OA21169A - A storage stable insecticidal composition. - Google Patents
A storage stable insecticidal composition. Download PDFInfo
- Publication number
- OA21169A OA21169A OA1202300047 OA21169A OA 21169 A OA21169 A OA 21169A OA 1202300047 OA1202300047 OA 1202300047 OA 21169 A OA21169 A OA 21169A
- Authority
- OA
- OAPI
- Prior art keywords
- composition
- cyhalothrin
- mixture
- lambda
- acid
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 541
- 230000000749 insecticidal effect Effects 0.000 title claims abstract description 187
- 238000003860 storage Methods 0.000 title abstract description 134
- ZXQYGBMAQZUVMI-RDDWSQKMSA-N (1S)-cis-(alphaR)-cyhalothrin Chemical compound CC1(C)[C@H](\C=C(/Cl)C(F)(F)F)[C@@H]1C(=O)O[C@@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 ZXQYGBMAQZUVMI-RDDWSQKMSA-N 0.000 claims abstract description 227
- 239000005910 lambda-Cyhalothrin Substances 0.000 claims abstract description 226
- 238000000034 method Methods 0.000 claims abstract description 55
- 239000002917 insecticide Substances 0.000 claims description 123
- 239000002253 acid Substances 0.000 claims description 88
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 57
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 51
- 239000004546 suspension concentrate Substances 0.000 claims description 51
- 241000607479 Yersinia pestis Species 0.000 claims description 50
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims description 50
- 239000005906 Imidacloprid Substances 0.000 claims description 48
- 229940056881 imidacloprid Drugs 0.000 claims description 48
- YWTYJOPNNQFBPC-UHFFFAOYSA-N imidacloprid Chemical compound [O-][N+](=O)\N=C1/NCCN1CC1=CC=C(Cl)N=C1 YWTYJOPNNQFBPC-UHFFFAOYSA-N 0.000 claims description 48
- 239000004490 capsule suspension Substances 0.000 claims description 42
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 32
- 238000009472 formulation Methods 0.000 claims description 31
- 150000003839 salts Chemical class 0.000 claims description 30
- 239000005886 Chlorantraniliprole Substances 0.000 claims description 29
- PSOVNZZNOMJUBI-UHFFFAOYSA-N chlorantraniliprole Chemical compound CNC(=O)C1=CC(Cl)=CC(C)=C1NC(=O)C1=CC(Br)=NN1C1=NC=CC=C1Cl PSOVNZZNOMJUBI-UHFFFAOYSA-N 0.000 claims description 29
- 238000002156 mixing Methods 0.000 claims description 29
- RLQJEEJISHYWON-UHFFFAOYSA-N flonicamid Chemical compound FC(F)(F)C1=CC=NC=C1C(=O)NCC#N RLQJEEJISHYWON-UHFFFAOYSA-N 0.000 claims description 26
- 239000005900 Flonicamid Substances 0.000 claims description 25
- 239000005931 Spirotetramat Substances 0.000 claims description 24
- CLSVJBIHYWPGQY-GGYDESQDSA-N spirotetramat Chemical group CCOC(=O)OC1=C(C=2C(=CC=C(C)C=2)C)C(=O)N[C@@]11CC[C@H](OC)CC1 CLSVJBIHYWPGQY-GGYDESQDSA-N 0.000 claims description 24
- -1 flucydoxuron Chemical compound 0.000 claims description 23
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 23
- 239000007788 liquid Substances 0.000 claims description 21
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 19
- 150000001412 amines Chemical class 0.000 claims description 19
- UHZZMRAGKVHANO-UHFFFAOYSA-M chlormequat chloride Chemical compound [Cl-].C[N+](C)(C)CCCl UHZZMRAGKVHANO-UHFFFAOYSA-M 0.000 claims description 19
- YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 claims description 18
- 229960002303 citric acid monohydrate Drugs 0.000 claims description 18
- 239000002245 particle Substances 0.000 claims description 18
- 229960004106 citric acid Drugs 0.000 claims description 17
- 239000001509 sodium citrate Substances 0.000 claims description 17
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 16
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 15
- XYFMGGWVGACNEC-UHFFFAOYSA-N n-carbamoyl-n-phenylbenzamide Chemical compound C=1C=CC=CC=1N(C(=O)N)C(=O)C1=CC=CC=C1 XYFMGGWVGACNEC-UHFFFAOYSA-N 0.000 claims description 15
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims description 13
- 229940038773 trisodium citrate Drugs 0.000 claims description 13
- RUXHWBMJNBBYNL-UHFFFAOYSA-N 3-hydroxy-1,2-dihydropyrrol-5-one Chemical compound OC1=CC(=O)NC1 RUXHWBMJNBBYNL-UHFFFAOYSA-N 0.000 claims description 11
- 239000008346 aqueous phase Substances 0.000 claims description 10
- 239000012948 isocyanate Substances 0.000 claims description 10
- 150000002513 isocyanates Chemical class 0.000 claims description 10
- 239000012074 organic phase Substances 0.000 claims description 10
- 239000000725 suspension Substances 0.000 claims description 10
- 239000002562 thickening agent Substances 0.000 claims description 10
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 9
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 9
- 235000019797 dipotassium phosphate Nutrition 0.000 claims description 9
- 229910000396 dipotassium phosphate Inorganic materials 0.000 claims description 9
- 238000009826 distribution Methods 0.000 claims description 9
- WCXDHFDTOYPNIE-RIYZIHGNSA-N (E)-acetamiprid Chemical compound N#C/N=C(\C)N(C)CC1=CC=C(Cl)N=C1 WCXDHFDTOYPNIE-RIYZIHGNSA-N 0.000 claims description 8
- 239000005875 Acetamiprid Substances 0.000 claims description 8
- 239000005888 Clothianidin Substances 0.000 claims description 8
- 239000005912 Lufenuron Substances 0.000 claims description 8
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 8
- ZXQYGBMAQZUVMI-UNOMPAQXSA-N cyhalothrin Chemical compound CC1(C)C(\C=C(/Cl)C(F)(F)F)C1C(=O)OC(C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 ZXQYGBMAQZUVMI-UNOMPAQXSA-N 0.000 claims description 8
- 229960000521 lufenuron Drugs 0.000 claims description 8
- PWPJGUXAGUPAHP-UHFFFAOYSA-N lufenuron Chemical compound C1=C(Cl)C(OC(F)(F)C(C(F)(F)F)F)=CC(Cl)=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F PWPJGUXAGUPAHP-UHFFFAOYSA-N 0.000 claims description 8
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 8
- 239000005889 Cyantraniliprole Substances 0.000 claims description 7
- UISUNVFOGSJSKD-UHFFFAOYSA-N chlorfluazuron Chemical compound FC1=CC=CC(F)=C1C(=O)NC(=O)NC(C=C1Cl)=CC(Cl)=C1OC1=NC=C(C(F)(F)F)C=C1Cl UISUNVFOGSJSKD-UHFFFAOYSA-N 0.000 claims description 7
- DVBUIBGJRQBEDP-UHFFFAOYSA-N cyantraniliprole Chemical compound CNC(=O)C1=CC(C#N)=CC(C)=C1NC(=O)C1=CC(Br)=NN1C1=NC=CC=C1Cl DVBUIBGJRQBEDP-UHFFFAOYSA-N 0.000 claims description 7
- 150000007524 organic acids Chemical group 0.000 claims description 7
- KNDVJPKNBVIKML-UHFFFAOYSA-N tetraniliprole Chemical compound CNC(=O)C1=CC(C#N)=CC(C)=C1NC(=O)C1=CC(CN2N=C(N=N2)C(F)(F)F)=NN1C1=NC=CC=C1Cl KNDVJPKNBVIKML-UHFFFAOYSA-N 0.000 claims description 7
- PGOOBECODWQEAB-UHFFFAOYSA-N (E)-clothianidin Chemical compound [O-][N+](=O)\N=C(/NC)NCC1=CN=C(Cl)S1 PGOOBECODWQEAB-UHFFFAOYSA-N 0.000 claims description 6
- RAMUASXTSSXCMB-UHFFFAOYSA-N 3-bromo-N-{2-bromo-4-chloro-6-[(1-cyclopropylethyl)carbamoyl]phenyl}-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide Chemical compound C1CC1C(C)NC(=O)C1=CC(Cl)=CC(Br)=C1NC(=O)C1=CC(Br)=NN1C1=NC=CC=C1Cl RAMUASXTSSXCMB-UHFFFAOYSA-N 0.000 claims description 6
- 150000007522 mineralic acids Chemical group 0.000 claims description 6
- 239000005893 Diflubenzuron Substances 0.000 claims description 5
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 5
- 239000005938 Teflubenzuron Substances 0.000 claims description 5
- 239000005941 Thiamethoxam Substances 0.000 claims description 5
- 239000005942 Triflumuron Substances 0.000 claims description 5
- QQQYTWIFVNKMRW-UHFFFAOYSA-N diflubenzuron Chemical compound FC1=CC=CC(F)=C1C(=O)NC(=O)NC1=CC=C(Cl)C=C1 QQQYTWIFVNKMRW-UHFFFAOYSA-N 0.000 claims description 5
- 229940019503 diflubenzuron Drugs 0.000 claims description 5
- RYLHNOVXKPXDIP-UHFFFAOYSA-N flufenoxuron Chemical compound C=1C=C(NC(=O)NC(=O)C=2C(=CC=CC=2F)F)C(F)=CC=1OC1=CC=C(C(F)(F)F)C=C1Cl RYLHNOVXKPXDIP-UHFFFAOYSA-N 0.000 claims description 5
- RGNPBRKPHBKNKX-UHFFFAOYSA-N hexaflumuron Chemical compound C1=C(Cl)C(OC(F)(F)C(F)F)=C(Cl)C=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F RGNPBRKPHBKNKX-UHFFFAOYSA-N 0.000 claims description 5
- 238000000265 homogenisation Methods 0.000 claims description 5
- 238000003801 milling Methods 0.000 claims description 5
- YTYGAJLZOJPJGH-UHFFFAOYSA-N noviflumuron Chemical compound FC1=C(Cl)C(OC(F)(F)C(C(F)(F)F)F)=C(Cl)C=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F YTYGAJLZOJPJGH-UHFFFAOYSA-N 0.000 claims description 5
- 239000011975 tartaric acid Substances 0.000 claims description 5
- 235000002906 tartaric acid Nutrition 0.000 claims description 5
- CJDWRQLODFKPEL-UHFFFAOYSA-N teflubenzuron Chemical compound FC1=CC=CC(F)=C1C(=O)NC(=O)NC1=CC(Cl)=C(F)C(Cl)=C1F CJDWRQLODFKPEL-UHFFFAOYSA-N 0.000 claims description 5
- NWWZPOKUUAIXIW-FLIBITNWSA-N thiamethoxam Chemical compound [O-][N+](=O)\N=C/1N(C)COCN\1CC1=CN=C(Cl)S1 NWWZPOKUUAIXIW-FLIBITNWSA-N 0.000 claims description 5
- XAIPTRIXGHTTNT-UHFFFAOYSA-N triflumuron Chemical compound C1=CC(OC(F)(F)F)=CC=C1NC(=O)NC(=O)C1=CC=CC=C1Cl XAIPTRIXGHTTNT-UHFFFAOYSA-N 0.000 claims description 5
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 4
- 239000004327 boric acid Substances 0.000 claims description 4
- YNKFZRGTXAPYFD-UHFFFAOYSA-N n-[[2-chloro-3,5-bis(trifluoromethyl)phenyl]carbamoyl]-2,6-difluorobenzamide Chemical compound FC1=CC=CC(F)=C1C(=O)NC(=O)NC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1Cl YNKFZRGTXAPYFD-UHFFFAOYSA-N 0.000 claims description 4
- OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 claims description 4
- 229940099402 potassium metaphosphate Drugs 0.000 claims description 4
- HELHAJAZNSDZJO-UHFFFAOYSA-L sodium tartrate Chemical compound [Na+].[Na+].[O-]C(=O)C(O)C(O)C([O-])=O HELHAJAZNSDZJO-UHFFFAOYSA-L 0.000 claims description 4
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 4
- 239000008158 vegetable oil Substances 0.000 claims description 4
- BTYQXKURSPAXLT-UHFFFAOYSA-N 2,6-dichloro-n-[(4-chlorophenyl)carbamoyl]benzamide Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC(=O)C1=C(Cl)C=CC=C1Cl BTYQXKURSPAXLT-UHFFFAOYSA-N 0.000 claims description 3
- JTHMHWAHAKLCKT-UHFFFAOYSA-N 2,6-difluoro-n-[[4-(trifluoromethyl)phenyl]carbamoyl]benzamide Chemical compound FC1=CC=CC(F)=C1C(=O)NC(=O)NC1=CC=C(C(F)(F)F)C=C1 JTHMHWAHAKLCKT-UHFFFAOYSA-N 0.000 claims description 3
- YPSCQJTUAKNUNF-UHFFFAOYSA-N 2-chloro-n-[(4-chlorophenyl)carbamoyl]benzamide Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC(=O)C1=CC=CC=C1Cl YPSCQJTUAKNUNF-UHFFFAOYSA-N 0.000 claims description 3
- ONILAONOGQYBHW-UHFFFAOYSA-N 5-bromo-n-[2,4-dichloro-6-(methylcarbamoyl)phenyl]-2-(3,5-dichloropyridin-2-yl)pyrazole-3-carboxamide Chemical compound CNC(=O)C1=CC(Cl)=CC(Cl)=C1NC(=O)C1=CC(Br)=NN1C1=NC=C(Cl)C=C1Cl ONILAONOGQYBHW-UHFFFAOYSA-N 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 3
- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 3
- 235000006408 oxalic acid Nutrition 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 239000001384 succinic acid Substances 0.000 claims description 3
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 claims description 2
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 claims description 2
- 239000005695 Ammonium acetate Substances 0.000 claims description 2
- 239000004254 Ammonium phosphate Substances 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 2
- 235000019257 ammonium acetate Nutrition 0.000 claims description 2
- 229940043376 ammonium acetate Drugs 0.000 claims description 2
- 229910000148 ammonium phosphate Inorganic materials 0.000 claims description 2
- 235000019289 ammonium phosphates Nutrition 0.000 claims description 2
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims description 2
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims description 2
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 claims description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 2
- 229910000397 disodium phosphate Inorganic materials 0.000 claims description 2
- 235000019800 disodium phosphate Nutrition 0.000 claims description 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 2
- 239000011976 maleic acid Substances 0.000 claims description 2
- 239000001508 potassium citrate Substances 0.000 claims description 2
- 229960002635 potassium citrate Drugs 0.000 claims description 2
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims description 2
- 235000011082 potassium citrates Nutrition 0.000 claims description 2
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 claims description 2
- 239000001632 sodium acetate Substances 0.000 claims description 2
- 235000017281 sodium acetate Nutrition 0.000 claims description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 2
- 229940074404 sodium succinate Drugs 0.000 claims description 2
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 claims description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- SGPGESCZOCHFCL-UHFFFAOYSA-N Tilisolol hydrochloride Chemical compound [Cl-].C1=CC=C2C(=O)N(C)C=C(OCC(O)C[NH2+]C(C)(C)C)C2=C1 SGPGESCZOCHFCL-UHFFFAOYSA-N 0.000 claims 1
- 238000002360 preparation method Methods 0.000 abstract description 2
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- OJQSISYVGFJJBY-UHFFFAOYSA-N 1-(4-isocyanatophenyl)pyrrole-2,5-dione Chemical compound C1=CC(N=C=O)=CC=C1N1C(=O)C=CC1=O OJQSISYVGFJJBY-UHFFFAOYSA-N 0.000 description 10
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- 239000003112 inhibitor Substances 0.000 description 10
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- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 8
- MTZUIIAIAKMWLI-UHFFFAOYSA-N 1,2-diisocyanatobenzene Chemical compound O=C=NC1=CC=CC=C1N=C=O MTZUIIAIAKMWLI-UHFFFAOYSA-N 0.000 description 7
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Abstract
The present invention relates to an insecticidal composition comprising lambda-cyhalothrin with other active ingredients. The insecticidal composition of the present invention is storage stable. The present invention also describe process of preparation and methods of use of the same.
Description
TITLE: A STORAGE STABLE INSECTICIDAL COMPOSITION
Field of the Invention: I
The présent invention relates to a storage stable insecticidal composition. The présent invention more particularly relates to a storage stable insecticidal 5 composition of lambda-cyhalothrin with other active ingrédients.
Background and the prior art:
The control of pests is important in achieving desired levels of crop efficiency.
Pest damage to growing and stored agronomie crops can cause significant h réduction in productivité which can resuit in increased costs to the consumer. 10 Many products are commercially available and commonly used for controlling pests, some of them are used as single active composition or some are used as combination of more than one active. However, due to acquired résistance over the years, compositions with more than one active are commonly and frequently been used. Such compositions broaden the spectrum of 15 applicability, and delay the development of résistance to pesticides, including insecticides, by combining the application of two or more products. P
Pyrethroid compounds hâve excellent pesticidal activity. Pyrethroid compounds are one of the preferred choices for pest-control. One such pyrethroid, Lambda-cyhalothrin is a synthetic pyrethroid, developed as an 20 insecticide for agricultural applications and it is used to control wide spectrum of insect pests, e. g. aphids, Colorado beetles, thrips, lepidoptera larvae, coleoptera larvae, etc. Lambda-cyhalothrin is a broad-spectrum insecticide effective at low rates of application against major insect pests in a wide range of crops, including cotton, soybean, green vegetables, tomato, potato, wheat, 25 barley, maize, sorghum, vines, fruit tree crops, among others.
L I 2
Cyhalothrin is a mixture of four isomers, and two of these isomers compose lambda-cyhalothrin. Chemically, lambda-cyhalothrin is a 1:1 mixture of Sisomer, (S)-a-cyano-3-phenoxybenzyl-(Z)-(1R,3R)-3-(2-chloro-3,3,3trifluoroprop-1-enyl)-2,2-dimethylcyclopropane carboxylate and R-isomer, 5 (R)-a-cyano-3-phenoxybenzyl (Z)-( 1 S,3S)-3-(2-chloro-3,3,3-trifluoroprop-1 enyl)-2,2-dimethylcyclopropane carboxylate. This 1:1 mixture is known to be active and hâve better insecticidal activity than other two isomers of cyhalothrin. It is known that upon storing lambda-cyhalothrin, these active isomers tend to transform to the inactive isomers of cyhalothrin. Such kind of 10 isomeric transformation lead to less biologically efficacious compositions of lambda-cyhalothrin. «
When lambda-cyhalothrin is combined with a second active, the problem of I isomeric transformation further exaggerates. Attempts hâve been made in the prior art to develop compositions of lambda-cyhalothrin either alone or in combination with another active Ingrédient which are storage stable.
IN259005 discloses lambda-cyhalothrin Emulsifiable Concentrate (EC) composition in which isomer transformation is prevented by addition of phosphate esters selected from alkyl or aryl alkoxylate, alkoxylates of fatty alcohol, alkoxylates of fatty acids, block co-polymers of ethylene oxide and 20 propylene oxide, polyaryl substituted aliphatic or aromatic alkoxylate and alkoxylated polyaryl substituted phénol, their dérivatives and mixtures.
3586/DEL/2013 discloses synergistic combination of imidacloprid and lambda-cyhalothrin formulated as soluble liquid (SL) using formulation ingrédients such as polyvinyl pyrrolidone copolymer, ethoxylated alkyl aryl 25 phénol emulsifier, dimethyl sulfoxide solvent and N-methyl pyrrolidone. It does not address isomeric transformation related issues while combining lambda-cyhalothrin and imidacloprid.
As a resuit, there has been an ongoing need to develop stable formulations in a suitable form containing lambda-cyhalothrin combining with another active ingrédient which has good shelf life and storage stability.
Objective of the invention: «
An object of the présent invention is to provide a storage stable insecticidal composition.
Another object of the présent invention is to provide a storage stable insecticidal composition of lambda-cyhalothrin in combination with another insecticide, i
Yet another object of the présent invention is to provide a storage stable insecticidal composition of lambda-cyhalothrin in combination with another insecticide which does not undergo isomeric transformation even after prolonged storage. l·
Still another object of the présent invention is to provide a process of preparing storage stable insecticidal composition of lambda-cyhalothrin in combination with another insecticide.
Summary of the Invention: » I
In an aspect, the présent invention provides a storage stable insecticidal composition comprising:
(a) Lambda-cyhalothrin in an amount of 0.1% to 50% by weight of the composition;
(b) atleast one insecticide in an amount of 0.1% to 50% by weight of the composition; and (c) mixture of a weak acid and its sait.
In another aspect, the présent invention provides a storage stable insecticidal composition comprising:
(a) Lambda-cyhalothrin in an amount of 0.1% to 50% by weight of the 5 composition;
(b) atleast one insecticide selected from group comprising of neonicotinoids and benzoylphenyl urea compounds in an amount of 0.1 % to 50% by weight of the composition; and (c) mixture of weak acid and its sait.
»
In another aspect, the présent invention provides a process for the préparation of storage stable insecticidal composition comprising (a) Lambda-cyhalothrin in an amount of 0.1% to 50% by weight of the composition; (b) atleast one insecticide in an amount of 0.1 % to 50% by weight of the composition; and (c) mixture of weak acid and its sait; wherein said process comprising steps of: J- t (a) mixing lambda- cyhalothrin with another insecticide in a suitable System, (b) optionally, adding other excipients(s) to obtain pre-mix, (c) adding mixture of weak acid and its sait to the pre-mix to obtain 20 storage stable insecticidal composition.
In yet another aspect, the présent invention provides use of storage stable insecticidal composition according to the présent invention to control wide range of insects.
In another aspect, the présent invention provides a method for controlling 25 pests, which comprises applying effective amounts of storage stable
i.
insecticidal composition comprising (a) Lambda-cyhalothrin in an amount of 0.1% to 50% by weight of the composition; (b) atleast one insecticide in an amount of0.1% to 50% by weight ofthe composition; and (c) mixture ofweak acid and its sait, to pests or a locus where the pests inhabit.
In another aspect, the présent invention provides a kit. The kit comprises a plurality of components, each of which components may include at least one, or more, ofthe ingrédients ofthe storage stable insecticidal composition of the présent invention.
Detailed Description ofthe invention: h
The inventors ofthe présent invention surprisinglyfound that addition ofthe mixture of weak acid and its salts in the composition comprising lambdaI cyhalothrin with another active ingrédient hâve an important effect on lambda-cyhalothrin stability. The presence ofthe mixture of weak acid and its salts found to control isomer transformation by preventing conversion of 15 active isomer to inactive isomer. The compositions and methods disclosed herein thus provide an important tool in solving the lambda-cyhalothrin stability problem associated with isomer transformation. » I
Theterm isomeric transformation as applied to an insecticidal composition means that lambda-cyhalothrin does not undergo conversion to inactive 20 isomer of lambda-cyhalothrin.
The term storage stable as applied to an insecticidal composition means that the insecticidal composition does not undergo isomeric transformation from active isomers of lambda-cyhalothrin to inactive isomers of lambdacyhalothrin for atleast two years at ambient température and within a range 25 of températures, which include extreme températures that. can be
experienced under normal storage conditions, for example a range from 0°C to 40°C or preferably a range from -5°C to 40°C.
Without being bound by theory, it is believed that mixture of weak acid and its sait in the présent invention acts to prevent isomeric transformation of 5 lambda-cyhalothrin from active form to the inactive form. Use of mixture of weak acid and its sait in liquid compositions comprising lambda-cyhalothrin imparts the physicochemical stability to the product.
The présent invention relates to a storage stable insecticidal composition comprising lambda-cyhalothrin in combination with another insecticide. J I I
According to an embodiment of the présent invention, there is provided an insecticidal composition comprising:
a) Lambda-cyhalothrin in an amount of 0.1% to 50% by weight of the composition;
b) atleast another insecticide in an amount of 0.1% to 50% by weight of the composition; and
c) a mixture of a weak acid and its sait.
According to an embodiment of the présent invention, a storage stable insecticidal composition comprises:
(a) Lambda-cyhalothrin in an amount of 0.1% to 50% by weight of the * composition;
(b) atleast one another insecticide in an amount of 0.1 % to 50% by weight of the composition; and (c) mixture of weak acid and its sait. I
I
According to an embodiment of the présent invention, a storage stable insecticidal composition comprises of Lambda-cyhalothrin.
According to an embodiment of the présent invention, said another 5 insecticide is selected from the group consisting of Acetylcholinesterase (AChE) inhibitors, GABA-gated chloride channel blockers, Sodium channel modulators, Nicotinic acétylcholine receptor (nAChR) compétitive modulators, Nicotinic acétylcholine receptor (nAChR) allosteric modulators Site I, Glutamate-gated chloride channel (GluCI) allosteric modulators, 10 Juvénile hormone mimics, Miscellaneous nonspecific (multi-site) inhibitors, Chordotonal organ TRPV channel modulators, Mite growth inhibitors affecting CHS1, Microbial disruptors of insect midgut membranes, Inhibitors of mitochondrial ATP synthase, Uncouplers of oxidative phosphorylation via !
disruption of the proton gradient, Nicotinic acétylcholine receptor (nAChR) 15 channel blockers, Inhibitors of chitin biosynthesis affecting CHS1, Inhibitors of chitin biosynthesis type 1, Moulting disruptors Dipteran, Ecdysone receptor agonists, Octopamine receptor agonists, Mitochondrial complex III électron h transport inhibitors, Mitochondrial complex I électron transport inhibitors, Voltage-dependent sodium channel blockers, Inhibitors of acetyl CoA 20 carboxylase, Mitochondrial complex IV électron transport inhibitors,
Mitochondrial complex II électron transport inhibitors, Ryanodine receptor modulators, Chordotonal organ Modulators - undefined target site, GABAgated chloride channel allosteric modulators, Baculoviruses, Nicotinic Acétylcholine Receptor (nAChR) Allosteric Modulators - Site II, Compounds of 25 unknown or uncertain MoA, Bacterial agents (nonBt) of unknown or uncertain
MoA, Botanical essence including synthetic, extracts and unrefined oils with
Ί unknown or uncertain MoA, Non-specific mechanical disruptors and combinations thereof.
«
In an embodiment, said another insecticide is selected from: Alanycarb, Aldicarb, Bendiocarb, Benfuracarb, Butocarboxim, Butoxycarboxim, Carbaryl, 5 Carbofuran, Carbosulfan, Ethiofencarb, Fenobucarb, Formetanate, Furathiocarb, Isoprocarb, Methiocarb, Methomyl, Metolcarb, Oxamyl, Pirimicarb, Propoxur, Thiodicarb, Thiofanox, Triazamate,Trimethacarb, XMC, Xylylcarb, Acephate, Azamethiphos, Azinphos-ethyl, Azinphosmethyl, Cadusafos, Chlorethoxyfos, Chlorfenvinphos, Chlormephos, Chlorpyrifos, 10 Chlorpyrifos-methyl, Coumaphos, Cyanophos, Demeton-S-methyl, Diazinon,
Dichlorvos/ DDVP, Dicrotophos, Dimethoate, Dimethylvinphos, Disulfoton, EPN, Ethion, Ethoprophos, Famphur, Fenamiphos, Fenitrothion, Fenthion, Fosthiazate, Heptenophos, Imicyafos, Isofenphos, Isopropyl O(methoxyaminothio-phosphoryl) salicylate, Isoxathion, Malathion, 15 Mecarbam, Methamidophos, Methidathion, Mevinphos, Monocrotophos,
Naled, Omethoate, Oxydemeton-methyl, Parathion, Parathion-methyl, Phenthoate, Phorate, Phosalone, Phosmet, Phosphamidon, Phoxim, Pirimiphos- methyl, Profenofos, Propetamphos, Prothiofos, Pyraclofos, Pyridaphenthion, Quinalphos, Sulfotep, Tebupirimfos, Temephos, Terbufos, 20 Tetrachlorvinphos, Thiometon, Triazophos, Trichlorfon, Vamidothion,
Chlordane, Endosulfan, Ethiprole, Fipronil, Acrinathrin, Allethrin, d-cis-trans Allethrin, d-trans Allethrin, Bifenthrin, Bioallethrin, Bioallethrin Scyclopentenyl isomer , Bioresmethrin, Cycloprothrin, Cyfluthrin, beta-Cyfluthrin, Cyhalothrin, lambdaCyhalothrin, gamma-Cyhalothrin, Cypermethrin, alpha25 Cypermethrin, beta-Cypermethrin, thetacypermethrin, zeta-Cypermethrin, Cyphenothrin , (1R)-trans- isomers], Deltamethrin, Empenthrin (EZ)- (1R)isomers], Esfenvalerate, Etofenprox, Fenpropathrin, Fenvalerate, Flùcythrinate, Flumethrin, tau-Fluvalinate, Halfenprox, Imiprothrin, Kadethrin,
Permethrin, Phenothrin [(IR)-trans- isomer], Prallethrin, Pyrethrins (pyrethrum), Resmethrin, Silafluofen, Tefluthrin, Tetramethrin, Tetramethrin [(IR)-isomers], Tralomethrin, Transfluthrin, DDT, Methoxychlor, Acetamiprid, Clothianidin, Dinotefuran, Imidacloprid, Nitenpyram, Thiacloprid, 5 Thiamethoxam, Nicotine, Sulfoxaflor, Flupyradifurone, Triflumezopyrim, Spinetoram, Spinosad, Abamectin, Emamectin benzoate, Lepimectin, Milbemectin, Hydroprene, Kinoprene, Methoprene, Fenoxycarb, Pyriproxyfen, Methyl bromide and other alkyl halides, Chloropicrin, Cryolite (Sodium aluminum fluoride), Sulfuryl fluoride, Borax, Boric acid, Disodium octaborate, 10 Sodium borate, Sodium metaborate, Tartar emetic, Dazomet, Metam, Pymetrozine, Pyrifluquinazon, Afidopyropen, Clofentezine, Diflovidazin, Hexythiazox, Etoxazole, Diafenthiuron, Azocydotin, Cyhexatin, Fenbutatin oxide, Propargite, Tetradifon, Chlorfenapyr, DNOC, Sulfluramid, Bensultap, Cartap hydrochloride, Thiocyclam, Thiosultap-sodium, Bistrifluron, 15 Chlorfluazuron, Diflubenzuron, Flucycloxuron, Flufenoxuron, Hexaflumuron, Lufenuron, Novaluron, Noviflumuron, Teflubenzuron, Triflumuron, l·
Buprofezin, Cyromazine, Chromafenozide, Halofenozide, Methoxyfenozide, Tebufenozide, Amitraz, Hydramethylnon, Acequinocyl, Fluacrypyrim, Bifenazate, Fenazaquin, Fenpyroximate, Pyridaben, Pyrimidifen, 20 Tebufenpyrad, Tolfenpyrad, Rotenone (Derris), Indoxacarb, Metaflumizone, Spirodiclofen, Spiromesifen, Spiropidion, Spirotetramat, Aluminium phosphide, Calcium phosphide, Phosphine, Zinc phosphide, Calcium cyanide, Potassium cyanide, Sodium cyanide, Cyenopyrafen, Cyflumetofen, Pyflubumide, Chlorantraniliprole, Cyantraniliprole, Cyclaniliprole 25 Flubendiamide, Tetraniliprole, Flonicamid, Broflanilide, Fluxametamide, Cydia pomonella GV, Thaumatotibia leucotreta GV, Anticarsia gemmatalis MNPV, Helicoverpa armigera NPV, GS-omega/kappa HXTX-Hv1a peptide, Azadirachtin, Benzoximate, Bromopropylate, Chinomethionat, Dicofol, Lime
ίο sulfur, Mancozeb, Pyridalyl, Sulfur, Burkholderia spp, Wolbachia pipientis (Zap), Chenopodium ambrosioides near ambrosioides extract, Fatty acid monoesters with glycerol or propanediol Neem oil, Beauveria bassiana Λ strains, Metarhizium anisopliae strain F52, Paecilomyces fumosoroseus 5 Apopka strain 97, Diatomaceous earth. I
According to an embodiment of the présent invention, said another insecticide is selected from the group consisting of neonicotinoids, .J I benzoylphenyl urea, tetramic acid, diamide insecticide, flonicamid and combinations thereof.
According to an embodiment of the présent invention, neonicotinoid insecticide is selected from the group consisting of clothianidin, imidacloprid, acetamiprid, thiamethoxam and thiadoprid.
According to preferred embodiment of the présent invention neonicotinoid insecticide is imidacloprid. *
According to preferred embodiment of the présent invention neonicotinoid insecticide is acetamiprid.
According to preferred embodiment of the présent invention neonicotinoid insecticide is clothianidin.
According to an embodiment of the présent invention, benzoylphenyl urea 20 insecticide is selected from the group consisting of bistrifluron, chlorbenzuron, chlorfluazuron, dichlorbenzuron, diflubenzuron, flucydoxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, penfluron, teflubenzuron and triflumuron.
According to preferred embodiment of the présent invention benzoylphenyl 25 urea insecticide is novaluron.
According to preferred embodiment of the présent invention benzoylphenyl urea insecticide is lufenuron.
According to preferred embodiment of the présent invention benzoylphenyl 1 urea insecticide is chlorfluazuron.
Λ
According to an embodiment of the présent invention, the tetramic acid insecticide is spirotetramat.
I s.
According to an embodiment of the présent invention, the diamide insecticide is selected from the group consisting of chlorantraniliprole, cyantraniliprole, cyclaniliprole, tetrachlorantraniliprole and tetraniliprole.
According to a preferred embodiment, the diamide insecticide is chlorantraniliprole.
According to a preferred embodiment, the diamide insecticide is cyantraniliprole.
According to a preferred embodiment, the diamide insecticide is l· cyclaniliprole.
ï
According to a preferred embodiment, the diamide insecticide is tetraniliprole.
According to an embodiment, said another insecticide is imidacloprid, novaluron, spirotetramat, flonicamid or chlorantraniliprole.
According to an embodiment of the présent invention, a storage stable I insecticidal composition comprises of lambda-cyhalothrin from about 0.1% w/w to about 50% w/w; and preferably, from about 0.5% to about 40% lambda-cyhalothrin of the total weight of the storage stable insecticidal composition.
In a preferred embodiment of the présent invention, a storage stable insecticidal composition comprises of lambda-cyhalothrin from about 1 % w/w to about 30% w/w of the total weight of the storage stable insecticidal composition.
According to an embodiment of the présent invention, the storage stable insecticidal composition comprises of atleastone more insecticide.
I.
The said one more insecticide is selected from a group consisting of
Alanycarb, Aldicarb, Bendiocarb, Benfuracarb, Butocarboxim,
Butoxycarboxim, Carbaryl, Carbofuran, Carbosulfan, Ethiofencarb, 10 Fenobucarb, Formetanate, Furathiocarb, Isoprocarb, Methiocarb, Methomyl,
Metolcarb, Oxamyl, Pirimicarb, Propoxur, Thiodicarb, Thiofanox,
Triazamate.Trimethacarb, XMC, Xylylcarb, Acephate, Azamethiphos,
I
Azinphos-ethyl, Azinphosmethyl, Cadusafos, Chlorethoxyfos,
Chlorfenvinphos, Chlormephos, Chlorpyrifos, Ch lorpyrifos-m ethyl,
Coumaphos, Cyanophos, Demeton-S-methyl, Diazinon, Dichlorvos/ DDVP,
Dicrotophos, Dimethoate, Dimethylvinphos, Disulfoton, EPN, Ethion, Ethoprophos, Famphur, Fenamiphos, Fenitrothion, Fenthion, Fosthiazate, Heptenophos, Imicyafos, Isofenphos, Isopropyl O- (methoxyaminothiophosphoryl) salicylate, Isoxathion, Malathion, Mecarbam, Methamidophos, 20 Methidathion, Mevinphos, Monocrotophos, Naled, Omethoate, Oxydemetonmethyl, Parathion, Parathion-methyl, Phenthoate, Phorate, Phosalone, Phosmet, Phosphamidon, Phoxim, Pirimiphos- methyl, Profenofos, 1
Propetamphos, Prothiofos, Pyradofos, Pyridaphenthion, Quinalphos,
Sulfotep, Tebupirimfos, Temephos, Terbufos, Tetrachlorvinphos, Thiometon, 25 Triazophos, Trichlorfon, Vamidothion, Chlordane, Endosulfan, Ethiprole,
Fipronil, Acrinathrin, Allethrin, d-cis-trans Allethrin, d-trans Allethrin, Bifenthrin, Bioallethrin, Bioallethrin Scydopentenyl isomer , Bioresmethrin,
Cycloprothrin, Cyfluthrin, beta-Cyfluthrin, Cyhalothrin, lambdaCyhalothrin, gamma-Cyhalothrin, Cypermethrin, alpha-Cypermethrin, beta-Cypermethrin, thetacypermethrin, zeta-Cypermethrin, Cyphenothrin , (1R)-trans- isomers], Deltamethrin, Empenthrin (EZ)- (1 R)- isomers], Esfenvalerate, Etofenprox, 5 Fenpropathrin, Fenvalerate, Flucythrinate, Flumethrin, tau-Fluvalinate, Halfenprox, Imiprothrin, Kadethrin, Permethrin, Phenothrin [(1R)-transisomer], Prallethrin, Pyrethrins (pyrethrum), Resmethrin, Silafluofen, Tefluthrin, Tetramethrin, Tetramethrin [(IR)-isomers], Tralomethrin, »
Transfluthrin, DDT, Methoxychlor, Acetamiprid, Clothianidin, Dinotefuran, 10 Imidadoprid, Nitehpyram, Thiacloprid, Thiamethoxam, Nicotine, Sulfoxaïlor, Flupyradifurone, Triflumezopyrim, Spinetoram, Spinosad, Abamectin, Emamectin benzoate, Lepimectin, Milbemectin, Hydroprene, Kinoprene, X
Methoprene, Fenoxycarb, Pyriproxyfen, Methyl bromide and other alkyl halides, Chloropicrin, Cryolite (Sodium aluminum fluoride), Sulfuryl fluoride, 15 Borax, Boric acid, Disodium octaborate, Sodium borate, Sodium metaborate,
Tartar emetic, Dazomet, Metam, Pymetrozine, Pyrifluquinazon, Afidopyropen, Clofentezine, Diflovidazin, Hexythiazox, Etoxazole, Diafenthiuron, Azocyclotin, Cyhexatin, Fenbutatin oxide, Propargite, Tetradifon, Chlorfenapyr, DNOC, Sulfluramid, Bensultap, Cartap hydrochloride, 20 Thiocydam, Thiosultap-sodium, Bistrifluron, Chlorfluazuron, Diflubenzuron, Flucydoxuron, Flufenoxuron, Hexaflumuron, Lufenuron, Novaluron, -,
Noviflumuron, Teflubenzuron, Triflumuron, Buprofezin, Cyromazine, Chromafenozide, Halofenozide, Methoxyfenozide, Tebufenozide, Amitraz, Hydramethylnon, Acequinocyl, Fluacrypyrim, Bifenazate, Fenazaquin, 25 Fenpyroximate, Pyridaben, Pyrimidifen, Tebufenpyrad, Tolfenpyrad,
Rotenone (Derris), Indoxacarb, Metaflumizone, Spirodiclofen, Spiromesifen, Spiropidion, Spirotetramat, Aluminium phosphide, Calcium phosphide, Phosphine, Zinc phosphide, Calcium cyanide, Potassium cyanide, Sodium
cyanide, Cyenopyrafen, Cyflumetofen, Pyflubumide, Chlorantraniliprole, Cyantraniliprole, Cyclaniliprole Flubendiamide, Tetraniliprole, Flonicamid, Broflanilide, Fluxametamide, Cydia pomonella GV, Thaumatotibia leucotreta GV, Anticarsia gemmatalis MNPV, Helicoverpa armigera NPV, GS5 omega/kappa HXTX-Hv1a peptide, Azadirachtin, Benzoximate, Bromopropylate, Chinomethionat, Dicofol, Lime sulfur, Mancozeb, Pyridalyl, Sulfur, Burkholderia spp, Wolbachia pipientis (Zap), Chenopodium ambrosioides near ambrosioides extract, Fatty acid monoesters with glycerol or propanediol Neem oil, Beauveria bassiana strains, Metarhizium anisopliae 10 strain F52, Paecilomyces fumosoroseus Apopka strain 97 and Diatomaceous earth. ri •v
According to an embodiment ofthe présent invention, the said storage stable insecticidal composition comprises of atleast one more insecticide selected from the group comprising of organophosphate, pyrethroids, benzoylphenyl L1- urea, neonicotinoids and the like.
According to an embodiment ofthe présent invention, one more insecticide ofthe storage stable insecticidal composition is flonicamid.
According to an embodiment ofthe présent invention, one more insecticide ofthe storage stable insecticidal composition is spirotetramat.
According to an embodiment of the présent invention, one more insecticide I ofthe storage stable insecticidal composition is spirodiclofen.
According to an embodiment ofthe présent invention, one more insecticide ofthe storage stable insecticidal composition is bifenthrin. *
According to an embodiment ofthe présent invention, one more insecticide 25 ofthe storage stable insecticidal composition is chlorantraniliprole.
According to an embodiment of the présent invention, the storage stable insecticidal composition comprises insecticide from about 0.1 % w/w to about 50% w/w; and preferably from about 0.5% w/w to about 40% w/w insecticide by weight of the storage stable insecticidal composition.
According to preferred embodiment of the présent invention, the storage stable insecticidal composition comprises insecticide from about 1% w/w to about 30% w/w by weight of the storage stable insecticidal composition.
According to an embodiment of the présent invention, a storage stable insecticidal composition comprises of a mixture of weak acid and its sait.
According to an embodiment of the présent invention, a storage stable insecticidal composition comprises of a mixture of weak organic acid and its sait or a mixture of weak inorganic acid and its sait.
According to an embodiment of the présent invention, the storage stable insecticidal composition comprises of the mixture of weak organic acid and 15 its salts.
According to an embodiment of the présent invention, the weak organic acids are selected are selected from the group comprising of citric acid, acetic acid, succinic acid, tartaric acid, oxalic acid and the like.
According to an embodiment of the présent invention, the storage stable 20 insecticidal composition comprises of citric acid and its salts selected from the group comprising of sodium citrate, sodium citrate monobasic, sodium citrate dibasic, potassium citrate and the like. L
According to an embodiment of the présent invention, the storage stable insecticidal composition comprises of acetic acid and its salts selected from 25 the group comprising of sodium acetate, ammonium acetate and the like.
According to an embodiment of the présent invention, the storage stable insecticidal composition comprises of succinic acid and its salts selected from sodium succinate mono and dibasic.
According to an embodiment of the présent invention, the storage stable 5 insecticidal composition comprises of tartaric acid and its salts selected from sodium tartarate monobasic and sodium tartarate dibasic. Ί
According to an embodiment of the présent invention, the salts of weak K organic acids may be added or may be generated in-situ by adding mixture of weak acid and a base, k S
According to an embodiment of the présent invention, the storage stable insecticidal composition comprises of the mixture of weak inorganic acid and its salts.
According to an embodiment of the présent invention, the weak inorganic acids are selected are selected from the group comprising of phosphoric acid, 15 nitrous acid, sulphurous acid, hydrofluoric acid and the like.
According to an embodiment of the présent invention, the storage stable insecticidal composition comprises of phosphoric acid and its salts selected
Ί from the group comprising of sodium phosphate dibasic, sodium phosphate monobasic, potassium metaphosphate, potassium phosphate dibasic, 20 potassium phosphate monobasic, ammonium phosphate, diluted potassium metaphosphate. I
According to an embodiment of the présent invention, the storage stable insecticidal composition comprising mixture of a weak acid (organic and inorganic) and its sait is selected from the group comprising of citric acid and 25 its salts; acetic acid and its salts; boric acid and its salts; succinic acid and its
salts; glutaric acid and its salts; maleic acid and its salts; tartaric acid and its salts; oxalic acid and its salts; and phosphoric acid and its salts.
According to preferred embodiment of the présent invention, the storage stable insecticidal composition comprising mixture of a weak acid and its sait 5 is selected from the group comprising of citric acid monohydrate and trisodium citrate dihydrate; tripotassium phosphate and phosphoric acid; tri sodium citrate and citric acid; sodium dihydrogen phosphate dihydrate and phosphoric acid and monobasic dihydrogen phosphate and dibasic monohydrogen phosphate.
According to an embodiment of the présent invention, a storage stable insecticidal composition comprises mixture of weak acid and its sait from about 0.1% to about 20% of the by weight of the storage stable insecticidal I composition.
According to preferred embodiment of the présent invention, a storage stable 15 insecticidal composition comprises mixture of weak acid and its sait from about 0.1% to about 10% of the by weight of the storage stable insecticidal composition.
According to an embodiment of the présent invention, the mixture of weak acid and its salts are in the storage stable composition is combined in a ratio 20 to achieve pH ranging from 4 to 5.5.
In another aspect, the présent invention provides an insecticidal composition comprising:
(a) Lambda-cyhalothrin in an amount of 0.1% to 50% by weight of the composition;
y (b) atleast one insecticide selected from group consisting of neonicotinoids, benzoylphenyl urea, tetramic acid, diamide insecticide and flonicamid in an amount of 0.1% to 50% by weight of the composition; and (c) mixture of weak acid and its sait.
In another aspect, the présent invention provides a storage stable insecticidal composition comprising:
(d) Lambda-cyhalothrin in an amount of 0.1% to 50% by weight of the composition;
(e) atleast one insecticide selected from group consisting of neonicotinoids, benzoylphenyl urea, tetramic acid, diamide insecticide and flonicamid compounds in an amount of 0.1 % to 50% by weight of the composition; and (f) mixture of weak acid and its sait.
According to an embodiment of the présent invention, the said storage stable insecticidal composition comprises of atleast one insecticide selected from the classes consisting of neonicotinoids, benzoylphenyl urea, tetramic acid, diamide insecticide and flonicamid.
According to an embodiment of the présent invention, neonicotinoid insecticide is selected from the group comprising of clothianidin, imidacloprid, acetamiprid, thiamethoxam and thiacloprid.
According to preferred embodiment of the présent invention neonicotinoid insecticide is imidacloprid.
According to preferred embodiment of the présent invention neonicotinoid insecticide is acetamiprid.
According to preferred embodiment of the présent invention neonicotinoid insecticide is clothianidin.
According to an embodiment of the présent invention, benzoylphenyl urea insecticide is selected from the group comprising of istrifluron, chlorbenzuron, chlorfluazuron, dichlorbenzuron, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, penfluron, teflubenzuron and triflumuron. h
According to preferred embodiment of the présent invention benzoylphenyl urea insecticide is novaluron.
According to preferred embodiment of the présent invention benzoylphenyl
I urea insecticide is lufenuron.
According to preferred embodiment of the présent invention benzoylphenyl urea insecticide is chlorfluazuron.
According to an embodiment of the présent invention, the tetramic acid insecticide is spirotetramat.
According to an embodiment of the présent invention, the diamide insecticide is selected from the group consisting of chlorantraniliprole, cyantraniliprole, 20 cyclaniliprole, tetrachlorantraniliprole and tetraniliprole.
According to a preferred embodiment, the diamide insecticide is h chlorantraniliprole.
According to a preferred embodiment, the diamide insecticide is cyantraniliprole.
According to a preferred embodiment, the diamide insecticide is cydaniliprole.
According to a preferred embodiment, the diamide insecticide is h tetraniliprole.
According to an embodiment of the présent invention, the ratio of active lambda-cyhalothrin to inactive lambda-cyhalothrin in the storage stable insecticidal composition is about 80: 20. «
According to an embodiment of the présent invention, the ratio of active lambda-cyhalothrin to inactive lambda-cyhalothrin in the storage stable 10 insecticidal composition is about 90:10.
According to an embodiment of the présent invention, the ratio of active
J lambda-cyhalothrin to inactive lambda-cyhalothrin in the storage stable insecticidal composition is about 95: 5.
According to an embodiment of the présent invention, the ratio of active 15 lambda-cyhalothrin to inactive lambda-cyhalothrin in the storage stable insecticidal composition is about 99:1.
According to an embodiment of the présent invention, the active isomer content of lambda-cyhalothrin in the storage stable insecticidal composition is not less than 85% ±10.
According to an embodiment of the présent invention, the active isomer content of lambda-cyhalothrin in the storage stable insecticidal composition is not less than 95%.
According to an embodiment of the présent invention, the active isomer content of lambda-cyhalothrin in the storage stable insecticidal composition is not less than 98%.
According to an embodiment ofthe présent invention the insecticide in the 5 stable insecticidal composition is selected from the group comprising of imidacloprid, acetamiprid, flonicamid, clothianidin, acephate, bifenthrin, fipronil, lufenuron, novaluron, diafenthiuron, spirotetramat and chlorantraniliprole. h
In an embodiment of the présent invention, the storage stable insecticidal 10 composition may further comprises one or more antifreeze agent, thickening agents, wetting agents, fillers, surfactants, preservatives, antifoaming agents, colorants and other formulation aids.
Suitable antifreeze agents that can be added to the storage stable insecticidal composition are aqueous polyols, for example ethylene glycol, propylene 15 glycol or glycerol.
Suitable thickening agents include xanthan gum, attagel 50, bentonite, silica and the like.
Suitable wetting agents that can be added to the storage stable insecticidal composition include, but are not limited to: polyarylalkoxylated phosphate 20 esters and their potassium salts (e.g., Soprophor® FLK, Stepfac TSP PE- K.
Other suitable wetting agents include Block copolymer of polyalkylene oxide , sodium dioctylsulfosuccinates (e.g., Geropon®SDS, Aérosol® OT) and ethoxylated alcohols (e.g., Trideth-6; Rhodasurf® BC 610; Tersperse® 4894), Poly(oxy-1,2-ethanediyl) and Silwet408.
Suitable fillers may indude ail substances which can normally be used for this purpose in insecticidal compositions and which do not act as thickeners. Examples of suitable inert fillers include inorganic particles, such as carbonates, silicates and oxides, and also organic substances, such as « urea/formaldehyde condensâtes. By way of more particular example, kaolin, rutile, silica, finely divided silica, silica gels, and natural and synthetic silicates, and also talc may be mentioned. Mixtures of inorganic and organic fillers, and of different spécifie fillers within each class may be used.
Suitable anionic surfactants include polyacrylates, alkylbezenesulfonates 10 (Example: TERWET 1004) such as dodecylbenzenesulfonates, for example calcium dodecylbenzensulfonate, ethoxylated and/or propoxylated di- ortristyrylphenol phosphates, ethoxylated and/or propoxylated di- or tristyrylphenol sulfates, phenyl sulfonates, lignosulphonates, alkynaphtalenesulphonates, ethoxylated and/or propoxylated alcohol 15 phosphate esters, ethoxylated and/or propoxylated alkylaryl phosphate esters, taurates, sulphosuccinates, and polycarboxylates, Sodium alkylnaphthalene sulfonate formalin condensate or modified styrene-maleic anhydride copolymer). Examples of the commercially available alkyl naphthalene sulfonate sodium formalin condensate include Morwet D425, 20 TERSPERSE 2020, Agrosurf WG-2300 and the like.
Suitable non-ionic surfactants include alkoxylated surfactants and block copolymer surfactants. Examples of useful alkoxylated surfactants for the invention include castor oil ethoxylate, tridecyl alcohol ethoxylate, nonyl phénol ethoxylate, octyl phénol ethoxylate, tristryl phénol ethoxylate, I phosphate ester ethoxylate, tallow amine ethoxylate, cocoa amine ethoxylate, and oleyl amine ethoxylate.
Suitable preservatives used may be benzisothiazolinone (Proxel GXL) or phénols, 2-bromo-2-nitropropane-1,3-diol (Bioban BP 30), 5-chloro-2-methyl4-isothiazolin-3-one & 2 methyl-4-isothiazolin -3 one (Kathon
CG/ICP),Glutaraldehyde (Ucarcide 50), Chloromethylisothiazolïnone (CMIT)/Methylisothiazolinone (MIT) (Isocil Ultra 1.5), 2.2-dibromo-3nitrilopropioamide (Reputain 20), Natamycin & Nisin, Bronopol/CMIT/MIT (Mergal 721K3).
Suitable antifoaming agents or defoamers are employed to stop any unwanted foam generated while manufacturing suspension concentrate 10 composition of the présent application. The preferred antifoaming agent is selected from the group consisting of silicone-based compounds, alcohols, glycol ethers, minerai spirits, acetylene diols, polysiloxanes, organosiloxanes, siloxane glycols, reaction products of Silicon dioxide and organosiloxane I lT polymer, polydimethylsiloxanes or polyalkylene glycols alone or in 15 combination. Préférable defoamers include AGNIQUE DFM 111S; SAG-10;
SAG-1000AP; SAG-1529; SAG-1538; SAG-1571; SAG-1572; SAG-1575; SAG-2001;
SAG-220; SAG-290; SAG-30; SAG-30E; SAG-330; SAG-47; SAG-5440; SAG-7133 and SAG-770.
Suitable colorants (for example in red, blue and green) are, preferably, 20 pigments, which are sparingly soluble in water, and dyes, which are watersoluble. Examples are inorganic coloring agents (for example iron oxide, titanium oxide, and iron hexacyanoferrate) and organic coloring agents (for example alizarin, azo and phthalocyanin coloring agents).
In an embodiment of the présent invention, an insecticidal composition comprises lambda-cyhalothrin from about 0.1% w/w to about 50% w/w, atleast one another insecticide from about 0.1% w/w to about 50% w/w and
- * mixture of weak acid and its sait from 0.1% w/wto 20% w/w of the total weight of the storage stable insecticidal composition.
In an embodiment of the présent invention, the storage stable insecticidal 5 composition comprises lambda-cyhalothrin from about 0.1% w/w to about 50% w/w, atleast one another insecticide from about 0.1% w/wto about 50% w/w and mixture of weak acid and its sait from 0.1% w/w to 20% w/w of the total weight of the storage stable insecticidal composition.
In an embodiment of the présent invention, an insecticidal composition comprises lambda-cyhalothrin from about 0.5% w/w to about 30% w/w, atleast one another insecticide from about 0.5% w/w to about 30% and mixture of weak acid and its sait from and 0.5% w/w to 20% w/w mixture of the total weight of the storage stable insecticidal composition.
In an embodiment of the présent invention, the storage stable insecticidal composition comprises lambda-cyhalothrin from about 0.5% w/w to about 30% w/w, atleast one another insecticide from about 0.5% w/w to about 30% and mixture of weak acid and its sait from and 0.5% w/w to 20% w/w mixture 20 of the total weight of the storage stable insecticidal composition, h
In an embodiment of the présent invention, an insecticidal composition comprises lambda-cyhalothrin from about 0.1% w/w to about 50% w/w, imidacloprid from about 0.1% w/w to about 50% w/w and mixture of weak 25 acid and its saitfrom 0.1% w/wto 20% w/w ofthe total weightof the storage stable insecticidal composition.
I
I «
In an embodiment of the présent invention, an insecticidal composition % comprises lambda-cyhalothrin from about 0.1% w/w to about 50% w/w, novaluron from about 0.1% w/w to about 50% w/w and mixture of weak acid and its saitfrom 0.1 % w/wto 20% w/w of the total weight of the storage stable 5 insecticidal composition.
In an embodiment of the présent invention, an insecticidal composition comprises lambda-cyhalothrin from about 0.1% w/w to about 50% w/w, spirotetramat from about 0.1% w/w to about 50% w/w and mixture of weak 10 acid and its sait from 0.1% w/w to 20% w/w of the total weight of the storage stable insecticidal composition. I
In an embodiment of the présent invention, an insecticidal composition comprises lambda-cyhalothrin from about 0.1% w/w to about 50% w/w, 15 chlorantraniliprole from about 0.1% w/w to about 50% w/w and mixture of weak acid and its sait from 0.1% w/w to 20% w/w of the total weight of the storage stable insecticidal composition. I
In an embodiment of the présent invention, an insecticidal composition 20 comprises lambda-cyhalothrin from about 0.1% w/w to about 50% w/w, flonicamid from about 0.1% w/w to about 50% w/w and mixture of weak acid and its sait from 0.1 % w/w to 20% w/w of the total weight of the storage stable h insecticidal composition. 4
In an embodiment of the présent invention, an insecticidal composition comprises lambda-cyhalothrin from about 0.5% w/w to about 30% w/w, imidacloprid from about 0.5% w/w to about 30% w/w and mixture of citric
acid monohydrate and trisodium citrate dihydrate from 0.5% w/wto 20% w/w of the total weight of the storage stable insecticidal composition, x
In an embodiment of the présent invention, an insecticidal composition 5 comprises lambda-cyhalothrin from about 0.5% w/w to about 30% w/w, novaluron from about 0.5% w/wto about 30% w/w and mixture of phosphoric acid and potassium hydrogen phosphate from 0.5% w/w to 20% w/w of the total weight of the storage stable insecticidal composition. L
In an embodiment of the présent invention, an insecticidal composition comprises lambda-cyhalothrin from about 0.5% w/w to about 30% w/w, T spirotetramat from about 0.5% w/w to about 30% w/w and mixture of citric acid monohydrate and trisodium citrate dihydrate from 0.5% w/wto 20% w/w of the total weight of the storage stable insecticidal composition.
In an embodiment of the présent invention, an insecticidal composition comprises lambda-cyhalothrin from about 0.5% w/w to about 30% w/w, 'r chlorantraniliprole from about 0.5% w/w to about 30% w/w and mixture of citric acid monohydrate and trisodium citrate dihydratefrom 0.5% w/wto 20% 20 w/w of the total weight of the storage stable insecticidal composition.
In an embodiment of the présent invention, an insecticidal composition comprises lambda-cyhalothrin from about 0.5% w/w to about 30% w/w, l· flonicamid from about 0.5% w/w to about 30% w/w and mixture of citric acid 25 monohydrate and trisodium citrate dihydrate from 0.5% w/w to 20% w/w of the total weight of the storage stable insecticidal composition.
In an embodiment of the présent invention, the storage stable insecticidal composition is formulated in the form of liquid composition. “I
In an embodiment of the présent invention, the storage stable insecticidal 5 composition is formulated as suspension concentrate (SC), a mixed formulation of CS and SC (ZC), soluble liquid (SL), emulsion-in-water (EW), formulation for seeds (FS). I
According to an embodiment of the présent invention, in the storage stable insecticidal composition comprising lambda-cyhalothrin in combination with 10 another insecticide , lambda-cyhalothrin is in the form of particulate when formulated as SC and in dissolved form when formulated as émulsion; and in both as capsulated or absorbed partide with solvent.
According to preferred embodiment of the présent invention, the storage stable insecticidal composition is formulated as suspension concentrate (SC).
According to an embodiment of the présent invention, lambda-cyhalothrin and an insecticide are suspended in the aqueous environment in the SC composition.
In an embodiment of the présent invention, an insecticidal composition comprising lambda-cyhalothrin from about 0.1% w/w to about 50% w/w, atleast one another insecticide from about 0.1% w/w to about 50% w/w and mixture of weak acid and its sait 0.1% w/wto 20% w/w of the total weight of the storage stable insecticidal composition, wherein the said composition is in the form of suspension concentrate (SC).
In an embodiment of the présent invention, an insecticidal composition comprises lambda-cyhalothrin from about 0.5% w/w to about 30% w/w, novaluron from about 0.5% w/wto about 30% w/w and mixture of phosphoric acid and potassium hydrogen phosphate from 0.5% w/w to 20% w/w of the 5 total weight of the storage stable insecticidal composition, wherein the said composition is in the form of suspension concentrate (SC).
In an embodiment of the présent invention, an insecticidal composition comprises lambda-cyhalothrin from about 0.5% w/w to about 30% w/w, 10 spirotetramat from about 0.5% w/w to about 30% w/w and mixture of citric acid monohydrate and trisodium citrate dlhydrate from 0.5% w/wto 20% w/w of the total weight of the storage stable insecticidal composition, wherein the said composition is in the form of suspension concentrate (SC). I
In an embodiment of the présent invention, an insecticidal composition comprises lambda-cyhalothrin from about 0.5% w/w to about 30% w/w, chlorantraniliprole from about 0.5% w/w to about 30% w/w and mixture of citric acid monohydrate and trisodium citrate dihydrate from 0.5% w/w to 20% w/w of the total weight of the storage stable insecticidal composition, wherein the said composition is in the form of suspension concentrate (SC).
In an embodiment of the présent invention, an insecticidal composition comprises lambda-cyhalothrin from about 0.5% w/w to about 30% w/w, flonicamid from about 0.5% w/w to about 30% w/w and mixture of citric acid 25 monohydrate and trisodium citrate dihydrate from 0.5% w/w to 20% w/w of the total weight of the storage stable insecticidal composition, wherein the said composition is in the form of suspension concentrate (SC).
I μ Δ
In an embodiment of the présent invention, an insecticidal composition l.
comprising lambda-cyhalothrin from about 0.5% w/w to about 30% w/w, imidadoprid from about 0.5% w/w to about 30% w/w and mixture of citric acid monohydrate and trisodium citrate dihydrate from 0.5% w/w to 20% w/w 5 ofthe total weight ofthe storage stable insecticidal composition wherein said composition is in the form of suspension concentrate (SC).
According to preferred embodiment of the présent invention, the storage stable insecticidal composition is formulated as a mixed formulation of 10 Capsule suspension (CS) and Suspension concentrate (SC) in which one insecticide is directly suspended in aqueous medium and another insecticide is encapsulated and suspended in the same aqueous medium; such formulation Is known as ZC formulation.
According to preferred embodiment of the présent invention, the ZC formulation composition comprises (i) microencapsulated lambdacyhalothrin suspended in water, characterised in that the microcapsules are made of polymeric material; and (ii) another insecticide suspended in water.
According to some embodiments ofthe présent invention, polymeric material of the microcapsules encapsulating lambda-cyhalothrin is selected from polyurea and polyuréthane.
According to some embodiments of the présent invention, storage stable 25 insecticidal composition comprises of microcapsules having polyurea wall encapsulating lambda-cyhalothrin wherein the polyurea wall of the microcapsule is from a mixture of polymethylene polyphenylisocyanate and an isomeric mixture of dicyclohexylmethane-4,4'diisocyanate .
In an embodiment of the présent invention, an insecticidal composition comprises lambda-cyhalothrin from about 0.1% w/w to about 50% w/w, atleast one another insecticide from about 0.1% w/w to about 50% w/w and mixture of weak acid and its sait from 0.1 % w/wto 20% w/w of the total weight of the storage stable insecticidal composition wherein said composition is in the form of ZC formulation. I. X *
In an embodiment of the présent invention, an insecticidal composition comprising from about lambda-cyhalothrin 0.5% w/w to about 30% w/w, novaluron from about 0.5% w/w to about 30% w/w and mixture of phosphoric « acid and potassium hydrogen phosphate from 0.5% w/w to 20% w/w of the total weight of the storage stable insecticidal composition, wherein the said composition is in the form of ZC formulation.
In an embodiment of the présent invention, an insecticidal composition comprises lambda-cyhalothrin from about 0.5% w/w to about 30% w/w, spirotetramat from about 0.5% w/w to about 30% w/w and mixture of citric acid monohydrate and trisodium citrate dihydrate frorh 0.5% w/w to 20% w/w of the total weight of the storage stable insecticidal composition, wherein the said composition is in the form of ZC formulation.
In an embodiment of the présent invention, an insecticidal composition comprises lambda-cyhalothrin from about 0.5% w/w to about 30% w/w, chlorantraniliprole from about 0.5% w/w to about 30% w/w and mixture of citric acid monohydrate and trisodium citrate dihydrate from 0.5% w/w to 20% w/w of the total weight of the storage stable insecticidal composition, wherein the said composition is in the form of ZC formulation.
In an embodiment of the présent invention, an insecticidal composition comprises lambda-cyhalothrin from about 0.5% w/w to about 30% w/w, flonicamid from about 0.5% w/w to about 30% w/w and mixture of citric acid monohydrate and trisodium citrate dihydrate from 0.5% w/w to 20% w/w of the total weight ofthe storage stable insecticidal composition, wherein the said composition is in the form of ZC formulation.
In an embodiment of the présent invention, an insecticidal composition 10 comprising lambda-cyhalothrin from about 0.5% w/w to about 30% w/w, imidadoprid from about 0.5% w/w to about 30% w/w and mixture of citric
R acid monohydrate and trisodium citrate dihydrate from 0.5% w/w to 20% w/w ofthetotal weightofthe storage stable insecticidal composition, wherein the said composition is in the form of ZC formulation.
I
According to an embodiment of the présent invention, a process for préparation of an insecticidal composition comprising (a) Lambdacyhalothrin in an amount of 0.1% to 50% by weight of the composition; (b) atleast one another insecticide in an amount of 0.1 % to 50% by weight of the composition; and (c) a mixture of a weak acid and its sait; wherein said process comprising steps of:
(a) mixing lambda- cyhalothrin with another insecticide in a suitable 1
System, (b) optionally, adding other excipients(s) to obtain pre-mix, (c) adding mixture of a weak acid and its sait to the pre-mix to obtain storage stable insecticidal composition.
According to an embodiment of the présent invention, a process for the préparation of storage stable insecticidal composition comprising (a) Lambda-cyhalothrin in an amount of 0.1% to 50% by weight of the composition; (b) atleast one another insecticide in an amount of 0.1 % to 50% by weight of the composition; and (c) a mixture of a weak acid and its sait; wherein said process comprising steps of:
(a) mixing lambda- cyhalothrin with another insecticide in a suitable System, (b) optionally, adding other excipients(s) to obtain pre-mix, (c) adding mixture of a weak acid and its sait to the pre-mix to obtain storage stable insecticidal composition.
According to an embodiment of the présent invention, a process for the préparation of an insecticidal composition comprising (a) Lambdacyhalothrin in an amount of 0.1% to 50% by weight of the composition; (b) atleast one another insecticide in an amount of 0.1 % to 50% by weight of the composition; and (c) mixture of a weak acid and its sait; wherein said process h comprising steps of:
i. mixing lambda-cyhalothrin and other insecticide in an aqueous condition and adding other excipients(s) to obtain pre-mix, ii. milling the resulting pre-mix;
iii. adding thickener and mixture of a weak acid and its salts to the premix followed by homogenization to obtain storage stable insecticidal composition in the form of suspension concentrate.
According to an embodiment of the présent invention, a process for the préparation of an insecticidal composition comprising (a) Lambdacyhalothrin in an amount of 0.1% to 50% by weight of the composition; (b)
atleast one another insecticide in an amount of 0.1 % to 50% by weight of the composition; and (c) a mixture of a weak acid and its sait; wherein said h process comprising steps of: v
i. mixing lambda-cyhalothrin and other insecticide in an aqueous condition and optionally, adding other excipients(s) to obtain pre-mix,
I ii. milling the resulting pre-mix;
iii. adding mixture of a weak acid and its salts to the pre-mix; and iv. gellifying the mixture by separately prepared thickener composition to obtain storage stable insecticidal composition in the form of suspension concentrate.
1. According to an embodiment of the présent invention, A process for the préparation of a composition comprising (a) Lambda-cyhalothrin in an amount of 0.1 % to 50% by weight of the composition; (b) atleast another insecticide in an amount of 0.1 %to 50% by weight ofthe composition; and (c) a mixture of a weak acid and its sait; wherein said process comprises:
i. preparing a capsule suspension of lambda-cyhalothrin; - 1 ii. preparing a suspension concentrate of another insecticide;
iii. separately dissolving an amine sait in water to obtain an amine solution;
I iv. mixing the suspension concentrate of step (ii), a mixture of a weak acid and its sait, the amine solution and the capsule suspension of lambda-cyhalothrin to obtain a ZC composition.
According to an embodiment of the présent invention, a process for the préparation of an insecticidal composition comprising (a) Lambda25 cyhalothrin in an amount of 0.1% to 50% by weight of the composition; (b) atleast one another insecticide in an amount of 0.1 % to 50% by weight of the
composition; and (c) a mixture of a weak acid and its sait; wherein said process comprises:
i. preparing an organic phase comprising lambda-cyhalothrin solubilized in vegetable oil or dérivatives thereof, and at least one isocyanate;
ii. preparing an aqueous phase by mixing suitable auxiliary ingrédients in water;
iii. separately dissolving an amine sait in water to obtain an amine solution;
iv. mixing the organic phase of step (i), the aqueous phase of step (ii) and the amine solution of step (iii) to obtain an encapsulated lambdacyhalothrin as capsule suspension;
v. separately preparing a suspension concentrate of another insecticide;
vi. mixing the capsule suspension of step (iv) with the suspension concentrate of step (v);
vii. adding the mixture of weak acid and its saltto obtain the composition in the form of a ZC formulation.
In an embodiment, the storage stable insecticidal composition of the 20 invention has a particle size distribution Dw of less than about 10 microns.
i.
In an embodiment, the storage stable insecticidal composition of the invention has a particle size distribution Dw of less than about 5 microns.
In an embodiment, the storage stable insecticidal composition of the invention has a particle size distribution Dso of less than about 10.0 microns.
In an embodiment, the storage stable insecticidal composition of the invention has a partide size distribution Dso of less than about 5 microns.
In an embodiment, the storage stable insecticidal composition of the P invention has a particle size distribution Dso of less than about 2 microns.
In an embodiment, the storage stable insecticidal composition of the invention has a particle size distribution D90 of less than or equal to about 20 microns.
In an embodiment, the storage stable insecticidal composition of the I invention has a particle size distribution D90 of less than or equal to about 15 microns, i I 1 H.
In an embodiment, the storage stable insecticidal composition of the invention has a particle size distribution D90 of less than or equal to about 10 l. microns.
According to an embodiment of the présent invention, the storage stable insecticidal composition prepared in above steps for obtaining suspension concentrate composition is subjected to particle size réduction by applying shear to the mixture of lambda-cyhalothrin, insecticide and mixture of weak acid and its sait and other auxiliary agents. Suitable devices for this purpose are the devices that offers milling operation e.g. high shear mixers like ROS HSM, Ultra-Turrax apparatus, and dissolvers, static mixers, e.g. Systems having mixing nozzles, bead mills, vibratory mills, agitator bead mills, colloid mills, cône mills, circulating mills (agitator bail mills with pin grinding System), disk mills, annular chamber mills, double cône mills, sprocket dispersers or homogenizers and other homogenizers.
According to an embodiment of the présent invention, the storage stable insecticidal composition is designed to be diluted with water (or a waterbased aqueous) to form the corresponding end-use agrochemical
T formulations, typically spray formulations.
According to an embodiment of the présent invention, the storage stable insecticidal composition requires a formulation which allows the active
I compounds to be taken up by the pests and insects.
According to an embodiment of the présent invention, the storage stable insecticidal composition is used as the source of active agrochemical ingrédients and will typically be diluted to form end-use formulations, typically spray formulations. The dilution may be with water at from 1 to
I
10,000, particularly 10 to 1,000, times the total weight ofthe storage stable insecticidal composition to form the spray formulation. Said storage stable insecticidal composition may be diluted for use having an agrochemical active concentration of about 0.5 wt.% to about 1 wt.%. In said diluted composition the agrochemical active concentration may be in the range from about 0.001 wt.% to about 1 wt.% ofthe total formulation as sprayed.
Spray formulations include ali the components which it is desired to apply to the plants or their environment. Spray formulations can be made up by simple dilution of aqueous insecticidal composition containing agrochemically active ingrédients, or by mixing ofthe individual agrochemically active ingrédients, or a combination of diluting the storage stable insecticidal composition and
Ί adding further individual agrochemically active ingrédients or mixtures of agrochemically active ingrédients. Typically, such end use mixing is carried out in the tank from which the formulation is sprayed, or altematively in a holding tank for filling the spray tank. Such mixing and mixtures are typically termed tank mixing and tank mixtures.
I
According to an embodiment of the présent invention, the storage stable f insecticidal composition is used to control wide range of insects.
In an embodiment of the présent invention, the storage stable insecticidal composition Controls pests and insects listed below;
Insects from the order of the Lepidoptera, for example Agrotisypsilon, Chilo infuscatellus, Chilo partellus, Chilo suppressalis, Cnaphalocrocis medinalis, Cydia pomonella, Earias vittella, Earias insulana, Helicoverpa armigera, *
Leucinodes orbonalis, Maruca testulalis, Mythimna separata, Pectinophora gossypiella, Phyllocnistis citrella, Pieris bras-sicae, Plutella xylostella,
Scirpophaga incertulas, Sesamia inferens, Spodoptera frugiperda, Spodoptera littoralis, Spodoptera litura, Tryporyza novella, Tuta absoluta and Zeiraphera Canadensis. Beetles (Coleoptera), for example Diabrotica longicornis, Diabrotica semipunctata, Diabrotica punctata, Diabrotica speciosa, Diabrotica virgifera, Dicladispa armigera, Epila-chna varivestis,
Holotrichia bicolor, Holotrichia consanguinea, Leptinotarsa decemlineata, flies (Diptera), e.g. Atherigona orientalis, Dacus cucurbi-tae, Liriomyza trifolii, Melanagromyza obtuse, thrips (Thysanoptera), e.g. Frankliniella occidentalis, Fra nkl iniel la tritici, Scirtothrips citri, Scirtothrips dorsalis, Thrips oryzae, Thrips h palmi and Thrips tabaci, termites (Isoptera), e.g. Calotermes flavicollis, 20 Coptotermes formosanus, Heterotermes aureus, Leucotermes flavipes, Microtermes obesi, Odontotermes obesus, Reticulitermes flavipes, Termes l natalensis. true bugs (Hemiptera), e.g. Amrasca biguttula biguttula, Amrasca devastans, Amritodus atkinsoni, Aphis gossypii, Aphis crassivora, Bemisia argentifolii, Bemisia tabaci, Dysdercus cingulatus, Empoasca fabae,
Idioscopus spp. My-zus persicae, Nilaparvata lugens, Nephotettix virescens, Nephotettix nigropictus, Planococcus spp., Pseudococcus spp., Pyrilla
I 1 perpusilla, Sogatella furcifera, Trialeurodes vaporariorum, Toxoptera I aurantiia, Psylla spp., Rhopalosiphum spp., Sitobion spp.
According to an embodiment of the présent invention, the storage stable I insecticidal composition can be applied to any and ail developmental stages of pests, such as egg, larva, pupa, and adult. The pests may be controlled by contacting the target pest, its food supply, habitat, breeding ground or its locus with an effective amount of said composition of the présent invention.
According to an embodiment of the présent invention, the storage stable insecticidal compositions comprising various mixtures are highly effective in controlling insect pests, in GMO (Genetically Modified Organism) and Non GMO varieties of Cotton (Gossypium spp.), Paddy (Oryza sativa), Wheat (Triticum aestavum), Maize (Zea mays), Sugarcane (Saccharum officinarum), Sugarbeet (Beta vu/garis), Soybean (Glycin max), Peanut (Arachis hypogaea), Green gram (Vigna radiata), Black gram (Vigna mungo), Chickpea (Cicer aritinum), Redgram (Cajanus cajan), Brinjal (Solanum me/ongena), Cabbage (Brassica oteracea var. capitata), Cauliflower (Brassica o/eracea var. botrytis), Okra (Abe/moschus escutentus), Onion (AHium cepa L), Tomato (Solanum lycopersicun), Potato (Solanum tuberosum), Chilly (Capsicum annum), Garlic (AHium sativum), Cucumber (Cucumissativus), Muskmelons (Cucumismeio), f-r
Watermelon (Citrullus lanatus), Bottle gourd (Lagenaria siceraria), Apple (Melus domestica), Banana (Musa spp.), Citrus groups (Citrus spp.), Grape Ί (Vitis vinifera), Guava (Psidium guajava), Litchi (Litchi chinensis), Mango (Mangifera indica), Papaya (Carica papaya), Pineapple (Ananas comosus), Pomegranate (Punica granatum) , Tea (Cameiiia sinensis), Coffea (Coffea
Arabica), Turmeric (Curcuma ionga), Ginger (Zingiber officinale), Cumin (Cuminum cyminum).
±
According to an embodiment of the présent invention, there is provided a method for controlling pests, which comprises applying effective amounts of an insecticidal composition comprising (a) Lambda-cyhalothrin in an amount of 0.1% to 50% by weight of the composition; (b) atleast one another 5 insecticide in an amount of 0.1% to 50% by weight of the composition; and (c) >
a mixture of a weak acid and its sait, to pests or a locus where the pests inhabit. J *
According to an embodiment of the présent invention, there is provided a method for controlling pests, which comprises applying effective amounts of 10 an insecticidal composition comprising (a) Lambda-cyhalothrin in an amount of 0.1% to 50% by weight of the composition; (b) imidacloprid in an amount of 0.1 % to 50% by weight of the composition; and (c) a mixture of a weak acid and its sait, to pests or a locus where the pests inhabit.
According to an embodiment of the présent invention, there is provided a 15 method for controlling pests, which comprises applying effective amounts of an insecticidal composition comprising (a) Lambda-cyhalothrin in an amount of 0.1% to 50% by weight of the composition; (b) imidacloprid in an amount of 0.1% to 50% by weight of the composition; and (c) and 0.5% w/w to 20% w/w mixture of citric acid monohydrate and trisodium citrate dihydrate, to 20 pests or a locus where the pests inhabit.
According to an embodiment of the présent invention, there is provided a method for controlling pests, which comprises applying effective amounts of storage stable insecticidal composition comprising (a) Lambda-cyhalothrin in an amount of 0.1% to 50% by weight of the composition; (b) novaluron in an 25 amount of 0.1% to 50% by weight of the composition; and (c) a mixture of a weak acid and its sait, to pests or a locus where the pests inhabit.
According to an embodiment of the présent invention, a method for controlling pests, which comprises applying effective amounts of storage stable insecticidal composition comprising (a) Lambda-cyhalothrin in an amount of 0.1% to 50% by weight of the composition; (b) novaluron in an 5 amount of 0.1% to 50% by weight of the composition; and (c) 0.5% w/wto 20% w/w mixture of phosphoricacid and potassium hydrogen phosphate, to pests or a locus where the pests inhabit.
According to an embodiment of the présent invention, there is provided a method for controlling pests, which comprises applying effective amounts of 10 an insecticidal composition comprising (a) Lambda-cyhalothrin in an amount of 0.1% to 50% by weight of the composition; (b) spirotetramat in an amount of 0.1% to 50% by weight of the composition; and (c) a mixture of a weak acid and its sait, to pests or a locus where the pests inhabit.
According to an embodiment of the présent invention, there is provided a 15 method for controlling pests, which comprises applying effective amounts of an insecticidal composition comprising (a) Lambda-cyhalothrin in an amount of 0.1% to 50% by weight of the composition; (b) spirotetramat in an amount of 0.1% to 50% by weight of the composition; and (c) and 0.5% w/w to 20% w/w mixture of citric acid monohydrate and trisodium citrate dihydrate, to 20 pests or a locus where the pests inhabit.
According to an embodiment of the présent invention, there is provided a method for controlling pests, which comprises applying effective amounts of
I an insecticidal composition comprising (a) Lambda-cyhalothrin in an amount of 0.1% to 50% by weight of the composition; (b) flonicamid in an amount of 1
0.1% to 50% by weight of the composition; and (c) a mixture of a weak acid and its sait, to pests or a locus where the pests inhabit.
According to an embodiment of the présent invention, there is provided a method for controlling pests, which comprises applying effective amounts of an insecticidal composition comprising (a) Lambda-cyhalothrin in an amount of 0.1% to 50% by weight of the composition; (b) flonicamid in an amount of 5 0.1 % to 50% by weight of the composition; and (c) and 0.5% w/w to 20% w/w mixture of citric acid monohydrate and trisodium citrate dihydrate, to pests or a locus where the pests inhabit.
According to an embodiment of the présent invention, there is provided a method for controlling pests, which comprises applying effective amounts of 10 an insecticidal composition comprising (a) Lambda-cyhalothrin in an amount of 0.1% to 50% by weight of the composition; (b) chlorantraniliprole in an amount of 0.1% to 50% by weight of the composition; and (c) a mixture of a weak acid and its sait, to pests or a locus where the pests inhabit.
According to an embodiment of the présent invention, there is provided a 15 method for controlling pests, which comprises applying effective amounts of an insecticidal composition comprising (a) Lambda-cyhalothrin in an amount of 0.1% to 50% by weight of the composition; (b) chlorantraniliprole in an amount of 0.1% to 50% by weight of the composition; and (c) and 0.5% w/w to 20% w/w mixture of citric acid monohydrate and trisodium citrate 20 dihydrate, to pests or a locus where the pests inhabit.
According to an embodiment of the présent invention, a kit is provided. The kit comprises of a plurality of components, each of which components may include at least one, or more, of the ingrédients of the storage stable insecticidal composition of the présent invention.
In accordance with the above objectives, the présent invention provides a kit comprising:
(a) a first component comprising Lambda-cyhalothrin ;
(b) a second component comprising another insecticide ; and (c) a third component comprising a mixture of a weak acid and its sait, wherein the first, second and third components are instructed to be J admixed before being applied to a locus.
According to an embodiment of the présent invention, the various components of the storage stable insecticidal composition can be used individually or already partially or completely mixed with one another to préparé the composition according to the invention. It is also possible for 10 them to be packaged and used further as combination composition such as a kit of parts.
In one embodiment of the invention, the kits may include one or more, including ail, components that may be used to préparé storage stable 1 insecticidal composition. E. g., kits may include active ingrédients and/or 15 mixture of weak acid and its sait. One or more of the components may already be combined together or pre-formulated. In those embodiments where more than two components are provided in a kit, the components may already be combined together and as such are packaged in a single container such as a vial, bottle, can, pouch, bag or canister.
In other embodiments, two or more components of a kit may be packaged separately, i. e., not pre-formulated. As such, kits may include one or more separate containers such as vials, cans, bottles, pouches, bags or canisters, each container containing a separate component for storage stable insecticidal composition.
In both forms, a component of the kit may be applied separately from or together with the further components or as a component of a combination
I
composition according to the invention for preparing the storage stable * insecticidal composition according to the invention.
In a preferred embodiment of the présent invention, an insecticidal composition comprising (a) Lambda-cyhalothrin in an amount of 0.1 % to 50% 5 by weight ofthe composition; (b) atleast one another insecticide in an amount of 0.1 % to 50% by weight of the composition; and (c) a mixture of a weak acid and its sait is in the form of a kit with single pack or multi pack.
Ail the features described herein may be combined with any of the above aspects, in any combination.
In order that the présent invention may be more readily understood, reference will now be made, by way of example, to the following description. It will be understood that ail tests and physical properties listed hâve been determined at atmospheric pressure and room température (i.e. 25°C), unless otherwise stated herein, or unless otherwise stated in the referenced test methods and procedures. It will be understood that the spécification and examples are illustrative but not limitative of the présent invention and that other embodiments within the spirit and scope ofthe invention will suggest themselves to those skilled in the art. Other embodiments can be practiced that are also within the scope of the présent invention. The following 20 examples illustrate the invention, but by no means intend to limit the scope I ofthe daims.
Example -1 Lambda-cyhalothrin 50 g/L +Imidacloprid 125 g/L SC
Ingrédients
Quantity (w/w)
100g 1,2,3-Propanetriol, 60g Amine sait of polyarylphenyl ether phosphate, 30g block copolymer of propylene oxide and ethylene oxide were charged in
a mixing vessel and homogenized using Remi table top homogenizer. 16g silicone antifoam, and about 610g water was added under continued homogenization. 240g imidacloprid and 97.4g lambda-cyhalothrin was also added to the same homogenizing vessel. This homogenized mixture was the taken to bead mill for particle size réduction to obtain slurry. To the ground slurry, separately, prepared solution obtained by dissolving 12g citric acid T monohydrate and 28g trisodium citrate dihydrate was added. Finally, remaining quantity of water and 160g xanthan gum containing 5g 1,2Benzisothiazolin was added to obtain suspension concentrate composition.
Example -2 Lambda-cyhalothrin 50 g/L +Imidacloprid 125 g/L SC (comparative example)
Ingrédients | Quantity (w/w) |
Imidacloprid | 240 |
I Lambda-cyhalothrin | 97.4 |
1,2,3-Propanetriol | 100 |
Amine sait of polyarylphenyl ether phosphate | 1 60 |
Clay | 30 |
Silicone antifoam | 16 |
Xanthan gum | 160 |
I.
»
100g 1,2,3-Propanetriol, 60g Amine sait of polyarylphenyl ether phosphate, 30g block copolymer of propylene oxide and ethylene oxide were charged in a mixing vessel and homogenized using Remi table top homogenizer. 16g silicone antifoam, and about 610g water was added under continued homogenization. 240g imidacloprid and 97.4g lambda-cyhalothrin were also added to the same homogenizing vessel. This homogenized mixture was the taken to bead mill for particle size réduction to obtain slurry. Finally, remaining quantity of water and 160g xanthan gum containing 5g 1,2Benzisothiazolin was added to obtain suspension concentrate composition.
Example-3 Lambda-cyhalothrin 20 g/L and Novaluron 100 g/L ZC
Lambda-cyhalothrin 23-24 % Conc CS | |
Ingrédients I | Quantity (% w/w) |
Lambda-cyhalothrin J | 24.74 |
Soyabean oil An oligomeric isocyanate, poly[methylene(phenylene isocyanate)](PMPI) T Hexamethylene diisocyanate (HMDI) | 17 0.02 0.61 |
Water | 40.29 |
Sodium lignosulfonate | 5 l· |
Silicone antifoam | 0.1 |
Ethylene diamine | 0.33 ï |
Propylene Glycol | 6 |
Block copolymer surfactant l | 2.5 |
Hydrochloricacid | 1.31 |
Xanthan gum | 2 |
1,2-Benzisothiazolin-3-One Solution % | 0.1 i. |
Total | 100 |
Novaluron Mill base |
Ί
Ingrédients
Quantity (% w/w)
Novaluron
52.61
Sodium lignosulfonate
3.00
Block copolymer of propylene oxide and ethylene oxide
1.50
Propylene glycol
6.00
Water
36.39
Silicone antifoam
0.50
Total
100.00
Novaluron 100 g/L + Lambda-cyhalothrin 20 g/L ZC
Ingrédients
Quantity (%w/w)
Novaluron mill base
193.2
Lambda-cyhalothrin CS
89.4
Water
516
Xanthan gum (2% gel) L | 88.5 |
Propylene Glycol | 83.00 |
Trisiloxane ethoxylate | 15 |
Clay | 8.5 |
I X 1,2-Benzisothiazolin-3-One Solution | 1.4 |
_ I Silicone antifoam | 5.0 |
Trlpotassium Phosphate | 12.19 |
F Phosphoric acid -I | 2.81 |
Total | 1015.00 |
Préparation of Lambda-cyhalothrin CS:
o Préparation of organic phase: 24.74g Lambda-cyhalothrin technical, 17g soyabean oil, 0.02g PMPI and 0.61 HMDI was mixed and 5 homogenized to obtain organic phase.
o Préparation of aqueous phase: 5g sodium lignosulphonate, 6g propylene glycol, 2.5g block copolymer surfactant, 0.1g silicone antifoam and 40.29g water were mixed and homogenized to obtain aqueous phase.
o Préparation of ethylene diamine: 0.33g ethylene diamine was dissolved in water to obtain solution.
Previously prepared organic phase was added to previously prepared aqueous phase and homogenized to get the desired particle size of D mean5 1.5-2.5 micron. Then previously prepared ethylene diamine solution was added under slow stirring to obtain mixture and the mixture was heated to 11.5 hr at 55-60°C. Mixture was then neutralized to pH 5-6 with 1.31g hydrochloric acid. *
Structuring of the mixture was done by adding 2g xanthan gum (adding 2% 10 gel) and 1.4g 1,2-Benzisothiazolin-3-One solution to obtain lambdacyhalothrin CS.
Préparation of Novaluron Mill Base:
Novaluron 50-51% concentrate mill base slurry was prepared by mixing 1.5g Block copolymer of propylene oxide and ethylene oxide, 3.0g sodium lignosulfonate, 6.0g propylene glycol, 0.5g silicone antifoam, 52.61 novaluron technical in 36.39g water. The slurry was then milled to the particle size of D90 -8-10 micron. This milled slurry was then used for the further mixing in ZC as
Novaluron mill base.
Préparation of Lambda-cyhalothrin 20 g/L and Novaluron 100 g/L ZC L
516g water, 50g clay, 1.4g 1,2-Benzisothiazolin-3-one solution, 83g propylene glycol and 193.2g novaluron( 50.5%) mill base was charged in the homogenizing vessel and mixed gently. 5g silicone antifoam and 88.5g
xanthan gum was added further. Then at low rpm 89.4g lambda-cyhalothrin CS and 15g trisiloxane ethoxylate was added. Further, 12.19g tripotassium phosphate and 2.81g phosphoric acid was added to obtain storage stable insecticidal composition.
Example-4 Lambda-cyhalothrin 20 g/L ZC and Novaluron 100 g/L (Comparative example)
K Ingrédients *k | h Quantity (%w/w) |
Lambda-cyhalothrin CS | 89.4 ♦ |
Novaluron mill base | 193.2 |
Water J- | 516 |
Xanthan gum | 88.5 |
Propylene Glycol | 83.00 |
Trisiloxane ethoxylate X | 15 |
Attapulgite clay | 8.5 |
1,2-Benzisothiazolin-3-One | 1.4 |
Silicone antifoam | 5.0 |
T Total | 1000.00 |
I
I
Lambda-cyhalothrin CS and Novaluron mill base was prepared as per Example-3 And then to préparé ZC composition, 516g water, 8.5g clay, 1.4g 1,2-Benzisothiazolin-3-one solution, 83g propylene glycol and 193.2g novaluron( 50.5%) mill base was charged in the homogenizing vessel. 5g silicone antifoam and 88.5g xanthan gum was added further. Then at low rpm 89.4g lambda-cyhalothrin CS and 15g trisiloxane ethoxylate was added and continued homogenization to obtain an insecticidal composition.
Example-5 Novaluron 100 g/L + Lambda-cyhalothrin 20 g/L ZC
Lambda-cyhalothrin 10-12 % CS * | |
Ingrédients | Quantity (% w/w) |
Lambda-cyhalothrin | 105 |
Soyabean oil | 200 |
An oligomeric isocyanate, poly[methylene(phenylene isocyanate)](PMPI) | 1.04 |
I Hexamethylene diisocyanate (HMDI) | 4.14 |
Water | 430.1 |
Sodium lignosulfonate | 50 |
I Silicone antifoam K | 1 |
«
Ethylene diamine
Diethylenetriamine
Propylene Glycol
Block copolymer surfactant
Hydrochloricacid
Xanthan gum 2% solution
100
1,2-Benzisothiazolin-3-One Solution
Total
1000.0
Novaluron Mill base
Ingrédients
Quantity (% w/w)
Novaluron
Sodium lignosulfonate
Block copolymer surfactant
Propylene glycol
I
Water | 308.8 |
Silicone antifoam | 0.5 |
Xanthan gum 2% solution | 50 |
Total | 1000.0 |
Novaluron 100 g/L + Lambda-cyhalothrin 20 g/L ZC | |
Ingrédients | Quantity |
Lambda-cyhalothrin CS | 200 |
Novaluron mill base | 198 |
Water | 380.2 |
Rhodopol 2% gel | 88.5 |
Propylene Glycol | 83 |
silwet408 | 15.4 |
Attagel 50 T | 8.5 |
Préparation of Lambda-cyhalothrin CS: Lambda-cyhalothrin, Soyabean oil, 4An oligomeric isocyanate, poly[methylene(phenylene isocyanate)](PMPI), Hexamethylene diisocyanate (HMDI), water, sodium lignosulfonate, silicone 5 antifoam, ethylene diamine, diethylene triamine, propylene glycol, Block copolymer surfactant, hydrochloric acid, Xanthan gum 2% solution and 1,2Benzisothiazolin-3-One Solution were mixed in above quantities and lambdacyhalothrin CS was prepared according to process given in Example-3.
Préparation of Novaluron Mill Base: Novaluron, sodium lignosulphonate, 10 block copolymer surfactant, propylene glycol, water, silicone antifoam, and xanthan gum 2% solution were mixed in above quantities and novaluron mill base was prepared according to process described in Example-3.
Lambda-cyhalothrin 20 g/L and Novaluron 100 g/L ZC: Lambda-cyhalothrin
CS, Novaluron mill base, water, xanthan gum 2% gel, propylene glycol, 15 trisiloxane ethoxylate, attapulgite clay, 1,2-Benzisothiazolin-3-One Solution, silicone antifoam, trisodium citrate and citric acid were mixed In above quantities and ZC composition was prepared according to process given in Example-3.
Physico-chemical Parameters of the composition of Example-5 | ||
Ambient | AHS, 2 weeks, 54° | |
Description | Off white color liquld Suspension concentrate | Off white color liquld Suspension concentrate |
Novaluron active content | J 10.69 | 10.10.47 |
Imidacloprid content | * * | L |
Lambda-cyhalothrin active content | 2.15 H | 2.01 |
Lambda-cyhalothrin activednactive content (%) | 99.42:0.58 ! r | 99.19:0.81 |
1% pH (aq Suspension in DW) | 5.46 | 5.37 |
Example-6 Lambda-cyhalothrin 20 g/L +Imidacloprid 125 g/L ZC
Lambda-cyhalothrin 10-12 % Conc CS
Ingrédients | Quantity (% w/w) |
Lambda-cyhalothrin | 105 |
Soyabean oil | 200 |
An oligomeric isocyanate, poly[methylene(phenylene isocyanate)](PMPI) | 1.04 |
Ί Hexamethylene diisocyanate (HMDI) | 4.14 |
Water | 430.1 |
Sodium lignosulfonate r | 50 |
Silicone antifoam | 1 |
Ethylene diamine | 1.25 |
-V Diethylene triamine | 1.25 |
Propylene Glycol | 75 |
Block copolymer surfactant ή l | 25 |
Hydrochloric acid | 5.2 |
I
Xanthan gum 2% solution I I T. | 100 |
1,2-Benzisothiazolin-3-One Solution | 1 |
Total | 1000.0 |
Imidacloprid mill base | |
Ingrédients X | Quantity (% w/w) |
Imidacloprid | 372.6 |
Ammonium lignosulphonate | 12.0 |
Polyarylphenyl ethoxylate | 18.0 |
Precipitated silica | 9 |
Silicone antifoam -L | 1.2 I |
Glycerin | 76.0 * |
Water | 511.2 |
Total | 1000.0 |
Ί |
II
Lambda-cyhalothrin 20 g/L +Imidacloprid 125 g/L ZC
Ingrédients
Quantity
Imidacloprid mill base
Lambda-cyhalothrin CS
485.00
Citric acid monohydrate
6.00
Trisodium citrate dihydrate
14.00
1,2-Benzisothiazolin-3-One Solution
Xanthan gum 2% Gel
water
114.34
1000.00
Préparation of Lambda-cyhalothrin CS: Lambda-cyhalothrin, Soyabean oil, An oligomeric isocyanate, poly[methylene(phenylene isocyanate)](PMPI), Hexamethylene diisocyanate (HMDI), water, sodium lignosulfonate, silicone % antifoam, ethylene diamine, diethylene triamine, propylene glycol, Block copolymer surfactant, hydrochloric acid, Xanthan gum 2% solution and 1,2Benzisothiazolin-3-One Solution were mixed in above quantities and lambdacyhalothrin CS was prepared according to process given in Example-3.
Préparation of Novaluron Mill Base: Imidacloprid, ammonium lignosulphonate, polyarylphenyl ethoxylate, precipitated silica, silicone antifoam, glycérine and water were mixed in given quantities and mill base was prepared according to the process given in Example-3.
Lambda-cyhalothrin 20 g/L +Imidacloprid 125 g/L ZC: Lambda-cyhalothrin CS, Imidacloprid mill base, citric acid monohydrate, trisodium citrate dihydrate, 1,2-Benzisothiazolin-3-One Solution water, xanthan gum 2% gel ί and water were mixed in above quantities and ZC composition was prepared according to process given in Example-3.
Physico-chemical Parameters of the composition of Example-6 l | ||
Ambient | AHS, 2 weeks, 54° | |
Description | Off white color liquid Suspension concentrate | Off white color liquid Suspension concentrate |
Novaluron active content | H M | to |
Imidacloprid content | 11.82 | 11.78 |
Lambda-cyhalothrin active content | 4.82 | 4.78 |
Study of the effect of mixture of weak acid and its sait in Lambdacyhalothrin 50 g/L + Imidacloprid 125 g/L SC composition t
Compositions of Example-1 and Example-2 were taken for stability study. 5 Compositions of Example-1 which was prepared by adding mixture of citric acid monohydrate and trisodium citrate dihydrate in the SC composition comprising lambda-cyhalothrin and imidacloprid found to remain stable in ail three test conditions viz. ambient, 6- week heat stability at 40°C and Freezethaw 7 cycle. Imidacloprid found to remain stable without much dégradation 10 in ail three test conditions. The active isomer of lambda-cyhalothrin remained quite stable without much déviation in its active content. Also, the inactive isomer remained quite stable without much déviation in its inactive content. Hence, the isomer transformation of Example-1 remained well within acceptable range without much déviation in terms of conversion of active 15 content of lambda-cyhalothrin to its inactive content.
Compositions of Example-2 which was prepared without adding mixture of weak acid and its sait in the SC composition comprising lambda-cyhalothrin and imidacloprid also tested for stability in ail three test conditions viz. ambient, 6 week heat stability at 40°C and Freeze-thaw 7 cycle conditions. 20 Imidacloprid found to remain stable without much dégradation in ail three test conditions. The active isomer content of lambda-cyhalothrin remained
I
quite stable without much déviation in its active content. But inactive isomer content of lambda-cyhalothrin increased from 1.02% to 7.27% in ambient,
I
3.45% to 47.5% in heat stability testing when kept for 6 weeks at 40°C and
0.84% to 8.2% in Freeze thaw study. This shows, in the absence of mixture of ’ weak acid and its sait, isomer transformation from active isomer to inactive isomer occurred rapidly, thus deteriorating the insecticidal composition of Example-2. (Table-1)
Table 1
Example-1
Ambient
Off white color
Heat
FreezeExample-2
Heat
FreezeDescriptio liquid
Suspensi on stability 6 week at 40°
Off color white liquid
Suspension thaw
Ambient stability week at
40° C thaw
Off white color liquid
Suspensi on
Off white color liquid
Suspensi on
Off white color liquid
Suspensi on
Off white color liquid
Suspension concentrate concentrate concentr concentr concentr concentr
Imidaclopr id active content
11.60
12.10
I
Study of the effect of mixture of weak acid and its sait in Lambdacyhalothrin 20 g/L and Novaluron 100 g/L ZC composition
Compositions of Example-3 and Example-4 were taken for stability study.
Compositions of Example-3 which was prepared by adding mixture of phosphoric acid and potassium dihydrogen phosphate in the ZC composition comprising lambda-cyhalothrin and novaluron found to remain stable in ambient as well as in Accelerated Heat Stability (AHS) test for 2 weeks at 54° C. Imidacloprid found to remain stable without much dégradation in ail three test conditions. The active isomer of lambda-cyhalothrin remained quite
I
stable without much déviation in its active content. Also, the inactive isomer ·- | remained quite stable without much déviation in its inactive content. Hence, the isomer transformation of Example-3 remained well within acceptable range without much déviation in terms of conversion of active content of * lambda-cyhalothrin to its inactive content. Compositions of Example-4 which was prepared without adding mixture of weak acid and its sait (e.g. mixture of phosphoric acid and potassium hydrogen phosphate as in Example-3) in the ZC composition comprising lambda-cyhalothrin and novaluron also tested for stability in in ambient as well as in AHS test for 2 weeks at 54° C.
Imidacloprid found to remain stable without much dégradation in ail three test conditions. The active isomer content of lambda-cyhalothrin remained quite stable without much déviation in its active content. But inactive isomer content of lambda-cyhalothrin increased from 4.35% to 17.16% in ambient, 8.44% to 45.65% in heat stability testing when kept for 6 weeks at 40°C. This shows, in the absence of mixture of weak acid and its sait, isomer transformation from active isomer to inactive isomer occurred rapidly, thus deteriorating the insecticidal composition of Example-4. (Table 2)
Table-2
Example-3 | 1 Example-4 | |||
Ambient | Heat stability 2 week at 54° | s Ambient | Heat stability 2 week at 54° | |
Description | Off white color liquid | Off white color liquid | Off wh ite color liquid | Off white color liquid |
I
Suspension
Suspension
Suspension
Suspension concentrate concentrate concentrate concentrate
Novaluron active
10.33
10.28
10.56
10.54 content
Lambda-cyhalothrin
2.031
2.022
1.905 active content
Lambda-cyhalothrin active:inactive content (%)
95.65:4.35
91.56:8.44 82.84:17.16 54.35:45.65
1% pH (aq
Suspension in DW)
5.80
5.74
6.38
Example -7 Lambda-cyhalothrin 10% CS
I Ingrédients | Quantity (% w/w) |
Lambda-cyhalothrin | 105 * |
Vegetable oil i | 200 |
An oligomeric isocyanate, poly[methylene(phenylene isocyanate)](PMPI) A | 1.04 |
Hexamethylene diisocyanate (HMDI) | 4.14 |
Water | 430.1 |
Anionic surfactant | 50 |
I Antifoam | 1 |
Ethylene diamine | 1.25 |
Diethylene triamine S | 1.25 |
Propylene Glycol | 75 |
Nonionic surfactant | 25 |
Hydrochloric acid | 5.2 |
Xanthan gum 2% solution | 100 |
k Biocide ·_ \ l | 1 |
Total | 1000.0 |
Process:Preparation of organic phase: 105g Lambda-cyhalothrin technical, 200g vegetable oil, 1.04g PMPI and 4.15g HMDI was mixed and homogenized to obtain organic phase.
Préparation of aqueous phase: 50g anionic surfactant, 75g propylene glycol, 25g non-ionic surfactant, 1g antifoam and 400.1g water were mixed and homogenized to obtain aqueous phase. I
Préparation of amine solution: 1.25g ethylene diamine and diethylene 5 triamine 1.25g was dissolved in 30 gm water to obtain solution, l· U
Previously prepared organic phase was added to previously prepared aqueous phase and homogenized to get the desired particle size of D mean1.5-2.5 micron. Then previously prepared amine solution was added under slow stirring to obtain mixture and the mixture was heated to 1-1.5 hr at 5510 60°C. Mixture was then neutralized to pH 5-6 with 5.2g hydrochloric acid.
Structuring of the mixture was done by adding 100g xanthan gum (adding
2% gel) and 0.1g biocide solution to obtain lambda-cyhalothrin CS.
Example -8 Lambda-cyhalothrin 23.5 % Conc CS using aromatic hydrocarbon
T Ingrédients | Quantity (% w/w) |
Lambda-cyhalothrin | 24.74 |
Solvent | 15.00 Ί |
Hexamethylene diisocynate | 0.47 |
An oligomeric isocyanate, poly[methylene(phenylene F isocyanate)](PMPI) 1 | 0.025 i-· r· |
1 Anionic surfactant | 5.00 |
Antifoam I | 0.10 |
Glycerin | 7.00 |
Non-ionic surfactant | 2.50 |
Hydrochloride acid (35% solution) | 0.52 |
Xanthan gum 2% solution | 0.06 |
biocide | L 0.10 |
Ethylene diamine | 0.165 |
Diethylene triamine | 0.165 |
Water | qs |
Total | 100.0 |
Lambda-cyhalothrin, solvent, hexamethylene diisocyanate, poly[methylene(phenylene isocyanate)](PMPI), anionic surfactant, antifoam, glycerin, non-ionic surfactant, hydrochloride acid (35% solution), xanthan gum 2% solution, biocide, ethylene diamine, diethylene triamine and water were mixed in above mentioned quantity and CS was prepared as per the process disclosed in Example-7.
Example-9 Chlorantraniliprole 50% w/w Mill base
T Ingrédients | Quantity (% w/w) |
Chlorantraniliprole | 526.31 |
Anionic surfactant | 60 |
Water s | 408.69 |
Antifoam | 5.00 |
Total | I 1000.0 * - S |
A mill base was préparée! the by mixing chlorantraniliprole, anionic surfactant, antifoam and water in the bead mill to obtain desired particle size. The same mill base was used in Processing various finished formulations developed according to the présent invention.
Example 10: Lambda-cyhalothrin 66.67 g/L and Chlorantraniliprole 80 g/L
ZC
Ingrédients | Quantity |
Chlorantraniliprole 50% mill base of Example-9 | 154.0 |
Lambda-cyhalothrin CS of Example-2 | 265.8 |
Water | 460.2 |
Xanthan gum (2% gel) | 99 |
Biocide | 1.0 |
Trisodium citrate | 14.0 |
* Citric acid | 6.0 |
Total | 1000.00 |
Process Chlorantraniliprole 50% mill base of example-9, water, trisodium citrate, citric acid, and xanthan gum were mixed together to obtain homogeneous mixture. Then lambda-cyhalothrin CS of Example-8 was added l to the mixture to obtain CS formulation.
Stability study of Lambda-cyhalothrin 66.67 g/L and Chlorantraniliprole 80 g/L ZC
IThe Lambda-cyhalothrin 66.67 g/L and Chlorantraniliprole 80 g/L ZC composition developed in Example-10 was taken for stability testing in various conditions such as ambient, AHS for 2 weeks at 54° C and freeze thaw. The compositions retained its acceptable physical appearance during ail the three testing conditions. The chlorantraniliprole active content remained stable without any noticeable dégradation. Similarly, lambdacyhalothrin active content remained stable without any noticeable dégradation. In ail the three testing conditions, the isomer transformation did not occur. The active isomer content remained above 99% in ambient, AHS as well as FT studies. pH of the composition remained in acceptable range. (Table
Ί3)
Table 3
Ambient | |
! Description | Off white color liquid Suspension concentrate |
Chlorantraniliprole active content | 7.96 |
Lambdacyhalothrin active content | 6.431 |
Lambdacyhalothrin active:inactive content (%) | 99.30:0.70 1- |
1% pH (aq Suspension in DW) | 5.01 |
AHS (2 weeks at 54 °C) 1. | b Freeze-thaw (FT) 7 cycle |
Off white color liquid Suspension concentrate | Off white color liquid Suspension concentrate |
7.92 | 7.96 |
6.63 | 6.40 |
99.05:0.95 | 99.16:0.84 h |
4.96 | 4.99 |
I
Example-11: Flonicamid 44% w/w Mill base
A mill base was prepared the by mixing flonicamid, solvent, non-ionic surfactant, antifoam, biocide, xanthan gum and water in the bead mill to i.
obtain desired particle size. The same mill base was used in processing 5 various finished formulations developed according to the présent invention.
Example 12A and 12B: Lambda-cyhalothrin 40 g/L and Flonicamid 160 g/L
ZC
Ingrédients | Example 12A | Example 12B |
J
Two compositions (12A and 12B) of Lambda-cyhalothrin 40 g/L and Flonicamid 160 g/L ZC were developed by mixing Flonicamid mill base of Example-11, trisodium citrate, citric acid, xanthan gum (2% gel) and water were mixed together to obtain homogeneous mixture, Then, in one composition Lambda-cyhalothrin CS of Example-7 was added and in other
Lambda-cyhalothrin CS of Example-8 was added to obtain two ZC « préparations.
Stability study of Lambda-cyhalothrin 40 g/L and Flonicamid 160 g/L ZC obtained in 12A and 12B
The two different compositions of Lambda-cyhalothrin 66.67 g/L and Chlorantraniliprole 80 g/L ZC composition developed in Example-12A and Example-12B were taken for stability testing in various conditions such as ambient, AHS for 2 weeks at 54° C and freeze thaw. The compositions retained 5 its acceptable physical appearance during ail the three testing conditions. The cflonicamid active content remained stable without any noticeable dégradation. Similarly, lambda-cyhalothrin active content remained stable without any noticeable dégradation. In ail the three testing conditions, the isomer transformation did not occur. The active isomer content remained 10 above 97% in ambient, AHS as well as FF studies. pH of the composition remained in acceptable range. (Table 4) «
Table 4
Example-12A | Example-12B | |||||
Ambien | AHS (2weeks , 54°C) | Freezethaw (FT) 7 cycle | Ambien t | AHS (2weeks, 54°C) i । | Freezethaw (FT) 7 cycle | |
Descriptio n | Off white color liquid Suspens! on | Off white color liquid Suspens! on | Off white color liquid Suspens! on | Off white color liquid Suspens! on | Off white color liquid Suspens! on concentr ate | Off white color liquid Suspens! on |
Flonicami concentr
15.73 active content concentr
15.69 concentr
Lambda4.24
4.24 cyhalothri content
Lambda99.0:0.98 cyhalothri n
active:inac tive content n active
1% pH (aq
Suspensio n in DW) concentr
15.91
4.30 concentr ate
15.84
98.8:1.19
97.36.02:
2.64
5.05
5.14
Example 13: Imidacloprid 43% w/w mill base
Ingrédients
98.66:1.3
Quantity (% w/w)
Imidacloprid technical | 1265.42 |
Anionic surfactant | 28.64 |
Polyarylphenyl ethoxylate | 42.96 |
Silica | 21.48 |
I Antifoam | 2.864 I |
τ Glycerin P | 186.16 |
Biocide | 2.864 |
water | 1313.612 |
total | 2864 |
A mill base was prepared the by mixing imidacloprid, anionic surfactant, polyarylphenyl ethoxylate, silica, antifoam, glycerin, biocide and water in the bead mill to obtain desired particle size. The same mill base was used in processing various finished formulations developed according to the présent 5 invention.
Example 14: Lambda-cyhalothrin 100 g/L and Imidacloprid 200 g/L ZC
Ingrédients
Example 6A
I
Imidacloprid mill base of Example-13 | 418.0 |
Lambda-cyhalothrin CS of Example-8 | 383.0 |
Water | 134 |
Xanthan gum (2% gel) | 44.75 |
Biocide | 0.25 |
1 Trisodium citrate | 14.0 |
Citric acid 1 | 6.0 |
Total | 1000.00 |
Imidacloprid mill base of Example-11, xanthan gum, biocide, citric acid, I trisodium citrate and water were mixed together to obtain homogeneous mixture. Lambda-cyhalothrin CS of Example-8 was added to the homogeneous mixture to obtain ZC formulation.
Stability study of Lambda-cyhalothrin 100 g/L and Imidacloprid 200 g/L
ZC
The Lambda-cyhalothrin 100g/L and Imidacloprid 200g/L ZC composition developed in Example-14 was taken for stability testing in various conditions 10 such as ambient, AHS for 2 weeks at 54° C and freeze thaw. The compositions retained its acceptable physical appearance during ail the three testing
I
conditions. The Imidacloprid active content remained stable without any noticeable dégradation. Similarly, lambda-cyhalothrin active content remained stable without any noticeable dégradation. In ail the three testing conditions, the isomer transformation did not occur. The active isomer content remained above 98% in ambient, AHS as well as FT studies. pH of the composition remained in acceptable range. (Table 5)
Table 5 «
Ambient | Heat stability 2 I week at 54 ° C | t Freeze-thaw 7 cycle | |
Description Ί | Off white color liquid Suspension concentrate | Off white color liquid Suspension concentrate | Off white color liquid Suspension ï concentrate |
Imidacloprid active content | 19.38 | 19.32 | 19.34 |
Lambdacyhalothrin active content | 9.56 | 9.54 | 9.55 |
Lambdacyhalothrin active:inactive content (%) | 98.94:1.06 | 98.90:1.1 | 98.93:1.07 Ί. |
1% pH (aq Suspension in DW) | 5.41 | 5.29 | 5.32 |
Example 15: Lambda-cyhalothrin 40 g/L and Spirotetramat 40 g/L ZC Step 1: Spirotetramat 40% w/w SC.
Ingrédient | Quantity |
Spirotetramat technical | 40.81 ' |
Propylene glycol | 5.00 |
Non-ionic surfactant | 2.00 |
Anionic surfactant | 1.50 |
Antifoa m | 0.50 |
Biocide | + 0.10 |
Thickener | 5.00 |
Water | 45.08 |
Total | 100.0 |
A suspension concentrate as a mill base was prepared by mixing spirotetramat, propylene glycol, non-ionic surfactant, anionic surfactant, antifoam, water, biocide and thickener in the above mentioned quantity in bead mill to attain desired particle size and kept for further processing.
Step 2: ZC préparation:
Ingrédient | Quantity |
Lambda-cyhalothrin CS of Example-7 | 40.00 |
Spirotetramat SC of step-1 | 10.00 |
Paraffin Oil | 30.00 |
Non-ionic surfactant | 2.00 |
Anionic surfactant | 2.00 |
Biocide | 0.10 |
Antifoam | 0.50 |
Propylene glycol | 4.50 |
Thickener | 4 5.00 |
Citric Acid | 0.60 |
Trisodium citrate | 1.40 |
Water | 3.90 |
Total | 100.00 |
Process Take the Spirotetramat 40% mill base prepared in step-1 and add water, non-ionic and anionic surfactant, propylene glycol, trisodium citrate , citric acid , biocide and mixed for homogeneity. Then paraffin oil was added ï and homogenized and further 2% Rhodopol gel was added and agaln 5 homogenized for uniformity . Then Lambda-cyhalothrin CS prepared as per example 7 was added and mixed for homogeneity. The samples were tested for heat stability for 2 week at 54° C and Freeze-thaw 7 cycle the results tabulated as below. (Table 6)
Table 6
Parameters | Example-10 | ||
Ambient | Heat stability 2 week at 54 ° C | Freeze-thaw 7 cycle | |
Description | Off white color liquid Suspension concentrate | Off white color liquid Suspension concentrate | 1 Off white color liquid Suspension concentrate |
Spirotetramat active content | 4.57 l. | 4.38 | 4.58 |
Lambda-cyhalothrin active content | 4.23 | C 4.23 | J 4.23 |
I
h Lambda-cyhalothrin active: inactive content (%) | 99.02: 0.98 | 98.96:1.04 | 99.13:0.87 |
1% pH (aq Suspension in DW) | 5.34 | 5.33 | 5.35 |
I I
Inventors of the présent invention thus successfully préparée! storage stable insecticidal compositions of lambda-cyhalothrin in combination with other * agrochemically active ingrédients. In the presence of mixture of weak acid 5 and its sait, lambda-cyhalothrin isomer transformation from active form to inactive form remain under control when a composition of lambdacyhalothrin is prepared along with another active ingrédient. The invention demonstrates effective composition with good shelf life.
Claims (31)
1. An insecticidal composition comprising:
a) Lambda-cyhalothrin in an amount of 0.1% to 50% by weight of the composition;
5 b) Atleast one another insecticide in an amount of 0.1 % to 50% by weight of the composition; and
Ί
c) a mixture of a weak acid and its sait.
2. The composition as claimed in claim 1, wherein said another insecticide is selected from the group consîsting of neonicotinoids, benzoylphenyl urea, 10 diamide insecticide, tetramic acid, flonicamid and combinations thereof.
3. The composition as claimed in claim 2, wherein said neonicotinoid insecticide is selected from the group consîsting of clothianidin, imidacloprid, acetamiprid, thiamethoxam, thiadoprid and combinations * thereof. I
15
4. The composition as claimed in claim 2, wherein said benzoylphenyl urea insecticide is selected from the group consîsting of bistrifluron, chlorbenzuron, chlorfluazuron, dichlorbenzuron, diflubenzuron, flucydoxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, penfluron, teflubenzuron, triflumuron and combinations 20 thereof.
5. The composition as claimed in claim 2, wherein said tetramic acid insecticide is spirotetramat.
S4
6. The composition as claimed in claim 2, wherein said diamide insecticide is selected from the group consisting of chlorantranlliprole, cyantraniliprole, cyclaniliprole, tetrachlorantraniliprole and tetraniliprole. I *
7. The composition as claimed in claim 2, wherein said another insecticide is imidacloprid, novaluron, spirotetramat, flonicamid or chlorantraniliprole.
I
8. The composition as claimed in claim 1, wherein said mixture ofa weak acid and its sait is an organic acid and its sait, said organic acid being selected * from the group consisting of citric acid, acetic acid, succinic acid, glutaric acid; maleic acid, tartaric acid, and oxalic acid .
9. The composition as claimed in claim 8, wherein the mixture ofa weak organic acid and its sait is selected from the group consisting of citric acid and its salts selected from the group comprising of sodium citrate, sodium t citrate monobasic, sodium citrate dibasic, potassium citrate; acetic acid and its salts selected from the group comprising of sodium acetate, ammonium acetate; succinic acid and its salts selected from sodium succinate mono and dibasic; tartaric acid and its salts selected from sodium tartarate monobasic and sodium tartarate dibasic;.
10. The composition as claimed in claim 1, wherein the mixture of weak acid I and its sait is an inorganic acid and its sait, said inorganic acid being selected from the group consisting of phosphoric acid, boric acid, and salts thereof.
I
11. The composition as claimed in daim 10, wherein the mixture of weak L inorganic acid and its sait is phosphoric acid and its salts selected from the group comprising of sodium phosphate dibasic, sodium phosphate monobasic, potassium metaphosphate, potassium phosphate dibasic, potassium phosphate monobasic, ammonium phosphate, diluted potassium metaphosphate.
12. An insecticidal composition comprising:
a. Lambda-cyhalothrin in an amount of 0.1 % to 50% by weight of the composition;
b. atleast one insecticide selected from the group consisting of neonicotinoids, benzoylphenyl urea, tetramic acid , diamide insecticide and flonicamid in an amount of 0.1% to 50% by r » weight of the composition; and
c. a mixture of a weak acid and its sait.
13. The insecticidal composition as claimed in claim 12, said composition comprising:
a. Lambda-cyhalothrin in an amount of 0.1 % to 50% by weight of the composition;
b. Atleast one neonicotinoid insecticide in an amount of 0.1% to 50% by weight of the composition; and
c. a mixture of a weak acid and its sait, wherein said neonicotinoid insecticide is imidadoprid.
14. The insecticidal composition as claimed in claim 12, wherein said composition comprising:
a. Lambda-cyhalothrin in an amount of 0.1 % to 50% by weight of the composition;
b. Atleast one benzoylphenyl urea insecticide in an amount of 0.1% to 50% by weight of the composition; and
c. a mixture of a weak acid and its sait, wherein said benzoylphenyl urea insecticide is novaluron.
15. The insecticidal composition as claimed in claim 12, said composition comprising:
a. Lambda-cyhalothrin in an amount of 0.1 % to 50% by weight of the composition;
b. Atleast one tetramic acid insecticide in an amount of 0.1% to 50% by weight of the composition; and
c. a mixture of a weak acid and its sait, « · wherein said tetramic acid insecticide is spirotetramat. «
16. The insecticidal composition as claimed in claim 12, said composition comprising:
a. Lambda-cyhalothrin in an amount of 0.1% to 50% by weight of the composition;
b. Atleast one diamide insecticide in an amount of 0.1% to 50% by I weight of the composition; and
c. a mixture of a weak acid and its sait, wherein said diamide insecticide is chlorantraniliprole.
17. The insecticidal composition as claimed in claim 12, said composition comprising:
a. Lambda-cyhalothrin in an amount of 0.1% to 50% by weight of the composition;
b. Flonicamid in an amount of 0.1% to 50% by weight of the L composition; and
c. a mixture of a weak acid and its sait.
18. The composition as claimed in daims 12 - 17, wherein said mixture of a weak acid and its sait is selected from the group consisting of: mixture of citric acid monohydrate and trisodium citrate dihydrate; and
I
mixture of phosphoric acid and potassium hydrogen phosphate.
19. The composition as claimed in daims 1-18, wherein said composition is a liquid composition.
20. The composition as claimed in claim 19, wherein said composition is a suspension concentrate (SC), a capsular suspension (CS) or a mixture of l_ both (ZC).
10
21. A process for the préparation of a composition comprising (a) Lambda- cyhalothrin in an amount of 0.1% to 50% by weight ofthe composition; (b) atleast another insecticide in an amount of 0.1% to 50% by weight of the composition; and (c) a mixture of a weak acid and its sait; wherein said
I.
process comprises:
15 a. mixing lambda- cyhalothrin with another insecticide in a suitable system, 1
b. optionally, adding other excipients(s) to obtain pre-mix,
c. adding mixture of a weak acid and its sait to the pre-mix to obtain an insecticidal composition.
22. A process for the préparation of a composition comprising (a) Lambdacyhalothrin in an amount of 0.1% to 50% by weight ofthe composition; (b) atleast another insecticide in an amount of 0.1% to 50% by weight ofthe composition; and (c) a mixture of a weak acid and its sait; wherein said
25 process comprises:
a. mixing lambda-cyhalothrin and another insecticide in an aqueous condition and adding other excipients(s) to obtain a pre-mix;
b. milling the resulting pre-mix;
c. adding a thickener and a mixture of a weak acid and its salts to the pre-mix followed by homogenization to obtain the composition in the form of suspension concentrate.
•k
5
23. A process for the préparation of a composition comprising (a) Lambda- cyhalothrin in an amount of 0.1 %to 50% by weight ofthe composition; (b) atleast another insecticide in an amount of 0.1% to 50% by weight ofthe composition; and (c) a mixture of a weak acid and its sait; wherein said process comprises:
10 a. mixing lambda-cyhalothrin and another insecticide in an aqueous condition and optionally, adding other excipients(s) to obtain a pre-mix,
L
b. milling the resulting pre-mix;
c. adding a mixture of a weak acid and its salts to the pre-mix; and 15 d. gellifÿing the mixture by adding a separately prepared thickener composition to obtain the composition in the form of suspension concentrate.
L
24. A process for the préparation of a composition comprising (a) Lambda20 cyhalothrin in an amount of 0.1 % to 50% by weight of the composition; (b) atleast another insecticide in an amount of 0.1% to 50% by weight of the
I composition; and (c) a mixture of a weak acid and its sait; wherein said process comprises:
i. preparing a capsule suspension of lambda-cyhalothrin;
25 ii. preparing a suspension concentrate of another insecticide;
iii. separately dissolving an amine sait in water to obtain an amine solution;
iv. mixing the suspension concentrate of step (ii), a mixture of a weak acid and its sait, the amine solution and the capsule suspension of lambda-cyhalothrin to obtain a ZC composition.
5
25. A process for the préparation of a composition comprising (a) Lambda- cyhalothrin in an amount of 0.1%to50% by weight ofthe composition; (b) atleast another insecticide in an amount of 0.1% to 50% by weight ofthe composition; and (c) a mixture of a weak acid and its sait; wherein said process comprises:
10 i. preparing an organic phase comprising lambda-cyhalothrin solubilized in vegetable oil or dérivatives thereof, and at least one isocyanate;
ii. preparing an aqueous phase by mixing suitable auxiliary ingrédients in water;
15 iii. separately dissolving an amine sait in water to obtain an amine solution;
iv. mixing the organic phase of step (I), the aqueous phase of step (ii) and the amine solution of step (iii) to obtain an encapsulated lambda-cyhalothrin as capsule suspension;
-I
20 v. separately preparing a suspension concentrate of another insecticide;
vi. mixing the capsule suspension of step (iv) with the suspension concentrate of step (v);
vii. adding the mixture of weak acid and its sait to obtain the * L
25 composition in the form of a ZC formulation.
26. The process as daimed in claim 25, wherein the composition has a particle size distribution D™ of less than about 10 microns, or Dso of less than about 10.0 microns or D90 of less than or equal to about 20 microns.
27. A method for controlling pests which comprises applying effective amounts of a composition comprising (a) Lambda-cyhalothrin in an amount of 0.1% to 50% by weight ofthe composition; (b) atleast another l insecticide in an amount of 0.1% to 50% by weight ofthe composition; and (c) a mixture of a weak acid and its sait, to pests or to a locus where the pests inhabït.
28. The method as claimed in claim 27, wherein said another insecticide is imidacloprid, novaluron, spirotetramat, flonicamid or chlorantraniliprole.
29. The method as claimed in claim 27, wherein the said mixture of weak acid and its sait is a mixture of citric acid monohydrate and trisodium citrate Ί di hydrate. 1
30. The method as claimed in claim 27, wherein the said mixture of weak acid and its sait is a mixture of phosphoric acid and potassium hydrogen phosphate.
31. A kit comprising:
(a) a first component comprising Lambda-cyhalothrin;
(b) a second component comprising another insecticide; and (c) a third component comprising a mixture of a weak acid and its sait, wherein the first, second and third components are instructed to be admixed before being applied to a locus.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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IN202021035156 | 2020-08-14 |
Publications (1)
Publication Number | Publication Date |
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OA21169A true OA21169A (en) | 2024-02-02 |
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