freezing Agent -Mono Ethylene Glycol /Propylene glycol/Diethylene glycol	01.00-10.00
07	Wetting Agent- Tristyrylphenol ethoxylate nonionic emulsifier/ Mixture of non-ionic surfactants & Alkoxileted Alcohol	01.00-10.00
08	Antifoaming Agent-Siloxane polyalkyleneoxide	00.01 - 1.00
09	Thickener- Silicon Dioxide/China Clay/Kaolin/Talc/starch	00.50-5.00
10	Anti-bacterial - Benzisothiazolin-3-one / Formaldéhyde	00.01 - 1.00
11	Xanthan Gum	00.01 - 1.00
12	DM Water	Q.S. to make 100%
	Total	100.00

Manufacturing Method:

Take required quantity of Pyriproxyfen technical and melt it at 48°C and add emulsifier blend of anionic & Non-ionic mix homogeneous, then add Ethoxylated Tristryl phénol Sulphate, Tristyrylphenol Ethoxylate and Acrylic polymer amine sait and mix homogeneous.

Take 75% of DM water of recipe in premix vessel and add require quantity of Dinotefuran technical under stirring, material should be in suspension form then add mono ethylene glycol, china clay, ppt silica and Tristyrylphenol ethoxylate nonionic emulsifier mix homogeneous and added Diafenthiuron technical, antifoam and premix of Pyriproxyfen solution, mix homogeneous suspension.

The above mixed mass is grinding in Bead Mill. Grinding is carried out until a mean particle size of 3-5(D-90) microns is obtained.

After the grinding, add 2% water solution of xanthan gum under low stirring. After homogeneous mixed, check for quality parameter.

EXAMPLE-3

Préparation of a Synergistic Pesticidal Composition comprising Pyriproxyfen 8% + Dinotefuran 5% + Diafenthiuron 18% SE

Sr. No.	Raw Materials Details	% w/w
01	Pyriproxyfen Technical (98% basis)	08.20
02	Dinotefuran Technical (99% basis)	05.05
03	Diafenthiuron Technical (97% basis)	18.56
04	Emulsifier - Blend of anionic & Non-ionic	05.00
05	Dispersing Agent- Tristyrylphenol Ethoxylate & craft polymer	03.00
06	Anti-freezing Agent - Propylene Glycol	05.00
07	Wetting Agent- Sodium lauryl sulphate	02.00
08	Antifoaming Agent-Siloxane polyalkyleneoxide	00.10
09	Thickener- Silicon Dioxide	00.40
10	Anti-bacterial - Benzisothiazolin-3-one	00.10
11	Xanthan Gum	00.20
12	DM Water	Q.S. to make 100%
	Total	100.00

Process for préparation of above said composition wherein the dispersing cum wetting agent/surfactant, emulsifier is first diluted in D.M. Water, and solubilized by high shear mixing then add anti freezing agent, Dinotefuran technical, déformer and mix to make homogeneous then add Pyriproxyfen, Diafenthiuron technical and mix to make homogeneous mass.

The above mixed mass is grinded in Bead Mill. Grinding is carried out until a mean particle size of 3-5(D-90) microns is obtained. After the grinding, add 2% water solution of xanthan gum under low stirring.

EXAMPLE-4

Préparation of a Synergistic Pesticidal Composition comprising Pyriproxyfen 8% + Dinotefiiran 5% + Diafenthiuron 18% WP

Sr. No.	Raw Materials Details	% w/w
01	Pyriproxyfen Technical (98% basis)	08.20
02	Dinotefiiran Technical (99% basis)	05.05
03	Diafenthiuron Technical (97% basis)	18.56
04	Dispersing Agent- Napthalene sulfonic acid branched and linear sodium sait	10.00
05	Wetting Agent- Sodium disopropyl naphthalene sulfonate	03.00
06	Antifoaming Agent-Siloxane polyalkyleneoxide	00.05
07	Fillers (Silica / clay)	Q.S. to make 100%
	Total	100.00

Process for préparation of above said composition: weigh ail the ingrédients as per table and mix well using proper ribbon blender type mixer.

Thereafter, mill this premixing with suitable air jet mill/ Air classifier mill. Keep the milling chamber 6 kg per cm2- 8 kg per cm² and feeding pressure 2 kg per cm². Mill the material to achieving desired particle size.

Withdraw milled material in ribbon blender type mixer for post mixing. Mix well proper homogeneous.

EXAMPLE-5

Préparation of a Synergistic Pesticidal comprising Pvriproxyfen 8% + Dinotefiiran 5% +

Diafenthiuron 18% WPG

Sr. No.	Raw Materials Details	% w/w
01	Pyriproxyfen Technical (98% basis)	08.20
02	Dinotefiiran Technical (99% basis)	05.05

03	Diafenthiuron Technical (97% basis)	18.56
04	Dispersing Agent- Methyl Napthalene sulfonic acid polymer with formaldéhyde sodium sait	12.00
05	Wetting Agent- Sodium lauryl sulphate	05.00
06	Antifoaming Agent-Siloxane polyalkyleneoxide	00.10
07	Disintegration Agent — Citric acid / Sod. bicarbonate	02.00
08	Fillers (Silica / clay)	Q.S. to make 100%
	Total	100.00

Process for préparation: The above said composition is produced by mixing ail the raw materials such as wetting agent, dispersing agent, Fillers and technical’s in the given proportion.

The above mass mix in blender properly and grinding by jet mill/ACM. Grinding is carried ont 5 until a desired particle size is obtained. After grinding mix homogeneous by blender then prepared dough by dough mixer and carried out granules by extrader. After making granules, granules dry by hot air (FBD) or oven.

EXAMPLE-6

Evaluation of synergistic effect of the pesticidal composition of the présent invention:

Evaluation of the synergistic insecticidal effect of the composition comprising Diafenthiuron,Pyriproxyfen and an insecticide Dinotefuran can be established by using any synergistic insecticidal composition prepared by the process described in the above examples. For these évaluations one or more of the synergistic insecticidal compositions prepared in the examples 15 are used here.

Active Compound	Dose Rate	Active compound Dinotefuran	Active Compound	Dose Rate
(ppm)	Dose Rate (ppm)	(ppm)
Diafenthiuron	0	0	15	30	45	60	75	90	Pyriproxyfen	0
60	0	15	30	45	60	75	90	24
120	0	15	30	45	60	75	90	48
180	0	15	30	45	60	75	90	72
240	0	15	30	45	60	75	90	96
360	0	15	30	45	60	75	90	120

480 0 15 30 45 60 75 90

144

Treatments of White fly which are used are shown in Table 2.

Synergistic insecticidal effect of a combination of Dinotefuran + Diafenthiuron + Pyriproxyfen
Sr. No.	Dinotefuran	Diafenthiuron	Pyriproxyfen	Observed Mortality %	Expected Mortality %	Différence
1	45	0	0	35.10	-
2	60	0	0	45.50
3	75	0	0	52.00	-
4	90	0	0	61.40	-
5	0	120	0	38.40
6	0	240	0	48.50	-
7	0	360	0	57.30	-
8	0	480	0	61.80	-
9	0	0	72	30.70
10	0	0	96	38.10	-
11	0	0	120	43.70
12	0	0	144	46.60
13	45	120	72	60.00	72.29	-12.29
14	45	240	96	83.10	79.31	3.79
15	45	360	120	87.10	84.40	2.70
16	45	480	144	90.90	86.76	4.14
17	60	120	72	67.30	76.73	-9.43
18	60	240	96	94.10	82.63	11.47
19	60	360	120	94.30	86.90	7.40
20	60	480	144	95.10	88.88	6.22
21	75	120	72	69.90	79.51	-9.61
22	75	240	96	94.00	84.70	9.30
23	75	360	120	95.80	88.46	7.34

24	75	480	144	96.70	90.21	6.49
25	90	120	72	69.00	83.52	-14.52
26	90	240	96	96.50	87.69	8.81
27	90	360	120	97.10	90.72	6.38
28	90	480	144	98.40	92.13	6.27

Treatments of Jassids which are used are shown in Table 3.

Synergistic insecticidal effect of a combination of Dinotefuran + Diafenthiuron + Pyriproxyfen
Sr. No.	Dinotefuran	Diafenthiuron	Pyriproxyfen	Observed Mortality %	Expected Mortality %	Différence
1	45	0	0	65.60	-
2	60	0	0	73.40
3	75	0	0	79.00	-
4	90	0	0	83.80	-
5	0	120	0	28.90
6	0	240	0	42.00	-
7	0	360	0	48.50	-
8	0	480	0	57.40	-
9	0	0	72	21.70
10	0	0	96	29.20	-
11	0	0	120	35.50	-
12	0	0	144	37.90	-
13	45	120	72	77.70	80.85	-3.15
14	45	240	96	81.60	85.87	-4.27
15	45	360	120	85.50	88.57	-3.07
16	45	480	144	90.90	90.90	0.00
17	60	120	72	85.50	85.19	0.31
18	60	240	96	93.90	89.08	4.82
19	60	360	120	95.00	91.16	3.84
20	60	480	144	96.60	92.96	3.64

21	75	120	72	90.40	88.31	2.09
22	75	240	96	95.00	91.38	3.62
23	75	360	120	95.00	93.02	1.98
24	75	480	144	96.70	94.44	2.26
25	90	120	72	94.40	90.98	3.42
26	90	240	96	97.50	93.35	4.15
27	90	360	120	98.20	94.62	3.58
28	90	480	144	98.40	95.71	2.69

EXAMPLE-7

Synergism can be calculated by using the Colby's method i.e. the expected (or predicted) response of the combination is calculated by taking the product of the observed response for each individual component of the combination when applied alone divided by 100 and subtracting this value from the sum of observed response for each component when applied alone. Synergism of the combination is then determined by comparing the observed response of the combination to the expected (or predicted) response as calculated from the observed response of each individual component alone. If the observed response of the combination is greater than the expected (or predicted) response then the combination is said to be synergistic and falls within the définition of synergistic effect. (Colby, S. R., Weeds, 1967(15), p. 20-22).

TABLE 4 Synergistic insecticidal effect of a combination of Diafenthiuron 18% + Dinotefuran5%+ Pyriproxyfen 8% -SC spray application Observed Expected No. Mortality (%) 15 White fly on days after spray.

Mortality (%) White fly on days after -Diafenthiuron 18% + Dinotefuran5%+ Pyriproxyfen
	8% -SC spray application
S.N 0.	Active Ingrédient g a.i./ha dose	Formula tion Quantity (g/ha)	Pre cou nt	Morta lity 7DAT after Ist Spray	Pre cou nt	Morta lity 7DAT after 2nd Spray	Pre cou nt	Morta lity 7DAT after 3rd Spray	Mean mortal ity due to 3 sprays
1	Diafenthiuron 18% + Dinotefuran5%+	99	300	45. 0	65.5	23. 3	63.5	18. 4	66.6	65.2

	Pyriproxyfen 8% -SC
2	Diafenthiuron 18% + Dinotefuran5%+ Pyriproxyfen 8% -SC	19 8	600	33. 3	86.5	11. 2	88.8	13. 5	90.7	88.7
3	Diafenthiuron 18% + Dinotefuran5%+ Pyriproxyfen 8% -SC	39 6	1200	42. 3	89.0	10. 1	88.5	12. 1	92.3	89.9
4	Dinotefuran 20%SG	30	150	36. 3	62.0	25. 6	67.7	24. 3	72.0	67.2
5	Pyriproxyfen 10% EC	50	500	51. 0	64.5	30. 0	60.3	26. 6	65.7	63.5
6	Diafenthiuron 47.8% SC	23 9	500	45. 5	69.0	18. 8	71.1	16. 8	74.3	71.5
7	Untreated control (water spray)	-	-	48. 6	-24.0	56. 6	-30.2	51. 7	-28.5	-27.6

As can be seen from the data shown in Table 4, combinations of Diafenthiuron + Dinotefuran + Pyriproxyfen demonstrate synergistic insect control of White fly.

TABLE 5 Synergistic insecticidal effect of a combination of Diafenthiuron 18% + Dinotefuran5%+ Pyriproxyfen 8% -SC spray application Observed Expected No. Mortality (%) Jassids on days after spray.

Mortality (%) Jassids on days after -Diafenthiuron 18% + Dinoteftiran5%+ Pyriproxyfen 8% SC spray application
S.N 0.	Active Ingrédient g a.i./ha dose	Formula tion Quantit y(g/ha)	Precou nt befo re Ist Spr ay	Morta lity 7DAT after lst Spray	Precou nt befo re 2nd spra y	Morta lity 7DAT after 2nd Spray	Precou nt befo re 3rd Spr ay	Morta lity 7DAT after 3rd Spray	Mean morta lity due to 3 sprays
1	99	300	12.2	63.4	14.5	63.5	9.6	72.1	66.3

	Diafenthiuron 18% + Dinotefuran5%+ Pyriproxyfen 8% -SC
2	Diafenthiuron 18% + Dinotefuran5%+ Pyriproxyfen 8% -SC	19 8	600	9.3	86.5	8.5	93.4	5.5	95.5	91.8
3	Diafenthiuron 18% + Dinotefuran5%+ Pyriproxyfen 8% -SC	39 6	1200	15.0	90.7	9.1	94.1	5.1	93.9	92.9
4	Dinotefuran 20%SG	30	150	18.1	88.7	7.6	87.9	6.1	90.3	89.0
5	Pyriproxyfen 10% EC	50	500	16.5	45.5	13.2	40.4	11.1	48.4	44.8
6	Diafenthiuron 47.8% SC	23 9	500	8.7	56.7	10.1	63.2	8.3	68.9	62.9
7	Untreated control (water spray)	-	-	10.2	-17.7	18.9	-28.9	15.9	-23.9	-23.5

As can be seen from the data shown in Table 5, combinations of Diafenthiuron + Dinotefuran + Pyriproxyfen demonstrate synergistic insect control of Jassids.

From Table-4 and 5, Diafenthiuron 18% + Dinotefuran5%+ Pyriproxyfen 8% -SC at concentrations of 300, 600, 1200, g/ha are effective and superior at first and second sprays respectively which are superior and or on par with standard checks tested against as compared Dinotefuran 20%SG 300 g/ha, Pyriproxyfen 10% EC 300 g/ha and Diafenthiuron 47.8% SC 300 g/ha and untreated is as effective as standard checks after the first spray.

EXAMPLE 8

Bio-efficacy of the pesticidal composition of the présent invention:

The following provides the évaluation of the synergistic insecticidal effect of a combination of Diafenthiuron + Dinotefuran + Pyriproxyfen against White fly and Jassids on cotton.

In this example most of the synergistic insecticidal compositions prepared by the process described in this invention are used to evaluate their activities.

In this évaluation, percent mortality of hoppers is worked out based on the number of White fly and Jassids counted before and after sprays and based on dead heart counts before and after sprays.

The data is averaged and analyzed for the test of significance.

Details of the Experiment:

• a. Design: Randomised block design • b. Réplication: Three • c. Product: Diafenthiuron 18% + Dinotefuran 5%+ Pyriproxyfen 8% · d. Treatment: Seven (as shown in details in the Table-6)

Table 6 Details of the treatments of combination of Dinotefuran + Diafenthiuron + Pyriproxyfen

Details of the treatments done
S.No.	Active Ingrédient g a.i./ha dose	Formulation Quantity (g/ha)
1	Diafenthiuron 18% + Dinotefuran5%+ Pyriproxyfen 8% -SC	99	300
2	Diafenthiuron 18% + Dinoteftiran5%+ Pyriproxyfen 8% -SC	198	600
3	Diafenthiuron 18% + Dinotefuran5%+ Pyriproxyfen 8% -SC	396	1200
4	Dinotefuran 20%SG	99	300
5	Pyriproxyfen 10% EC	99	300
6	Diafenthiuron 47.8% SC	99	300

7

Untreated control

-

In this évaluation, White fly and Jassids are studied for effect of Pesticidal Composition of Pyriproxyfen, Dinotefuran and Diafenthiuron. On the Cotton crop, Ist Spray was done at the emergence of the pest at ETL level. 2nd Spray was done 15 days after the First Spray and 3rd Spray 15 days after the Second Spray.

Plot Size	5 X 4 m = 20 Sq. m.
Cotton Variety .	RCH-773
Spacing	90 X 60 cm
Fertilizer	N:P:K 50:25:25 kg/ha
Sprayer used	Knapsack sprayer
Spray volume	1.25 litre per 20 sq. m. plot

Method: Required quantity of spray fluid is prepared before spray application and for phytotoxicity studies concentration of Dinotefuran + Diafenthiuron + Pyriproxyfen at 300, 600,1200g/ha is laid out separately by the side of the bio-efficacy trial plot to avoid drift of the Chemical.

Ist Spray	-	At the emergence of the pest at ETL level
2nd Spray		15 days after the First Spray
3rd Spray	•	15 days after the Second Spray

Observations recorded: i. Pre and post treatment data of green leaf hopper in three leaves from the base, middle and top position of the plants, brown plant hoppers on the stem portions.

o Phytotoxicity of higher concentrations, o yield.

Method of Observation: Phytotoxicity in terms of yellowing, Stunting, Chlorosis, Leaf tip injury, Wilting, Hyponasty/Epinasty for ail treatments of leaves is recorded. When the crop attained maturity the 1 st., 2nd picking, subséquent the final picking. The total yield was computed to Mt/ha. The data is analyzed statistically to discriminate the treatment superiority for control leaf eating pests and variation in the yield.

Table 7 Observation

1	Bio- efficacy : On 0 Day (pre count), 7th and 14th Day after each spray test count for whitefly and Jassids (Adults+ nymphs)
2	Phytotoxicity: Recorded plant phtotoxicity after sprays based on 0-10 scale of assessment of yellowing, Stunting, Chlorosis, Leaf tip injury, Wilting, Hyponasty/Epinasty for ail treatments
3	Yield : Ist., 2nd picking, subséquent the final picking. The total yield was converted in Mt/ha

Table 8 Cotton seed lint yield kg/ha

Cotton seed lint yield kg/ha	Seed cotton kg/ha
S.No.	Active Ingrédient g a.i./ha dose	Formulation Quantity (g/ha)
1	Diafenthiuron 18% + Dinotefuran5%+ Pyriproxyfen 8% -SC	99	300	1798
2	Diafenthiuron 18% + Dinotefuran 5%+ Pyriproxyfen 8% -SC	198	600	2334
3	Diafenthiuron 18% + Dinotefuran5%+ Pyriproxyfen 8% -SC	396	1200	2386
4	Dinotefuran 20%SG	99	300	1866
5	Pyriproxyfen 10% EC	99	300	1806
6	Diafenthiuron 47.8% SC	99	300	1976
7	Untreated control		-	1455

Table 9 Phytotoxicity

Phytotoxicity due to application of pesticides	Mean of Cumulative Phytotoxicity (%) on 14th Day
S.No.	Active Ingrédient g a.i./ha dose	Formulation Quantity (g/ha)
1	Diafenthiuron 18% + Dinotefuran5%+ Pyriproxyfen 8% -SC	99	300	NP
2	Diafenthiuron 18% + Dinotefuran5%+ Pyriproxyfen 8% -SC	198	600	NP
3	Diafenthiuron 18% + Dinotefuran5%+ Pyriproxyfen 8% -SC	396	1200	*3.00%
4	Dinotefuran 20%SG	99	300	NP
5	Pyriproxyfen 10% EC	99	300	NP
6	Diafenthiuron 47.8% SC	99	300	NP
7	Untreated control	-	-	NP

NP : No Phytotoxicity * - Phytotoxicity is negligible (3%) at the highest concentration of pre- mixture, slight reddening 5 of leaves at early stage of crop only which were required completely after some time.

Results: The results of the field trial carried out to evaluate the bio-efficacy of and standardization ofdoses ofDiafenthiuron 18% + Dinotefuran 5%+ Pyriproxyfen 8% at doses 300,600,1200, g/ha as compared to Dinotefuran 20%SG 300 g/ha, Pyriproxyfen 10% EC 300 g/ha and Diafenthiuron

47.8% SC 300 g/ha and untreated check are presented in the above tables.

Diafenthiuron 18% + Dinotefuran 5%+ Pyriproxyfen 8% at 300, 600, 1200, g/ha are effective against White fly and Jassids. Irrespective of concentrations yields are superior over standard checks. Phytotoxicity is negligible (2 and 3%) at the highest concentrations of 1200 g/ha.

From the foregoing it will be observed that numerous modifications and variations can be 5 effectuated without departing from the true spirit and scope of the novel concepts of the présent invention. It is to be understood that no limitations with respect to the spécifie embodiments illustrated is intended or should be inferred. It should be understood that ail such modifications and improvements hâve been deleted herein for the sake of conciseness and readability but are properly within the scope of the following daims.

Claims

[CLAIM 1]. A synergistic pesticidal composition comprising;

(a) Diafenthiuron;

(b) Pyriproxyfen;

(c) at least one insecticide selected from Thiamethoxam, Imidacloprid, Thiacloprid, Dinotefuran, Clothianidin, Pymetrozine;

(d) one or more inactive excipients selected from the group comprising surfactant, dispersing agent, anti-freezing agent, wetting agent, anti-foaming agent, suspension aid, anti-microbial/bacterial agent, thickener, quick coating agent or sticking agents, buffering agent, binder and fîller.

[CLAIM 2]. The synergistic pesticidal composition as claimed in claim l, wherein

A) Diafenthiuron is présent in an amount in the range from 5.0 to 60%w/w;

B) Pyriproxyfen is présent in an amount in the range from l .0 to 25%w/w;

C) at least one more insecticide selected from Thiamethoxam, Imidacloprid, Thiacloprid, Dinotefuran, Clothianidin, Pymetrozine, is présent in an amount in the range from 0.5 to 50%w/w.

[CLAIM 3]. The synergistic pesticidal composition as claimed in claim 1, wherein the composition of the active ingrédients in the said pesticidal composition comprises of

a) Diafenthiuron, in an amount in the range from 15-35% w/w, pyriproxyfen in an amount in the range from 5-25% w/w, thiamethoxam in an amount in the range from 2.5-15% w/w and one or more inactive excipients, or

b) Diafenthiuron in an amount in the range from 5-14% w/w, Pyriproxyfen in an amount in the range from 2.8-4% w/w, Thiamethoxam in an amount in the range from 15.1-35% w/w and one or more inactive excipients, or

c) Diafenthiuron in an amount in the range from 40-60% w/w, Pyriproxyfen in an amount in the range from 1-2.7% w/w,

Thiamethoxam in an amount in the range from 35.1-50 % w/w and one or more inactive excipients, or

d) Diafenthiuron in an amount in the range from 15-35% w/w, Pyriproxyfen in an amount in the range from 5-25% w/w, Imidacloprid in an amount in the range from 5-15% w/w and one or more inactive excipients, or

e) Diafenthiuron in an amount in the range from 5-14% w/w, Pyriproxyfen in an amount in the range from 2.8-4.9% w/w, Imidacloprid in an amount in the range from 15.1-35% w/w and one or more inactive excipients, or

f) Diafenthiuron in an amount in the range from 40-60% w/w, Pyriproxyfen in an amount in the range from 1-2.7% w/w, Imidacloprid in an amount in the range from 35.1-50% w/w and one or more inactive excipients, or

g) Diafenthiuron in an amount in the range from 15-35% w/w, Pyriproxyfen in an amount in the range from 5-25% w/w, Thiacloprid in an amount in the range from 2.5-10% w/w and one or more inactive excipients, or

h) Diafenthiuron in an amount in the range from 5-14% w/w, Pyriproxyfen in an amount in the range from 2.8-4.9% w/w, Thiacloprid in an amount in the range from 10-20% w/w and one or more inactive excipients, or

i) Diafenthiuron in an amount in the range from 40-60% w/w, Pyriproxyfen in an amount in the range from 1-2.7% w/w, Thiacloprid in an amount in the range from 20.1-50% w/w and one or more inactive excipients, or

j) Diafenthiuron in an amount in the range from 15.0-35.0% w/w, Pyriproxyfen in an amount in the range from 5.0-25% w/w, Dinotefuran in an amount in the range from 0.5-15% w/w and one or more inactive excipients, or

k) Diafenthiuron in an amount in the range from 5.0-14% w/w, Pyriproxyfen in an amount in the range from 2.8-4.9% w/w, Dinotefuran in an amount in the range from 15.1-35% w/w and one or more inactive excipients, or

l) Diafenthiuron in an amount in the range from 40-60% w/w, Pyriproxyfen in an amount in the range from l .0-2.7% w/w, Dinotefuran in an amount in the range from 35.1-50% w/w and one or more inactive excipients, or

m) Diafenthiuron in an amount in the range from 15-35% w/w, Pyriproxyfen in an amount in the range from 5-25% w/w, Clothianidin in an amount in the range from 2.5-15% w/w and one or more inactive excipients, or

n) Diafenthiuron in an amount in the range from 5-14% w/w, Pyriproxyfen in an amount in the range from 2.8-4.9% w/w, Clothianidin in an amount in the range from 15.1-25% w/w and one or more inactive excipients, or

o) Diafenthiuron in an amount in the range from 40-60% w/w, Pyriproxyfen in an amount in the range from 1-2.7% w/w, Clothianidin in an amount in the range from 25.1 -40% w/w and one or more inactive excipients, or

p) Diafenthiuron in an amount in the range from 15-35% w/w, Pyriproxyfen in an amount in the range from 5-25% w/w, Pymetrozine in an amount in the range from 0.5-15% w/w and one or more inactive excipients, or

q) Diafenthiuron in an amount in the range from 5-14% w/w, Pyriproxyfen in an amount in the range from 2.8-4.9% w/w, Pymetrozine in an amount in the range from 15.1-35% w/w and one or more inactive excipients, or

r) Diafenthiuron in an amount in the range from 40-60% w/w, Pyriproxyfen in an amount in the range from 1-2.7% w/w, Pymetrozine in an amount in the range from 35.1-50% w/w and one or more inactive excipients.

[CLAIM 4]. The synergistic pesticidal composition as claimed in claim 1-3, wherein the surfactant is selected from the group comprising non-ionic surfactants, cationic surfactants and anionic surfactants or blend of anionic & Non-ionic/Catanionic or a combination thereof and présent in an amount in the range from 1.00 to 10.00 %w/w

[CLAIM 5]. The synergistic pesticidal composition as claimed in claim 1-3, wherein the dispersing agent is selected from the group comprising Tristyrylphenol Ethoxylate Amine sait of phosphate tristyryl phénol ethylated /Acrylic

Copolymer/ Ethoxylated Tristryl phénol Sulphate or a combination thereof and présent in an amount in the range from 0.5 to 10.00%w/w.

[CLAIM 6]. The synergistic pesticidal composition as claimed in claim 1-3, wherein antifreezing agent is selected from the group comprising Mono Ethylene Glycol /Propylene glycol/Diethylene glycol or a combination thereof and présent in an amount in the range from 0.1 to 10.00 %w/w.

[CLAIM 7]. The synergistic pesticidal composition as claimed in claim 1-3, wherein wetting agent is selected from the group comprising Tristyrylphenol ethoxylate nonionic emulsifier/ Mixture of non-ionic surfactants & Alkoxylated Alcohol or a combination thereof and présent in an amount in the range from 0.1 to 10.00 %w/w.

[CLAIM 8]. The synergistic pesticidal composition as claimed in claim 1-3, wherein antifoaming agent is selected from the group comprising Siloxane polyalkyleneoxide, and is présent in an amount in the range from 0.01 to 1.00 %w/w

[CLAIM 9]. The synergistic pesticidal composition as claimed in claim 1-3, wherein thickener is selected from the group comprising Silicon Dioxide/China Clay/Kaolin/Talc/starch or a combination thereof and présent in an amount in the range from 0.50 to 5.00 %w/w.

[CLAIM 10]. The synergistic pesticidal composition as claimed in claim 1-3, wherein the binder is selected as Xanthum Gum and is présent in an amount in the range from 0.01 to 1.00 %w/w

[CLAIM 11].The synergistic pesticidal composition as claimed in claim 1-3 wherein the composition is formulated as selected from Emulsifiable concentrate (EC), Emulsifiable granule (EG), Emulsion water-in-oil (EO), Emulsifiable powder (EP), Emulsion for seed treatment (ES), Emulsion oil-in-water (EW), Flowable Slurry (FS), Flowable Suspension(FS), Suspension Concentrate (SC), Suspension concentrate for direct application (SD), Suspo- émulsion (SE), Water soluble granule (SG), Soluble concentrate (SL), Water soluble powder (SP ), Water dispersible powder for slurry seed treatment (WS), Water dispersible granules (WDG),Wettable powders (WP), Water dispersible powder for slurry seed treatment (WS), Water dispersible tablet (WT), a mixed formulation of CS and SC (ZC) or A mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW).

[CLAIM 12]. The synergistic pesticidal composition as claimed in claim 1-11, wherein the suspoemulsion (SE), formulation comprises of:

a) Pyriproxyfen in an amount of 8%w/w by weight of the composition;

b) Dinotefuran in an amount of 5% w/w by weight of the composition;

c) Diafenthiuron in an amount of 18% w/w by weight of the composition;

d) Surfactant/ Emulsifier selected form Blend of anionic & Non-ionic;

e) Dispersing Agent selected form Tristyrylphenol Ethoxylate & craft polymer;

f) Propylene Glycol as Anti-freezing Agent

g) Sodium lauryl sulphate as Wetting Agent;

h) Siloxane polyalkyleneoxide as Antifoaming Agent ;

i) Silicon Dioxide as thickener;

j) Benzisothiazolin-3-one as Anti-bacterial;

k) Xanthan Gum as binder.

[CLAIM 13]. The synergistic pesticidal composition as claimed in claim 1-11, wherein the wettable powder (WP) formulation comprises of:

a) Pyriproxyfen in an amount of 8%w/w by weight of the composition;

b) Dinotefuran in an amount of 5% w/w by weight of the composition;

c) Diafenthiuron in an amount of 18% w/w by weight of the composition;

d) Dispersing Agent selected from Napthalene sulfonic acid branched and linear sodium sait;

e) Sodium disopropyl naphthalene sulfonate as Wetting Agent;

f) Siloxane polyalkyleneoxide as Antifoaming Agent;

g) Fillers.

[CLAIM 14]. The synergistic pesticidal composition as claimed in claim 1-11, wherein the Water Dispersible Granules (WDG) formulation comprises of:

a) Pyriproxyfen in an amount of 8%w/w by weight of the composition;

b) Dinotefuran in an amount of 5% w/w by weight of the composition;

c) Diafenthiuron in an amount of 18% w/w by weight of the composition;

d) Dispersing Agent is selected from Methyl Napthalene sulfonic acid polymer with formaldéhyde sodium sait;

e) Sodium lauryl sulphate as Wetting Agent;

f) Siloxane polyalkyleneoxide as Antifoaming Agent;

g) Citric acid / Sod. Bicarbonate as Disintegration Agent;

h) Fillers.