OA18822A - Hematophagous arthropod control method, and hematophagous arthropod control composition for treating living space forming element. - Google Patents
Hematophagous arthropod control method, and hematophagous arthropod control composition for treating living space forming element. Download PDFInfo
- Publication number
- OA18822A OA18822A OA1201800258 OA18822A OA 18822 A OA18822 A OA 18822A OA 1201800258 OA1201800258 OA 1201800258 OA 18822 A OA18822 A OA 18822A
- Authority
- OA
- OAPI
- Prior art keywords
- arthropod control
- hematophagous arthropod
- forming element
- space forming
- living space
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- OMFRMAHOUUJSGP-IRHGGOMRSA-N κ-bifenthrin Chemical compound C1=CC=C(C=2C=CC=CC=2)C(C)=C1COC(=O)[C@@H]1[C@H](\C=C(/Cl)C(F)(F)F)C1(C)C OMFRMAHOUUJSGP-IRHGGOMRSA-N 0.000 description 1
Abstract
A hematophagous arthropod control method of treating a living space forming element with a hematophagous arthropod control composition for treating a living space forming element, the composition including, as an effective ingrédient, at least one amide derivative represented by the following Formula (1), wherein, in Formula (1), Q represents a phenyl group or a phenyl group substituted with a fluorine atom, R represents a hydrogen atom or a methyl group, and Y1 and Y2 each independently represents a bromine atom, an iodine atom, or a trifluoromethyl group. (1)
Description
DESCRIPTION
HEMATOPHAGOUS ARTHROPOD CONTROL METHOD, AND HEMATOPHAGOUS ARTHROPOD CONTROL COMPOSITION FOR TREATING LIVING SPACE FORMING ELEMENT
Technical Field
[0001] The present invention relates to a hematophagous arthropod control method and a hematophagous arthropod control composition for treating a living space forming element for preventing rampancy of infections diseases transmitted by a hematophagous arthropod.
Background Art
[0002] Many hematophagous arthropods transmit pathogens to humans or animais, causing infectious diseases. Especially, in tropical areas, mosquito-borne infectious diseases, such as malaria and dengue fever, kill a lot of people and also hinder économie development. As an insect pest control method for exterminating the disease-transmitting insect pests, a method of spraying insecticide containing an insect pest control ingrédient, a method of applying a contact insecticide on to the surface of an indoor wall, and a method of immersing a mosquito net in an insecticide hâve been used. As an insect pest control ingrédient, a pyrethroid compound, a neonicotinoid compound, etc. hâve been known.
[0003] Various compounds as an amide dérivative having pest control activity and a method of using the same hâve been disclosed (see, for example, Patent Literature 1 to 5).
[Patent Literature 1] International Publication No. WO 2005/21488
[Patent Literature 2] International Publication No. WO 2005/73165
[Patent Literature 3] International Publication No. WO 2006/137376
[Patent Literature 4] International Publication No. WO 2006/137395
[Patent Literature 5] International Publication No. WO 2010/013567
SUMMARY OF INVENTION
Technical Problem
[0004] However, the pest control methods described above are not adéquate in terms of sustainability, and further a disease-transmitting insect, which has acquired résistance to a pyrethroid compound, has appeared in recent years causing a big problem.
[0005] Although the above Patent Literature 1 to 5 describe the possibility of control of a disease-transmitting insect pest, a spécifie effective concentration or a detailed application method hâve not been disclosed. Further, an insect pest control method using the above amide dérivative has not been substantially disclosed.
[0006] Consequently, an object of an aspect of the invention is to provide a hematophagous arthropod control method and a hematophagous arthropod control composition for treating a lîving space forming element, which are superior in sustainabilîty, and are also effective against a résistant insect pest.
Solution to Problem
[0007] As a resuit of extensive research for achieving the object, the present inventors hâve found that by using a composition containing an amide dérivative represented by Formula (I) ,as an effective ingrédient, and applying the same to a living space forming element, such as a house wall, or a mosquito net, an insect pest control for a long term is possible, and the same is also effective against a résistant insect pest.
An embodiment of the invention is as follows.
[0008] <]> A hematophagous arthropod control method of treating a living space forming element with a hematophagous arthropod control composition for treating a living space forming element, the composition including, as an effective ingrédient, at least one amide dérivative represented by the following Formula (I):
[0010] wherein, in Formula (I), Q represents a phenyl group or a phenyl group substituted with a fluorine atom, R represents a hydrogen atom or a methyl group, and Yj and Y2 each independently represents a bromine atom, an iodine atom, or a trifluoromethyl group.
[001l] <2> The hematophagous arthropod control method according to <1>, wherein the amide dérivative represented by Formula (1) is 2-fluoro-3-(Af-methylbenzamido)-A/-(2-bromo-6-trifluoromethyl-4-(heptafluoropropan-2-yl)p henyljbenzamide.
[0012] <3> The hematophagous arthropod control method according to <1 > or <2>, wherein the living space formîng element is a house wall or a mosquito net.
[0013] <4> The hematophagous arthropod control method according to any one of <l> to <3>, wherein the method of treating the living space formîng element is a spraying treatment or an immersion treatment.
[0014] <5> The hematophagous arthropod control method according to any one of <l> to <4>, wherein the hematophagous arthropod to be controlled is at least one selected from the group consisting of an insect of the genus Anopheles, an insect of the genus Aedes, and an insect of the genus Culex, which belong to the family Culicidae of the order Diptera.
[0015] <6> The hematophagous arthropod control method according to <5>, wherein the insect of the family Culicidae of the order Diptera is an insect of the genus Anopheles.
[0016] <7> The hematophagous arthropod control method according to <5> or <6>, wherein insects of the genus Anopheles are at least one of Anopheles gambiae or Anopheles sinensis.
[0017] <8> The hematophagous arthropod control method according to any one of <l> to <7>, wherein the composition further includes, as an effective ingrédient, at least one compound selected from the group consisting of permethrin, alpha-cypermethrin, deltamethrin, and etofenprox.
[0018] <9> The hematophagous arthropod control method according to any one of <1> to <8>, wherein the composition is a wettable powder or a (lowable.
[0019] <IO> A hematophagous arthropod control composition to be used for the hematophagous arthropod control method according to any one of <l> to <9>.
[0020] <11> The hematophagous arthropod control composition according to <10> used for treating a living space formîng element.
[0021] <12> A hematophagous arthropod control composition for treating a living space formîng element. the composition including, as an effective ingrédient, at least one amide dérivative represented by the following Formula (1):
[0023] wherein, in Formula (I), Q represents a phenyl group or a phenyl group substituted with a fluorine atom, R represents a hydrogen atoin or a methyl group, and Yi and Y? each independently represents a bromine atom, an iodine atom, or a trîfluoromethyl group.
[0024] <13> The hematophagous arthropod control composition for treating a living space forming element according to <!2>, wherein the amide derivatîve represented by Formula (!) is
2-fluoro-3-(7V-methylbenzamido)-/V-(2-bromo-6-trifluoromethyl-4-(heptafluoropropan-2-yl)p henyl)benzamide.
[0025] <14> The hematophagous arthropod control composition for treating a living space forming element according to <12> or <13>, used for treating a house wall or a mosquito net as the living space forming element.
[0026] <15> The hematophagous arthropod control composition for treating a living space forming element according to any one of <12> to <14> used for controlling at least one selected from the group consisting of an insect of the genus Anopheles, an insect of the genus Aedes, and an insect of the genus Culex, which belong to the family Ctdicidae of the order Diptera as a hematophagous arthropod.
[0027] <I6> The hematophagous arthropod control composition for treating a living space forming element according to <l5>, wherein the insect of the family Culicidae of the order Diptera is an insect of the genus Anopheles.
[0028] <17> The hematophagous arthropod control composition for treating a living space forming element according to <15> or <16>, wherein the insect of the genus Anopheles is at least one of Anopheles ganibiae or Anopheles sinensis.
[0029] <18> The hematophagous arthropod control composition for treating a living space forming element according to any one of <12> to <17>, further including, as an effective ingrédient, at least one compound selected from the group consisting of permethrin, alpha-cypermethrin, deltamethrin, and etofenprox.
[0030] <19> The hematophagous arthropod control composition for treating a living space forming element according to any one of <12> to <18>, which is a wettable powder or a flowable.
Advantageous Effects of Invention
[0031 ] According to an embodiment of the invention, the hematophagous arthropod control method, and the hematophagous arthropod control composition for treating a living space forming element, which are superior in sustainability and also effective against a résistant insect pest, may be provided.
DESCRIPTION OF EMBODIMENTS
[0032] A hematophagous arthropod control composition for treating a living space forming element according to an embodiment of the invention (hereinafter also referred to simply as composition) contains as an effective ingrédient at least one amide dérivative represented by the following Formula (I). Owing to such a constitution, when a living space forming element is treated with the composition according to the embodiment, a high pest control effect superior in sustainability and also effective against a résistant insect pest may be obtained. Further, by a hematophagous arthropod control method according to an embodiment of the invention, a living space forming element is treated with a hematophagous arthropod control composition for treating a living space forming element containing as an effective ingrédient at least one amide dérivative represented by the following Formula (l). Owing to such a constitution, also by a hematophagous arthropod control method according to the embodiment, a high pest control effect superior in sustainability and also effective against a résistant insect pest may be obtained.
[0034] In Formula (l), Q represents a phenyi group or a phenyl group substituted with a fluorine atom, R represents a hydrogen atom or a methyl group, and Yi and Y2 each independently represents a bromîne atom, an îodine atom, or a trifluoromethyl group
[0035] Amide dérivatives represented by Formula (!) used in the embodiment hâve in some cases one or plural asymmetric carbon atoms, or asymmetric centers in their structural formulas, where two or more kinds of optical isomers may be présent, and include each of such optical isomers, and a mixture of the same at an arbitrary ratio. Further, amide dérivatives represented by Formula (l) used in the embodiment hâve in some cases two or more géométrie isomers derived from a carbon-carbon double bond in their structural formulas, and include each of such géométrie isomers, and a mixture of the same at an arbitrary ratio.
[0036] A compound represented by Formula (!) is preferably 2-fluoro-3-(JV-methylbenzamido)-X-(2-bromo-6-trifluoromethyl-4-(heptafluoropropan-2-yl)p henyl)benzamide represented by the following Formula (2).
[0037]
[0038] A compound represented by Formula (l) used in the embodiment may be produced according to the method described in International Publication No. WO 2010/013567.
[0039] Spécifie examples of a hematophagous arthropod, which can be controlled by the composition according to the embodiment, and the hematophagous arthropod control method, may include the following hematophagous arthropods, provided, however, that the invention be not limited thereto.
[0040] Examples of an insect of the family Culicidae of the order Diplera include Anopheles gambiae, Anopheles arabiensis, Anopheles funestus, Anopheles mêlas, Anopheles minimus, Anopheles diras, Anopheles stephensi, Anopheles sinensis, and Anopheles albimanus, belonging to the genus Anopheles, Culex pipiens molestus, Culex pipiens pipiens, Culex quinquefasciatus, Culex pipiens pollens, Culex résilions, Culex tarsalis, Culex modestus, and Culex tritaeniorhynchus, belonging to the genus Culex, Aedes aegypti, Aedes albopictus, Aedes japonicus, and Aedes vexons, belonging to the genus Aedes, and an insect, such as a deer fly, a fly, a buffalo gnat, a sandfly, a biting midge, a tsetse fly, a midge, a flea, a lice, a bedbug, an assassin bug, a mite, and a tick.
[0041] In the embodiment, the hematophagous arthropod is preferably an insect of the family Culicidae of the order Diplera from the viewpoint of controlling efifect.
[0042] When an amide dérivative represented by Formula (I) is used in the embodiment, the saine is ordinarily mixed with a suitable solid or liquid carrier, and may be put to practical use ί
in an optional formulation, such as a soluble concentrate, an emulsiflable concentrate, a wettable powder, a flowable, a water soluble powder, a water dispersible granule, a water soluble granule, a suspension concentrate, a concentrated émulsion, a suspoemulsion, a microemulsion, a dustable powder, a granule, a tablet, and emulsiflable gel, if desired, by adding a surfactant, a pénétrant, a spreader, a thickener, a protective colloid agent, an anti-freezing agent, a bînder, an anti-caking agent, a disintegrant. a defoaming agent, an antifungal agent, a stabilizing agent, etc. Further, from the viewpoint of labor saving and safety improvement, it is also possible to enclose a drug of any of the above formulations in a water-soluble package, such as a water-soluble capsule or a water-soluble film bag, and put it into use.
For example, the composition according to the embodiment may be a wettable powder or a flowable.
[0043] An inert carrier to be used in a composition according to the embodiment may be solid or liquid.
[0044] Examples of a material to be used as a solid inert carrier include soy flour, cereal flour, wood flour, bark powder, saw dust, tobacco stem flour, walnut shell powder, bran, cellulose powder, a residue after extraction of a plant extract, a synthetic polymer such as a pulverized synthetic resin, a clay (such as kaolin, bentonite, and acidic clay), a talc (such as talc, and pyrophyllite), a silica (such as diatomaceous earth, silica sand, mica, white carbon [synthetic highly dispersible silica, also called as hydrated silica fine powder, or hydrated silica, some products of which contain calcium silicate as the main component]), an inorganic minerai powder, such as activated carbon, sulfur powder, pumice, calcined diatomaceous earth, pulverized brick (e.g. clay), fly ash, sand, calcium carbonate, and calcium phosphate, a Chemical fertilizer, such as ammonium sulfate, ammonium phosphate, ammonium nitrate, urea. and ammonium chloride, and compost. These may be used sîngly or în a form of a mixture of two or more kinds.
[0045] A material which can be used as a liquid inert carrier, may be selected from those having solvent power in themselves, or those having no solvent power in themselves but being able to disperse an effective ingrédient compound with the aid of an adjuvant (for example, a surfactant). Examples thereof include water, an alcohol (such as methanoi, éthanol, isopropanol, butanol, and ethylene glycol), a ketone (such as acetone, ethyl methyl ketone, methyl isobutyl ketone, diisobutyî ketone, and cyclohexanone), an ether (such as diethyl ether, dioxane, cellosolve, diisopropyl ether, and tetrahydrofuran), an aliphatic hydrocarbon (such as kerosene and minerai oil), an aromatic hydrocarbon (such as benzene, toluene, xylene, solvent naphtha. and an alkyl naphthalene), a halogenated hydrocarbon (such as dichloromethane, chloroform, carbon tetrachloride, and chlorobenzene), an ester (such as ethyl acetate, butyl acetate, ethyl propionate, diisobutyl phthalate, dibutyl phthalate, and dioctyl phthalate), an amide (such as dimethylformamide, diethylformamide, and dimethylacetamide), and a nitrile (such as acetonitrile). These may be used singîy or in a form of a mixture of two or more kinds.
[0046] These solid carriers and liquid carriers may be used singîy, or in a combination of two or more thereof.
[0047] Examples of a surfactant include a nonionic surfactant, such as a polyoxyethylene (mono or dï-)alkyl etiier, a polyoxyethylene alkyl (mono, or di-)phenyl ether, a polyoxyethylene (mono, di, or tri-)styrylphenyl ether, a polyoxyethylene / polyoxypropylene block copolymer, a polyoxyethylene fatty acid (mono, or di-)ester, a sorbîtan fatty acid ester, a polyoxyethylene sorbitan fatty acid ester, a castor oil ethylene oxide adduct. acetylene glycol, acetylene alcohol, an acetylene glycol ethylene oxide adduct, an acetylene alcohol ethylene oxide adduct, and an alkyl glycosîde; an anionic surfactant, such as an alkyl sulfate ester, an alkyl benzene sulfonate, a lignin sulfonate, an alkyl sulfosuccinate, a dialkyl sulfosuccinate, a naphthalene sulfonate, an alkyl naphthalene sulfonate, a sait of a condensation product of naphthalene sulfonic acid and formalin (formaldéhyde condensate), a sait of a condensation product of alkyl naphthalene sulfonic acid and formalin (formaldéhyde condensate), a polyoxyethylene alkyl ether sulfate or phosphate, a polyoxyethylene (mono, or di-)alkylphenyI ether sulfate or phosphate, a polyoxyethylene (mono, di, or tri-)styrylphenyl ether sulfate or phosphate, a polycarboxyiate (e.g. a polyacrylate, a polymaleate, and a copolymer of maleîc acid and olefin), and polystyrène sulfonate; a cationic surfactant, such as an alkylamine sait, and an alkyl quaternary ammonium sait; an amphoterîc surfactant, such as an amino acid type, and a betaine type; a silicone surfactant; and a fluorochemical surfactant.
[0048] Although there is no particular restriction on the content of the surfactant, it is preferably in a range of from 0.05 to 20 parts by weight with respect to 100 parts by weight of the formulation. These surfactants may be used singîy, or in a combination of two or more thereof.
[0049] Examples of a thickener include a natural gum, such as xanthan gum, welan gum, guar gum, tragacanth gum, and gum arabic; a fine powder of an inorganic minerai, such as smectite, sepiolite, attapulgite, laponite, montmorillonite, and hectorîte; a cellulose dérivative, such as carboxymethy [cellulose, hydroxyethylcellulose, carboxyethylcellulose, methylcellulose, and hydroxypropylcellulose, and a sait thereof; a starch dérivative, such as various grades of dextrin, and a carboxymethyl starch sodium sait; a natural product, such as sodium alginate, and sodium caseinate, and a dérivative thereof; and a water-soluble synthetic polymer, such as polyfvinyl alcohol), and poiy(acrylic acid), and a dérivative thereof, and polyvinylpyrrolidone. These thickeners may be used singly, or in a combination of two or more thereof.
[0050] Examples of a protective colloid agent include a water-soluble cellulose, such as methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropyl methylcellulose, and carboxymethyîcellulose, a polyalkylene glycol, such as poly(ethylene glycol), and poly(propylene glycol), poly(vinyl alcohol), polyvinylpyrrolidone, guar gum, gum arabic, gelatin, polyacrylate, and alginate. These protective colloid agents may be used singly, or in a combination of two or more thereof.
[0051] Examples of an antifreezing agent include ethylene glycol, diethylene glycol, propylene glycol, and glycerin. These anti-freezing agents may be used singly, or în a combination of two or more thereof.
[0052] Examples of an antifoaming agent include a silicone type, an acetylene glycol type, a fluorochemical type, and a fatty acid type. These defoaming agents may be used singly, or in a combination of two or more thereof.
[0053] Examples of an antifungal agent include a benzothîazole dérivative, sorbic acid, potassium sorbate, and butyl /?-oxybenzoate. These antifungal agents may be used singly, or in a combination of two or more thereof.
[0054] A composition according to the embodiment may contaîn at least one of another commonly known insecticidal ingrédient (insect pest control ingrédient) or a synergist in addition to the amide dérivative represented by Formula (l).
Examples of such other insecticidal ingrédient include a pyrethroid compound, such as acrinathrin, permethrin, phenothrin, d-phenothrin, allethrîn, d-allethrin, dd-allethrin, pyrethrin, prallethrin, cyphenothrin, cyfluthrin, beta-cyfluthrin, bifenthrin, cycloprothrin, cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, cypermethrîn, sigma-cypennethrin, alpha-cypermethrin, zeta-cypermethrin, dimetoflulhrin, empenthrin, deltamethrin, terarethrin, tefluthrin, fenvalerate, esfenvalerate, flucythrinate, flufenprox, flumethrin, fluvalinate, tau-fluvaiinate, profluthrin, halfenprox, imiprothrin, benfluthrin, resmethrin, d-resmethrin, sîlafluofen, tralomethrin, tetramethrin, d-tetramethrin, furamethrin, metofluthrin, fenpropathrîn, transfluthrin, and etofenprox; an organophosphorus compound, such as acephate, butathiofos, chlorethoxyfos, chlorfenvinfos, chlorpyrifos, chlorpyrifos-methyl, cyanophos, diazinon, DCIP, diclofenthion, dichlorvos, dimethoate, dimethylvinphos, disulfoton, EPN, ethion, ethoprophos, etrîmfos, fenthion, fenitrothion, fosthiazate, fbrmothion, isophenphos, isoxathion, malathîon, mesulfenfos, methidathion, monocrotophos, naled, parathion, phosalone, phosmet. pirîmiphos-methyl, pyridafenthion, quinalphos, phenthoate, profenofos, propaphos, prothîofos, pyraciofos, salithion, sulprofos, temephos, terbufos, trichlorfon, and cadusafos; an Λ'’-phenylpyrazole compound, such as fipronil; a carbamate compound, such as alanycarb, benfuracarb, BPMC, carbaryl, carbofuran, carbosulfan, cloethocarb, ethiofencarb, fenobucarb, methomyl, methiocarb, N AC, oxamyl, pirimicarb, propoxur, XMC, thiodicarb, xylylcarb, and aldicarb; a neonicotinoid compound, such as imidacloprid, clothianidin, thiamethoxam, and dinotefuran; an insect growth regulator, such as pyriproxyfen, methoprene, hydroprene, fenoxycarb, etoxazole, chlorfluazuron, triazuron, novaluron, hexaflumuron, diflubenzuron, cyromazine, flufenoxuron, teflubenzuron, triflumuron, and lufenuron; and a macrolide compound, such as milbemycin, abamectin, and ivermectin.
Examples of a synergist may include compounds, such as piperonyl butoxide, O-propargyl O-propylphenylphosphonate (NIA 16388), isobornyl thiocyanoacetate (1BTA), N- (2-ethylhexyl)-bicyclo[2.2.1 ]-hept-5-ene-2,3-dicarboximide (MGK-264), 2,2',3,3,3,3',3',3’-octachlorodipropyl ether (S-421), synepirin 500, propylisom, piperonyl cyclonene, sesamolin, sesamex, sesamin, a sulfoxide, safroxane, and benzyl benzoate.
A composition according to the embodiment may further contain at least one compound selected from the group consisting of permethrin, alpha-cypermethrin, deltamethrin, and etofenprox as another insecticidal ingrédient in addition to an amide dérivative represented by Formula (1), because they tend to improve the insecticidal effect on a hematophagous arthropod.
[0055] As for the weight ratio of the total of another insecticidal ingrédient and a synergist to an amide dérivative represented by Formula (I), such other insecticidal ingrédient with respect to 1 part by weight of the amide dérivative represented by Formula (1) is usually from 0.01 to 100 parts by weight, and preferably from 0.02 to 50 parts by weight.
[0056] It is préférable that usually the content of an effective ingrédient of the composition according to the embodiment is in a dustable powder from 0.1 to 20% by weight, in an emulsifiable concentrate from 5 to 50% by weight, in a wettable powder from 3 to 90% by weight, în a granule from 0.1 to 20% by weight, in a flowable from 5 to 90% by weight, and in a water dispersible granule from 3 to 90% by weight. Meanwhile, it is préférable that usually the content of a carrier in each formulation is in a dustable powder from 60 to 99.9% by weight, in an emulsîfiable concentrate from 40 to 95% by weight, in a wettable powder from 10 to 90% by weight, in a granule from 80 to 99.9% by weight, in a flowable from 10 to 95% by weight, and in a water dispersible granule from 10 to 90% by weight. Further, it is préférable that usually the content of an adjuvant is in a dustable powder from 0.1 to 20% by weight, in an emulsifiable concentrate from 1 to 20%, in a wettable powder from 0.1 to 20% by weight in a granule from 0.1 to 20 % by weight, in a flowable from 0.1 to 20% by weight, and in a water dispersible granule from 0.1 to 20% by weight.
[0057] In a hematophagous arthropod control method according to the embodiment, a composition according to the embodiment may be used as it is, or it may be appropriately diluted or suspended with water, etc. before use. It is préférable to use the same usually at a concentration of from 0.0001 to 5000 ppm in terms of an effective ingrédient, and more preferably at a concentration of from 0.01 to 1000 ppm.
[0058] A living space means herein a space where at least one of human or animal dwells, and examples of a living space forming element include a house wall, a ceiling, a pillar, a transom, a window, a door, a tent. and a mosquito net.
[0059] When a house wall surface is treated with a composition according to the embodiment. the house wall surface may be treated by spraying, coating, évaporation, or the like. Such treatment of a house wall surface includes also a case where materials sprayed, coated, evaporated, immersed, înjected, or otherwise with the same are used as a house wall surface.
[0060] Examples of a material for a house wall surface include concrète (cernent), brick, bamboo, wood, tile, ceramic, and mud, and examples of a material for a ceiling include straw, zinc-coated Steel, concrète (cernent), bamboo, and wood, provided that the invention is not limited thereto.
[0061] When a mosquito net is treated with a composition according to the embodiment, a mosquito net may be immersed in the composition according to the embodiment. or a mosquito net may be immersed in a liquid, which is a solution prepared by diluting the composition according to the embodiment appropriately with water, etc., or a suspension prepared by suspending the same. Alternatively, a mosquito net may be subjected to a treatment, such as spraying and coating.
[0062] Examples of the material for a mosquito net include a resin, and a fiber material, such as a natural fiber, and a glass fiber, and among them a resin is préférable. In this regard, examples of a natural fiber include pulp, cellulose, cotton, hemp, and haïr.
As a resin a thermoplastic resin is préférable. Examples of a thermoplastic resin include a polyolefin resin, poly(vinyl alcohol), poly(vinyl acetate), polycarbonate, polyester, polyamide (e.g. nylon), polystyrène, poly(methyl méthacrylate), an acrylonitrile / butadîene / styrene copolymer, and poly(vinyl chloride).
Among them, a polyolefin resin is préférable as the thermoplastic resin. As the polyolefin resin, the compounds listed în the following (i) to (iii) are préférable.
(i) A homopolymer of α-olefin: for example, polyethylene, or polypropylene.
(ii) A copolymer of ethylene / α-olefin: for example, an ethylene / propylene copolymer, an ethylene / 1-butene copolymer, an ethylene / 4-methyl-l-pentene copolymer, or an ethylene / hexene copolymer.
(lit) A copolymer of an organic carboxylate derivatîve having an ethylenic unsaturated bond with ethylene: for example, an ethylene / methyl méthacrylate copolymer, an ethylene / vinyl acetate copolymer, an ethylene / acrylic acid copolymer, or an ethylene / vinyl acetate / methyl méthacrylate copolymer.
[0063] A mosquito net may be formed using a material for a mosquito net treated with a composition according to the embodiment.
Alternatively, a yarn may be spun using a resin containing an amide derivatîve represented by Formula (1), and the résultant yarn may be woven into a mosquito net.
[0064] The amount of an effective ingrédient to be coated on the surface of a living space forming element may be appropriately adjusted according to the application time, the application place, the treatment method, etc., and it is preferably from 0.1 to 3000 mg/m2, and more preferably from 1 to 500 mg/m2.
[0065] Although the composition according to the embodiment is for treating a living space forming element. by applying the same to an aqueous environment, such as a lake or a pond, wetlands, paddy fields, a réservoir, a septic tank, and a drainage canal, inhabited by larvae of hematophagous arthropods, such as insects of the family Cidicidae of the order Diptera, it may be expected that infection with malaria, dengue fever, Zîka fever, etc. may be prophylactically prevented.
[0066] In addition, a composition according to the embodiment may be mixed according to need with various kinds of insecticides, miticides, nematicides, fungicides, synergists, etc. for use.
Examples
[0067] Next, spécifie examples of a formulation of a composition according to the embodiment will be presented, provided that the invention be not limited thereto. Meanwhile, part means herein part by weight.
[0068] Firstly, as shown in Préparation Examples 1 to 3 below, a broflanilide slurry, a thickener solution A, and a thickener solution B were prepared.
<Preparation Example 1>
Fifty (50.0) parts of the compound represented by Formula (2), namely 2-fluoro-3-(Af-methylbenzamido)-Ar-(2-bromo-6-trifluoromethyl-4-(heptafluoropropan-2-yl)p henyl)benzamide, 2.0 parts of a polyoxyethylene styrylated phénol phosphate, i.O paît of dioctyl suîfosuccinate, 0.1 parts of a silicone antifoaming agent, and 46.9 parts of water were mixed uniformly, and w'et-disintegrated to obtain a broflanilide slurry.
<Preparation Example 2>
By mixing uniformly 0.47 parts of xanthan gum, 0.33 parts of a benzothiazoîe dérivative, 13.33 parts of propylene glycol, and 85.87 parts of water, a thickener solution A was obtained.
<Preparation Example 3>
By mixing uniformly 0.47 parts of xanthan gum, 0.50 parts of a benzothiazoîe dérivative, 18.75 parts of propylene glycol, and 80.28 parts of water, a thickener solution B was obtained.
[0069]
[Example 1] <Formulation Example l>
By disintegrating and mixing uniformly 50.0 parts of the compound represented by Formula (2), 2.5 parts of diethylene glycol monododecyl ether (polyoxyethylene monoalkyl ether), 2.5 parts of nonaethylene glycol monododecyl ether (polyoxyethylene monoalkyl ether), 2.0 parts of a polyfvinyl alcohol), 38.0 parts of kaolin, and 5.0 parts of white carbon, a wettable powder was obtained.
[0070]
[Example 2] <Formulation Example 2>
By disintegrating and mixing uniformly 50.0 parts of the compound represented by Formula (2), 3.0 parts of an alkyl sulfate sait. 4.0 parts of a dialkyl suîfosuccinate, 3.0 parts of a polyoxyethylene monoalkyl ether, 2.0 parts of a poly(vinyl alcohol), and 38.0 parts of kaolin, a wettable powder was obtained.
[0071]
[Example 3] <Formulation Example 3>
By disintegrating and mixing uniformly 50.0 parts of the compound represented by Formula (2), 4.0 parts of a dialkyl sulfosuccinate, 3.0 parts of a polyoxyethylene aikyl ether, 3.0 parts of a sait of a condensation product of an alkylnaphthalene sulfonic acid with formalin (formaldéhyde condensate), 39.5 parts of kaolin, and 0.5 parts of a silicone antifoaming agent, a wettable powder was obtained.
[0072]
[Example 4] <Fonnulation Example 4>
By disintegrating and mixing uniformly 50.0 parts of the compound represented by Formula (2), 5.0 parts of an alkylnaphthalenesulfonate, 3.0 parts of lignin sulfonate, 36.5 parts of kaolin, 5.0 parts of white carbon, and 0.5 parts of a silicone antifoaming agent, a wettable powder was obtained.
[0073]
[Example 5] <Formulation Example 5>
By mixing uniformly and wet-disintegrating 50.0 parts of the compound represented by Formula (2), 1.8 parts of polyoxyethylene tristyrylphenyl ether sulfate ammonium sait (number of moles of ethylene oxide added 14), 1.2 parts of a polyoxyethylene / polyoxypropylene block copolymer, 5.0 parts of propylene glycol, 0.5 parts of a silicone antifoaming agent. 0.1 parts of bentonite, and 41.4 parts of water, homogeneously mixing the above, a flowable was obtained.
[0074]
[Example 6] <Formulatîon Example 6>
By mixing uniformly 10.0 parts of the broflaniiide slurry obtained in Préparation Example 1, 3.0 parts of polyoxyethylene tristyrylphenyl ether sulfate ammonium sait (number of moles of ethylene oxide added 14), 5.0 parts of a sait of a condensation product of an alkylnaphthalene sulfonic acid with formalin (formaldéhyde condensate), 60.0 parts of the thîckener solution A obtained in Préparation Example 2, and 22.0 parts of water, a flowable was obtained.
[0075]
[Example 7] <Formulation Example 7>
A flowable was obtained in the same manner as in Example 6, except that 5.0 parts of a sait of a condensation product of an alkylnaphthalene sulfonic acid with formai in (formaldéhyde condensate) in Example 6 was changed to 10.0 parts, and 22.0 parts of water was also changed to 17.0 parts.
[0076]
[Example 8] <Formulation Example 8>
A flowable was obtained in the same manner as in Example 7, except that 3.0 parts of polyoxyethylene tristyrylphenyl ether sulfate ammonium sait (number of moles of ethylene oxide added 14) in Example Ί was changed to 5.0 parts, and 17.0 parts of water was also changed to 15.0 parts.
[0077]
[Example 9] <Formulation Example 9>
A flowable was obtained in the same manner as in Example 6, except that polyoxyethylene tristyrylphenyl ether sulfate ammonium sali (number of moles of ethylene oxide added 14) in Example 6 was changed to polyoxyethylene tristyrylphenyl ether sulfate ammonium sait (number of moles of ethylene oxide added 9).
[0078]
[Example 10] <Formulation Example 10>
By mixing 40.0 parts of the broflanilide slurry, 3.0 parts of polyoxyethylene tristyrylphenyl ether sulfate ammonium sait (number of moles of ethylene oxide added 14), 5.0 parts of a sait of a condensation product of an alkylnaphthalene sulfonic acid with forma!in (formaldéhyde condensate), 40.0 parts of the thîckener solution B obtained in Préparation Example 3, and 12.0 parts of water, a flowable was obtained.
[0079]
[Example 11 ] <Formulation Example 11>
A flowable was obtained in the same manner as in Example 6, except that polyoxyethylene tristyrylphenyl ether sulfate ammonium sait (number of moles of ethylene oxide added 14) in Example 6 was changed to polyoxyethylene tristyrylphenyl ether sulfate ammonium sait (number of moles of ethylene oxide added 16).
[0080]
Next, the usefulness of the composition and the hematophagous arthropod control method according to the embodiment will be specifically described referring to the following Test Examples, provided that the invention be not limited thereto.
[0081] <Test Example 1>
Indoor residual spraying (1RS) test using various wall materials with respect to Anopheles gambiae:
Reagents tested: The wettable powder (Example 2) prepared according to Formulation Example 2, and a bendiocarb WP (Reference Example 1)
Wall material: Wood, Tile, and Cernent
Insect tested: Anopheles gambiae, Kisumu strain
Treatment method: In October, a diluted solution of the above formulation was sprayed on each of the wall materials with a tower sprayer so as to reach a prescrîbed dosage, and after drying the material was stored in a thennostatic chamber at a température of 30 X? and a humidity of 80%.
Insecticidal test: A standard WHO plastic cône was placed on the treated wall material, and female adults of Anopheles gambiae were placed therein and covered. After exposure for 3 min, the Anopheles gambiae were transferred to a separate container, and after 24 hours, the viability was examined and the mortality was calculated. This was iterated from November to the next April to evaluate the residual effectiveness (in triplicate).
[0082] The results are shown in Table I.
[0083]
[Table 1]
Wall material: Wood | Mortalitv (%) | ||||||
November | December | Expo sure timing | Mardi | March/April | |||
Reagents tested | Dosage | Januarv | Febniary | ||||
Wettable powder | 0.025 g a.i./m: | 86.67 | 67.58 | 96.97 | 100 | 76.67 | 93.94 |
0.05 g a.i./nf | 83.33 | 96.67 | 93.94 | 100 | 100 | 100 | |
0.1 g a.i./m2 | 88.57 | 100 | 100 | 100 | 100 | 100 | |
0.2 g a.i./m2 | 92.96 | 100 | 100 | 100 | 100 | 100 | |
Bendiocarb WP Négative Control | 0.4 g a.i./m2 | 100 8.16 | 83.3 6.67 | 23.33 20.37 | 3.33 21.11 | 10 | 0 |
Wall material: Tile | Mortality (%) | ||||||
November | December | Exposure timing | March | March/April | |||
Reagents tested | Dosage | January | Febniary | ||||
Wettable powder | 0.025 g a.i./m2 | 96.67 | 100 | 96.67 | 100 | 100 | 100 |
0.05 g a.i./m2 | 100 | 100 | 100 | 100 | 100 | 100 | |
0.1 g a.i./m2 | 100 | 100 | 100 | 100 | 100 | 100 | |
0.2 g a.i./nr | 100 | 100 | 100 | 100 | 100 | 100 | |
Bendiocarb WP Négative Control | 0.4 g a.i./m2 | 100 10 | 100 3.33 | 73.06 5.81 | 35.19 3.33 | 3.33 | 0 |
Wall material: Cernent | Mortalitv (%) | ||||||
November | December | Exposure timing | March | March/April | |||
Reagents tested | Dosage | Januarv | Febniary | ||||
Wettable powder | 0.025 g a.i./m2 | 96.3 | 100 | 100 | 100 | 100 | 100 |
0.05 g a.i./m2 | 100 | 100 | 100 | 100 | 100 | 100 | |
0.1 g a.i./m2 | 100 | 100 | 100 | 100 | 100 | 100 | |
0.2 g a.î./m2 | 100 | 100 | 100 | 100 | 100 | 100 | |
Bendiocarb WP Négative Control | 0.4 g a.i./m2 | 100 27.78 | 82.75 16.67 | 11.11 2.22 | 7.41 14.14 | 10 | 12.27 |
[0084] <Test Example 2>
Residual effectiveness test with respect to Culex pipiens molestus
Formulation tested: A flowable (Example 6) prepared according to Formulation
Example 6, and ICON 10 CS (Reference Example 2, comparator lambda-cyhalothrin) Wall material: Fancy plywood, plywood, cernent, and sun-dried brick
Insect tested: Culex pipiens molestus
Treatment method: A diluted solution of the above formulation in an amount of 7 mL was sprayed on each of the wall materials with a tower sprayer, and after drying the material was stored in a thennostatic chamber at a température of 25 U and a humidity of 60%.
Insecticidal test: A plastic cup was placed on the wall material, and female adults of Culex pipiens molestus were placed therein and covered. After exposing for 30 min, Culex pipiens molestus were transferred to a separate plastic cup, and after 24 hours, the viabilïty was examined and the mortality was calculated (in duplicate).
[0085] The results are shown in Table 2.
[0086]
[Table 2]
Wall material: Fancy plywood | Mortality (%) | |||||||
3 | 28 | Days after treatment | 210 | 270 | ||||
Reagents tested | Dosage | 60 | 90 | 150 | ||||
Flowable | 0.03 g a.i./m2 | 100.0 | 100,0 | 88.9 | 100.0 | 90.0 | 80.0 | 100.0 |
0.1 ga.i./nf | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | |
0.3 g a.i./m2 | 100.0 | 90.0 | 100.0 | 100.0 | 90.0 | 100.0 | 100.0 | |
ICON 10CS | 0.03 g a.i./m1 | lOD.O | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 |
Négative Control | 0.0 | 0.0 | 10.0 | 0.0 | 0.0 | 0.0 | 0.0 |
Wall material: Plywood | Mortality (%) | |
Days after treatment 3 28 60 90 150 210 270 | ||
Reagents tested | Dosage | |
Flowable | 0.03 g a.i./m3 0.1 g a.i./m3 0.3 g a.i./m3 | 63.6 50.0 30.0 80.0 50.0 40.0 90.9 100.0 80.0 100.0 90.0 90.0 70.0 100.0 88.9 100.0 100.0 90.0 100.0 100.0 |
ICON 10CS Négative Control | 0.03 g a.i./m3 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 0.0 0.0 10.0 0.0 0.0 0.0 0.0 |
Wall material: Cernent | Mortality (%) | |||||||
3 | 28 | Days after treatment | 210 | 270 | ||||
Rcagents tested | Dosage | 60 | 90 | 150 | ||||
Flowable | 0.03 g a.i./m2 | 100.0 | 88.9 | 100.0 | 100.0 | 40.0 | 20.0 | - |
0.1 ga.î./m3 | 100.0 | 100.0 | 100.0 | 100.0 | 90.0 | 100.0 | 100.0 | |
0.3 g a.i./m3 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | |
ICON I0CS | 0.03 g a.i./m3 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 |
Négative Control | 0.0 | 0.0 | 10.0 | 0.0 | 0.0 | 0.0 | 0.0 |
Wall material: Sun-dried brick | Mortality (%) | |||||||
3 | 28 | Days after treatment | 210 | 270 | ||||
Reagents tested | Dosage | 60 | 90 | 150 | ||||
Flowable | 0.03 g a.i./m2 | 100.0 | 55.6 | 20.0 | 10.0 | 10.0 | 0.0 | - |
0.1 g a.î./m3 | 100.0 | 100.0 | 100.0 | 90.0 | 30.0 | 20.0 | - | |
0.3 g a.i./nt3 | 100.0 | 100.0 | 100.0 | 100.0 | 90.0 | 100.0 | 100.0 | |
ICON I0CS | 0.03 g a.i./m3 | 90.0 | 87.5 | 90.0 | 100.0 | 80.0 | 80.0 | 50.0 |
Négative Control | 0.0 | 0.0 | 10.0 | 0.0 | 0.0 | 0.0 | 0.0 |
[0087] <Test Example 3>
Mosquito net immersion test with respect to Anophelesgambiae
Formulation tested: The flowable (Example 5) prepared according to Formulation
Example 5, and PERMANET 2.0 (Reference Example 3, Deltamethrin)
Insect tested: Anophelesgambiae Kisumu strain
Treatment method: A polyester net was immersed in the diluted solution of the above formulation, and dried.
Insecticidal test: A standard WHO plastic cône was placed on the net, and female adults of 15 Anopheles gambiae were released therein for exposure. After the exposure duration of 3 min or 20 min, Anopheles gambiae were transferred to a separate container, and each time after 1, 24, 48, and 72 hours, the knocked-down (KD) number was examined and the KD rate was calculated (in triplicate).
[0088] The results are shown in Table 3.
[0089]
[Table 3]
Exposure duration: 3 min | KD rate (%) | ||||
Reagents tested | Dosage | 1 h | 24 h | 48 h | 72 h |
Wettable powder | 10 mg a.i./m2 | 0.0 | 3.0 | 48.6 | 56.0 |
50 mg a.i./m2 | 0.0 | 15.9 | 56.4 | 80.8 | |
100 mg a.i./m2 | 0.0 | 48.5 | 78.8 | 93.9 | |
500 mg a.i./m2 | 0.0 | 84.2 | 100.0 | 100.0 | |
Deltamethrin | 25 mg a.i./m2 | 100.0 | 100.0 | 100.0 | 96.7 |
Négative Control | 3.3 | 3.3 | 3.3 | 6.7 |
Exposure duration: 20 min | KD rate (%) | ||||
Reagents tested | Dosage | l h | 24 h | 48 h | 72 h |
Wettable powder | 10 mg a.î./nr | 0.0 | 17.5 | 46.8 | 64.5 |
50 mg a.i./m2 | 0.0 | 13.2 | 60.6 | 88.7 | |
100 mg a.i./m: | 0.0 | 61.9 | 92.2 | 100.0 | |
500 mg a.i./m2 | 0.0 | 57.6 | 91.7 | 94.4 | |
Deltamethrin | 25 mg a.i./m2 | 100.0 | 100.0 | 100.0 | 100.0 |
Négative Control | 3.7 | 6.5 | 6.5 | 13.0 |
[0090] <Test Example 4>
Indoor residual spraying (1RS) test with respect to résistant Anopheles gambiae Reagents tested: A wettable powder (Example 2) prepared according to Formulation Example 2, Bendiocarb WP (Reference Example 1), and Deltamethrin WG (Reference Example 4) Wall Material: Wood
Insect tested: Anopheles gambiae Kisumu strain, and Tiassale 2 strain
Treatment method: A diluted solution of the above formulation was sprayed on the wall material with a tower sprayer so as to reach a prescribed dosage, and dried.
Insecticidal test: A standard WHO plastic cône was placed on the treated wall material, and female adults of Anopheles gambiae were placed therein and covered. After the exposure duration of 3 min, the Anopheles gambiae were transferred to a separate container. Then, each time after 1, 24, 48, and 72 hours, the knocked-down (KD) number was examined and the KD rate was calculated (in triplicate).
[0091] The results are shown in Table 4.
[0092]
[Table 4]
Kisumu strain | KD rate (%) | ||||
Reagents tested | Dosage | l h | 24 h | 48 h | 72 h |
Wetlable powder | 0.025 g a.i./nt2 | 14.1 | 86.7 | 96.7 | 100.0 |
0.05 g a.i./m2 | 8.9 | 83.3 | 100.0 | 100.0 | |
0.I ga.i./nf | 6.7 | 88.6 | 100.0 | 100.0 | |
0.2 ga.i./m2 | 0.0 | 93.0 | 100.0 | 100.0 | |
Bendiocarb WP | 0.4 ga.i./m2 | 100.0 | 100.0 | 100.0 | 100.0 |
Deltamethrin WG | 0.025 g a.i./m2 | 100.0 | 100.0 | 100.0 | 100.0 |
Négative Control | 5.6 | 8.2 | 13.8 | 16.8 |
Tiassale 2 strain | KD rate (%) | ||||
Reagents tested | Dosage | 1 h | 24 h | 48 h | 72 h |
Wettable powder | 0.025 g a.i./m2 | 3.3 | 63.3 | 96.7 | 100.0 |
0.05 g a.i./m2 | 0.0 | 93.6 | 100.0 | 100.0 | |
0.1 ga.i./m2 | 14.4 | 81.9 | 100.0 | 100.0 | |
0.2 g a.i./m2 | 4.8 | 100.0 | 100.0 | 100.0 | |
Bendiocarb WP | 0.4 g a.i./m2 | 100.0 | 100.0 | 100.0 | 100.0 |
Deltamethrin WG | 0.025 g a.i./m2 | 70.0 | 32.8 | 48.3 | 48.3 |
Négative Control | 0.0 | 11.1 | ll.l | ll.l |
[0093] <Test Example 5>
Cross résistance test (i) Susceptibility test for each strain of Anopheles gambiae and Aedes aegypti
Reagents tested: The compound represented by Formula (2)
Insect tested: Anopheles gambiae Kisumu strain, Kisumu R.DL strain, Akron strain, and Tiassale 2 strain, and Aedes aegypti Cayman strain, and New Orléans strain
Insecticidai test: The compound represented by Formula (2) was diluted with acetone to a predetermined concentration, and applied to the thorax of female adults of the target insect using a micro-dispenser. The mortality was examined after 24 hours.
[0094] The results are shown in Table 5.
[0095]
[Table 5]
Rc agent tested | Dosage (% W/V) | Mortality after 24 hours | |
Anopheles gambiae | Aedes aegypti | ||
Kisumu Kisumu Akron Tiassale 2 RDL | Cayman New Orléans | ||
Compound represented by Formula (2) | 0.000001 0.0001 0.001 0.01 0.1 1 | 39 7 17 31 76 68 0 30 100 100 100 100 100 100 100 89 100 100 100 100 100 100 100 100 | 0 33 4 27 79 100 100 97 100 100 100 100 |
[0096] <Test Example 6>
Sensitivity test with respect to Anopheles sinensis
Reagent tested: The compound represented by Formula (2)
Insect tested: The strain of Anopheles sinensis collected in Shiga Préfecture in August 2016
Insecticidal test: The compound represented by Formula (2) was diluted with acetone to a predetermined concentration, and 0.2 pL / female was applied to the thorax of the female adult insects using a micro-dispenser. Then, each time after 1, 24, 48 and 72 hours, the knocked-down (KD) number was examined, and the KD rate was calculated (in triplicate). [0097] The results are shown in Table 6.
[0098]
[Table 6]
Reagent tested | Treatment concentration (ppm) | KD rate | |||
1 h | 24 h | 48 h | 72 h | ||
Compound represented | 0.1 | 0.0 | 0.0 | 23.3 | 20.0 |
by Formula (2) | 1 | 0.0 | 50.0 | 83.3 | 93.3 |
10 | 3.3 | 96.7 | 100.0 | 100.0 | |
No treatment | 0.0 | 0.0 | 6.7 | 16.7 |
[0099] <Test Example 7>
Indoor residual spraying (1RS) test with respect to Anopheles gambiae
Reagents tested: The wettable powder (Example 3) prepared according to Formulation Example 3, Bendiocarb WP (Reference Example 1), and Deltamethrin WG (Reference Example 4)
Wall material: Mud
Insect tested: Anopheles gambiae, Kisumu strain
Treatment method: In April, a diluted solution of the above formulation was sprayed on the wall material with a tower sprayer so as to reach a prescribed dosage, and after drying the material was stored in a thermostatic chamber at a température of 30 “C and a humidity of 80%.
Insecticidal test: A standard WHO plastic cône was placed on the treated wall material, and female adults of Anopheles gambiae were placed therein and covered. After exposure duration of 3 min, the Anopheles gambiae were transferred to a separate container, and after 24 hours, the viability was examined and the mortality was calculated. This was iterated from May to November to evaluate the residual effectiveness (in triplicate).
[0100] The results are shown in Table 7.
[0101]
[Table 7]
Wall material: Mud | Mortality (%) | |
Exposure timing May Jun. Jul. Aug. Sep. Oct. Nov. | ||
Reagents tested | Dosage | |
Wettable powder | 0.025 g a.i./m: 0.05 g a.i./m2 0.I ga.i./nr 0.2 g a.i./m: | 96.97 100 90.89 92.59 I00 100 52.22 100 97.22 96.3 100 I00 76.39 52.73 100 100 100 100 100 100 100 100 100 100 100 100 100 100 |
Bendiocarb WP Deltamethrin WG Négative Control | 0.4 g a.i./m: 0.025 g a.i./nr | 25.45 7,04 100 67.39 37.27 58.33 3.7 3.03 5.56 12,56 3.7 10.74 13.26 |
[ΟΙ 02] <Test Example 8>
Insecticidal test with respect to larvae of Culexpipiens molestus
Reagent tested: The compound represented by Formula (2)
Insect tested: Culexpipiens molestus
Insecticidal test: Into a glass tube 25 mL of water was placed, and then 250 pL of an acetone solution of the compound represented by Formula (2) was added to a predetermined concentration. Then I0 last instar larvae were released therein, and 2 days later, the viability was examined and the mortality was calculated.
As a resuit, the compound represented by Formula (2) gave a mortality of 70% or higher at 0.001 ppm.
[0103] <Test Example 9>
Mosquito net immersion test with respect to Anopheles gambiae
Compositions tested: Composition I to Composition 8 set forth in the following Table 8 Insect tested: Anophelesgambiae Kisumu strain, and a pyrethroid résistant strain Treatment method: A polyester net was immersed in the dîluted solution of the above composition, and dried.
Insecticidal test: A standard WHO plastic cône was placed on the net, and female adults of Anopheles gambiae were released therein for exposure. After the exposure duration of 3 niîn or 20 min, Anopheles gambiae were transferred to a separate container, and then each time after l, 24, 48, and 72 hours, the knocked-down (KD) number was examined and the KD rate was calculated (in triplicate).
[0104]
[Table 8]
Composition No. | Effective ingrédient | Dosage (mg a.j./m2) |
1 | Etofenprox | 500 |
2 | Deltamethrin | 55 |
3 | Alpha-Cypermethrin | 261 |
4 | Permethrin | 500 |
5 | Compound represented by Formula (2) | 200 |
6 | Compound represented by Formula (2) + Etofenprox | 200 + 500 |
7 | Compound represented by Formula (2) + Deltamethrin | 200 + 55 |
8 | Compound represented by Formula (2) + Alpha-Cypermethrin | 200 + 261 |
9 | Compound represented by Formula (2) + Permethrin | 200 + 500 |
[ΟΙ 05] In Test Example 9, the mosquîto net treated with a mixed composition (compositions to 9 in Table 8) exhibited a significantly high insecticidal effect over the control 5 (compositions l to 5 in Table 8).
[0I06] The entire contents of the dîsclosures by Japanese Patent Application No. 2016-003657 filed on 12 January 2016 are incorporated herein by reference.
Ail the literature, patent application, and technical standards cited herein are also herein incorporated to the same extern as provided for specifically and severally with respect 10 to an individual literature, patent application, and technical standard to the effect that the same should be so incorporated by reference.
Industrial Applîcability
[0107] Since the composition according to the embodiment has long-term residual activity, and is also effective for a résistant insect pest, its industrial appticability is high.
Claims (19)
- CLAIMS [Claim l] A hematophagous arthropod control method of treating a living space forming element with a hematophagous arthropod control composition for treating a living space forming element, the composition comprising, as an effective ingrédient, at least one amide dérivative represented by the following Formula ( I ):wherein, in Formula (I), Q represents a phenyl group or a phenyl group substituted with a fluorine atom, R represents a hydrogen atom or a methyl group, and Yi and Y2 each independently represents a bromine atom, an iodine atom, or a trifluoromethyl group.
- [Claim 2] The hematophagous arthropod control method according to claim l, wherein the amide dérivative represented by Formula (I) is 2-fhioro-3-(7V-methy[benzamido)-jV-(2-bromo-6-trifhioromethyl-4-(heptafluoropropan-2-yl)p henyl)benzamide.
- [Claim 3] The hematophagous arthropod control method according to claim l or 2, wherein the living space forming element is a house wall or a mosquito net.
- [Claim 4] The hematophagous arthropod control method according to any one of daims l to 3, wherein the method of treating the living space forming element is a spraying treatment or an immersion treatment.
- [Claim 5] The hematophagous arthropod control method according to any one of daims I to 4, wherein the hematophagous arthropod to be controlled is at least one selected from the group consisting of an insect of the genus Anopheles, an insect of the genus Aedes, and an insect of the genus Cidex, which bdong to the family Culicidae of the order Diptera.
- [Claim 6] The hematophagous arthropod control method according to daim 5, wherein the insect of the family Culicidae of the order Diptera is an insect of the genus Anopheles.
- [Claim 7] The hematophagous arthropod control method according to claim 5 or 6, wherein insects of the genus Anopheles are at least one of Anopheles gambiae or Anopheles sinensis.
- [Claim 8] The hematophagous arthropod control method according to any one of claims l to 7, wherein the composition further comprises, as an effective ingrédient, at least one compound selected from the group consisting of permethrin, alpha-cypermethrin, deltamethrin, and etofenprox.
- [Claim 9] The hematophagous arthropod control method according to any one of claims l to 8, wherein the composition is a wettable powder or a flowable.
- [Claim 10] A hematophagous arthropod control composition to be used for the hematophagous arthropod control method according to any one of claims 1 to 9.
- [Claim 11] The hematophagous arthropod control composition according to claim 10 used for treating a living space forming element.
- [Claim 12] A hematophagous arthropod control composition for treating a living space forming element, the composition comprising, as an effective ingrédient, at least one amide derivatîve represented by the following Formula (1):wherein, in Formula (I), Q represents a phenyl group or a phenyl group substituted with a fluorine atom, R represents a hydrogen atom or a methyl group, and Yi and Y2 each independently represents a bromine atom, an iodine atom, or a trifluoromethyl group,
- [Claim 13] The hematophagous arthropod control composition for treating a living space forming element according to claim 12, wherein the amide dérivative represented by Formula (1) is2-fliioro-3-(jV-methylbenzamido)-/V-(2-bromo-6-trifluoromethyl-4-(heptafluoropropan’2-yl)p henyl)benzamide.
- [Claim 14] The hematophagous arthropod control composition for treating a living space forming element according to claim 12 or 13, used for treating a house wall or a mosquito net as the living space forming element.
- [Claim 15] The hematophagous arthropod control composition for treating a living space forming element according to any one of claims 12 to I4 used for controlling at least one selected from the group consisting of an insect of the genus Anopheles, an insect of the genus Aedes, and an insect of the genus Ctdex, which belong to the family Culicidae of the 5 order Diptera as a hematophagous arthropod.
- [Claim 16] The hematophagous arthropod control composition for treating a living space forming element according to claim 15, wherein the insect of the family Cnlicidae of the order Diptera is an insect of the genus Anopheles.
- [Claim 17] The hematophagous arthropod control composition for treating a living 10 space forming element according to claim 15 or 16, wherein the insect of the genus Anopheles is at least one of Anopheles gambiae or Anopheles sinensis.
- [Claim 18] The hematophagous arthropod control composition for treating a living space forming element according to any one of claims 12 to 17, further comprising, as an effective ingrédient, at least one compound selected from the group consisting of permethrin, 15 alpha-cypennethrin, deltamethrin, and etofenprox.
- [Claim 19] The hematophagous arthropod control composition for treating a living space forming element according to any one of claims 12 to 18, which is a wettable powder or a flowable.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2016-003657 | 2016-01-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
OA18822A true OA18822A (en) | 2019-07-19 |
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